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Japanese journal of medicine最新文献

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Post transplanted infective endocarditis. 移植后感染性心内膜炎。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.458
M Masutani, K Ikeoka, R Sasaki, S Nagasawa, S Kawashima, Y Mitani, K Fujitani, T Iwasaki, Y Sawada, K Uematsu
{"title":"Post transplanted infective endocarditis.","authors":"M Masutani,&nbsp;K Ikeoka,&nbsp;R Sasaki,&nbsp;S Nagasawa,&nbsp;S Kawashima,&nbsp;Y Mitani,&nbsp;K Fujitani,&nbsp;T Iwasaki,&nbsp;Y Sawada,&nbsp;K Uematsu","doi":"10.2169/internalmedicine1962.30.458","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.458","url":null,"abstract":"<p><p>The patient, a 51-year-old man, was receiving immunosuppressants for 2 yr after renal allotransplantation. He had heart failure with aortic regurgitation, fever, anemia and a history of odontectomy on admission. He was resistant to medical treatments and died from cerebral emboli. On autopsy, vegetation of the aortic valve was identified. Progression of atherosclerosis, which may have been due to steroids and chronic rejection, was prominent. This report is the first case of infective endocarditis following organ transplantation in Japan. Such complications as infective endocarditis and atherosclerosis will be on the rise with the increase of numbers or organ transplantations.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"458-63"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Cytokines cast new insight into myeloma therapy. 细胞因子为骨髓瘤治疗提供了新的见解。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.395
A Kuramoto
{"title":"Cytokines cast new insight into myeloma therapy.","authors":"A Kuramoto","doi":"10.2169/internalmedicine1962.30.395","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.395","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"395"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of interleukin 2 (IL-2) and responsiveness to IL-2 of peripheral blood lymphocytes in minimal change nephrotic syndrome. 微小变化肾病综合征外周血淋巴细胞白细胞介素2 (IL-2)的产生和对IL-2的反应。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.396
K Dohi, H Morita, S Ogawa, T Hirayama, H Yamada, H Ishikawa
{"title":"Production of interleukin 2 (IL-2) and responsiveness to IL-2 of peripheral blood lymphocytes in minimal change nephrotic syndrome.","authors":"K Dohi,&nbsp;H Morita,&nbsp;S Ogawa,&nbsp;T Hirayama,&nbsp;H Yamada,&nbsp;H Ishikawa","doi":"10.2169/internalmedicine1962.30.396","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.396","url":null,"abstract":"<p><p>We investigated the role cell-mediated immunity in minimal change nephrotic syndrome (MCNS) by measuring interleukin 2 (IL-2) production and the responsiveness to IL-2 of peripheral blood lymphocytes (PBL). PBL from patients with MCNS, who were in the nephrotic stage prior to initiation of prednisolone (PSL) treatment or who were in remission for less than 1 yr, exhibited significantly lower levels of IL-2 production. In contrast, PBL from patients with MCNS, who were in remission for more than 1 yr or who could remit from the PSL regimen, showed normal IL-2 production. IL-2 production by CD4+ cells from patients with MCNS in the nephrotic stage was normal, but that by CD8+ cells was markedly reduced, however returned to normal when the disease was in remission. The responsiveness to exogenous IL-2 of concanavalin A-induced lymphoblasts from patients with MCNS was significantly lower, although the proportion of Tac antigen-positive cells did not differ from that of healthy volunteers. These findings suggest that defective IL-2 production and IL-2 responsiveness of PBL in patients with MCNS contribute to the pathogenesis of MCNS.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"396-401"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The tissue thromboplastin inhibition test in diabetics without cerebro-cardiovascular diseases. 无脑血管疾病的糖尿病患者组织凝血活素抑制试验。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.408
O Mizuno
{"title":"The tissue thromboplastin inhibition test in diabetics without cerebro-cardiovascular diseases.","authors":"O Mizuno","doi":"10.2169/internalmedicine1962.30.408","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.408","url":null,"abstract":"<p><p>In 45 patients with diabetes mellitus (DM) without cerebro-cardiovascular diseases (CCVD) the modified method of the tissue thromboplastin inhibition test (TTIT) was studied. TTIT is the method of detection of the lupus anticoagulant (LA), LA, first recognized in patients with systemic lupus erythematosus, is presented by a prolonged activated partial thromboplastin time (APTT), a slightly to moderately prolonged prothrombin time (PT), and high incidence of biological false-positive seroreactions for syphilis (BFP). In patients with LA, thrombotic events have been reported. Six of the 45 diabetic patients were TTIT-positive (13.3%). All control subjects were TTIT-negative. In the TTIT-positive diabetics APTT and PT were normal. BFP also were not observed. The difference between LA and these results in TTIT-positive diabetics remains unclear. Clinical profiles except for duration of DM between the TTIT-negative and TTIT-positive diabetics did not differ. Follow-up studies may resolve an association between the results of TTIT and DM.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"408-11"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral neuropathy associated with Sjögren's syndrome: pathologic and immunologic study of two patients. 与Sjögren综合征相关的周围神经病变:两例患者的病理和免疫学研究。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.452
A Inoue, C S Koh, N Tsukada, N Yanagisawa
{"title":"Peripheral neuropathy associated with Sjögren's syndrome: pathologic and immunologic study of two patients.","authors":"A Inoue,&nbsp;C S Koh,&nbsp;N Tsukada,&nbsp;N Yanagisawa","doi":"10.2169/internalmedicine1962.30.452","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.452","url":null,"abstract":"<p><p>Two cases of Sjögren's syndrome accompanied by peripheral neuropathy are reported. The level of anti-endothelial cell antibody was increased in both patients. Immunofluorescent deposits of immunoglobulin and C3 component were detected in the vasa nervorum of both cases. The pathological findings showed damage to the endothelial cells in the same vessels. The findings suggest that injury from immune complex and anti-endothelial cell antibody may be the immunological factor in the induction of peripheral neuropathy.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"452-7"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12831767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Alcoholic hepatitis with hyperleukocytosis. 酒精性肝炎伴白细胞增多。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.473
Y Koyama, M Imoto, Y Fukuda, I Nakano, M Hattori, F Urano, D A Muzzillo, D Nishimura, K Kato, M Kanzaki
{"title":"Alcoholic hepatitis with hyperleukocytosis.","authors":"Y Koyama,&nbsp;M Imoto,&nbsp;Y Fukuda,&nbsp;I Nakano,&nbsp;M Hattori,&nbsp;F Urano,&nbsp;D A Muzzillo,&nbsp;D Nishimura,&nbsp;K Kato,&nbsp;M Kanzaki","doi":"10.2169/internalmedicine1962.30.473","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.473","url":null,"abstract":"<p><p>We report a fatal case of alcoholic hepatitis with hyperleukocytosis mainly consisting of mature granulocytes in a 43-year-old woman. White blood cell count was increased in parallel with clinical deterioration to 54,800/mm3 with no immature neutrophils on a differential count. The bone marrow aspirate revealed normal maturation and no evidence of hematological malignancy. It has been postulated that severe leukocytosis accompanied by alcoholic hepatitis may be provoked by release of high levels of colony stimulating factor from damaged hepatic cells. However, the present patient showed a normal level of serum granulocyte colony stimulating factor, and could not prove the above assumption.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"473-6"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12888831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The in vitro effect of vincristine on the blast cell renewal in acute myeloblastic leukemia. 长春新碱对急性髓母细胞白血病细胞更新的体外影响。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.412
Y Yamashita, S Tohda, K Nagata, T Suzuki, Y Imai, N Nara
{"title":"The in vitro effect of vincristine on the blast cell renewal in acute myeloblastic leukemia.","authors":"Y Yamashita,&nbsp;S Tohda,&nbsp;K Nagata,&nbsp;T Suzuki,&nbsp;Y Imai,&nbsp;N Nara","doi":"10.2169/internalmedicine1962.30.412","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.412","url":null,"abstract":"The goal of chemotherapy for acute myeloblastic leukemia (AML) may only be achieved by eradicating the self-renewal capacity of the blast progenitors. In this regard, chemotherapeutic drugs should be screened according to their effects against self-renewal. The present report was aimed to study the effect of the vinca alkaloid, vincristine (VCR), on the terminal divisions and self-renewal of the blast progenitors. A primary colony assay was utilized to reflect the former and a secondary colony assay and suspension culture to reflect the latter in AML patients. The results indicated that in many of the cases studied, VCR was considered to be almost equally toxic to terminal divisions and self-renewal of the blast progenitors. An almost equivalent cytotoxicity of VCR was also noted against normal hematopoietic cells, assessed by colony-forming unit granulocyte-macrophage (CFU-GM) assay. This study suggested that successful chemotherapy with VCR may be more easily achieved in combination with other drugs that are highly inhibitory to the self-renewal of the blast progenitors.","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"412-9"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic significance of serum angiotensin-converting enzyme activity in biochemical tests with special reference of chronic liver diseases. 血清血管紧张素转换酶活性生化检测对慢性肝病的诊断意义。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.402
T Sakata, N Takenaga, T Endoh, O Wada, K Matsuki
{"title":"Diagnostic significance of serum angiotensin-converting enzyme activity in biochemical tests with special reference of chronic liver diseases.","authors":"T Sakata,&nbsp;N Takenaga,&nbsp;T Endoh,&nbsp;O Wada,&nbsp;K Matsuki","doi":"10.2169/internalmedicine1962.30.402","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.402","url":null,"abstract":"<p><p>To assess the degree of the differential ability of serum angiotensin-converting enzyme (ACE) activity as compared with 13 conventional biochemical tests, we studied 76 healthy subjects and 107 patients with chronic liver diseases. It was found that the mean values of serum ACE activity were significantly different between the healthy group and groups with liver disease. According to discriminant function analysis, the diagnostic accuracy reached 82.2% in 14 tests. In order to analyze the extent of contribution of each test to the entire diagnostic accuracy, we made an indicator of the relative decrease rate expressed as a percentage, which is 100-100 x (13-test diagnostic accuracy less one test/14-test diagnostic accuracy). The relative decrease rate of serum ACE activity was 11.4%, the largest in value. In conclusion, serum ACE activity may be one of the best discriminators to characterize chronic liver disease.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"402-7"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12831764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Multiple pulmonary nodules caused by zygomycosis in a patient without predisposing factors. 无易感因素之接合菌病致多发性肺结节。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.435
T Kutsuzawa, Y Matsuura, H Sakuma, H Narimatsu, Y Ohta, H Yamabayashi
{"title":"Multiple pulmonary nodules caused by zygomycosis in a patient without predisposing factors.","authors":"T Kutsuzawa,&nbsp;Y Matsuura,&nbsp;H Sakuma,&nbsp;H Narimatsu,&nbsp;Y Ohta,&nbsp;H Yamabayashi","doi":"10.2169/internalmedicine1962.30.435","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.435","url":null,"abstract":"<p><p>We report a case of a 61-year-old male without any predisposing factors. His X-ray film showed multiple nodular lesions in bilateral lung fields. Open lung biopsy revealed Zygomycetes in the granuloma. The patient was treated with amphotericin B and miconazole, and remains alive more than 32 months later.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"435-7"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Multiple myeloma with coexistent myelofibrosis: improvement of myelofibrosis following recovery from multiple myeloma after treatment with melphalan and prednisolone. 多发性骨髓瘤伴骨髓纤维化:多发性骨髓瘤经美伐兰和强的松龙治疗后，骨髓纤维化改善。
Japanese journal of medicine Pub Date : 1991-09-01 DOI: 10.2169/internalmedicine1962.30.483
K Kawauchi, H Mori, H Sugiyama, K Oshimi, A Hirayama
{"title":"Multiple myeloma with coexistent myelofibrosis: improvement of myelofibrosis following recovery from multiple myeloma after treatment with melphalan and prednisolone.","authors":"K Kawauchi,&nbsp;H Mori,&nbsp;H Sugiyama,&nbsp;K Oshimi,&nbsp;A Hirayama","doi":"10.2169/internalmedicine1962.30.483","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.483","url":null,"abstract":"We describe a case of multiple myeloma associated with myelofibrosis. This patient had hepatosplenomegaly, moderate anemia with anisocytosis and nucleated red blood cells, and Bence-Jones protein (kappa) in the urine. A bone marrow biopsy showed extensive marrow fibrosis and proliferation of numerous immature plasma cells containing kappa light chain in the cytoplasm. Melphalan-prednisolone therapy not only facilitated the disappearance of the immature plasma cells but also resulted in an improvement of myelofibrosis in the bone marrow. The immature plasma cell proliferation and marrow fibrosis in the bone marrow were seen again after interruption of chemotherapy. Therefore, this myelofibrosis may be secondary to the coexistent multiple myeloma.","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 5","pages":"483-6"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12965292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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