Pediatrics Sciences Journal最新文献

{"title":"Clinical and laboratory profiles of pediatric asthma patients with house dust mite (HDM)–specific subcutaneous immunotherapy: A single center, cross sectional study","authors":"Desy Wulandari, Wisnu Barlianto","doi":"10.51559/pedscij.v1i2.17","DOIUrl":"https://doi.org/10.51559/pedscij.v1i2.17","url":null,"abstract":"Introduction: House dust mite (HDM) allergy has been reported as an actual cause of asthma in children. Subcutaneous immunotherapy (SCIT) is a recommended treatment for HDM allergy patients. However, there were limited data about the characteristic of pediatric patients with HDM-SCIT, particularly in Indonesia. This study was aimed to evaluate the characteristic of pediatric patients with allergic asthma. \u0000Methods: Study participants were pediatric patients confirmed with HDM allergy from Skin Prick Test (SPT) in the pediatric allergy-immunology outpatient clinic in Saiful Anwar Hospital Malang, Indonesia. Patients who were treated with HDM-SCIT in the early build-up phase of treatment were included in this study. Demographic and clinical characteristics of the patients were recorded. Peripheral blood samples were drawn to evaluate the total eosinophil count (TEC), total basophil count (TBC), neutrophil-lymphocyte ratio (NLR), specific IgE (sIgE) and total IgE (t-IgE) level. Clinical diagnosis of asthma was classified according to the Global Initiative for Asthma (GINA) criteria. The evaluation of asthma control was assessed by the Asthma Control Test (ACT) score.  \u0000Results: Thirty-two patients were enrolled in this study, including 14 male and 18 female. The mean age of children was 6.92 ± 2.60 years old. There were 21 subjects with uncontrolled asthma and 11 subjects with partially controlled asthma. Demographic characteristics including age, sex, nutritional status and family history were not significantly different between uncontrolled and partially controlled asthma groups (p> 0.05). TEC, TBC, NLR, and tIgE were not different significantly among groups (p> 0.05). This study showed that the mean of sIgE serum level was higher in uncontrolled asthma compared to partially controlled asthma group (p= 0.022). Moreover, it was a negative significant correlation between sIgE serum level and ACT score (p= 0.002, r= -0.532).  \u0000Conclusion: Higher sIgE levels were correlated with poor asthma control in HDM-SCIT patients. ","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120955077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke in pediatric: a review","authors":"Nugroho Danu, Melinda, Astarini Hidayah","doi":"10.51559/pedscij.v2i1.23","DOIUrl":"https://doi.org/10.51559/pedscij.v2i1.23","url":null,"abstract":"Stroke in children was defined as the clinical and radiological manifestation of stroke, with radiological evidence of cerebral infarction or hemorrhage. Pediatric stroke can be divided into ischemic and hemorrhagic stroke. The etiology is very different, and diagnostic procedures are often more in-depth to look for etiology. Stroke is classically characterized by acute focal neurologic deficits such as hemiplegia, speech, or gait disturbances; presentation is highly dependent on the child’s age and may be non-specific. When acute focal neurologic deficits are found in childhood, one should think about stroke until proven otherwise. There is no standard therapy based on a systematic review of a randomized clinical trial. Therapeutic recommendations are the consensus of experts, extrapolated from the recommendations for stroke therapy for the adult population. Understanding stroke in children is complicated because it has broad differential diagnosis, and complications that occur. Therefore, early recognition of childhood stroke by pediatricians is very important with the implementation of targeted and neuroprotective therapies. \u0000 ","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127373658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good outcome of newborn septic arthritis with holistic treatment: a case report","authors":"Muhammad Irvan Avandi, Brigitta Ida Resita Vebrianti Corebima, Eko Sulistijono, Talita Clarissa Sinatra","doi":"10.51559/pedscij.v2i2.25","DOIUrl":"https://doi.org/10.51559/pedscij.v2i2.25","url":null,"abstract":"Introduction: Septic arthritis (SA) is a serious joint infection associated with significant morbidity that can cause permanent damage with articular cartilage destruction, osteonecrosis, and lifelong deformities. Here we present a good outcome of newborn septic arthritis with prompt treatment. \u0000Case Presentation: A one-month-old boy was brought with swelling of both knee joints two weeks before admission. He has a history of preterm birth and was hospitalized in the Neonatal Intensive Care Unit (NICU) because of neonatal pneumonia and sepsis. Several days after treatment, he came with swollen on both knees, both knee joint synovial liquid and sputum culture showed Klebsiella pneumoniae. Magnetic Resonance Imaging (MRI) was found intra articular fluid and erosion of the epiphyseal cartilage suspect infection process. After establishing the diagnosis of SA, we initiated treatment with cloxacillin 60 mg/kgs body weight for 14 days. He underwent debridement and physiotherapist. One year after discharge, the physical examinations showed normal findings and had a normal gait. \u0000Conclusion: It can be concluded that prompt diagnosis and treatment of SA on the newborn will have a good outcome with no sequelae. An early diagnosis of SA can guide clinicians to initiate a standardized treatment and improve patient outcomes.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132622699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case distribution and survival rate in Pediatric Intensive Care Unit (PICU) at Banjarmasin, Indonesia","authors":"Choirul Anam, Niarsari Anugrahing Putri, Rahmad Ramadhani, Yasmin Musfirah","doi":"10.51559/pedscij.v2i2.29","DOIUrl":"https://doi.org/10.51559/pedscij.v2i2.29","url":null,"abstract":"Introduction: Epidemiological studies about case distribution and survival in PICU is important to do. Knowledge of these epidemiological studies can assist in decision-making to improve patient quality of care. So far there is no data about the case distribution and survival rate of the patients in the PICU in Banjarmasin, Indonesia. This study aims to provide an overview of case distribution and survival rates of patients treated at the PICU of Ulin Hospital Banjarmasin. \u0000Methods: A retrospective study was conducted at the PICU of Ulin Hospital Banjarmasin. Data was taken from patients’ records from January 2017 to December 2018. \u0000Results: A total of 202 patients were admitted to the PICU, males 109 and females 93. The mortality rate was 17% with a survival rate, 83% with a mean length of stay of 10 days. The most common patient diagnosis was pneumonia 23%, meningoencephalitis 10%, and dengue shock syndrome 6%. The system commonly involved was respiratory system 26%, central nervous system 17%, and infection 13%. The median length of stay for overall admission was 9 days with a mean of 10 days. The cardiovascular and respiratory systems tend to have lower survival rates, 78%, and 79% respectively. \u0000Conclusions: This study shows that respiratory, neurological, and infectious diseases are the most common diseases that cause children to be admitted to the PICU. The mortality rate in this study was 17% with a mean length of stay of 10 days. It is necessary to focus on medical facilities and interventions to reduce respiratory-related mortality.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130044247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting stunted growth in children aged 6-24 months in Bawean Island, Indonesia","authors":"Arini Haq, Luthfiana Eka Sari, Pitra Sekarhandini, Brigitta Ida Resita Vebrianti Corebima","doi":"10.51559/pedscij.v2i2.26","DOIUrl":"https://doi.org/10.51559/pedscij.v2i2.26","url":null,"abstract":"Background: Stunted is defined as a condition where body length and height are less than -2 SD of the WHO height-for-age z score. The number of stunted children worldwide reaches 129 million or 23.8% of the population. This study aims to scrutinize the factors affecting stunted growth in children aged 6-24 months old in Sangkapura district, Bawean. \u0000Methods: This cross-sectional quantitative study in Bawean island, involving children aged 6-24 months old who came to posyandu for height measurement. The purposive sampling technique was used in the study, in which the samples filled a questionnaire consisting of several questions. The data analyses presented are univariate analysis, Chi-Square, and Binary Regression Analysis.   \u0000Results: The analysis results showed that the factors affecting stunted growth in toddlers are birth weight (<2500 grams), gestational age (<37 weeks), exclusive breastfeeding, and weaning foods. If the baby’s birth weight is less than 2500 grams, is born before week 37 of pregnancy, does not get exclusive breastfeeding, and is given homemade weaning foods, the possibility of the baby being stunted is 91.5%. \u0000Conclusion: Several factors affect stunted growth in children aged 6-24 months old in Bawean island. Children who experience all of the factors mentioned above have a 91.5% possibility of being stunted. Among the other factors, babies not exclusively breastfed are 190,019 times more likely to be stunted.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"346 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116550083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rationalization of personal protective equipment usage and the solution of its limitation during COVID-19 era","authors":"Irene Ratridewi, Saptadi Yuliarto","doi":"10.51559/pedscij.v1i1.8","DOIUrl":"https://doi.org/10.51559/pedscij.v1i1.8","url":null,"abstract":"Covid-19 pandemic is a global burden health problem caused by Coronavirus. The disease can be transmitted swiftly by droplets after sneezing, coughing, or holding stuff (droplet contaminated). The contagion is eased by bad habit like does not wash hand after touching others or stuff. To date, data says that The Covid-19 morbidity rate is still highest in a densely populated place. Even though several mechanisms in the community have been done to prevent the spreading of this disease, but the spread is still relatively high and needs medical treatment intervention in the health care system especially in the hospital.1 Moreover, the daily hospital treatment of Covid-19 patients’ needs appropriate personal protective equipment (PPE) to protect and to minimalize the risk of infection to health workers.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128305249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The difficulty of establishing the diagnosis of pediatric COVID-19 in Indonesia","authors":"Kurniawan Taufiq Kadafi","doi":"10.51559/pedscij.v1i1.10","DOIUrl":"https://doi.org/10.51559/pedscij.v1i1.10","url":null,"abstract":"The Covid-19 pandemic has not shown any signs of ending soon. Until May 1, 2020, the latest data recorded that Covid-19 cases in the world have reached 3,336,680 cases, with 235,245 people died and 1,054,786 people recovered. Of  the number of still-active cases, 98% are mild cases, while the remaining 2% are severe. Since it was first identified (December 2019) until it was announced as a pandemic on March 11, 2020), cases of children have not escaped the effects of infection.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125770868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Strategy to Encounter Limited Capacity of Critical Care for COVID-19 Children","authors":"Saptadi Yuliarto","doi":"10.51559/pedscij.v1i1.9","DOIUrl":"https://doi.org/10.51559/pedscij.v1i1.9","url":null,"abstract":"Coronavirus disease (COVID) – 19 morbidity rates in Indonesia have exponentially increased since its first case in March 2020. To date, 15,438 (0.004%) Indonesian population have been confirmed with Covid-19. Although it is only 0.004% from all of Indonesian, the patient's enhancement is high, also, the patients who recover just only 21.3%, It would endanger the healthcare capacity in Indonesia.1 \u0000Recent data from the Indonesian Health Ministry revealed 1,065 (6.9%) confirmed COVID-19 are at young ages. Considering confirmed to suspected/ probable case ratio was 1:2.1, it is estimated that 2,236 children in Indonesia require treatment with COVID-19 protocols. According to the China data’s, the prevalence of moderate to critical illness in children was 44.5%.2 If applied in Indonesia, to date, about 995 children need intensive care treatment, which it will rise around 10-40 patients in each day","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124893426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The levels of Human Beta Defensin-2 (HBD-2) in premature neonates’ feces at Saiful Anwar Hospital, Malang, Indonesia","authors":"Eko Sulistijono, Putri Primawardani, Krisni Subandiyah, Anik Puryatni","doi":"10.51559/pedscij.v1i1.2","DOIUrl":"https://doi.org/10.51559/pedscij.v1i1.2","url":null,"abstract":"Background: Clinical evidence shows that the etiology of neonatal sepsis is translocation of the digestive tract of premature neonates. Human ß-defensor 2 has a protective effect during inflammation and apoptosis. This study aimed to determine the levels of fecal human ß-defensus-2 (HBD-2) as an inflammatory biomarker in premature neonates related to nutrition consumption. \u0000Methods: A cohort study design used in thirty-nine premature neonates according to inclusion criteria were collected in January to March 2019 in the neonatology room of RSUD Dr. Saiful Anwar Malang. The levels of premature neonatal feces HBD-2 were taken from all three sample groups on the seventh and fourteenth days and measured by the ELISA method. Data were analyzed using SPSS version 20 for Windows. \u0000Results: The mean levels of HBD-2 premature neonatal feces consuming formula milk alone were higher than other groups (349.16 + 67.66 vs 330.24 + 44.08 vs 215.65 + 51.34). There is a relationship between levels of HBD-2 premature neonatal feces with only breastfeeding (p=0,005; r=0.731), breast milk (p=0,005; r=0,727) and, formula milk only (p=0,003; r=0,761). \u0000Conclusion: The levels of HBD-2 in premature neonatal stools who consuming formula milk alone were significantly higher than levels of human HBD-2 premature neonatal stools that consumed only breast milk. \u0000 ","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121767081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The low level of vitamin D3 among Type 1 Diabetes Mellitus (T1DM) children at Saiful Anwar General Hospital, Malang, Indonesia","authors":"Harjoedi Adji Tjahjono, Wisnu Barlianto, Dian Handayani, Handono Kalim","doi":"10.51559/pedscij.v1i1.3","DOIUrl":"https://doi.org/10.51559/pedscij.v1i1.3","url":null,"abstract":"Background:  The Type 1 Diabetes Melitus (T1DM) is a disease which is occurred because of autoimmune destruction in pancreas islet (insulin-producing ß cells). A Failure mechanism of immunoregulator causes inflammatory process in the islets and continue to damage the pancreatic β cell.  Vitamin D deficiency may increase the risk of autoimmune diseases including type 1 diabetes mellitus. The aim of this study was to know the level of vitamin D in type 1 diabetes mellitus. \u0000Methods: An observational analytic cross-sectional design was conducted among 40 T1DM subjects and 40 healthy controls aged between 10-18-year-old. They were not having local or systemic infection, nor liver and kidney disorders. Vitamin D levels were measured by the ELISA method (ng/ ml). Subjects’ data were collected and processed by 2007 Microsoft Excel software, then analyzed with SPSS version 16.0 for Windows. \u0000Results: Most of respondents in T1DM group were female (57.5%) and 15.94±1.00 years old for average age but not statistically significant compared with control group (p>0.05). There was a significant different of the mean level of vitamin D3 in the T1DM group (10.41 + 2,20 ng/ml) compared with control group (18.41 + 1.41 ng/ml) (p<0,05). \u0000Conclusion:  The level of vitamin D (25 (OH) D3) in the T1 DM group were significantly lower compared to the control group \u0000 ","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"25 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116096253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}