Journal of Addiction Medicine最新文献

Attitudes Toward Psychedelic Treatments by Individuals With Histories of Substance Use or Psychiatric Disorders: A Survey Study. 有药物使用史或精神疾病的个体对迷幻药治疗的态度：一项调查研究。

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-28 DOI: 10.1097/ADM.0000000000001517

Sara Prostko, Alexander Wu, Samuel Maddams, Veronica Szpak, Naomi Rosenblum, Lori M Hilt, Joji Suzuki

{"title":"Attitudes Toward Psychedelic Treatments by Individuals With Histories of Substance Use or Psychiatric Disorders: A Survey Study.","authors":"Sara Prostko, Alexander Wu, Samuel Maddams, Veronica Szpak, Naomi Rosenblum, Lori M Hilt, Joji Suzuki","doi":"10.1097/ADM.0000000000001517","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001517","url":null,"abstract":"Objectives: Psychedelics may be promising treatments for substance use disorders (SUD). This study aims to understand how individuals with alcohol use disorder (AUD), opioid use disorder (OUD), and psychiatric disorders perceive and experience psychedelics for both nonmedical and medical use.Methods: Data for this cross-sectional survey study were collected from June 2023 to February 2024 at a large, tertiary hospital through the hospital's patient portal, inpatient floors, and flyers. English-speaking adults with AUD, OUD, and psychiatric disorders were recruited. The response rate was 1.9% and the cooperation rate was 13.7%. The survey collected participants' demographic information, substance use treatment and history, and perceived risks and harms associated with psychedelics and psychedelic treatment.Results: Of 192 participants surveyed, 66% had previously tried psychedelics, 72.4% believed psychedelics could help patients with SUD or psychiatric disorders, and 69.8% said they would personally try psychedelic-assisted treatment for a SUD or psychiatric condition. Participants were significantly more likely to want to try psychedelic treatment for their own SUD or psychiatric disorder if they had previously used psilocybin (90.0% vs. 47.8%, P<0.001), MDMA (89.7% vs. 61.2%, P<0.001), or ketamine (100% vs. 65.7%, P=0.003). Participants against psychedelic treatment were significantly more likely to think that the risks associated with using a psychedelic included depression, anxiety, heart damage, brain damage, addiction, and more.Conclusion: A majority of participants supported psychedelics as a treatment and would accept receiving psychedelics as a treatment. However, further safety trials and educational interventions to best understand the benefits and risks of psychedelic-assisted therapy need to be completed.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and Associations in Patient Ratings Using the American Society of Addiction Medicine Criteria, 2013-2022. 使用美国成瘾医学协会标准的患者评分趋势和关联，2013-2022。

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-27 DOI: 10.1097/ADM.0000000000001516

Martin T Hall, Garrett C Hardy, Jennifer S Tinman, Amelia J Brooks

{"title":"Trends and Associations in Patient Ratings Using the American Society of Addiction Medicine Criteria, 2013-2022.","authors":"Martin T Hall, Garrett C Hardy, Jennifer S Tinman, Amelia J Brooks","doi":"10.1097/ADM.0000000000001516","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001516","url":null,"abstract":"Objectives: Matching individuals to the appropriate substance use treatment level is related to treatment and other health outcomes. However, only 1 study has explored whether ASAM Criteria for placement ratings differ based on demographic or contextual factors. This study aims to determine if factors commonly related to treatment outcomes correlate with ASAM placement ratings.Methods: This repeated cross-sectional study examined 1955 assessments of individuals served by Kentucky's Sobriety Treatment and Recovery Teams (START) program from 2013 to 2022. START serves parents referred to child welfare services because of substance use. Ordinal logistic regression was used to analyze the relationship between demographic factors and ASAM level of care recommendations.Results: Over the study period, recommendations for intensive outpatient decreased, while recommendations for outpatient and inpatient/residential increased. The ordinal logistic regression model identifying correlates of ASAM level of care ratings found that age and being a woman were positively associated with the odds of being assessed as needing a higher level of care, whereas compared with White people, Black people and people of other races had lower odds of being recommended higher levels of care. The year of assessment and the county were also associated with ASAM recommendations.Conclusions: Future studies should explore whether differences in ASAM ratings among racial groups are consistent across samples. If so, it will be critical for the field to understand whether these differences are driven predominantly by variations in substance use severity among racial groups or whether they represent underassessment among members of minoritized groups.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a High-sensitivity Rapid Xylazine Dipstick for Clinical Urine Testing. 临床尿液检测高灵敏度快速二嗪试纸的研制与验证。

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-23 DOI: 10.1097/ADM.0000000000001513

Ping Wang, William Butler, Niluksha Walalawela Abeykoon, Bridgit O Crews, Xiaofeng Xia

{"title":"Development and Validation of a High-sensitivity Rapid Xylazine Dipstick for Clinical Urine Testing.","authors":"Ping Wang, William Butler, Niluksha Walalawela Abeykoon, Bridgit O Crews, Xiaofeng Xia","doi":"10.1097/ADM.0000000000001513","DOIUrl":"10.1097/ADM.0000000000001513","url":null,"abstract":"Objectives: Xylazine has been increasingly identified in human overdose deaths. Detection of xylazine in clinical urine samples has clinical utility when treating overdoses. No screening method for xylazine has been approved by the US Food and Drug Administration (FDA). We aim to develop and validate a rapid and high sensitivity xylazine test for clinical urine testing.Methods: Monoclonal antibodies with high sensitivity and specificity against xylazine were developed. The leading clone was used to develop a competitive lateral flow immunoassay. The analytical cutoff, specificity, and clinical performance of this test was characterized using standards in drug-free urine and clinical urine samples.Results: The rapid xylazine dipstick test has a test time of 5 minutes and a cutoff of 10 ng/mL xylazine in drug-free urine. No cross reactivity with other commonly used drugs or endogenous metabolites were observed, except for 3% cross reactivity with clonidine. In 190 mass spectrometry confirmed clinical urine samples with xylazine concentrations ≥10 ng/mL and 168 urine samples with xylazine concentrations <10 ng/mL, the dipstick demonstrated a clinical sensitivity of 100% and a clinical specificity of 98%. All 4 false positives had combined xylazine and 4-hydroxy-xylazine concentrations in the 5-10 ng/mL range, with additional xylazine metabolites detected by mass spectrometry.Conclusions: When used with 10 ng/mL cutoff, the rapid xylazine dipstick demonstrates high clinical sensitivity and clinical specificity in urine samples, compared with gold standard mass spectrometry methods. This novel test has the potential to enable informed clinical decisions in cases with suspected xylazine exposure.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Clinician Education on the Americans With Disabilities Act for People With Opioid Use Disorder-A Prospective Study. 临床医生教育对美国残疾人法案对阿片类药物使用障碍患者的疗效-一项前瞻性研究

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-21 DOI: 10.1097/ADM.0000000000001509

Anna-Maria South, Anthony A Mangino, Laura C Fanucchi, Michelle R Lofwall

{"title":"Efficacy of Clinician Education on the Americans With Disabilities Act for People With Opioid Use Disorder-A Prospective Study.","authors":"Anna-Maria South, Anthony A Mangino, Laura C Fanucchi, Michelle R Lofwall","doi":"10.1097/ADM.0000000000001509","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001509","url":null,"abstract":"Objectives: Medication for opioid use disorder (MOUD) is a standard of care for mortality-reducing treatment for people with opioid use disorder (OUD). Some health care settings have blanket policies forbidding MOUD treatment, which can increase mortality risk and violate the Americans with Disabilities Act (ADA). Clinicians are not routinely educated on the ADA as it applies to OUD.Methods: This prospective survey study conducted in 2023 evaluates clinicians' knowledge, attitudes and current clinical practice before and after a 1-hour educational intervention (interactive didactic session) focused on patients with OUD who are experiencing discrimination under the ADA for being in MOUD treatment.Results: Seventy-nine participants were invited to participate in the study; 84.8% completed the baseline survey and 60.8% completed both surveys. Before the intervention, participants identified understanding the protections for people with OUD under the ADA as important (38.3%) or extremely important (57.5%). Yet, the minority (17.4%) felt they were able to identify a potential ADA violation or knew how to report one (13.1%). After the intervention, the majority of participants (99.6%) were confident in identifying potential ADA violations, knew how to report them (97.9%), and reported intent to report potential violations (89.3%).Conclusions: Education on the ADA as it applies to people with OUD significantly increased participants' self-reported ability to identify and willingness to report ADA violations (P < 0.001). More research is needed to assess whether education translates into increased reporting and sustained clinical practice change.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"My Recovery and My Work Are Separate": Perceptions of MOUD Among Certified Peer Recovery Supporters. “我的康复和我的工作是分开的”：认证同伴康复支持者对mod的看法。

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-21 DOI: 10.1097/ADM.0000000000001507

Isabelle Fox, Sydney Silverstein, Anna Murley Squibb

{"title":"\"My Recovery and My Work Are Separate\": Perceptions of MOUD Among Certified Peer Recovery Supporters.","authors":"Isabelle Fox, Sydney Silverstein, Anna Murley Squibb","doi":"10.1097/ADM.0000000000001507","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001507","url":null,"abstract":"Objectives: Ongoing high rates of opioid use and overdose death have prompted expansion of care options for people with substance use disorder (SUD), including medications for opioid use disorder (MOUD) and diverse forms of care linkage and support. The utilization of Certified Peer Recovery Supporters (CPRS) in the recovery field is an evidence-based practice to improve the continuum of care for SUD and has been increasingly incorporated into the recovery field. This study examines perceptions of MOUD among CPRS and how this shapes the collaborative provision of care within local treatment and recovery ecosystems.Methods: Qualitative interviews were conducted with CPRS (n=22) who were recruited via snowball sampling. Eligible participants were above 18 years old and had CPRS certification and self-reported work experience in treatment ecosystems in Dayton, OH. Interviews were transcribed and uploaded to Taguette software for coding and analysis. Select codes were analyzed using Iterative Categorization for further thematic analysis and data interpretation. All 22 participants were included in the analysis.Results: Three key findings pertaining to perceptions of MOUD among CPRS were identified, including stigma against MOUD within treatment and recovery ecosystems, the value of MOUD as treatment and harm reduction, and structural frustrations within the health care system. Participants expressed multiple, complex viewpoints surrounding the utilization of MOUD, specifically related to treatment, work environments, and health care settings.Conclusions: Results indicate that while many CPRS believe MOUD to be a successful treatment, stigma and institutional mistrust remain as barriers to both collaboration with medical providers and utilization of MOUD.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Financial Well-being and Impact on Alcohol and Mental Health Outcomes During the COVID-19 Pandemic. COVID-19大流行期间的财务状况及其对酒精和心理健康结果的影响

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-19 DOI: 10.1097/ADM.0000000000001510

Rishika V Shah, Jeremy W Luk, Melanie L Schwandt, Courtney L Vaughan, Andrew Waters, Nancy Diazgranados, Vijay A Ramchandani, Bethany L Stangl

{"title":"Financial Well-being and Impact on Alcohol and Mental Health Outcomes During the COVID-19 Pandemic.","authors":"Rishika V Shah, Jeremy W Luk, Melanie L Schwandt, Courtney L Vaughan, Andrew Waters, Nancy Diazgranados, Vijay A Ramchandani, Bethany L Stangl","doi":"10.1097/ADM.0000000000001510","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001510","url":null,"abstract":"Objectives: The COVID-19 pandemic has had widespread effects on the global economy. The present study seeks to examine the enduring impact of the COVID-19 pandemic on the relationship between financial well-being, alcohol use, and mental health outcomes in individuals with and without an alcohol use disorder (AUD).Methods: Participants who were enrolled in the NIAAA COVID-19 Pandemic Impact on Alcohol Study (C19-PIA) were invited to complete questionnaires on financial well-being, alcohol use, and mental health symptoms as part of an online anniversary survey collected between April 6, 2022, and July 2, 2022. The analytic sample included 250 participants who had valid data on key study variables, including past year AUD previously assessed in the NIAAA Natural History Protocol using structured clinical interviews.Results: Individuals with AUD were less likely to apply for financial assistance and reported greater worries about their financial well-being. Lower financial well-being during the pandemic was associated with higher problematic drinking and worse mental health outcomes. Significant covariates included age, sex, and race.Conclusions: The findings suggest an association between financial stress and problematic alcohol use during financial instability that appeared to persist 2 years into the COVID-19 pandemic. This highlights the potential impact of outreach efforts to improve accessibility of financial assistance, particularly for vulnerable individuals with AUD with financial worries and uncertainties during the pandemic.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Qualitative Study of Patients' Experiences With Collaborative Care for Co-occurring Opioid Use and Mental Health Disorders in Primary Care. 初级保健中阿片类药物使用与精神健康障碍患者协同护理经历的定性研究

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-19 DOI: 10.1097/ADM.0000000000001511

Grace M Hindmarch, Karen Chan Osilla, Alex R Dopp, Kirsten Becker, Vanessa Miller, Lauren Kelly, Jasen Christensen, Virginia Chitwood-Sedore, Miriam Komaromy, Katherine E Watkins

{"title":"A Qualitative Study of Patients' Experiences With Collaborative Care for Co-occurring Opioid Use and Mental Health Disorders in Primary Care.","authors":"Grace M Hindmarch, Karen Chan Osilla, Alex R Dopp, Kirsten Becker, Vanessa Miller, Lauren Kelly, Jasen Christensen, Virginia Chitwood-Sedore, Miriam Komaromy, Katherine E Watkins","doi":"10.1097/ADM.0000000000001511","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001511","url":null,"abstract":"Objectives: Individuals with co-occurring opioid use disorder (OUD) and mental health disorders experience complex treatment trajectories. The collaborative care model (CoCM) is an effective approach for improving behavioral health outcomes in primary care, but has not been tested for patients with co-occurring disorders. We sought to understand patients' experiences receiving CoCM for co-occurring OUD and depression and/or PTSD.Methods: We conducted interviews with patients (N=24) who received CoCM for co-occurring disorders as part of a randomized trial. CoCM was delivered across 18 clinics by 10 care managers who were community health workers embedded into primary care teams. Themes were identified by 2 coders using rapid content analyses.Results: We identified 4 major themes. First, patients hoped CoCM would provide an opportunity to make OUD treatment possible by helping them navigate barriers. Second, patients thought that OUD and mental health disorders were connected and that treatment should be integrated. Third, patients felt that care managers improved their treatment, emphasizing how their compassionate style and commitment facilitated access to and retention in medications for OUD and mental health disorders. Finally, patients reported experiencing barriers to accessing mental health therapy, although support from care managers sometimes helped address those barriers.Conclusions: Patients expressed how care managers facilitated their positive experience with treatment and decreased access barriers common for individuals with co-occurring conditions. Our findings inform how community health workers in the role of care managers can facilitate access to and retention in care for people with co-occurring disorders.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics of Oral and Extended-release Naltrexone in Pregnant and Lactating Individuals and their Infants. 口服和缓释纳曲酮在孕妇和哺乳期个体及其婴儿中的药代动力学。

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-19 DOI: 10.1097/ADM.0000000000001512

Nicole Iannella, Jeremiah Momper, Mark Mirochnick, Raymond T Suhandynata, Kelley Saia, Martha Werler, Hendree E Jones, Elisha M Wachman

{"title":"Pharmacokinetics of Oral and Extended-release Naltrexone in Pregnant and Lactating Individuals and their Infants.","authors":"Nicole Iannella, Jeremiah Momper, Mark Mirochnick, Raymond T Suhandynata, Kelley Saia, Martha Werler, Hendree E Jones, Elisha M Wachman","doi":"10.1097/ADM.0000000000001512","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001512","url":null,"abstract":"Objectives: Naltrexone may be utilized for the treatment of opioid and/or alcohol use disorder during pregnancy. However, limited information is available on the pharmacokinetics of naltrexone during pregnancy and lactation. The objective of this study was to evaluate maternal and infant concentrations of naltrexone and its major metabolite 6β-naltrexol in relevant matrices across pregnancy and the immediate postpartum period.Methods: Pregnant individuals receiving naltrexone were enrolled in this prospective cohort study. Maternal plasma and urine samples were collected serially during pregnancy at up to 6 time points. At delivery, cord blood, maternal plasma, infant plasma, and infant urine were collected. Four weeks after delivery, breastmilk, maternal plasma, and infant plasma samples were collected. All samples were analyzed for naltrexone and 6β-naltrexol using a validated liquid chromatography tandem mass spectrometry assay.Results: A total of 7 pregnant individuals were enrolled: 4 receiving extended-release and 3 receiving oral naltrexone. Concentrations of naltrexone in maternal plasma in pregnancy remained detectable across the dosing interval for both formulations. The ratio of median cord blood to maternal plasma concentration was 1.11 in the extended-release and 0.74 in the oral group. Of the 7 infants, 1 remained breastfed at 4 weeks. The relative infant naltrexone dose via breastmilk at 31 days after delivery from the 1 infant was 0.83%.Conclusions: While limited due to sample size, these data provide valuable information about the pharmacokinetics of prenatal use of naltrexone and perinatal transfer, guiding counseling and clinical management of the parent-infant dyad.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First 100 Days: The Trump Administration and Changes to Addiction Policy. 前100天：特朗普政府和成瘾政策的变化。

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-16 DOI: 10.1097/ADM.0000000000001515

Regina M LaBelle

引用次数: 0

Cannabis Use Disorder Among People With and Without HIV. 艾滋病毒感染者和非艾滋病毒感染者的大麻使用障碍。

IF 4.2 3区医学

Journal of Addiction Medicine Pub Date : 2025-05-13 DOI: 10.1097/ADM.0000000000001505

Danielle F Haley, Kaku So-Armah, Amy C Justice, Farah Kidwai-Khan, Ziming Xuan, Rachel Sayko Adams, Matthew P Fox, E Jennifer Edelman, Aleksandra Wrona, Michael J Silverberg, Derek D Satre, Adam Trickey, Suzanne M Ingle, Kathleen A McGinnis

{"title":"Cannabis Use Disorder Among People With and Without HIV.","authors":"Danielle F Haley, Kaku So-Armah, Amy C Justice, Farah Kidwai-Khan, Ziming Xuan, Rachel Sayko Adams, Matthew P Fox, E Jennifer Edelman, Aleksandra Wrona, Michael J Silverberg, Derek D Satre, Adam Trickey, Suzanne M Ingle, Kathleen A McGinnis","doi":"10.1097/ADM.0000000000001505","DOIUrl":"https://doi.org/10.1097/ADM.0000000000001505","url":null,"abstract":"Objectives: In the United States, adults aged 65 and older are the fastest-growing age group using cannabis. People living with HIV (PLWH) are an aging population with prevalent cannabis use exceeding the general population. We examined cannabis use disorder (CUD) diagnoses from 2000 to 2022, by age, race/ethnicity, sex, comorbidity, and HIV status.Methods: This analysis (2000-2022) includes electronic health records from 185,372 individuals in the Veterans Aging Cohort Study-HIV, a national US cohort of PLWH matched 1:2 to people without HIV (PLWoH). Annual CUD diagnosis was determined by dividing the number with CUD International Classification of Diseases-Clinical Modification codes by total observations. We examined trends by age, race/ethnicity, sex, comorbidity, and HIV status graphically and with multivariable logistic models.Results: Demographic characteristics were comparable for PLWH (n=58,959) versus PLWoH (n=126,413): 45% Black non-Hispanic (NH); 35% White NH; 7% Hispanic; 3% women, mean age 48 years. Twenty percent of PLWH had a CUD from 2000 to 2022. CUD increased in all subgroups and was consistently higher among PLWH (odds ratio=1.14 [95% CI=1.11-1.18]). Individuals 65 and older experienced the greatest relative increase: PLWH (0.9% vs. 4.0%) and PLWoH (0.03% vs. 3.15%).Conclusions: CUD increased dramatically among all subgroups over time and was higher among PLWH. CUD increase among older PLWH and those with multimorbidity is especially concerning as cannabis interacts with many prescription medications. Universal screening and treatment advances are needed, as is research characterizing patterns and modalities of cannabis use, CUD, and potential harms and benefits in PLWH and PLWoH.","PeriodicalId":14744,"journal":{"name":"Journal of Addiction Medicine","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0