Pediatrics Sciences Journal最新文献

Post-Traumatic Stress Disorder Following Surgery: A Case Report of A Three-Year-Old Child with Deep Dermal Burn Injury 手术后创伤后应激障碍:1例3岁儿童深部皮肤烧伤

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v1i2.15

Hajeng Wulandari, Ariani

引用次数: 0

Effect Of Vitamin D3 On Transforming Growth Factor - Β1 In Pediatric Patients With Stage 1 To 3 Chronic Kidney Disease: An Experimental Study And Randomized Controlled Trials 维生素D3对儿科1 ~ 3期慢性肾病患者转化生长因子- Β1的影响:一项实验研究和随机对照试验

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v1i2.14

Krisni Subandiyah, Richi Aditya

{"title":"Effect Of Vitamin D3 On Transforming Growth Factor - Β1 In Pediatric Patients With Stage 1 To 3 Chronic Kidney Disease: An Experimental Study And Randomized Controlled Trials","authors":"Krisni Subandiyah, Richi Aditya","doi":"10.51559/pedscij.v1i2.14","DOIUrl":"https://doi.org/10.51559/pedscij.v1i2.14","url":null,"abstract":"Introduction: In Indonesia, Chronic Kidney Disease (CKD) is a severe health problem both in terms of treatment and health costs. One way to reduce mortality is by blocking the progression of the disease. Transforming Growth Factor-β1 (TGF-β1) is a marker of progression from CKD through its fibrosis pathway. One mechanism for interfering with the TGF-β1 signaling pathway is by giving vitamin D3(cholecalciferol). This study aims to find out that supplementation of vitamin D3 can increase plasma 25(OH)D levels and reduce TGF-β1 levels in children with CKD. \u0000Methods: The study was approved by the hospital's ethical committee, designed as a randomized clinical trial, double-blind, pre and post-test control group, which involved 30 subjects diagnosed as CKD stage 1-3. Subjects were divided into two groups; the vitamin D3-treated group and the placebo group. TGF-β1 and vitamin D plasma level was measured by ELISA method. \u0000Results: Vitamin D levels increased by 9.35 compared to the placebo group. The magnitude of the increase from the Wilcoxon statistical test results obtained p=0.001 (p<0.05), so there was a significant increase in vitamin D levels after supplementing vitamin D3. In the group given vitamin D3 supplementation, it was found that TGF-β1 levels had decreased by 108.64. The reduction from the Wilcoxon statistical test results obtained p=0.001 (p<0.05), so there was a significant decrease after vitamin D3 supplementation. Based on the Spearman correlation test, there is a meaningful relationship between increased vitamin D levels with a reduction of TGF-β1 levels. The correlation coefficient is -0.753, which is harmful. The correlation coefficient is in a substantial range. \u0000Conclusion: We concluded that vitamin D3 could increase 25(OH)D plasma level and decrease TGF-β1 levels significantly in children with stage 1 until 3 of CKD.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128363283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical ventilation practice of pediatric patients with Covid-19 in Indonesian tertiary hospital 印尼三级医院新冠肺炎患儿机械通气实践

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v2i1.22

Kurniawan Taufiq Kadafi, Erviani Maulidya, William Prayogo Susanto, Saptadi Yuliarto

{"title":"Mechanical ventilation practice of pediatric patients with Covid-19 in Indonesian tertiary hospital","authors":"Kurniawan Taufiq Kadafi, Erviani Maulidya, William Prayogo Susanto, Saptadi Yuliarto","doi":"10.51559/pedscij.v2i1.22","DOIUrl":"https://doi.org/10.51559/pedscij.v2i1.22","url":null,"abstract":"Background: Coronavirus Disease-2019 (COVID-19) in children tend to have milder clinical manifestation. However, some develop critical conditions and require mechanical ventilation in the Pediatric Intensive Care Unit (PICU). Various modalities are recommended for mechanical ventilation, such as High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP), or invasive ventilation with intubation. This study aims to describe the clinical feature, ventilation modalities usage, and the outcome of children with critical COVID-19. \u0000Methods: This is a retrospective study in COVID-19 children with respiratory distress who were treated in the COVID-19 isolation PICU room of Saiful Anwar General Hospital for one year. The data was gained from the medical record and analyzed descriptively. Data were analyzed using Ms. Excel for Windows. \u0000Results: A total of 51 children with COVID-19 were admitted to Saiful Anwar general Hospital in one year period, with 12 of them in critical condition and 6 children require mechanical ventilation. The main signs developed were fever and dyspnea. Invasive mechanical ventilation applicated in 5 patients, and only 1 patient received Non-Invasive Ventilation (NIV). The mean of PEEP used in invasive ventilation is 7-9 cmH2O, lower than ESPNIC’s recommendation of 8-10 cmH2O. Length of ventilator usage is 2-21 days, with 2 patients passed away, both with a comorbid and organ system injury. \u0000Conclusion: The mechanical ventilation setting must be determined individually based on the patients’ condition, despite several guidelines providing the recommendation.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"2598 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128836141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Screening for congenital hypothyroidism in Malang, East Java in 2020 2020年东爪哇玛琅先天性甲状腺功能减退筛查

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v2i2.28

Irfan Agus Salim, Berlian Ristina Putri, Tiara Afia Rosmalawati, Haryudi Aji Cahyono, Fadhilah Muttaqin

{"title":"Screening for congenital hypothyroidism in Malang, East Java in 2020","authors":"Irfan Agus Salim, Berlian Ristina Putri, Tiara Afia Rosmalawati, Haryudi Aji Cahyono, Fadhilah Muttaqin","doi":"10.51559/pedscij.v2i2.28","DOIUrl":"https://doi.org/10.51559/pedscij.v2i2.28","url":null,"abstract":"Introduction: Congenital hypothyroidism is defined as a state of thyroid hormone deficiency present at birth. Congenital hypothyroidism must be diagnosed immediately because delay in therapy may cause irreversible neurological deficits, such as mental retardation in children. However, this condition can be prevented by screening in newborns so that congenital hypothyroidism can be diagnosed and treated early, and can result in better neurological development. This study aims to determine the congenital hypothyroidism ratio in Malang from March to November 2020. Methods: The descriptive analysis method was used in this research. The subjects were neonates aged 0 – 28 days with a gestational age of 36 weeks and were involving the Health Office in both the Regency and the City of Malang. The data about identity, gender, age at screening, and gestational age were collected. A laboratory screening test was performed by taking a blood sample from the heel or vein for a TSH test. If the result was positive with a TSH value > 20 U/mL, the subject would be recalled for having a confirmation test and referred to a pediatric endocrinologist. Results: There were 2024 (88.34%) subjects were successfully screened from a total of 2291 subjects. The recall rate for congenital hypothyroidism was 1:2024 (0.04%). Conclusion: The ratio of congenital hypothyroidism cases in Malang from March to November 2020 was higher than the global ratio, which was 1:3000. The high rate of congenital hypothyroidism in Malang indicated the need for congenital hypothyroidism screening in newborns.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131399427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Eleven Year Old Boy with Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) 11岁男孩药物性皮疹伴嗜酸性粒细胞增多及全身症状(DRESS)

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v2i1.20

Desy Wulandari, Wisnu Barlianto, Nisak Humairok

引用次数: 0

Cytogenetic and clinical features of down syndrome in malang, east java, indonesia 印度尼西亚东爪哇玛琅唐氏综合征的细胞遗传学和临床特征

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v1i2.12

Ariani

{"title":"Cytogenetic and clinical features of down syndrome in malang, east java, indonesia","authors":"Ariani","doi":"10.51559/pedscij.v1i2.12","DOIUrl":"https://doi.org/10.51559/pedscij.v1i2.12","url":null,"abstract":"Introduction: Down syndrome (DS) is the most common chromosomal disorder. DS characterized by multiple congenital anomaly caused by trisomy 21This study was designed to evaluate the karyotype pattern, clinical features and risk factors of patients with Down syndrome. Method: Data were obtained from a retrospective analysis of a questionnaire from Down syndrome patients. Result: A total of 34 patients were studied, with 67,6% of males. Out of 34 patients, there were 25 children (73,5%) with no cytogenetic test, 4 children (11,7%) with lost cytogenetic test, 3 children (8,82%) with free trisomy (non-disjunction), 1 (2,9%) with translocation, and 1 (2,9%) with mosaics. Maternal age categories showed one mother less than 20 years, two mothers between 21-25 years, four mothers were between 25 and 30 years, 12 mothers were between 31 and 35 years, ten mothers were between 31 and 40 years, and five mothers were over 41 years of age. The most common clinical features in this study are Congenital Heart Disease (CHD), which was recognized in 9 (26,4%) patients with five patients had Atrial Septal Defect (ASD), two patients had ASD and Ventricular Septal Defect (VSD), two patients had Patent Ductus Arteriosus (PDA). All of them followed by dental problems in 8 (23,5%) patients, ophthalmology problems in 6 (17,6%) patients, digestive problems in 4 (11,7%) patients, seizure in 1 (2,9%) patient, hormonal problems in 1 (2,9%) patient, and hearing problem in 1 (2,9%) patient. There is no significant difference in CHD prevalence between each maternal age group (p = 0776, p>0.05). Conclusion: Down syndrome has a higher prevalence in males and is frequently seen among mothers between 31 -35 years of age, yet maternal age did not seem to influence CHD prevalence significantly. Early diagnosis and proper screening should be undertaken among these patients.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"351 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115896319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fecal secretory immunoglobulin a, human ß defensin-2, and calprotectin levels in preterm neonates who consumes breast milk only, formula milk only, and combination 只吃母乳、只吃配方奶和混合配方奶的早产儿粪便分泌免疫球蛋白a、人ß防御素-2和钙保护蛋白水平

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v1i2.16

Eko Sulistijono, Putri Primawardani, Rusdian N. Ningsih, Bernardinus P.A. Pradipta

引用次数: 0

Correlation of Regulatory T Cells Percentage and Lung Tuberculosis in Children 调节性T细胞百分比与儿童肺结核的相关性

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v2i1.21

Melinda, Ery Olivianto, HMS Chandra Kusuma

{"title":"Correlation of Regulatory T Cells Percentage and Lung Tuberculosis in Children","authors":"Melinda, Ery Olivianto, HMS Chandra Kusuma","doi":"10.51559/pedscij.v2i1.21","DOIUrl":"https://doi.org/10.51559/pedscij.v2i1.21","url":null,"abstract":"Introduction: The prevalence of TB in Indonesia reaches 1.59 new cases per 1000 population and 27.3% are pediatric patients. Currently in Indonesia, the incidence of TB in children is still high, even though the Bacille Calmette Guerin (BCG) vaccination has been a mandatory immunization program since 1977. The role of T-Regulatory Cell (Treg) in the Mtb infection is very complicated. \u0000Method: This observational study using cross sectional analyzed quantity of Treg Cells in the circulation of pediatric TB and non-TB patients. Measurement of circulatory Treg cell percentage was performed using Flow Cytometry. \u0000Result: We found that pediatric TB patients have significantly higher that were almost two-fold higher Treg cell percentage compared to non-TB patients (3.51% vs. 1.86%; p < 0.001). It is concluded that there is an increase in the percentage of Treg cells in children with pulmonary TB compared to children who didn’t had TB infection. \u0000Conclusion:This finding provides an understanding of the complex mechanism of Treg cells in children with pulmonary tuberculosis, so that it can become the basis for the development of management of pediatric pulmonary TB and reduce morbidity and mortality of children due to pulmonary TB.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121025033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingomonas paucimobilis an unusual cause of subdural empyema in pediatric: a case report 少动鞘单胞菌是小儿硬膜下脓肿的罕见病因:1例报告

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v2i1.19

Annisa Muhyi, Amalia Aswin

{"title":"Sphingomonas paucimobilis an unusual cause of subdural empyema in pediatric: a case report","authors":"Annisa Muhyi, Amalia Aswin","doi":"10.51559/pedscij.v2i1.19","DOIUrl":"https://doi.org/10.51559/pedscij.v2i1.19","url":null,"abstract":"Introduction: Acute bacterial meningitis continues to be a neurological emergency with high mortality and morbidity \u0000Case: We report the case of a pediatric patient with subdural empyema due to Sphingomonas paucimobilis. A 2-month-old infant developed fever, generalized seizures, and worsening general status. He had a cough for two weeks, and a chest X-ray showed pneumonia. Laboratory tests reveal marked leukocytosis, a white blood cell count of 28.500/mL, and an elevated platelet level of 654.000 mg/dL. A computerized brain tomography revealed an empyema subdural. A cerebrospinal fluid analysis showed unclear fluid, revealed cell count 3560 cells, 90% mononuclear and 10% polymorphonuclear, red blood cell count of 0/mm3, protein of 370 mg/dL, and glucose of 35 mg/dL. His cerebrospinal fluid culture showed Sphingomonas paucimobilis sensitive to cephalosporin, levofloxacin, meropenem, imipenem, gentamycin, tobramycin and amikacin. He was treated empirically with meropenem. The patient had a rapid recovery from the seventh day of treatment and was discharged on hospital day 14. \u0000Conclusion: We highly recommend raising awareness about subdural empyema as a complication for acute bacterial meningitis caused by S. paucimobilis in community-acquired infection.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"288 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131612440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Relationship of Epidermal Growth Factor (EGF) and Insulin-Like Growth Factor-1 (IGF-1) levels in breast milk colostrum with the occurrence of necrotizing enterocolitis in neonates 母乳初乳中表皮生长因子(EGF)和胰岛素样生长因子-1 (IGF-1)水平与新生儿坏死性小肠结肠炎发生的关系

Pediatrics Sciences Journal Pub Date : 2022-02-03 DOI: 10.51559/pedscij.v2i2.30

A. Puryatni, Prasetya Ismail, F. Juniantika, Bayu Kurniawan

{"title":"Relationship of Epidermal Growth Factor (EGF) and Insulin-Like Growth Factor-1 (IGF-1) levels in breast milk colostrum with the occurrence of necrotizing enterocolitis in neonates","authors":"A. Puryatni, Prasetya Ismail, F. Juniantika, Bayu Kurniawan","doi":"10.51559/pedscij.v2i2.30","DOIUrl":"https://doi.org/10.51559/pedscij.v2i2.30","url":null,"abstract":"Background: Colostrum contains various bioactive compounds that have various roles and potentials in preventing the occurrence of necrotizing enterocolitis (NEC). EGF and IGF-1 are growth factors found in breast milk colostrum in the form of polypeptides that play a role in regulating and stimulating cell proliferation and differentiation processes. The purpose of this study was to determine the relationship between EGF and IGF-1 levels in breast milk colostrum with the occurrence of NEC in neonates. \u0000Methods: This analytical observational study was conducted at Saiful Anwar Hospital Malang during June-August 2019 on mothers and neonates who were breastfed. Maternal colostrum was collected at 72 hours postpartum, while NEC incidence in infants was determined prospectively. EGF and IGF-1 levels in colostrum were examined using the ELISA method. The data were processed by SPSS 21 program and analyzed using Spearman’s test and logistic regression. \u0000Results: 24 mother and baby pair samples were included in the study. The mean level of EGF in maternal colostrum was 466±304 ng/ml, and the mean level of IGF-1 was 1.99±0.96 ng/ml with no significant difference in levels based on gestational age. There is a strong negative correlation between the levels of EGF (r = -0.630; p=0.001) and IGF-1 (r = -0.646; p=0.001) on the occurrence of NEC. With the regression test, there was no significant effect between the levels of IGF-1 (p=0.995) and EGF (p=0.997) on NEC occurrence. \u0000Conclusion: EGF and IGF-1 levels have a significant relationship to the occurrence of NEC. The higher levels of EGF and IGF-1 contained in breast milk colostrum reduced the incidence of necrotizing enterocolitis in neonates.","PeriodicalId":147743,"journal":{"name":"Pediatrics Sciences Journal","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130852684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0