JAMA Network Open最新文献

{"title":"Correction to Meta-Analysis to Acknowledge Retracted Study.","authors":"","doi":"10.1001/jamanetworkopen.2025.0896","DOIUrl":"10.1001/jamanetworkopen.2025.0896","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e250896"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Costs of Family Building for Physicians and Medical Students.","authors":"Morgan S Levy, Amelia G Kelly, Alyssa D Brown, Roohi Jeelani, Hina Talib, Jane W Liang, Arghavan Salles","doi":"10.1001/jamanetworkopen.2024.57287","DOIUrl":"10.1001/jamanetworkopen.2024.57287","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2457287"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salt and Nutritional Content of Foods Advertised During Televised Professional Football Games.","authors":"Lara Al-Zoubaidi, Nadya Vinsdata, R Eric Heidel, Paul J Hauptman","doi":"10.1001/jamanetworkopen.2024.57307","DOIUrl":"10.1001/jamanetworkopen.2024.57307","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2457307"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatrics-Focused Primary Care for Veterans-Reassurance, Disappointment, and Hope.","authors":"David B Reuben","doi":"10.1001/jamanetworkopen.2024.54872","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2024.54872","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2454872"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Meditation to Target Employee Stress: A Randomized Clinical Trial.","authors":"Rachel M Radin, Julie Vacarro, Elena Fromer, Sarah E Ahmadi, Joanna Y Guan, Sarah M Fisher, Sarah D Pressman, John F Hunter, Kate Sweeny, A Janet Tomiyama, Lauren Tiongco Hofschneider, Matthew J Zawadzki, Larisa Gavrilova, Elissa S Epel, Aric A Prather","doi":"10.1001/jamanetworkopen.2024.54435","DOIUrl":"10.1001/jamanetworkopen.2024.54435","url":null,"abstract":"<p><strong>Importance: </strong>Mindfulness meditation may improve well-being among employees; however, effects of digital meditation programs are poorly understood.</p><p><strong>Objective: </strong>To evaluate the effects of digital meditation vs a waiting list condition on general and work-specific stress and whether greater engagement in the intervention moderates these effects.</p><p><strong>Design, setting, and participants: </strong>This randomized clinical trial included a volunteer sample of adults (aged ≥18 years) employed at a large academic medical center who reported mild to moderate stress, had regular access to a web-connected device, and were fluent in English. Exclusion criteria included being a regular meditator. Participants were recruited from May 16, 2018, through September 28, 2019, and completed baseline, 8-week, and 4-month measures assessing stress, job strain, burnout, work engagement, mindfulness, depression, and anxiety. Data were analyzed from March 2023 to October 2024.</p><p><strong>Intervention: </strong>Participants were randomized 1:1 to a digital meditation program or the waiting list control condition. Participants in the intervention group were instructed to complete 10 minutes of meditation per day for 8 weeks. The control group was instructed to continue their normal activities and not add any meditation during the study period.</p><p><strong>Main outcomes and measures: </strong>The primary outcome measure was change in Perceived Stress Scale (PSS) score at 8 weeks. Secondary outcome measures included changes in job strain, measured as work effort-reward imbalance.</p><p><strong>Results: </strong>A total of 1458 participants (mean [SD] age, 35.54 [10.30] years; 1178 [80.80%] female) were included. Those randomized to meditation (n = 728) vs waiting list (n = 730) showed improvements in PSS (Cohen d, 0.85; 95% CI, 0.73-0.96) and in all secondary outcome measures (eg, job strain: Cohen d, 0.34; 95% CI, 0.23-0.46) at 8 weeks. These improvements were maintained at 4 months after randomization (PSS: Cohen d, 0.71; 95% CI, 0.59-0.84; job strain: Cohen d, 0.37; 95% CI, 0.25-0.50). Those using the app from 5 to 9.9 min/d vs less than 5 min/d showed greater reduction in stress (mean PSS score difference, -6.58; 95% CI, -7.44 to -5.73).</p><p><strong>Conclusions and relevance: </strong>The findings suggest that a brief, digital mindfulness-based program is an easily accessible and scalable method for reducing perceptions of stress. Future work should seek to clarify mechanisms by which such interventions contribute to improvements in work-specific well-being.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT03527303.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2454435"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferred and Actual Location of Death in Adolescents and Young Adults With Cancer.","authors":"Oreofe O Odejide, Colin Cernik, Hajime Uno, Lauren Fisher, Lanfang Xu, Cecile A Laurent, Nancy Cannizzaro, Julie Munneke, Robert M Cooper, Joshua R Lakin, Corey M Schwartz, Mallory Casperson, Andrea Altschuler, Lori Wiener, Lawrence Kushi, Chun R Chao, Jennifer W Mack","doi":"10.1001/jamanetworkopen.2024.54000","DOIUrl":"10.1001/jamanetworkopen.2024.54000","url":null,"abstract":"<p><strong>Importance: </strong>Adolescent and young adult (AYA) patients with advanced cancer often die in hospital settings. Data characterizing the degree to which this pattern of care is concordant with patient goals are sparse.</p><p><strong>Objective: </strong>To evaluate the extent of concordance between the preferred and actual location of death among AYA patients with cancer.</p><p><strong>Design, setting, and participants: </strong>This multicenter retrospective cohort study included AYA patients (aged 12-39 years) with cancer who died between January 1, 2003, and December 31, 2019, after receiving care at Dana-Farber Cancer Institute and Kaiser Permanente Northern California or who died between January 1, 2009, and December 31, 2019, after receiving care at Kaiser Permanente Southern California. Data were analyzed from January 12 to July 1, 2024.</p><p><strong>Exposure: </strong>Death due to cancer.</p><p><strong>Main outcomes and measures: </strong>Medical record documentation of discussions about preferred location of death, actual location of death, and concordance between preferred and actual location of death.</p><p><strong>Results: </strong>The analytic population included 1929 AYA decedents, of whom 1049 (54.4%) were female; 227 (11.8%), Asian; 157 (8.1%), Black; 514 (26.6%), Hispanic; and 1184 (61.4%), White. Median age at death was 32 (IQR, 25-37) years. A total of 1226 AYA patients (63.6%) had a documented discussion about preferred location of death. Among those with a documented discussion, 594 (48.5%) did not have a documented preference, 402 (32.8%) wanted to die at home, 177 (14.4%) preferred a hospital death, and 48 (3.9%) desired inpatient hospice. Eight hundred and thirty patients (43.0%) died in acute care settings (256 [13.3%] intensive care unit [ICU], 548 [28.4%] hospital [non-ICU], and 26 [1.3%] emergency department), while 643 (33.3%) died at home and 47 (2.4%) in an inpatient hospice. Among the 528 patients with both a documented preferred death location of home, hospital, or inpatient hospice and documented death in one of these locations, the concordance between preferred and actual location of death was 401 (75.9%). One hundred and sixty-four of 172 patients (95.3%) who preferred a hospital death died there; 224 of 317 (70.7%) who preferred a home death died at home, and 13 of 39 (33.3%) who desired to die in inpatient hospice did so.</p><p><strong>Conclusions and relevance: </strong>Although many AYA patients with cancer died in their preferred location, over one-quarter of those who desired to die at home did not realize this goal. These findings highlight the need for effective solutions to enable goal-concordant care for this population.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2454000"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and Inequities in Poor Mental Health Across 3 US Surveys, 2011 to 2022.","authors":"Emily Wright, Emily C Dore, Karestan C Koenen, Christina Mangurian, David R Williams, Rita Hamad","doi":"10.1001/jamanetworkopen.2024.54718","DOIUrl":"10.1001/jamanetworkopen.2024.54718","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2454718"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double CHEK2 Pathogenic and Low-Risk Variants and Associated Cancer Phenotypes.","authors":"Brittany L Bychkovsky, Nihat B Agaoglu, Carolyn Horton, Linda Polfus, Marcy E Richardson, Colin Young, Rochelle Scheib, Judy E Garber, Huma Q Rana","doi":"10.1001/jamanetworkopen.2024.51361","DOIUrl":"10.1001/jamanetworkopen.2024.51361","url":null,"abstract":"<p><strong>Importance: </strong>CHEK2 pathogenic and likely pathogenic variants (PVs) are common, and low-risk (LR) variants, p.I157T, p.S428F, and p.T476M, are even more common. Biallelic CHEK2 PVs are associated with specific cancer phenotypes, including early age at onset of breast cancers. Whether biallelic LR variants are associated with cancer predisposition is unknown.</p><p><strong>Objective: </strong>To characterize the cancer phenotype among individuals with biallelic CHEK2 variants, specifically those that have been associated with lower cancer risk in the heterozygous state.</p><p><strong>Design, setting, and participants: </strong>This retrospective observational cohort study examining cancer phenotype by CHEK2 genotype was conducted at a single diagnostic genetic testing laboratory. Of 36 821 individuals who underwent genetic testing, 3783 (10.3%) with CHEK2 PVs or LR variants were ascertained from July 1, 2012, to September 30, 2019. Analyses were conducted from September 2022 to January 2024.</p><p><strong>Exposures: </strong>Cancer phenotype among individuals with 2 LR variants and those with 1 PV and 1 LR variant was compared with cancer phenotype among individuals with wild type (WT) (n = 33 034), single LR variant (n = 1566), single PV controls (n = 2167), and 2 PVs (n = 21). Cancer phenotypes were investigated for any cancer, multiple primary cancers, female breast cancer, and bilateral female breast cancers.</p><p><strong>Main outcomes and measures: </strong>Cancer phenotype of CHEK2 2 LRs and 1 PV and 1 LR.</p><p><strong>Results: </strong>Of 36 821 individuals, 92.1% were female, and the median age at testing was 53 years (IQR, 44-63 years); 3787 (10.3%) were identified as having a CHEK2 PV or LR variant. There were 13 individuals with 2 LR variants and 20 with 1 PV and 1 LR variant. Among those with 2 LR variants, prevalence of any cancer (76.9%) and breast cancer (60.0%) were similar to those with WT (any cancer, 69.8%; breast cancer, 52.7%) and those with a single LR variant (any cancer, 70.9%; breast cancer, 57.5%). Among participants with 1 PV and 1 LR variant, 95.0% had a prior cancer diagnosis, a higher rate than among those with a single PV (76.8%), but the difference was not statistically significant. Among female individuals with 1 PV and 1 LR variant, 86.7% had a breast cancer diagnosis, compared with 67.1% with a single PV, although these differences were not statistically significant.</p><p><strong>Conclusions and relevance: </strong>In this cohort study, individuals with 2 LR variants in CHEK2 had a cancer phenotype similar to those with a single LR variant and similar to WT controls. Individuals with 1 PV and 1 LR variant may have a more penetrant cancer phenotype than individuals with a single PV. Future studies focused on CHEK2 LR variants will aid in better understanding whether these variants are genetic modifiers associated with cancer risk.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2451361"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemolytic Disease of the Fetus and Newborn-A Need for Management Consensus and More Worldwide Representation.","authors":"Tina M Slusher, Emmanuela Ambrose, Alexander A Boucher","doi":"10.1001/jamanetworkopen.2024.54342","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2024.54342","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2454342"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Brain Stimulation and Holistic Therapies for Sleep and Cognition.","authors":"Giuseppe Lanza, Maria Paola Mogavero, Raffaele Ferri","doi":"10.1001/jamanetworkopen.2024.54316","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2024.54316","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 1","pages":"e2454316"},"PeriodicalIF":10.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}