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Journal de toxicologie clinique et experimentale最新文献

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[Fatal poisoning involving amitriptyline: toxicologic data]. [涉及阿米替林的致命中毒:毒理学数据]。
Journal de toxicologie clinique et experimentale Pub Date : 1992-03-01
A Tracqui, P Kintz, P Mangin
{"title":"[Fatal poisoning involving amitriptyline: toxicologic data].","authors":"A Tracqui,&nbsp;P Kintz,&nbsp;P Mangin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A fatality involving amitriptyline is described. The drug and its metabolite nortriptyline were separately quantified in various post-mortem samples, including hair. Results are discussed in the light of the existing literature.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"12 1","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12630544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Toxicologic evaluation of propyneb on the Wistar rat]. [丙烯醚对Wistar大鼠毒理学评价]。
Journal de toxicologie clinique et experimentale Pub Date : 1991-12-01
R Vachkova-Petrova, L Vassileva, G Antov, N Choumkov, N Dontchev, M Stavreva, E Tyagounenko, S Dinoeva, J Halkova, L Ivanova-Tchemichanska
{"title":"[Toxicologic evaluation of propyneb on the Wistar rat].","authors":"R Vachkova-Petrova,&nbsp;L Vassileva,&nbsp;G Antov,&nbsp;N Choumkov,&nbsp;N Dontchev,&nbsp;M Stavreva,&nbsp;E Tyagounenko,&nbsp;S Dinoeva,&nbsp;J Halkova,&nbsp;L Ivanova-Tchemichanska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This experiment was performed in Wistar rats of both sexes exposed subchronically to 1:100, 1:500, 1:1000 and 1:1500 LD50. The evaluation was based on endpoints measured on the 30th and 90th after starting exposure and after a recovery period of 30 days: these included clinical signs, functional changes, hematological parameters, urine analysis, biochemical, histochemical, immunomorphological endpoints, electron microscopy of internal organs, chromosome examination of bone marrow. A high lethality was shown to occur with a characteristic clinical picture: interruption of weight gain, behavioural changes, leucopenia mainly involving neutrophil leucocytes, biochemical changes characteristic of liver, cardio-vascular system (myocardium and aorta) together with pathologic, biochemical, histochemical and ultrastructural changes in liver, brain, thyroid gland, myocardium, spleen and bone marrow. Endpoints were shown to be clearly dose-dependently related with small variations with the low dose, i.e. 1:1500 LD50 (5 mg/kg-1 bw).</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 7-8","pages":"407-16"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13001281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Electroencephalographic silence after intoxication with a carbamate tranquilizer]. [氨基甲酸酯镇静剂中毒后的脑电图沉默]。
Journal de toxicologie clinique et experimentale Pub Date : 1991-12-01
P Tirot, P Harry, G Bouachour, A Turcant, P Bourrier, P Audeguy, P Alquier, P Allain
{"title":"[Electroencephalographic silence after intoxication with a carbamate tranquilizer].","authors":"P Tirot,&nbsp;P Harry,&nbsp;G Bouachour,&nbsp;A Turcant,&nbsp;P Bourrier,&nbsp;P Audeguy,&nbsp;P Alquier,&nbsp;P Allain","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of acute meprobamate poisoning in a 43 year-old-woman is reported. Twenty five hours after admission in the intensive care unit, deep coma and cerebral electrical silence were observed whereas the meprobamate plasmatic concentration was 250 mg/l. The patient recovery was uneventful. Meprobamate analysis must be performed for unexplained coma with isoelectric EEG.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 7-8","pages":"417-20"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13001282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Subacute and subchronic oral toxicity of beta-bis carboxyethyl sesquioxide of germanium in the rat]. [β -二羧基乙基倍半氧化锗对大鼠的亚急性和亚慢性口服毒性]。
Journal de toxicologie clinique et experimentale Pub Date : 1991-12-01
F Anger, J P Anger, L Guillou, P A Sado, A Papillon
{"title":"[Subacute and subchronic oral toxicity of beta-bis carboxyethyl sesquioxide of germanium in the rat].","authors":"F Anger,&nbsp;J P Anger,&nbsp;L Guillou,&nbsp;P A Sado,&nbsp;A Papillon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After a brief recall of toxicological data about germanium compounds, the authors relate subacute and subchronic oral toxicities of beta bis carboxyethyl-germanium sesquioxide in rats. During 28 days and six months, male and female animals have received 1 mg/kg/day. No particular toxic symptoms, no behaviour trouble except a small decrease of body weight, in male rats, at the end of the 6-month experimentation, were observed. A light decrease of erythropoiesis and a general stimulation of cellular metabolism has been noticed after 28 days. The only marked effect was a moderate renal deficiency characterized by a tubular disease with presence of cylinders, swelling of tubulus cells and floculus amounts after 6 months. Germanium urinary excretion was constant and linked to the received dose. Six months later, no preferential accumulation in organs was observed.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 7-8","pages":"421-36"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13001285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ingestion of caustics by children. Report of 23 deep lesions. Therapeutic attitude and long-term results]. 儿童误食苛性碱。报告23例深部病变。治疗态度和长期结果]。
Journal de toxicologie clinique et experimentale Pub Date : 1991-12-01
J P Marie, D Dehesdin, E De Sevin, J Andrieu-Guitrancourt
{"title":"[Ingestion of caustics by children. Report of 23 deep lesions. Therapeutic attitude and long-term results].","authors":"J P Marie,&nbsp;D Dehesdin,&nbsp;E De Sevin,&nbsp;J Andrieu-Guitrancourt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In children, 23 caustic injuries of oesophagus with deep lesions (second or third degree of burn) were treated in pediatric ENT department (Pr ANDRIEU--Rouen) during a 19 years long period. Endoscopy in emergency, nasogastric tube for stent and repeated dilatations were the bases of the treatment. 14 second degree burns and 7 third degree burns were complicated of 9 stenosis and one death. The mean duration of total treatment was 43 months. The mean number of dilatations was 38 months. 4 stenosis were definitely cured. 8 children had normal feeding. Mean following was 8 years with good long term results.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 7-8","pages":"387-400"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13002068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repeated doses of activated charcoal and cholestyramine for digitoxin overdose: pharmacokinetic data and urinary elimination. 重复剂量的活性炭和胆甾胺治疗地黄霉素过量:药代动力学数据和尿排泄。
Journal de toxicologie clinique et experimentale Pub Date : 1991-12-01
P Hantson, O Vandenplas, P Mahieu, P Wallemacq, A Hassoun
{"title":"Repeated doses of activated charcoal and cholestyramine for digitoxin overdose: pharmacokinetic data and urinary elimination.","authors":"P Hantson,&nbsp;O Vandenplas,&nbsp;P Mahieu,&nbsp;P Wallemacq,&nbsp;A Hassoun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 48-year-old man chronically treated with digitoxin and verapamil for prevention of atrial fibrillation voluntarily ingested 2.2 mg of digitoxin. Serum digitoxin concentrations and the urinary elimination of the drug were followed over a 12-day period. Urinary data indicate that a large percentage (50%) of the drug was eliminated renally despite administration of multiple doses of activated charcoal, cholestyramine and hyperosmotic laxatives. The possible interaction with two other drugs, heparin and verapamil, is also discussed.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 7-8","pages":"401-5"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13002069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutralization of the activity of vipera ammodytes ammodytes snake venom on myocardium of rats by antitoxinum viperinum: a histopathological study. 蛇毒抗毒素中和蛇毒对大鼠心肌活性的组织病理学研究。
Journal de toxicologie clinique et experimentale Pub Date : 1991-10-01
D Petkovic, M Pavlovic, T Jovanovic, V Panic-Drzajic, K Zdjelar, S Unkovic, D Matejevic, N Alekisic, M Cvetkovic
{"title":"Neutralization of the activity of vipera ammodytes ammodytes snake venom on myocardium of rats by antitoxinum viperinum: a histopathological study.","authors":"D Petkovic,&nbsp;M Pavlovic,&nbsp;T Jovanovic,&nbsp;V Panic-Drzajic,&nbsp;K Zdjelar,&nbsp;S Unkovic,&nbsp;D Matejevic,&nbsp;N Alekisic,&nbsp;M Cvetkovic","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antitoxinum viperinum was tested for its ability to prevent alteration of the myocardium induced by Vipera ammodytes ammodytes venom. Antivenom was injected intraperitoneally either immediately, 30 min or 2 hr after the intraperitoneal injection of venom. The light microscopic examination showed that the antiserum neutralized the effects of venom and antivenom might be useful in treating V.a. ammodytes venom poisoning.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 6","pages":"343-7"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12980828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biochemical and histological changes after acute oral poisoning with the acetanilide herbicide acetochlor]. [乙酰苯胺类除草剂乙草胺急性口服中毒后的生化和组织学变化]。
Journal de toxicologie clinique et experimentale Pub Date : 1991-10-01
G Antov, C Zaikov, A Bouzidi, S Mitova, A Michaelova, J Halkova, N Choumkov
{"title":"[Biochemical and histological changes after acute oral poisoning with the acetanilide herbicide acetochlor].","authors":"G Antov,&nbsp;C Zaikov,&nbsp;A Bouzidi,&nbsp;S Mitova,&nbsp;A Michaelova,&nbsp;J Halkova,&nbsp;N Choumkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Changes in the liver of male rats were studied on the 1, 3, 5, 7, 10 and 14 days after a single oral application of 1/5 DL 50 of the chloracetanilic herbicide Acetochlor (DL50 = 1063 mg/kg-1). Two main periods in the action of acetochlor can be identified: between 1-2 days when the influence of the compound itself is predominant and between 5-7 days, when the toxic action of the slowly eliminated metabolites is most pronounced. These two periods provoke a biphasic activation/inhibition response of the liver. Remarkable is the compensatory effect of the cytochrome P-450 system responsible for the metabolism of acetochlor. The phase-specific changes were are followed by pathomorphological observations of liver tissue as well as by the time-course of the biochemical parameters studied in different liver fractions.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 6","pages":"349-56"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12980830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Beta-adrenergic mediation of the central control of respiration: myth or reality]. [呼吸中枢控制的-肾上腺素能调解:神话还是现实]。
Journal de toxicologie clinique et experimentale Pub Date : 1991-10-01
D Annane
{"title":"[Beta-adrenergic mediation of the central control of respiration: myth or reality].","authors":"D Annane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Self poisoning with beta-blocking drugs might increase with the extension of their therapeutic fields. Usually the management of this intoxication is mainly directed toward antagonizing the beta-adrenoreceptor blocking effects. Thus attention is specially directed to the cardiovascular condition and to the bronchoconstrictor effect. Nonetheless, in spite of this treatment, fatal cases have been reported, suggesting that other complications are responsible of the clinical course of this acute poisoning. In fact, in some cases, a respiratory arrest appeared as the major determinant of death, although the cardiovascular effects were correctly antagonized. Furthermore, the few studies in animals and in healthy volunteers indicated that beta-adrenergic mechanisms in the brain stem stimulate the ventilatory control system. Beta 1 lipophilic antagonists induce a central ventilatory depression and consecutively a respiratory arrest, which is not antagonized by beta mimetic drugs. Awareness of this complication may lead to a greater care in managing the poisoned patients and in starting early mechanical ventilation, which influence the outcome favourably.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 6","pages":"325-36"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Accidental chloral hydrate poisoning]. [意外水合氯醛中毒]。
Journal de toxicologie clinique et experimentale Pub Date : 1991-10-01
A P Jonville, J Mesny, L Quillet, C Soyez, E Autret, M Breteau
{"title":"[Accidental chloral hydrate poisoning].","authors":"A P Jonville,&nbsp;J Mesny,&nbsp;L Quillet,&nbsp;C Soyez,&nbsp;E Autret,&nbsp;M Breteau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 42-year-old woman had an accidental overdose of chloral hydrate due to repeated absorption of a therapeutic dose of chloral syrup for insomnia. The total ingestion was estimated at 8 g. Overnight slight loss of consciousness associated with severe cardiac arrhythmia (bigeminia ventricular extra-systole) needed admission to the intensive care unit and intravenous lignocaine for two days. The evolution was satisfactory.</p>","PeriodicalId":14732,"journal":{"name":"Journal de toxicologie clinique et experimentale","volume":"11 6","pages":"337-41"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12980827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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