Japanese journal of pharmacology最新文献_第3页

Psychogenic Stuttering Following a Gastric Bypass Operation: Case Report 胃旁路手术后心因性口吃1例报告

Japanese journal of pharmacology Pub Date : 2006-01-01 DOI: 10.29046/JJP.020.1.002

D. Raphael, F. Schoenfeld

{"title":"Psychogenic Stuttering Following a Gastric Bypass Operation: Case Report","authors":"D. Raphael, F. Schoenfeld","doi":"10.29046/JJP.020.1.002","DOIUrl":"https://doi.org/10.29046/JJP.020.1.002","url":null,"abstract":"We evaluated a 44-year-old female with bipolar affective disorder who presented with a 4-month history of severe stuttering and vague neurologic complaints. She had lost 200 pounds after gastric bypass surgery two years before. A childhood sexualabuse victim, she admits that she “hid” in her weight for most of her life. Neurological evaluation of this patient was negative, and speech-pathology evaluation revealed highly atypical stuttering. Gastric bypass patients with a history of psychiatric disorders and childhood sexual abuse may be particularly vulnerable to somatoform disorders. It has been widely reported that psychological complications are prevalent among the morbidly obese, although this point has been controversial (1). Glinski et al. elucidated that 70% of patients evaluated for gastric bypass surgery meet criteria for an Axis I disorder in the past or present and 36% for Axis II disorder (2). In his study, he found that the lifetime prevalence of depressive disorders alone in this population was 56%, compared with the known lifetime prevalence of depressive disorders of about 17% in the general population. Glinski noted that gastric bypass surgical candidates tend to use denial as a defense mechanism for avoiding negative emotions. In keeping with this, overeating may serve as distraction from negative emotion in these individuals. Somatization is another tendency in this particular population. Some improvement of psychosocial functioning after surgical treatment of obesity has been reported (3). Van Gemert et al. recently investigated the longterm effects of surgically induced weight loss on the psychological functioning of morbidly obese patients. They found that preoperative subjects had elevated values on negativism, somatization, and shyness scales on personality profiles; postoperatively, all these values normalized except somatization. Thus, postoperative patients still were concerned about their health and still were inclined to react to psychological stress with physical complaints.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"2 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75050279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Duty to Warn/Protect Doctrine and Its Application in Pennsylvania 警告/保护义务原则及其在宾夕法尼亚州的适用

Japanese journal of pharmacology Pub Date : 2005-01-01 DOI: 10.29046/JJP.019.1.002

C. Watson

引用次数: 1

Electroconvulsive Therapy: A Review of Its Current Status 电休克疗法的现状综述

Japanese journal of pharmacology Pub Date : 2005-01-01 DOI: 10.29046/JJP.019.1.001

T. Kenning, R. Mago, Steven F Huege, K. Certa, R. Pelchat

引用次数: 2

Use of Clozapine in Women of Childbearing Age: A Literature Review and Recommendations 氯氮平在育龄妇女中的应用:文献综述和建议

Japanese journal of pharmacology Pub Date : 2003-01-01 DOI: 10.29046/JJP.018.1.001

S. Friedman, Adit Yanjee

引用次数: 2

5-Hydroxytryptamine receptors, especially the 5-HT4 receptor, in guinea pig urinary bladder. 豚鼠膀胱中5-羟色胺受体，特别是5-HT4受体。

Japanese journal of pharmacology Pub Date : 2002-08-01 DOI: 10.1254/jjp.89.349

Akira Yoshida, Yasuko S-Yamashita, Muneshige Kaibara, Kohtaro Taniyama, Nobuyuki Tanaka

{"title":"5-Hydroxytryptamine receptors, especially the 5-HT4 receptor, in guinea pig urinary bladder.","authors":"Akira Yoshida, Yasuko S-Yamashita, Muneshige Kaibara, Kohtaro Taniyama, Nobuyuki Tanaka","doi":"10.1254/jjp.89.349","DOIUrl":"https://doi.org/10.1254/jjp.89.349","url":null,"abstract":"<p><p>The function of 5-hydroxytryptamine (5-HT) receptors, especially the 5-HT4 receptor, in the urinary bladder were examined in preparations isolated from the guinea pig by in vitro receptor autoradiography and determinations of mechanical activity and acetylcholine (ACh) release. Specific [125I]SB207710 binding sites were detected evenly throughout the urinary bladder. 5-HT (3 x 10(-8)-10(-4) M) caused contractions of strips of the urinary bladder, in a concentration dependent manner. Ketanserin antagonized the 5-HT-induced contractions, while granisetron and SB204070 antagonized the contractions induced by high concentrations of 5-HT. Atropine inhibited the contractions induced by high concentrations of 5-HT. Ketanserin prevented the 5-HT-induced contractions in the presence of atropine, but granisetron and SB204070 did not affect the contractions under such a condition. 5-HT enhanced the electrically-stimulated (5 Hz, 0.5 ms) outflow of [3H]acetylcholine from strips preloaded with [3H]choline, and the enhancement was antagonized by granisetron and SB204070. Thus, the contractile response to 5-HT was mediated by activations of 5-HT2, 5-HT3 and 5-HT4 receptors. The 5-HT2 receptor may be a property of high affinity to 5-HT and located on the smooth muscle cells. The 5-HT4 as well as 5-HT3 receptor may be a property of low affinity to 5-HT and located on the cholinergic neurons.</p>","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"89 4","pages":"349-55"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1254/jjp.89.349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21992964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Endomorphin-induced motivational effect: differential mechanism of endomorphin-1 and endomorphin-2. 内啡肽诱导的动机效应:内啡肽-1和内啡肽-2的差异机制。

Japanese journal of pharmacology Pub Date : 2002-07-01 DOI: 10.1254/JJP.89.224

M. Narita, S. Ozaki, Tsutomu Suzuki

{"title":"Endomorphin-induced motivational effect: differential mechanism of endomorphin-1 and endomorphin-2.","authors":"M. Narita, S. Ozaki, Tsutomu Suzuki","doi":"10.1254/JJP.89.224","DOIUrl":"https://doi.org/10.1254/JJP.89.224","url":null,"abstract":"The newly discovered endogenous mu-opioid receptor (MOP-R) ligands endomorphin-1 (EM-1) and -2 (EM-2) exhibit the highest specificity and affinity for the MOP-R of any endogenous substance so far described in the mammalian nervous system. This review focuses on differential mechanism of the motivational effects induced by EM-1 and EM-2. In the [35S]GTPgammaS binding assay, either EM-1 or EM-2 causes a concentration-dependent G-protein activation in brain membrane of normal mice, whereas neither EM-1 nor EM-2 produces any activation of G-protein in membranes obtained from the MOP-R knockout mice. These results provide direct evidence at the molecular level that both EMs act on the MOP-R as the endogenous MOP-R agonists. Based on the conditioned place preference paradigm in mice, EM-1 given intracerebroventriculally produced a dose-related place preference. This effect was abolished by pretreatment with the MOP-R antagonist beta-funaltrexamine (FNA) but not the delta-opioid receptor (DOP-R) antagonist naltrindole and the kappa-opioid receptor (KOP-R) antagonist nor-bialtorphimine (BNI). Unlike EM-1, EM-2 exhibited a place aversion. The aversive effect was inhibited by not only beta-FNA but also nor-BNI. Place aversion produced by EM-2 was also attenuated by pretreatment with an antiserum against an endogenous KOP-R ligand dynorphin A(1-17). These findings indicate that EM-1 may produce its rewarding effect via MOP-Rs. Furthermore, the aversive effect induced by EM-2 may be associated with the stimulation of the EM-1-insensitive MOP-R subtype and necessarily activate an endogenous KOPergic system in the mouse brain.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"30 1","pages":"224-8"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81637119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

An involvement of granulocyte medullasin in phenytoin-induced gingival overgrowth in rats. 粒细胞髓质蛋白参与苯妥英诱导的大鼠牙龈过度生长。

Japanese journal of pharmacology Pub Date : 2002-07-01 DOI: 10.1254/JJP.89.235

Y. Ozaki, K. Kunimatsu, Y. Hara, I. Kato, Y. Aoki, Kenji Yamamoto, Y. Kato

{"title":"An involvement of granulocyte medullasin in phenytoin-induced gingival overgrowth in rats.","authors":"Y. Ozaki, K. Kunimatsu, Y. Hara, I. Kato, Y. Aoki, Kenji Yamamoto, Y. Kato","doi":"10.1254/JJP.89.235","DOIUrl":"https://doi.org/10.1254/JJP.89.235","url":null,"abstract":"To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in phenytoin-induced gingival overgrowth, we established a rat model of gingival overgrowth. Thirty-two, 20-day-old male Fischer 344 rats were fed a diet containing phenytoin and sacrificed at 1, 2, 4 and 8 weeks. Control rats (n = 40) were fed the same diet, but without the drug and killed at the same weeks as experimental rats (n = 32) and 0 week (n = 8). The mandible specimens were resected and sectioned bucco-lingually between the first and second molars. A marked inflammatory-cell infiltration and elongated rete pegs were seen in the phenytoin-treated group. The extent of the overgrowth assessed by computer image analysis and the density of medullasin-positive cells by immunohistochemistry in the approximal gingiva showed a significant increase in the phenytoin-treated group compared to the control group. A marked infiltration of the positive cells in experimental rats was observed as early as 2 weeks when gingival overgrowth was not fully established. Medullasin-positive cells were mostly neutrophils and partly macrophage-like cells. These findings suggest that medullasin may be involved in mainly host defense and secondarily collagen metabolism in the phenytoin-induced rat model of gingival overgrowth.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"63 1","pages":"235-41"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86135586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of anions on ATP-induced [Ca2+], increase in NG108-15 cells. 阴离子对atp诱导的NG108-15细胞[Ca2+]增加的影响。

Japanese journal of pharmacology Pub Date : 2002-07-01 DOI: 10.1254/JJP.89.302

T. Watano, I. Matsuoka, K. Ogawa, J. Kimura

引用次数: 12

Inhibitory effects of metals on ATP-induced current through P2X7 receptor in NG108-15 cells. 金属对atp诱导电流通过NG108-15细胞P2X7受体的抑制作用。

Japanese journal of pharmacology Pub Date : 2002-07-01 DOI: 10.1254/JJP.89.296

T. Watano, I. Matsuoka, J. Kimura

引用次数: 9

Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin. 内源性mu-阿片肽、内啡肽和内啡肽诱导g蛋白活化的差异机制。

Japanese journal of pharmacology Pub Date : 2002-07-01 DOI: 10.1254/JJP.89.229

H. Mizoguchi, L. Tseng, Tsutomu Suzuki, I. Sora, M. Narita

{"title":"Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin.","authors":"H. Mizoguchi, L. Tseng, Tsutomu Suzuki, I. Sora, M. Narita","doi":"10.1254/JJP.89.229","DOIUrl":"https://doi.org/10.1254/JJP.89.229","url":null,"abstract":"It is well documented that the mu-opioid receptor (MOP-R) is expressed by neurons in several central nervous system regions. Its occupancy with agonist drugs modulate a variety of physiological processes including pain, reward, stress, immune responses, neuroendocrine functions, and cardiovascular control. Based on the receptor binding assay, endomorphin-1 and endomorphin-2 have the highest specificity and affinity for the MOP-R of any endogenous substance so far described in the mammalian nervous system. In contrast, beta-endorphin exhibits the strongest actions among endogenous opioid peptides mainly through the MOP-R; however, it also shows the distinct pharmacological actions. Recent cloning and expression studies have indicated that MOP-Rs are seven-transmembrane domain receptors whose actions are mediated through activation of heterotrimeric guanine nucleotide binding proteins (G-proteins). The activation of G-proteins by MOP-Rs can be measured by assessing agonist-induced stimulation of membrane binding of guanosine-5'-o-(3-[35S]thio)triphosphate ([35S]GTPgammaS). The subject of the present review is to focus on the differential mechanism underlying G-protein activation induced by these mu-opioid peptides using the [35S]GTPgammaS binding assay.","PeriodicalId":14750,"journal":{"name":"Japanese journal of pharmacology","volume":"50 1","pages":"229-34"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78916981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21