Japanese journal of pharmacology最新文献_第9页

A peroxisome proliferator-activated receptor gamma agonist influenced daily profile of energy expenditure in genetically obese diabetic rats. 过氧化物酶体增殖物激活受体γ激动剂影响遗传性肥胖糖尿病大鼠的每日能量消耗。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.279

Y. Yoshida, M. Ichikawa, M. Ohta, S. Kanai, M. Kobayash, Y. Ichimaru, T. Shimazoe, Shigenori Watanabe, A. Funakoshi, Kyoko Miyasak

{"title":"A peroxisome proliferator-activated receptor gamma agonist influenced daily profile of energy expenditure in genetically obese diabetic rats.","authors":"Y. Yoshida, M. Ichikawa, M. Ohta, S. Kanai, M. Kobayash, Y. Ichimaru, T. Shimazoe, Shigenori Watanabe, A. Funakoshi, Kyoko Miyasak","doi":"10.1254/JJP.88.279","DOIUrl":"https://doi.org/10.1254/JJP.88.279","url":null,"abstract":"Otsuka Long Evans Tokushima Fatty (OLETF) rats were developed as a model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. We reported that the daily profiles of energy expenditure associated with two peaks (one between 05:00 and 08:00 and the other between 20:00 and 22:00) were observed at 8 weeks of age (without NIDDM), while these two peaks disappeared at 24 weeks of age with NIDDM. As a new anti-diabetic drug, a peroxisome proliferator-activated receptor y agonist pioglitazone hydrochloride has been developed, we examined whether pioglitazone normalized daily profiles of energy expenditure at 24 weeks of age. A control diet and pioglitazone (0.1%)-containing diet were fed from 6 weeks of age. The two peaks of daily profiles of energy expenditure, which disappeared in OLETF rats with the control diet at 24 weeks of age, were reproduced by administration of pioglitazone. The respiratory quotient was lower and fat derived energy used for combustion was increased by pioglitazone at both ages. The body weight, daily food intake, plasma levels of fat, insulin, leptin and the wet weight of visceral fat were not influenced, but the levels of blood hemoglobin Alc and plasma tumor necrosis factor a were decreased by pioglitazone. Administration of pioglitazone improved daily profiles of energy expenditure via affecting glucose and fat metabolisms.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"62 1","pages":"279-84"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79028436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Cerebrovascular inflammation following subarachnoid hemorrhage. 蛛网膜下腔出血后脑血管炎症。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.227

R. Sercombe, Y. T. Dinh, P. Gomis

{"title":"Cerebrovascular inflammation following subarachnoid hemorrhage.","authors":"R. Sercombe, Y. T. Dinh, P. Gomis","doi":"10.1254/JJP.88.227","DOIUrl":"https://doi.org/10.1254/JJP.88.227","url":null,"abstract":"Aneurysmal subarachnoid hemorrhage frequently results in complications including intracranial hypertension, rebleeding and vasospasm. The extravasated blood is responsible for a cascade of reactions involving release of various vasoactive and pro-inflammatory factors (several of which are purported to induce vasospasm) from blood and vascular components in the subarachnoid space. The authors review the available evidence linking these factors to the development of inflammatory lesions of the cerebral vasculature, emphasizing: 1) neurogenic inflammation due to massive release of sensory nerve neuropeptides; 2) hemoglobin from lysed erythrocytes, which creates functional lesions of endothelial and smooth muscle cells; 3) activity, expression and metabolites of lipoxygenases cyclooxygenases and nitric oxide synthases; 4) the possible role of endothelin-1 as a pro-inflammatory agent; 5) serotonin, histamine and bradykinin which are especially involved in blood-brain barrier disruption; 6) the prothrombotic and pro-inflammatory action of complement and thrombin towards endothelium; 7) the multiple actions of activated platelets, including platelet-derived growth factor production; 8) the presence of perivascular and intramural macrophages and granulocytes and their interaction with adhesion molecules; 9) the evolution, origins, and effects of pro-inflammatory cytokines, especially IL-1, TNF-alpha and IL-6. Human and animal studies on the use of anti-inflammatory agents in subarachnoid hemorrhage include superoxide and other radical scavengers, lipid peroxidation inhibitors, iron chelators, NSAIDs, glucocorticoids, and serine protease inhibitors. Many animal studies claim reduced vasospasm, but these effects are not always confirmed in human trials, where symptomatic vasospasm and outcome are the major endpoints. Despite recent work on penetrating vessel constriction, there is a paucity of studies on inflammatory markers in the microcirculation.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"19 1","pages":"227-49"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81791711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 184

Necessity of enzymatic activity of alkaline phosphatase for mineralization of osteoblastic cells. 碱性磷酸酶活性对成骨细胞矿化的必要性。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.262

Y. Sugawara, Kuniaki Suzuki, M. Koshikawa, M. Ando, J. Iida

{"title":"Necessity of enzymatic activity of alkaline phosphatase for mineralization of osteoblastic cells.","authors":"Y. Sugawara, Kuniaki Suzuki, M. Koshikawa, M. Ando, J. Iida","doi":"10.1254/JJP.88.262","DOIUrl":"https://doi.org/10.1254/JJP.88.262","url":null,"abstract":"Alkaline phosphatase (ALP) is supposed to be important for bone formation; however, its role is not clear. In this study, we examined the importance of enzymatic activity of ALP and anchoring of ALP protein to the cells for mineralization of an osteoblastic cell line, MC3T3-E1. While we cultured the cells in the presence of tetramisole, an inhibitor of ALP activity, ALP protein was expressed at a similar level to that in the control. Although tetramisole showed no effect on cell growth and increased hydroxyproline accumulation, it decreased the osteocalcin production and the accumulation of calcium and phosphate in the matrices. Tetramisole also inhibited mineralized nodule formation, which was observed by optical microscopy and detected by Von Kossa staining. On the other hand, when ALP protein was released from the cell membranes with the use of phosphatidylinositol-specific phospholipase C, no marked changes were detected in hydroxyproline, calcium and phosphate accumulations in the matrices at late calcification stage, which was consistent with the morphological findings. These results clearly show that enzymatic activity of ALP is necessary for mineralization of MC3T3-E1 cells, but not the presence of ALP protein or anchoring of ALP to the cells.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"24 1","pages":"262-9"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78800473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75

Itch-associated response induced by experimental dry skin in mice. 实验性干燥皮肤诱导小鼠瘙痒相关反应。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.285

Takayuki Miyamoto, H. Nojima, Tomoko Shinkado, T. Nakahashi, Y. Kuraishi

{"title":"Itch-associated response induced by experimental dry skin in mice.","authors":"Takayuki Miyamoto, H. Nojima, Tomoko Shinkado, T. Nakahashi, Y. Kuraishi","doi":"10.1254/JJP.88.285","DOIUrl":"https://doi.org/10.1254/JJP.88.285","url":null,"abstract":"The present study was conducted to establish a new mouse model of dry skin pruritus. The rostral back was treated daily with cutaneous application of acetone/ether (1:1) mixture (AE), water following AE (AEW), 1% sodium lauryl sulfate (SLS) or tape stripping (TS). On the day after 5-day treatment, although all four treatments significantly decreased stratum corneum (SC) hydration and increased transepidermal water loss (TEWL), only AEW treatment significantly increased spontaneous scratching. An increase in the frequency of TS produced the marked increase of TEWL, without significant effects on SC hydration and spontaneous scratching. In AEW-treated mice, changes in SC hydration and TEWL were marked in the initial 2-day period, while spontaneous scratching increased gradually from 3 days after starting the treatment. The degranulation of cutaneous mast cells was increased by SLS treatment but not by other treatments. There was no apparent difference in AEW-induced spontaneous scratching between mast cell-deficient mice (WBB6F1-W/Wv) and normal littermates (WBB6F1-+/+). Opioid antagonists, naloxone and naltrexone, (1 mg/kg, subcutaneously) significantly suppressed spontaneous scratching in AEW-treated mice. It is suggested that spontaneous scratching of AEW-treated mice is an itch-related response and a useful model for studying the mechanisms of dry skin pruritus.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"43 1","pages":"285-92"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90396194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 176

Cardiac effects of a selective rho-associated kinase inhibitor, Y-27632, assessed in canine isolated, blood-perfused heart preparations. 选择性rho相关激酶抑制剂Y-27632在犬分离血灌注心脏制剂中的心脏效应评估

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.359

A. Sugiyama, Y. Yatomi, A. Takahara, Y. Satoh, K. Hashimoto

引用次数: 9

Effect of methamphetamine and imipramine on cerebral ischemia-induced hyperactivity in Mongolian gerbils. 甲基苯丙胺和丙咪嗪对蒙古沙鼠脑缺血多动的影响。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.293

H. Araki, Takahiko Yamamoto, Yuri Kobayashi, K. Futagami, H. Kawasaki, Y. Gomita

引用次数: 8

Existence of Functional α1A- and α1D- but No α1B-Adrenoceptor Subtypes in Rat Common Carotid Arteries 大鼠颈总动脉存在功能性α1A-和α1D-亚型，不存在α 1b -亚型

Japanese journal of pharmacology Pub Date : 2002-02-01 DOI: 10.1254/JJP.88.146

S. Chiba, M. Tsukada

引用次数: 3

Novel mutations in C-terminal channel region of the ryanodine receptor in malignant hyperthermia patients. 恶性高热患者ryanodine受体c端通道区域的新突变。

Japanese journal of pharmacology Pub Date : 2002-02-01 DOI: 10.1254/JJP.88.159

H. Oyamada, K. Oguchi, N. Saitoh, T. Yamazawa, K. Hirose, Y. Kawana, Kazunao Wakatsuki, K. Oguchi, M. Tagami, K. Hanaoka, M. Endo, M. Iino

{"title":"Novel mutations in C-terminal channel region of the ryanodine receptor in malignant hyperthermia patients.","authors":"H. Oyamada, K. Oguchi, N. Saitoh, T. Yamazawa, K. Hirose, Y. Kawana, Kazunao Wakatsuki, K. Oguchi, M. Tagami, K. Hanaoka, M. Endo, M. Iino","doi":"10.1254/JJP.88.159","DOIUrl":"https://doi.org/10.1254/JJP.88.159","url":null,"abstract":"Malignant hyperthermia (MH) is a pharmacogenetical complication of general anesthesia resulting from abnormal Ca2+-induced Ca2+ release (CICR) via the type 1 ryanodine receptor (RyR1) in skeletal muscles. In this study, we analyzed the genomic DNAs prepared for determination of all the 106 exons of the RyR1 gene from blood samples donated by two MH patients with extremely high CICR rates in their biopsied skeletal muscles and a clear history of MH incidence. Two novel point mutations were found in the exons 96 and 101 with alterations in the coded amino acids within the C-terminal channel region, i.e., Pro4668 to Ser and Leu4838 to Val. The latter mutation was found in both MH patients. Rabbit RyR1 channels carrying corresponding mutations were expressed in CHO cells for functional assay. It was found that the L to V but not the P to S mutation of the RyR1 resulted in enhanced Ca2+ release activity. These results indicate that the L4838V mutation is responsible for the MH incidence. The L4838V mutation is unique because it is the mutation first found within a hydrophobic transmembrane segment of the channel region and should provide further information on the function of the RyR1 as well as for genetic diagnosis of MH.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"35 1","pages":"159-66"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86260210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Augmented natriuretic peptide-induced guanylyl cyclase activity and vasodilation in experimental hyperglycemic rats. 利钠肽增强诱导实验性高血糖大鼠胍基环化酶活性和血管舒张。

Japanese journal of pharmacology Pub Date : 2002-02-01 DOI: 10.1254/JJP.88.167

H. Kook, Jongun Lee, S. Kim, Sang Woo Kim, Y. H. Baik

{"title":"Augmented natriuretic peptide-induced guanylyl cyclase activity and vasodilation in experimental hyperglycemic rats.","authors":"H. Kook, Jongun Lee, S. Kim, Sang Woo Kim, Y. H. Baik","doi":"10.1254/JJP.88.167","DOIUrl":"https://doi.org/10.1254/JJP.88.167","url":null,"abstract":"The present study was aimed to investigate whether hyperglycemia may alter the regulation of vascular natriuretic peptide receptors (NPR). The hyperglycemia was induced in rats by the treatment with streptozotocin (50 mg/kg, i.v.). The expression of different subtypes of NPR was determined in the thoracic aorta by reverse transcriptase-polymerase chain reaction and quantitative in vitro receptor autoradiography. The isometric tension and the guanylyl cyclase activity of the isolated thoracic aorta in response to natriuretic peptides were also determined. Following the treatment with streptozotocin, the plasma concentration of atrial natriuretic peptide (ANP) was significantly increased. The expression of NPR-A was increased, while that of NPR-C was reduced. The receptor binding study demonstrated an increased maximal binding capacity of NPR, with its affinity not significantly altered. The magnitude of vasodilation and guanylyl cyclase activity in response to ANP was significantly increased. On the other hand, the vasodilator response as well as the tissue formation of cGMP in response to acetylcholine or sodium nitroprusside was significantly reduced. These results indicate that the hyperglycemia may cause an altered regulation of vascular NPR.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"14 1","pages":"167-73"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90102246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Novel monoamine oxidase inhibitors, 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, and their differential reversibility. 新型单胺氧化酶抑制剂3-(2-氨基乙氧基)-1,2-苯并恶唑衍生物及其差异可逆性。

Japanese journal of pharmacology Pub Date : 2002-02-01 DOI: 10.1254/JJP.88.174

K. Yoshimi, M. Kozuka, J. Sakai, Tomoko Iizawa, Y. Shimizu, I. Kaneko, K. Kojima, N. Iwata

{"title":"Novel monoamine oxidase inhibitors, 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, and their differential reversibility.","authors":"K. Yoshimi, M. Kozuka, J. Sakai, Tomoko Iizawa, Y. Shimizu, I. Kaneko, K. Kojima, N. Iwata","doi":"10.1254/JJP.88.174","DOIUrl":"https://doi.org/10.1254/JJP.88.174","url":null,"abstract":"Although possible usefulness of non-selective monoamine oxidase (MAO) inhibitors for Parkinson's disease therapy has been suggested in the literature, MAO inhibitors whose inhibition is reversible and have dual action to both MAO-A and -B subtypes is not available yet. Subtype selectivity and reversibility of a series of novel MAO inhibitors, 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, were studied. Several dual MAO inhibitors, which inhibit both MAO-A and -B, were obtained. When administered to mice, their effects were generally reversible. Among the derivatives, RS-1636 and RS-1653 had much longer duration of brain MAO-B inhibition than that of MAO-A. In vitro, the inhibited MAO-A activity by these compounds was partially recovered by buffer change at 4 degrees C, while little MAO-B activity was recovered. Although it is not fully elucidated yet, the reversibility of these inhibitors is probably determined primarily by this dissociation profile. This unique differential reversibility indicates that optimization of the balance of actions can be achieved by differentiating reversibility to each target molecule.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"28 1","pages":"174-82"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89418828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10