发布求助
文献互助 智能选刊 最新文献

Japanese journal of medicine最新文献

筛选
英文 中文
Clinical evaluation of newly developed antihypertensive drugs. 新型降压药的临床评价。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.491
K Yoshinaga
{"title":"Clinical evaluation of newly developed antihypertensive drugs.","authors":"K Yoshinaga","doi":"10.2169/internalmedicine1962.30.491","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.491","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"491"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A specific binding site for lipoproteins containing apolipoprotein A-I on human hepatoma cell line HepG2. 人肝癌细胞系HepG2上含有载脂蛋白A- i的脂蛋白的特异性结合位点。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.524
S Ueno, S Kobori, M Ide, K Suzaki, H Takeda, S Horiuchi, M Shichiri
{"title":"A specific binding site for lipoproteins containing apolipoprotein A-I on human hepatoma cell line HepG2.","authors":"S Ueno,&nbsp;S Kobori,&nbsp;M Ide,&nbsp;K Suzaki,&nbsp;H Takeda,&nbsp;S Horiuchi,&nbsp;M Shichiri","doi":"10.2169/internalmedicine1962.30.524","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.524","url":null,"abstract":"<p><p>Interactions of lipoproteins containing apolipoprotein (apo) A-I with or without apoA-II with human hepatoma cell line HepG2 were studied to investigate the ligand specificity for high density lipoprotein receptor on human hepatic cells and their metabolism. The two types of lipoproteins were isolated by immunoaffinity chromatography, in which apoE-containing lipoproteins were removed. Specific binding kinetics at 0 degrees C were observed for the apoA-I-containing lipoproteins with or without apoA-II (Kd = 18 or 20 micrograms protein/ml, Bmax = 110 or 120 ng/mg cell protein, respectively). The binding of these lipoproteins to HepG2 cells was competitively inhibited by excess unlabeled apoA-I-containing lipoproteins or apoA-I-phospholipid complexes, but not by apoA-II.phospholipid complexes. Interactions of these lipoproteins with HepG2 cells at 37 degrees C were further examined. These results suggested that HepG2 cells have a specific binding site for apoA-I-containing lipoproteins, and that apoA-I might be a crucial component in the binding of these lipoproteins to human hepatic cells.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"524-33"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.524","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12830934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Interleukin-2 and its receptor in adult T cell leukemia. 白细胞介素-2及其受体在成人T细胞白血病中的作用。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.602
T Uchiyama
{"title":"Interleukin-2 and its receptor in adult T cell leukemia.","authors":"T Uchiyama","doi":"10.2169/internalmedicine1962.30.602","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.602","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"602-6"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
HTLV-I-associated myelopathy (HAM) in Tokushima Prefecture--geographical and clinical studies in an area between endemic and non-endemic areas of HTLV-I infection. 德岛县htlv - 1相关脊髓病(HAM)——htlv - 1感染流行区和非流行区之间地区的地理和临床研究
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.534
H Kawai, Y Nishida, Y Sano, M Takagi, M Mizobuchi, M Miyake, S Kashiwagi, T Naruo, T Inui, K Masuda
{"title":"HTLV-I-associated myelopathy (HAM) in Tokushima Prefecture--geographical and clinical studies in an area between endemic and non-endemic areas of HTLV-I infection.","authors":"H Kawai,&nbsp;Y Nishida,&nbsp;Y Sano,&nbsp;M Takagi,&nbsp;M Mizobuchi,&nbsp;M Miyake,&nbsp;S Kashiwagi,&nbsp;T Naruo,&nbsp;T Inui,&nbsp;K Masuda","doi":"10.2169/internalmedicine1962.30.534","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.534","url":null,"abstract":"The geographic distribution and clinical features of patients with HTLV-I-associated myelopathy (HAM) in Tokushima prefecture were investigated. Nine patients were found prior to December 1990. The minimal prevalence was estimated as 1.1 per 100,000 in the general population, and 1 per 1,309 in HTLV-I-seropositive persons. Seven patients were found in the southern district facing the Pacific Ocean, but only 1 patient each was found in the northern and western districts. The age at disease onset ranged from 15 to 53 yr (average 33 yr). The ratio of male to female patients was 1:8. Adult T cell leukemia was associated with HAM in 1 patient, and Hashimoto's disease in 2 patients. These cases have not been reported previously. The route of transmission of HTLV-I was concluded to be vertical in 4 patients and horizontal in 4 patients, but was uncertain in 1 patient. No evidence of transmission by blood transfusion was found in these patients.","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"534-41"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Idiopathic acute interstitial nephritis associated with uveitis. 伴有葡萄膜炎的特发性急性间质性肾炎。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.548
N Yano, M Miyazaki, M Endoh, T Kuramoto, K Eguchi, M Yagame, Y Nomoto, H Sakai
{"title":"Idiopathic acute interstitial nephritis associated with uveitis.","authors":"N Yano,&nbsp;M Miyazaki,&nbsp;M Endoh,&nbsp;T Kuramoto,&nbsp;K Eguchi,&nbsp;M Yagame,&nbsp;Y Nomoto,&nbsp;H Sakai","doi":"10.2169/internalmedicine1962.30.548","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.548","url":null,"abstract":"<p><p>A case of acute interstitial nephritis associated with uveitis is presented, An 18-year-old man developed uveitis followed by renal dysfunction. Moderate renal dysfunction (sCr 3.0 mg/dl), and increased levels of urinary beta 2 microglobulin (over 8,000 micrograms/I) were observed. Renal tissue obtained by open renal biopsy revealed severe infiltration of mononuclear cells in the tubulo-interstitial area. The majority of infiltrating cells were CD4-positive T cells demonstrated by immunoperoxidase staining, suggesting the involvement of T cell-mediated delayed hypersensitivity. Corticosteroid was effective against both uveitis and renal dysfunction. The possible pathogenesis of this syndrome is reviewed from the literature.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"548-52"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.548","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Sex and age differences in ventricular gradient. 心室梯度的性别和年龄差异。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.504
K Yamauchi, I Sotobata
{"title":"Sex and age differences in ventricular gradient.","authors":"K Yamauchi,&nbsp;I Sotobata","doi":"10.2169/internalmedicine1962.30.504","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.504","url":null,"abstract":"<p><p>Sex and age differences of ventricular gradient (G) were analyzed and normal ranges were determined in normal Japanese subjects (120 men and 74 women), whose resting heart rate was within the range of 65 to 75 beats/min. Women showed a larger Z component in AT and a smaller Y and larger Z component in G than men. The common trend in age differences was a decrease in Y component of G in both men and women. The ranges obtained in the present study can be applied in automatic VCG analysis, in particular for the differentiation of primary and secondary ST-T changes.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"504-8"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pathogenesis and correspondence of diabetic retinopathy--approach from polyol metabolism. 糖尿病视网膜病变的发病机制及对应关系——从多元醇代谢角度探讨。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.626
N Hotta, N Sakamoto
{"title":"Pathogenesis and correspondence of diabetic retinopathy--approach from polyol metabolism.","authors":"N Hotta,&nbsp;N Sakamoto","doi":"10.2169/internalmedicine1962.30.626","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.626","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"626-9"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.626","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Treatment of infective endocarditis with granulocyte colony-stimulating factor. 粒细胞集落刺激因子治疗感染性心内膜炎。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.593
Y Hanazono, K Miyazono, H Tsuchimochi, K Yamaoki, K Miyagawa, H Hirai, Y Yazaki, F Takaku
{"title":"Treatment of infective endocarditis with granulocyte colony-stimulating factor.","authors":"Y Hanazono,&nbsp;K Miyazono,&nbsp;H Tsuchimochi,&nbsp;K Yamaoki,&nbsp;K Miyagawa,&nbsp;H Hirai,&nbsp;Y Yazaki,&nbsp;F Takaku","doi":"10.2169/internalmedicine1962.30.593","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.593","url":null,"abstract":"<p><p>Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein hormone which stimulates the proliferation and differentiation of a subset of granulocyte precursors and enhances some functional activities of mature neutrophils. We tested the effects of G-CSF on a patient with intractable infective endocarditis. The white blood cell count was increased 3-fold and the inflammatory reactions such as C-reactive protein and erythrocyte sedimentation rate were completely normalized without any side effects. This is the first report describing the use of G-CSF for infective endocarditis. Administration of G-CSF might be suitable for treating intractable infections which cannot be controlled by antibiotics alone.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"593-6"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12888585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. igm相关性系膜增生性肾小球肾炎伴巨大系膜旁球形沉积物1例。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.588
S Inokuchi, M Yokomatsu, K Funabiki, I Shirato, S Nakayama, M Yoshida, Y Tomino, H Koide
{"title":"A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit.","authors":"S Inokuchi,&nbsp;M Yokomatsu,&nbsp;K Funabiki,&nbsp;I Shirato,&nbsp;S Nakayama,&nbsp;M Yoshida,&nbsp;Y Tomino,&nbsp;H Koide","doi":"10.2169/internalmedicine1962.30.588","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.588","url":null,"abstract":"<p><p>We report a case of IgM-associated mesangial proliferative glomerulonephritis with microscopic hematuria and renal tubular dysfunction. On electron microscopy, a giant spherical deposit was observed in the glomerular paramesangial area. Deposition of C3 in the glomerular mesangial areas was not observed by immunofluorescence. IgM-associated mesangial proliferative glomerulonephritis is clinically characterized by nephrotic syndrome, mild proteinuria and/or hematuria, tubular dysfunction or renal failure, suggesting that it is considered to be a heterogeneous disorder.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"588-92"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between clinico-pathological findings and prognosis in diabetic nephropathy patients. 糖尿病肾病患者临床病理表现与预后的关系。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.612
Y Suzuki, M Arakawa
{"title":"The relationship between clinico-pathological findings and prognosis in diabetic nephropathy patients.","authors":"Y Suzuki,&nbsp;M Arakawa","doi":"10.2169/internalmedicine1962.30.612","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.612","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"612-6"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书