Journal de pharmacologie最新文献_第10页

[Calmodulin and the effect of calcium antagonists]. 钙调素和钙拮抗剂的作用。

Journal de pharmacologie Pub Date : 1985-10-01

J C Stoclet

引用次数: 0

Therapeutic application of iron chelators--present state and research trends. 铁螯合剂的治疗应用——现状及研究趋势。

Journal de pharmacologie Pub Date : 1985-10-01

H H Peter

引用次数: 0

Activators and inactivators of Ca++ channels: new perspectives. Ca++通道的激活剂和失活剂:新视角。

Journal de pharmacologie Pub Date : 1985-10-01

M Spedding

引用次数: 0

[Association des Pharmacologistes. Grenoble, 25-26 April 1985. Abstracts]. [药理学家协会，格勒诺布尔，1985年4月25日至26日。摘要]。

Journal de pharmacologie Pub Date : 1985-10-01

引用次数: 0

Solubilization and characterization of [3H] 5HT high affinity binding sites (5HT1 and 5HT3). [3H] 5HT高亲和结合位点(5HT1和5HT3)的增溶和表征。

Journal de pharmacologie Pub Date : 1985-10-01

J C Rousselle, G Gillet, G Fillion

{"title":"Solubilization and characterization of [3H] 5HT high affinity binding sites (5HT1 and 5HT3).","authors":"J C Rousselle, G Gillet, G Fillion","doi":"","DOIUrl":"","url":null,"abstract":"The solubilization of the serotonergic 5HT1 and 5HT3 sites was performed with digitonin and sodium cholate at 1% (final concentration). Two binding sites for [3H]5HT were observed on rat or horse brain synaptosomal membranes solubilized with these detergents. The corresponding dissociation constants (KD) were 1-3 nM and 13-30 nM respectively. These values were closely similar to those corresponding to 5HT1 and 5HT3 sites located in intact membranes. The solubilized sites specifically bound 5HT. The effect of GTP decreasing the binding to 5HT1 sites was lost on solubilized 5HT1 sites; it was recovered, however, by addition of phospholipids (asolectin 0,2%). The apparent molecular weights of these sites were determined using the gel filtration method (438 and 235 K daltons). The photoactivation of [3H]5HT by U.V. light was used to label 5HT1 and 5HT3 sites irreversively in membranes. The binding of [3H]5HT following U.V. irradiation was not dissociated after dilution; it was saturable and prevented by serotonergic drugs and not by adrenergic or dopaminergic antagonists. Moreover, GTP added prior to the irradiation reduced it markedly thus showing that 5HT1 sites were labelled. Electrophoretic and fluorographic analyses of the labelled material evidenced a 60 K dalton-band specifically labelled with [3H]5HT (5 or 20 nM). These results tend to indicate that the 60 K dalton-proteic band might represent a proteic subunit constituting part of 5HT1 and 5HT3 sites.","PeriodicalId":14817,"journal":{"name":"Journal de pharmacologie","volume":"16 4","pages":"421-38"},"PeriodicalIF":0.0,"publicationDate":"1985-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15206590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary vasodilation and positive inotropic effect of non steroidal cardiotonics. 非甾体强心剂的冠状血管舒张和正性肌力作用。

Journal de pharmacologie Pub Date : 1985-10-01

N Decker, M Grima, J Schwartz

引用次数: 0

[Inhibition of degranulation of human basophils by calcium antagonists]. 钙拮抗剂对人嗜碱性细胞脱颗粒的抑制作用。

Journal de pharmacologie Pub Date : 1985-10-01

C Frisch, F Leynadier, A Nassar, J Dry

{"title":"[Inhibition of degranulation of human basophils by calcium antagonists].","authors":"C Frisch, F Leynadier, A Nassar, J Dry","doi":"","DOIUrl":"","url":null,"abstract":"The human basophil degranulation test (HBDT) quantifies the apparent disappearance of basophils after contact with the sensitizing allergen. The inhibition of degranulation by pharmacological products can be appreciated by incubating beforehand the basophils with the substance concerned during various times. The inhibitory effect is evaluated by the difference of degranulation with or without it. EDTA, sodium cromoglycate, verapamil and bepridil have been tested at different concentrations and at 3 times of basophils preincubation (0,15 and 30 minutes). Results obtained confirm previous reports concerning cromoglycate which didn't inhibit degranulation of basophils. EDTA at 3.4*10(-2)M and 3.4*10(-3)M concentration has an inhibitory effect, not increasing with the time of preincubation. The inhibition with verapamil is of the same order at 1*10(-4)M for the 3 times of incubation and weaker, but significant, at 1*10-M5 after 30 minutes of preincubation. Bepridil inhibits at 1*10(-4)M, but this effect disappears if basophils are preincubated 30 minutes with the drug. The inhibition of the specific basophil degranulation by these drugs is probably du to their calcium antagonist property. However their effect is not quite similar when cells are preincubated at different times with the drug. On the other hand, one can study with HBDT the inhibitory effect of a new product, even if the therapeutic indications would have to be studied afterwards.","PeriodicalId":14817,"journal":{"name":"Journal de pharmacologie","volume":"16 4","pages":"381-90"},"PeriodicalIF":0.0,"publicationDate":"1985-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15052215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat]. [劳巴辛和四氢alstonine对大鼠交感神经刺激和静脉注射去甲肾上腺素的血管加压反应的差异抑制]。

Journal de pharmacologie Pub Date : 1985-10-01

J Roquebert, P Demichel, P Dufour

{"title":"[Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat].","authors":"J Roquebert, P Demichel, P Dufour","doi":"","DOIUrl":"","url":null,"abstract":"The effects of raubasine and tetrahydroalstonine (THA) on the vasopressor response to sympathetic nerve stimulation and to i.v. administration of noradrenaline were studied in the pithed rat to ascertain whether raubasine and THA would preferentially block pressor responses due to exogenous versus endogenous noradrenaline alpha-adrenergic receptor activation. Raubasine (0.5 to 4 mg/kg i.v.) was more effective in blocking the response due to sympathetic nerve stimulation than that due to i.v. noradrenaline. On the other hand THA (0.5 to 4 mg/kg i.v.) produced greater inhibition of the i.v. noradrenaline response than the sympathetic nerve stimulation response. THA (0.5, 1, 2 mg/kg i.v.) enhanced the nerve stimulation response, while at the 4 mg/kg dose the response was slightly reduced. This may be explained by a preferential block by THA at low doses, of presynaptic alpha 2-adrenoceptors. In pithed rat raubasine and THA showed dose-related blocking effects on the pressor response of phenylephrine and B-HT 933, respectively. This suggest that raubasine preferentially blocks alpha-1 and THA alpha 2-adrenoceptors. The results suggest that raubasine and THA preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to endogenous and exogenous noradrenaline, respectively.","PeriodicalId":14817,"journal":{"name":"Journal de pharmacologie","volume":"16 4","pages":"412-20"},"PeriodicalIF":0.0,"publicationDate":"1985-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14005689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of iron in infection and neoplasia. 铁在感染和肿瘤中的作用。

Journal de pharmacologie Pub Date : 1985-10-01

E D Weinberg

引用次数: 0

Modulation of action of kainic acid on the behavior of rats by p-chlorophenylalanine and by gaba-mimetic drugs. Biochemical correlation between behavior and treatments. 对氯苯丙氨酸和gaba类药物对桂酸对大鼠行为的调节作用。行为与治疗的生化相关性。

Journal de pharmacologie Pub Date : 1985-07-01

C Molla-Hosseini, P M Lenicque, J Wepierre, Y Cohen

{"title":"Modulation of action of kainic acid on the behavior of rats by p-chlorophenylalanine and by gaba-mimetic drugs. Biochemical correlation between behavior and treatments.","authors":"C Molla-Hosseini, P M Lenicque, J Wepierre, Y Cohen","doi":"","DOIUrl":"","url":null,"abstract":"Systemic injection of kainic acid (KA, 11 mg/kg i.p.) to male albino Sprague-Dawley rats produced a sequence of behavioral events: stereotypies, convulsions, aphagia and aggressiveness in the form of sparring at artificial night fall, as well as a decline in brain-Gaba and brain-dopamine (DA)-levels followed by an increase in DA-levels on days 6 and 10 after treatment. No notable variations in serotonin (5-HT) was observed. Pretreatments of rats with GABA-mimetic drugs (gamma-vinyl GABA, 900 mg/kg i.p.; THIP, 1 microgram/1 microliter/rat, i.c.v.) prevented the occurrence of convulsion, aphagia and aggressiveness. Systemic injection of p-chlorophenylalanine (PCPA) (300 mg/kg i.p.) induced aggressiveness in the form of sparring at night fall. Treatment with PCPA followed by injection of KA shifted mild aggressive behavior to a violent one in the form of biting and killing familiar rats. The findings suggest that KA-neurotoxicity is due in part to its effects on GABA- and DA-neurotransmissions. It is shown also that convulsions are induced by a decline in GABA-level while sparring is provoked by an enhancement in DA-level. Violent aggressiveness is induced by the additive disruptive effects on GABA- and 5-HT-neurotransmissions in PCPA + KA treated animals.","PeriodicalId":14817,"journal":{"name":"Journal de pharmacologie","volume":"16 3","pages":"299-312"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14068477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0