Japanese journal of pharmacology最新文献_第8页

Hyperpolarization-activated current I(h) in nucleus of solitary tract neurons: regional difference in serotonergic modulation. 孤立束神经元核超极化激活电流I(h):血清素能调节的区域差异。

Japanese journal of pharmacology Pub Date : 2002-04-01 DOI: 10.1254/JJP.88.459

Yuki Iwahori, Y. Ikegaya, N. Matsuki

引用次数: 12

Effects of angiotensin II on the renal interstitial concentrations of NO2/NO3 and cyclic GMP in anesthetized rats. 血管紧张素II对麻醉大鼠肾间质NO2/NO3和环GMP浓度的影响。

Japanese journal of pharmacology Pub Date : 2002-04-01 DOI: 10.1254/JJP.88.436

Matlubur Rahman, S. Kimura, H. Yoneyama, H. Kosaka, T. Fukui, A. Nishiyama, Y. Abe

{"title":"Effects of angiotensin II on the renal interstitial concentrations of NO2/NO3 and cyclic GMP in anesthetized rats.","authors":"Matlubur Rahman, S. Kimura, H. Yoneyama, H. Kosaka, T. Fukui, A. Nishiyama, Y. Abe","doi":"10.1254/JJP.88.436","DOIUrl":"https://doi.org/10.1254/JJP.88.436","url":null,"abstract":"The present study was conducted to determine whether exogenous angiotensin II (Ang II) may increase the renal interstitial fluid concentrations of NO2/NO3 (NOx) and cyclic guanosine monophosphate (cGMP) concomitantly and which Ang II receptor subtypes may induce these changes in anesthetized rats, using a microdialysis method. Ang II (50 ng/kg per min, i.v.) significantly increased mean blood pressure (MBP), extraction rates of renal interstitial NOx from 23.9+/-1.0 to 31.2+/-1.9 pmol/min, and cGMP from 4.1+/-0.3 to 6.4+/-0.5 fmol/min, and decreased renal blood flow (RBF). The AT1-receptor antagonist CV11974 alone significantly increased RBF, but did not alter MBP, renal interstitial concentrations of NOx and cGMP. A superimposition of Ang II on CV11974 did not affect MBP and RBF, but significantly increased renal interstitial concentrations of NOx and cGMP. The AT2-receptor antagonist PD123319 alone did not change any of the parameters. However, superimposition of Ang II on PD123319 increased MBP and decreased RBF without any effects on renal interstitial concentrations of NOx and cGMP. These results suggest that Ang II stimulates NO production via the AT2-receptor in the kidney.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"32 1","pages":"436-41"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76895156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Molecular diversity of structure and function of the voltage-gated Na+ channels. 电压门控Na+通道结构和功能的分子多样性。

Japanese journal of pharmacology Pub Date : 2002-04-01 DOI: 10.1254/JJP.88.365

N. Ogata, Yoshiaki Ohishi

{"title":"Molecular diversity of structure and function of the voltage-gated Na+ channels.","authors":"N. Ogata, Yoshiaki Ohishi","doi":"10.1254/JJP.88.365","DOIUrl":"https://doi.org/10.1254/JJP.88.365","url":null,"abstract":"A variety of different isoforms of voltage-sensitive Na+ channels have now been identified. The recent three-dimensional analysis of Na+ channels has unveiled a unique and unexpected structure of the Na+ channel protein. Na+ channels can be classified into two categories on the basis of their amino acid sequence, Nav1 isoforms currently comprising nine highly homologous clones and Nax that possesses structure diverging from Nav1, especially in several critical functional motifs. Although the functional role of Nav1 isoforms is primarily to form an action potential upstroke in excitable cells, recent biophysical studies indicate that some of the Nav1 isoforms can also influence subthreshold electrical activity through persistent or resurgent Na+ currents. Nav1.8 and Nav1.9 contain an amino acid sequence common to tetrodotoxin resistant Na+ channels and are localized in peripheral nociceptors. Recent patch-clamp experiments on dorsal root ganglion neurons from Nav1.8-knock-out mice unveiled an additional tetrodotoxin-resistant Na+ current. The demonstration of its dependence on Nav1.9 provides evidence for a specialized role of Nav1.9, together with Nav1.8, in pain sensation. Although Nax has not been successfully expressed in an exogenous system, recent investigations using relevant native tissues combined with gene-targeting have disclosed their unique \"concentration\"-sensitive but not voltage-sensitive roles. In this context, these emerging views of novel functions mediated by different types of Na+ channels are reviewed, to give a perspective for future research on the expanding family of Na+ channel clones.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"1 1","pages":"365-77"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85361882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 164

Prostate apoptosis response-4 involved in the protective effect of salvianolic acid B against amyloid beta peptide-induced damage in PC12 cells. 前列腺凋亡反应-4参与丹酚酸B对淀粉样肽诱导的PC12细胞损伤的保护作用。

Japanese journal of pharmacology Pub Date : 2002-04-01 DOI: 10.1254/JJP.88.422

M. Tang, Juntian Zhang

{"title":"Prostate apoptosis response-4 involved in the protective effect of salvianolic acid B against amyloid beta peptide-induced damage in PC12 cells.","authors":"M. Tang, Juntian Zhang","doi":"10.1254/JJP.88.422","DOIUrl":"https://doi.org/10.1254/JJP.88.422","url":null,"abstract":"To observe the effect of salvianolic acid-B (SalB) against the cytoxicity of amyloid beta peptide (A-beta)(25-35) to PC12 cells, the cells were incubated with A-beta, and the cytoxicity was investigated by MTT, flow cytometry and a cell free apoptotic system. The expression of prostate apoptotic response-4 (Par-4) was detected by Western blot. Aged A-beta 10 micromol/L significantly inhibited the MTT reduction of PC12 cells, SalB1 micromol/L inhibited the toxicity induced by A-beta. In flow cytometric analysis, PC12 cells treated with A-beta exhibited degraded DNA content characteristic of apoptosis cells (1.53% vs 19.9%). PC12 cells pretreated with SalB (10 nmol/L, 100 nmol/L, 1 micromol/L) manifested relatively low proportion of apoptosis (15.7%, 13.5%, 11.8%, respectively). SalB (10 nmol/L - 1 micromol/L) when added at the beginning of the cell free apoptotic reaction had no apparent effect on the nuclei apoptosis. Pretreatment of PC12 cells with SalB largely prevented the increase in Par-4 expression of the cells when they were exposed to A-beta. The results suggest that Par-4 is involved in the protective effect of SalB against A-beta-induced damage in PC12 cells.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":" 28","pages":"422-7"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91414405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Intradermal cholinergic agonists induce itch-associated response via M3 muscarinic acetylcholine receptors in mice. 皮内胆碱能激动剂通过M3毒蕈碱乙酰胆碱受体诱导小鼠瘙痒相关反应。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.351

Takayuki Miyamoto, H. Nojima, Y. Kuraishi

引用次数: 26

Effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in dentate gyrus of alcohol-intoxicated Sprague-Dawley rats. 葛根对酒精中毒大鼠齿状回细胞增殖及一氧化氮合酶表达的影响。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.355

M. Jang, M. Shin, J. Chung, Hyun-Dae Shin, Yeunhee J. Kim, Ee-Hwa Kim, Chang-Ju Kim

引用次数: 6

Renal protective effect of candesartan cilexetil in spontaneously hypercholesterolemic rats. 坎地沙坦西莱地酯对自发性高胆固醇血症大鼠肾脏的保护作用。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.300

T. Matsuo, E. Ishikawa, M. Ohta, Y. Shibouta, Y. Ishimura, Y. Imura, Y. Sugiyama

{"title":"Renal protective effect of candesartan cilexetil in spontaneously hypercholesterolemic rats.","authors":"T. Matsuo, E. Ishikawa, M. Ohta, Y. Shibouta, Y. Ishimura, Y. Imura, Y. Sugiyama","doi":"10.1254/JJP.88.300","DOIUrl":"https://doi.org/10.1254/JJP.88.300","url":null,"abstract":"Spontaneously hypercholesterolemic (SHC) rats exhibit hypercholesterolemia, proteinuria and focal glomerulosclerosis with age, and they finally die as a result of renal failure. In this study, the renoprotective effects of candesartan cilexetil, an angiotensin II type 1 receptor antagonist, and enalapril, an angiotensin I converting enzyme inhibitor, were examined in SHC rats. Candesartan cilexetil (0.1 and 1 mg /kg) and enalapril (10 mg/kg) were administered orally to 10-week-old SHC rats for a 6-week period. Candesartan cilexetil (1 mg/kg) and enalapril (10 mg/kg) significantly inhibited proteinuria and hypercholesterolemia to a similar extent. In untreated 16-week-old SHC rats, glomerulosclerosis, basophilic change, cast formation and interstitial mononuclear cell infiltration were observed. Candesartan cilexetil (1 mg/kg) inhibited all of these histological changes. Enalapril inhibited glomerulosclerosis and cast formation. These results show that candesartan cilexetil and enalapril have renal protective effects in SHC rats. Thus, angiotensin II might play an important role in renal pathogenesis in a model of focal glomerulosclerosis with hypercholesterolemia.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"71 1","pages":"300-6"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90445146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Enhanced cAMP response of naturally occurring mutant of human beta3-adrenergic receptor. 人β -肾上腺素能受体自然突变体cAMP反应增强。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.314

M. Isogaya, T. Nagao, H. Kurose

引用次数: 19

Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs. rho相关蛋白激酶和组胺在溶血磷脂酸诱导豚鼠气道高反应性中的作用。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.256

T. Hashimoto, Yuuki Nakano, M. Yamashita, Yang-Il Fang, H. Ohata, K. Momose

引用次数: 26

Cardiac effects of clinically available Kampo medicine assessed with canine isolated, blood-perfused heart preparations. 临床可用的汉布药对心脏的影响评估与犬分离，血液灌注心脏制剂。

Japanese journal of pharmacology Pub Date : 2002-03-01 DOI: 10.1254/JJP.88.307

A. Sugiyama, A. Takahara, Y. Satoh, M. Yoneyama, Y. Saegusa, K. Hashimoto

{"title":"Cardiac effects of clinically available Kampo medicine assessed with canine isolated, blood-perfused heart preparations.","authors":"A. Sugiyama, A. Takahara, Y. Satoh, M. Yoneyama, Y. Saegusa, K. Hashimoto","doi":"10.1254/JJP.88.307","DOIUrl":"https://doi.org/10.1254/JJP.88.307","url":null,"abstract":"Cardiac effects of 10 kinds of clinically available Kampo medicines were investigated: Kakkon-to (TJ-1), Dai-saiko-to (TJ-8), Boi-ogi-to (TJ-20), Chorei-to (TJ-40), Rokumi-gan (TJ-87), Tsu-do-san (TJ-105), Gosha-jinki-gan (TJ-107), San'o-shashin-to (TJ-113), Sairei-to (TJ-114) and Inchin-gorei-san (TJ-117). Chronotropic and inotropic effects were studied using canine isolated, blood-perfused heart preparations, while subcellular mechanisms were analyzed by measuring the drug-induced changes of the adenylate cyclase activity in the canine ventricular membrane preparation. Intracoronary injections of TJ-1, TJ-20, TJ-105 and TJ-113 increased the sinoatrial rate and developed tension of papillary muscle in a dose-related manner, which was significantly attenuated by the pretreatment of the preparations with beta-blocker propranolol. Meanwhile, the other extracts hardly affected these parameters. TJ-1, TJ-20 and TJ-113 increased the adenylate cyclase activity in a dose-related manner, but their potency was significantly less compared with that by an equivalent concentration of isoproterenol. Moreover, TJ-105 did not increase the adenylate cyclase activity. These results suggest that the positive chronotropic and inotropic effects of TJ-1, TJ-20, TJ- 105 and TJ-113 may be exerted through the direct stimulation of the beta-adrenoceptor and/or the norepinephrine release from the postganglionic nerve terminals in the heart.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"473 1","pages":"307-13"},"PeriodicalIF":0.0,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79087729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9