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Japanese journal of medicine最新文献

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Cytokines and liver disease. 细胞因子和肝脏疾病
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.606
Y Fukuda
{"title":"Cytokines and liver disease.","authors":"Y Fukuda","doi":"10.2169/internalmedicine1962.30.606","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.606","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"606-9"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12830936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
Hematopoietic factors and hematological diseases. 造血因子与血液病。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.600
T Suda
{"title":"Hematopoietic factors and hematological diseases.","authors":"T Suda","doi":"10.2169/internalmedicine1962.30.600","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.600","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"600-2"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ascertainment of IgA1 (kappa)-transferrin complex in a case of multiple myeloma associated with hypersiderinemia. 确定多发性骨髓瘤伴高黄素血症的IgA1 (kappa)-转铁蛋白复合物。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.498
Y Numata, F Tanioka, K Yoshida, T Nishioka, K Hisatake, T Yamano, F Ohno
{"title":"Ascertainment of IgA1 (kappa)-transferrin complex in a case of multiple myeloma associated with hypersiderinemia.","authors":"Y Numata,&nbsp;F Tanioka,&nbsp;K Yoshida,&nbsp;T Nishioka,&nbsp;K Hisatake,&nbsp;T Yamano,&nbsp;F Ohno","doi":"10.2169/internalmedicine1962.30.498","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.498","url":null,"abstract":"<p><p>IgA1(kappa)-transferrin complex was ascertained in a case of multiple myeloma with hypersiderinemia. On gel filtration, this complex disclosed an orange-colored protein with two peaks between the 19S and 7S fractions. On polyacrylamide gel electrophoresis and Western blotting analysis, the complex migrated at molecular weights of 430 and 700 kD in the non-reducing condition. A small amount of free transferrin was detected simultaneously. The complex was further separated into monoclonal IgA1(kappa) and transferrin at pH 4.5; these recombined at pH 7.2 after incubation (37 degrees C, 2 h). We also showed that the pepsin-digested F(ab')2 fragment of IgA1(kappa) combined with the transferrin. From these results it can be suggested that monoclonal IgA1(kappa) has an antibody activity for the transferrin. Clinically, this complex distributed the iron transport to erythroid cells in the bone marrow, resulting in hypersiderinemia, anemia, and iron deposits in the liver.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"498-503"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Determination of the glycemic threshold for the regression or prevention of diabetic microangiopathies, and the insulin injection regimen to establish strict glycemic control in NIDDM. 确定血糖阈值以恢复或预防糖尿病微血管病变，以及胰岛素注射方案以建立严格的NIDDM血糖控制。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.618
R Kawamori, T Kamada
{"title":"Determination of the glycemic threshold for the regression or prevention of diabetic microangiopathies, and the insulin injection regimen to establish strict glycemic control in NIDDM.","authors":"R Kawamori,&nbsp;T Kamada","doi":"10.2169/internalmedicine1962.30.618","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.618","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"618-21"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Cohort study of hepatotropic virus and human T lymphotropic virus type-I infections in an area endemic for adult T cell leukemia. 某地成人T细胞白血病流行区嗜肝病毒和人T淋巴病毒i型感染的队列研究
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.492
S Kamihira, S Momita, S Ikeda, Y Yamada, H Sohda, S Atogami, M Tomonaga, K Kinoshita, K Toriya, R Furukawa
{"title":"Cohort study of hepatotropic virus and human T lymphotropic virus type-I infections in an area endemic for adult T cell leukemia.","authors":"S Kamihira,&nbsp;S Momita,&nbsp;S Ikeda,&nbsp;Y Yamada,&nbsp;H Sohda,&nbsp;S Atogami,&nbsp;M Tomonaga,&nbsp;K Kinoshita,&nbsp;K Toriya,&nbsp;R Furukawa","doi":"10.2169/internalmedicine1962.30.492","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.492","url":null,"abstract":"<p><p>We tested for antibodies to hepatitis B virus (HBV), hepatitis C virus (HCV), and human T lymphotropic virus type-I (HTLV-I) in 629 normal inhabitants of an adult T cell leukemia (ATL) endemic area and in patients with ATL, HTLV-I associated myelopathy (HAM), and hepatocellular carcinoma (HCC) from the same district. The prevalence of serological positivity for each virus was 28.0, 6.4, and 32.6%, respectively, among the 629 inhabitants. There was a positive association between the presence of anti-HCV and serological HTLV-I positive or negative status of these subjects (9.3% vs 5.0%). Conversely, there was no correlation between HBV and HTLV-I serologic prevalence. Only inhabitants positive for anti-HCV showed significantly high serum aminotransferase levels. The levels were not affected by superimposed HTLV-I infection among anti-HCV positives. Fifty three percent of HCC patients were positive for anti-HCV; 35% of whom were simultaneously positive for antibody to HTLV-I. On the other hand, only 2 ATL patients (4.2%) and 2 HAM patients (7.7%) had anti-HCV. These findings suggest that high serum aminotransferase levels are mainly caused by HCV infection and persons with HCV and HTLV-I double infections are at a high risk for the development of HCC but not ATL or HAM.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"492-7"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12830932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Studies on the cause and the treatment of hyporeninemic selected hypoaldosteronism in diabetic nephropathy. 糖尿病肾病低肾素血症选择性低醛固酮增多症的病因及治疗研究。
Japanese journal of medicine Pub Date : 1991-11-01
S Fukuchi
{"title":"Studies on the cause and the treatment of hyporeninemic selected hypoaldosteronism in diabetic nephropathy.","authors":"S Fukuchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"617-8"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exacerbation of myasthenia gravis shortly after administration of methimazole for hyperthyroidism. 甲巯咪唑治疗甲亢后不久重症肌无力加重。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.578
Y Kuroda, C Endo, R Neshige, R Kakigi
{"title":"Exacerbation of myasthenia gravis shortly after administration of methimazole for hyperthyroidism.","authors":"Y Kuroda,&nbsp;C Endo,&nbsp;R Neshige,&nbsp;R Kakigi","doi":"10.2169/internalmedicine1962.30.578","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.578","url":null,"abstract":"<p><p>We report a case of myasthenia gravis (MG) which became worse shortly after the administration of methimazole (MMI) for hyperthyroidism. The activation of immune responses was found during the worsening of MG. The findings suggests the possibility that the worsening of MG might be induced by MMI, presumably by its immunomodulatory property.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"578-81"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
A role of mesangial dysfunction in the development of diabetic nephropathy. 肾小球系膜功能障碍在糖尿病肾病发展中的作用。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.622
Y Shigeta, R Kikkawa
{"title":"A role of mesangial dysfunction in the development of diabetic nephropathy.","authors":"Y Shigeta,&nbsp;R Kikkawa","doi":"10.2169/internalmedicine1962.30.622","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.622","url":null,"abstract":"<p><p>The pathogenic mechanism of diabetic nephropathy has been extensively investigated, and the significance of alteration in glomerular hemodynamics or mesangial cell metabolism has been recently clarified. It is expected that in the near future these pathologically important alterations can be corrected, and the development diabetic nephropathy can be halted.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"622-4"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Successful treatment of acute right cardiac failure due to pulmonary thromboembolism in mixed connective tissue disease. 混合性结缔组织病肺血栓栓塞所致急性右心衰的成功治疗。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.568
Y Ueda, Y Yamauchi, K Makizumi, R Kaji, H Ishibashi, K Nagasawa, Y Niho
{"title":"Successful treatment of acute right cardiac failure due to pulmonary thromboembolism in mixed connective tissue disease.","authors":"Y Ueda,&nbsp;Y Yamauchi,&nbsp;K Makizumi,&nbsp;R Kaji,&nbsp;H Ishibashi,&nbsp;K Nagasawa,&nbsp;Y Niho","doi":"10.2169/internalmedicine1962.30.568","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.568","url":null,"abstract":"<p><p>Mixed connective tissue disease (MCTD) is characterized as a benign rheumatic disease with a favorable response to therapy. When pulmonary hypertension is a complication, however, it is often reported to be fatal. A 32-year-old female patient with MCTD who had developed rapidly progressive pulmonary hypertension and disseminated intravascular coagulopathy was admitted to our hospital and was successfully treated with corticosteroids and anticoagulants. The failure of microcirculation due to coagulopathy is considered to be one of the possible entities of pulmonary hypertension.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"568-72"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Primary amyloidosis with dry eyes and dry mouth--a case report. 原发性淀粉样变性伴眼口干涩1例报告。
Japanese journal of medicine Pub Date : 1991-11-01 DOI: 10.2169/internalmedicine1962.30.597
T Itoh, S Ohashi, T Tsujino, M Takenaka, H Kodama, M Kishihara, T Inatome, T Inoh
{"title":"Primary amyloidosis with dry eyes and dry mouth--a case report.","authors":"T Itoh,&nbsp;S Ohashi,&nbsp;T Tsujino,&nbsp;M Takenaka,&nbsp;H Kodama,&nbsp;M Kishihara,&nbsp;T Inatome,&nbsp;T Inoh","doi":"10.2169/internalmedicine1962.30.597","DOIUrl":"https://doi.org/10.2169/internalmedicine1962.30.597","url":null,"abstract":"<p><p>We report a rare case of dry eyes and dry mouth caused by primary amyloidosis. A 66-year-old woman with keratoconjunctivitis sicca and xerostomia died of acute respiratory failure. Shirmer's test, gum test, and sialography indicated Sjögren's syndrome. Lip biopsy revealed amyloid deposition around the salivary ducts. Bence-Jones protein was noted in the urine. At autopsy, amyloid deposition was identified histochemically in many organs, mainly on the vessel walls. Primary amyloidosis should be considered as a differential diagnosis of Sjögren's syndrome.</p>","PeriodicalId":14798,"journal":{"name":"Japanese journal of medicine","volume":"30 6","pages":"597-9"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2169/internalmedicine1962.30.597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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