Japanese journal of medicine最新文献_第2页

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.606

Y Fukuda

引用次数: 40

Hematopoietic factors and hematological diseases. 造血因子与血液病。

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.600

T Suda

引用次数: 1

Ascertainment of IgA1 (kappa)-transferrin complex in a case of multiple myeloma associated with hypersiderinemia. 确定多发性骨髓瘤伴高黄素血症的IgA1 (kappa)-转铁蛋白复合物。

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.498

Y Numata, F Tanioka, K Yoshida, T Nishioka, K Hisatake, T Yamano, F Ohno

{"title":"Ascertainment of IgA1 (kappa)-transferrin complex in a case of multiple myeloma associated with hypersiderinemia.","authors":"Y Numata, F Tanioka, K Yoshida, T Nishioka, K Hisatake, T Yamano, F Ohno","doi":"10.2169/internalmedicine1962.30.498","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.498","url":null,"abstract":"IgA1(kappa)-transferrin complex was ascertained in a case of multiple myeloma with hypersiderinemia. On gel filtration, this complex disclosed an orange-colored protein with two peaks between the 19S and 7S fractions. On polyacrylamide gel electrophoresis and Western blotting analysis, the complex migrated at molecular weights of 430 and 700 kD in the non-reducing condition. A small amount of free transferrin was detected simultaneously. The complex was further separated into monoclonal IgA1(kappa) and transferrin at pH 4.5; these recombined at pH 7.2 after incubation (37 degrees C, 2 h). We also showed that the pepsin-digested F(ab')2 fragment of IgA1(kappa) combined with the transferrin. From these results it can be suggested that monoclonal IgA1(kappa) has an antibody activity for the transferrin. Clinically, this complex distributed the iron transport to erythroid cells in the bone marrow, resulting in hypersiderinemia, anemia, and iron deposits in the liver.","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"498-503"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Determination of the glycemic threshold for the regression or prevention of diabetic microangiopathies, and the insulin injection regimen to establish strict glycemic control in NIDDM. 确定血糖阈值以恢复或预防糖尿病微血管病变，以及胰岛素注射方案以建立严格的NIDDM血糖控制。

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.618

R Kawamori, T Kamada

引用次数: 8

Cohort study of hepatotropic virus and human T lymphotropic virus type-I infections in an area endemic for adult T cell leukemia. 某地成人T细胞白血病流行区嗜肝病毒和人T淋巴病毒i型感染的队列研究

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.492

S Kamihira, S Momita, S Ikeda, Y Yamada, H Sohda, S Atogami, M Tomonaga, K Kinoshita, K Toriya, R Furukawa

{"title":"Cohort study of hepatotropic virus and human T lymphotropic virus type-I infections in an area endemic for adult T cell leukemia.","authors":"S Kamihira, S Momita, S Ikeda, Y Yamada, H Sohda, S Atogami, M Tomonaga, K Kinoshita, K Toriya, R Furukawa","doi":"10.2169/internalmedicine1962.30.492","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.492","url":null,"abstract":"We tested for antibodies to hepatitis B virus (HBV), hepatitis C virus (HCV), and human T lymphotropic virus type-I (HTLV-I) in 629 normal inhabitants of an adult T cell leukemia (ATL) endemic area and in patients with ATL, HTLV-I associated myelopathy (HAM), and hepatocellular carcinoma (HCC) from the same district. The prevalence of serological positivity for each virus was 28.0, 6.4, and 32.6%, respectively, among the 629 inhabitants. There was a positive association between the presence of anti-HCV and serological HTLV-I positive or negative status of these subjects (9.3% vs 5.0%). Conversely, there was no correlation between HBV and HTLV-I serologic prevalence. Only inhabitants positive for anti-HCV showed significantly high serum aminotransferase levels. The levels were not affected by superimposed HTLV-I infection among anti-HCV positives. Fifty three percent of HCC patients were positive for anti-HCV; 35% of whom were simultaneously positive for antibody to HTLV-I. On the other hand, only 2 ATL patients (4.2%) and 2 HAM patients (7.7%) had anti-HCV. These findings suggest that high serum aminotransferase levels are mainly caused by HCV infection and persons with HCV and HTLV-I double infections are at a high risk for the development of HCC but not ATL or HAM.","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"492-7"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12830932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Studies on the cause and the treatment of hyporeninemic selected hypoaldosteronism in diabetic nephropathy. 糖尿病肾病低肾素血症选择性低醛固酮增多症的病因及治疗研究。

Japanese journal of medicine Pub Date : 1991-11-01

S Fukuchi

引用次数: 0

Exacerbation of myasthenia gravis shortly after administration of methimazole for hyperthyroidism. 甲巯咪唑治疗甲亢后不久重症肌无力加重。

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.578

Y Kuroda, C Endo, R Neshige, R Kakigi

引用次数: 14

A role of mesangial dysfunction in the development of diabetic nephropathy. 肾小球系膜功能障碍在糖尿病肾病发展中的作用。

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.622

Y Shigeta, R Kikkawa

引用次数: 2

A specific binding site for lipoproteins containing apolipoprotein A-I on human hepatoma cell line HepG2. 人肝癌细胞系HepG2上含有载脂蛋白A- i的脂蛋白的特异性结合位点。

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.524

S Ueno, S Kobori, M Ide, K Suzaki, H Takeda, S Horiuchi, M Shichiri

{"title":"A specific binding site for lipoproteins containing apolipoprotein A-I on human hepatoma cell line HepG2.","authors":"S Ueno, S Kobori, M Ide, K Suzaki, H Takeda, S Horiuchi, M Shichiri","doi":"10.2169/internalmedicine1962.30.524","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.524","url":null,"abstract":"Interactions of lipoproteins containing apolipoprotein (apo) A-I with or without apoA-II with human hepatoma cell line HepG2 were studied to investigate the ligand specificity for high density lipoprotein receptor on human hepatic cells and their metabolism. The two types of lipoproteins were isolated by immunoaffinity chromatography, in which apoE-containing lipoproteins were removed. Specific binding kinetics at 0 degrees C were observed for the apoA-I-containing lipoproteins with or without apoA-II (Kd = 18 or 20 micrograms protein/ml, Bmax = 110 or 120 ng/mg cell protein, respectively). The binding of these lipoproteins to HepG2 cells was competitively inhibited by excess unlabeled apoA-I-containing lipoproteins or apoA-I-phospholipid complexes, but not by apoA-II.phospholipid complexes. Interactions of these lipoproteins with HepG2 cells at 37 degrees C were further examined. These results suggested that HepG2 cells have a specific binding site for apoA-I-containing lipoproteins, and that apoA-I might be a crucial component in the binding of these lipoproteins to human hepatic cells.","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"524-33"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.524","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12830934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Interleukin-2 and its receptor in adult T cell leukemia. 白细胞介素-2及其受体在成人T细胞白血病中的作用。

Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.602

T Uchiyama

引用次数: 1