Japanese journal of pharmacology最新文献_第5页

Curative effect of combined treatment with alendronate and 1 alpha-hydroxyvitamin D3 on bone loss by ovariectomy in aged rats. 阿仑膦酸钠联合1 α -羟基维生素D3治疗老年大鼠卵巢切除术后骨质流失的疗效观察。

Japanese journal of pharmacology Pub Date : 2002-07-01 DOI: 10.1254/JJP.89.255

Masaya Ito, Y. Azuma, H. Takagi, K. Komoriya, T. Ohta, H. Kawaguchi

{"title":"Curative effect of combined treatment with alendronate and 1 alpha-hydroxyvitamin D3 on bone loss by ovariectomy in aged rats.","authors":"Masaya Ito, Y. Azuma, H. Takagi, K. Komoriya, T. Ohta, H. Kawaguchi","doi":"10.1254/JJP.89.255","DOIUrl":"https://doi.org/10.1254/JJP.89.255","url":null,"abstract":"We investigated the combined effects of alendronate and 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) on the bone mass and strength in aged ovariectomized rats and compared them with those of single treatments. Forty-week-old female rats underwent ovariectomy or sham operation, and after 15 weeks, ovariectomized rats were daily administered vehicle alone, alendronate (0.2 or 1.0 mg/kg,p.o.), 1alpha(OH)D3 (0.02 microg/kg, p.o.), or the combinations of 0.2 or 1.0 mg/kg of alendronate and 1alpha(OH)D3. After 12 weeks, the groups receiving combined treatments had significantly increased bone density and mechanical strength of the 4th lumbar vertebral body and the midfemur compared to the vehicle-treated group, and the effects were almost equal to or slightly less than the addition of those of the respective single treatments. The increase in mechanical strength was proportional to that in bone mineral density, suggesting that the stimulatory effects of these treatments on bone strength are ascribable primarily to those on bone mass. Analyses of histology, computed tomography, and biochemical markers confirmed the strong effect of the combined treatment on trabecular bone in particular, which was associated with increased trabecular number and decreased bone turnover. We propose that the combination of daily alendronate and 1alpha(OH)D3 is clinically promising as a curative treatment of established postmenopausal osteoporosis.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"16 1","pages":"255-66"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76643273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Pharmacological aspects of erectile dysfunction. 勃起功能障碍的药理学方面。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.101

J. Thomas

{"title":"Pharmacological aspects of erectile dysfunction.","authors":"J. Thomas","doi":"10.1254/JJP.89.101","DOIUrl":"https://doi.org/10.1254/JJP.89.101","url":null,"abstract":"Erectile dysfunction (ED) is a common problem with a prevalence of approximately 50% in men aged 40 to 70. There are several etiologies for ED including vasculogenic, neurogenic, hormonal and/or psychogenic factors; one-fourth of ED cases can be drug-related. Penile erection involves a complex interaction between the CNS and local factors. It is a neurovascular event modulated by psychological and hormonal factors. Pharmacologically, neural modulation and endocrine status are very important to attaining penile erection. There have been several significant advances for the pharmacologic treatment of ED. Treatments include agents that are not only orally effective, but possess either local or central acting mechanisms of action. Apomorphine, a centrally-acting agent, is effective in the treatment of ED. Sildenafil, another orally effective agent, acts by inhibiting cyclic GMP-specific phosphodiesterase Type V. Testosterone can be effective transdermally. Non-orally active agents include alprostadil and papaverine. Phentolamine and trazodone are effective in selected cases. Some agents can interact with other medications. Several pharmacological agents, some with central-acting mechanisms and some with Iocally-acting vascular effects, are therapeutically useful in the treatment of ED.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"120 1","pages":"101-12"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77411619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs. 豚鼠吸入pinacidil，一种atp敏感的K+通道打开剂和mogusteine具有有效的止咳作用。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.171

K. Morita, K. Onodera, J. Kamei

{"title":"Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.","authors":"K. Morita, K. Onodera, J. Kamei","doi":"10.1254/JJP.89.171","DOIUrl":"https://doi.org/10.1254/JJP.89.171","url":null,"abstract":"We investigated whether inhaled pinacidil and moguisteine inhibit capsaicin-induced coughs in guinea pigs. Inhaled pinacidil (15 - 60 microg/ml), an ATP-sensitive K+ channel opener, and moguisteine (15 - 60 microg/ml) each dose-dependently inhibited the number of capsaicin-induced coughs. The antitussive effects of pinacidil and moguisteine were significantly antagonized by pretreatment with glibenclamide (10 mg/kg, i.p.), an ATP-sensitive K+ channel blocker. However, pretreatment with naloxone methiodide (10 mg/kg, s.c.) had no significant effect on the antitussive effects of either pinacidil or moguisteine. On the other hand, inhaled dihydrocodeine (15 - 60 microg/ml) also dose-dependently suppressed the number of capsaicin-induced coughs. The antitussive effect of inhaled dihydrocodeine was significantly antagonized by pretreatment with naloxone methiodide (10 mg/kg, s.c.), but not by glibenclamide (10 mg/kg, i.p.). These results indicate that inhaled pinacidil and moguisteine both attenuate capsaicin-induced coughs. Pinacidil and moguisteine may exert their antitussive effects through the activation of ATP-sensitive K+ channels in the tracheobronchial tract. Furthermore, it is possible that ATP-sensitive K+ channels may be involved in the antitussive effects of peripherally acting non-narcotic antitussive drugs.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"3 1","pages":"171-5"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78784278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Laxative and anti-diarrheal activity of polycarbophil in mice and rats. 多碳粒细胞对小鼠和大鼠的通便和止泻作用。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.133

Takaharu Saito, F. Mizutani, Y. Iwanaga, K. Morikawa, H. Kato

{"title":"Laxative and anti-diarrheal activity of polycarbophil in mice and rats.","authors":"Takaharu Saito, F. Mizutani, Y. Iwanaga, K. Morikawa, H. Kato","doi":"10.1254/JJP.89.133","DOIUrl":"https://doi.org/10.1254/JJP.89.133","url":null,"abstract":"We investigated the laxative and anti-diarrheal activity of polycarbophil, an insoluble hydrophilic polymer, in comparison with other agents used for treating functional bowel disorder (FBD). In naive rats, polycarbophil (500 mg/kg) increased fecal weight and water contents without producing diarrhea. Carboxymethylcellulose (CMC) did not produce evident changes in bowel movement. Picosulfate markedly produced diarrhea. Loperamide, trimebutine and granisetron decreased stool output dose-dependently. Constipation, indicated by decrease in fecal weight, was produced by loperamide and clonidine in rats. Polycarbophil (500 mg/kg) and CMC increased fecal weight without diarrhea. Conversely trimebutine further decreased fecal weight in constipated rats. Polycarbophil (500 mg/kg) suppressed diarrhea induced by castor oil, and at 250-500 mg/kg, it produced shaped stools in animals with stools loosened by prostaglandin E2, serotonin or carbachol in mice. Polycarbophil (500 mg/kg) also reduced stools in rats with stool output increased by wrap restraint stress (WRS). CMC had no effect in the diarrhea models, except for carbachol-induced diarrhea, and WRS-induced evacuation. Loperamide, trimebutine and granisetron inhibited diarrhea production and WRS-induced evacuation, except for carbachol-induced diarrhea. The results show that polycarbophil prevents constipation and diarrhea without inducing diarrhea or constipation, which is different from the other agents. Hydrophilic polymers such as polycarbophil will be promising agents for the treatment of FBD.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"14 1","pages":"133-41"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76440656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Antagonistic interaction between BIIE 0246, a neuropeptide Y Y2-receptor antagonist, and omega-conotoxin GVIA, a Ca2+ channel antagonist, in presynaptic transmitter releases in dog splenic arteries. 神经肽yy2受体拮抗剂BIIE 0246和Ca2+通道拮抗剂omega- concontoxin GVIA在狗脾动脉突触前递质释放中的拮抗相互作用

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.188

Xiao‐ping Yang, S. Chiba

引用次数: 3

Functional study on nitroxidergic nerve in isolated dog pulmonary arteries and veins. 狗离体肺动脉、肺静脉氮氧能神经功能研究。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.197

K. Ayajiki, T. Okamura, K. Noda, N. Toda

引用次数: 13

Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats. 辣椒平抑制蛋白酶激活受体-2引发的大鼠热痛觉过敏，但对伤害感觉无抑制作用。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.184

N. Kawao, Chiho Shimada, H. Itoh, R. Kuroda, A. Kawabata

引用次数: 30

Organ culture as a useful method for studying the biology of blood vessels and other smooth muscle tissues. 器官培养是研究血管和其他平滑肌组织生物学的有效方法。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.93

H. Ozaki, H. Karaki

引用次数: 31

Influence of angiotensin II type 1-receptor antagonist CV11974 on infarct size and adjacent regional function after ischemia-reperfusion in dogs. 血管紧张素II型1受体拮抗剂CV11974对狗缺血再灌注后梗死面积和邻近区域功能的影响。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.120

H. Miyoshi, Y. Takayama, S. Kitashiro, T. Izuoka, D. Saito, Y. Imuro, J. Mimura, Satoshi Yamamoto, Mari Tokioka, T. Iwasaka

{"title":"Influence of angiotensin II type 1-receptor antagonist CV11974 on infarct size and adjacent regional function after ischemia-reperfusion in dogs.","authors":"H. Miyoshi, Y. Takayama, S. Kitashiro, T. Izuoka, D. Saito, Y. Imuro, J. Mimura, Satoshi Yamamoto, Mari Tokioka, T. Iwasaka","doi":"10.1254/JJP.89.120","DOIUrl":"https://doi.org/10.1254/JJP.89.120","url":null,"abstract":"The presence of nonischemic regional dysfunction at the adjacent region of the ischemic myocardium was demonstrated in clinical studies. Recent studies demonstrated an angiotensin II type 1 (AT1)-receptor antagonist reduced myocardial ischemia-reperfusion injury. We investigated the role of the adjacent region after reperfusion by studying the effects of AT1-receptor antagonist on myocardial function and infarct size. We investigated 12 open-chest anesthetized dogs undergoing 90 min of left anterior descending coronary artery occlusion followed by 4 h of reperfusion. Six dogs injected with an AT1-receptor antagonist (CV11974) immediately after reperfusion were compared with 6 control dogs. Percent systolic shortening (%SS) was measured by two sets of the pair sonomicrometer crystals implanted to adjacent and remote nonischemic myocardium. After 4 h of reperfusion, infarct size was measured. There were no significant differences of the %SS at baseline between two regions. In both groups, %SS at adjacent region after reperfusion was significantly decreased as compared with remote region. There were no significant differences between the two groups. Infarct size, as a percentage of the area at risk, was smaller in the AT, group than in control group (25.49+/-7.53% vs 68.58+/-26.88% P<0.01). AT1-receptor antagonist reduces infarct size. This effect is not related to the change of regional myocardial function at adjacent region after reperfusion.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"1 1","pages":"120-5"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89620309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Antioxidative and hypolipidemic effects of barley leaf essence in a rabbit model of atherosclerosis. 大麦叶精对动脉粥样硬化兔模型的抗氧化和降血脂作用。

Japanese journal of pharmacology Pub Date : 2002-06-01 DOI: 10.1254/JJP.89.142

Ya‐Mei Yu, C. Wu, Y. Tseng, Chingmin E. Tsai, Weng‐Cheng Chang

{"title":"Antioxidative and hypolipidemic effects of barley leaf essence in a rabbit model of atherosclerosis.","authors":"Ya‐Mei Yu, C. Wu, Y. Tseng, Chingmin E. Tsai, Weng‐Cheng Chang","doi":"10.1254/JJP.89.142","DOIUrl":"https://doi.org/10.1254/JJP.89.142","url":null,"abstract":"The antioxidative and hypolipidemic effects of barley leaf essence (BL) were investigated in a rabbit model of atherosclerosis. Twenty-four New Zealand White male rabbits were assigned randomly into four dietary groups. The normal group was fed regular rabbit chow and the control group was fed a chow containing 0.5% cholesterol and 10% corn oil. The BL group and the probucol group were fed the same diet as the control group plus 1% (w/w) BL or 1% (w/w) probucol, respectively. The plasma levels of total cholesterol, triacylglycerol, lucigenin-chemiluminescence (CL) and luminol-CL were increased in the control group compared to the normal group; and they were decreased in the BL group and the probucol group compared to the control group. The value of T50 of red blood cell hemolysis and the lag phase of low-density lipoprotein oxidation increased in the BL group and in the probucol group compared to the controls. Ninety percent of the intimal surface of the thoracic aorta was covered with atherosclerotic lesions in the control group, but only 60% of the surface was covered in the BL group. This 30% inhibition of hyperlipidemic atherosclerosis by BL was associated with a decrease in plasma lipids and an increase in antioxidative abilities (as measured by T50, lag phase and CL). These results suggest that the antioxidant and hypolipidemic effects of BL could be useful in the prevention of cardiovascular disease in which atherosclerosis is important.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"3 1","pages":"142-8"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77650251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48