{"title":"Reviewers.","authors":"","doi":"10.1093/jncics/pkae055","DOIUrl":"https://doi.org/10.1093/jncics/pkae055","url":null,"abstract":"","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":"8 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yvonne L Eaglehouse, Sarah Darmon, Michele M Gage, Craig D Shriver, Kangmin Zhu
{"title":"Racial comparisons in treatment of rectal adenocarcinoma and survival in the military health system.","authors":"Yvonne L Eaglehouse, Sarah Darmon, Michele M Gage, Craig D Shriver, Kangmin Zhu","doi":"10.1093/jncics/pkae074","DOIUrl":"10.1093/jncics/pkae074","url":null,"abstract":"<p><strong>Background: </strong>Racial disparities in treatment and outcomes of rectal cancer have been attributed to patients' differential access to care. We aimed to study treatment and outcomes of rectal cancer in the equal access Military Health System (MHS) to better understand potential racial disparities.</p><p><strong>Methods: </strong>We accessed the MilCanEpi database to study a cohort of patients aged 18 and older who were diagnosed with rectal adenocarcinoma between 1998 and 2014. Receipt of guideline recommended treatment per tumor stage, cancer recurrence, and all-cause death were compared between non-Hispanic White and Black patients using multivariable regression models with associations expressed as odds (AORs) or hazard ratios (AHRs) and their 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The study included 171 Black and 845 White patients with rectal adenocarcinoma. Overall, there were no differences in receipt of guideline concordant treatment (AOR = 0.76, 95% CI = 0.45 to 1.29), recurrence (AHR = 1.34, 95% CI = 0.85 to 2.12), or survival (AHR = 1.08, 95% CI = 0.77 to 1.54) for Black patients compared with White patients. However, Black patients younger than 50 years of age at diagnosis (AOR = 0.34, 95% CI = 0.13 to 0.90) or with stage III or IV tumors (AOR = 0.28, 95% CI = 0.12 to 0.64) were less likely to receive guideline recommended treatment than White patients in stratified analysis.</p><p><strong>Conclusions: </strong>In the equal access MHS, although there were no overall racial disparities in rectal cancer treatment or clinical outcomes between Black and White patients, disparities among those with early-onset or late-stage rectal cancers were noted. This suggests that factors other than access to care may play a role in the observed disparities and warrants further research.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Margarita Cariolou, Sofia Christakoudi, Marc J Gunter, Tim Key, Aurora Pérez-Cornago, Ruth Travis, Raul Zamora-Ros, Kristina Elin T Petersen, Anne Tjønneland, Elisabete Weiderpass, Rudolf Kaaks, Petra Seibold, Elif Inan-Eroglu, Matthias B Schulze, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Chiara Di Girolamo, Amaia Aizpurua, Miguel Rodriguez-Barranco, Carmen Santiuste, Marcela Guevara, Dagfinn Aune, Doris S M Chan, David C Muller, Konstantinos K Tsilidis
{"title":"Adiposity assessed close to diagnosis and prostate cancer prognosis in the EPIC study.","authors":"Margarita Cariolou, Sofia Christakoudi, Marc J Gunter, Tim Key, Aurora Pérez-Cornago, Ruth Travis, Raul Zamora-Ros, Kristina Elin T Petersen, Anne Tjønneland, Elisabete Weiderpass, Rudolf Kaaks, Petra Seibold, Elif Inan-Eroglu, Matthias B Schulze, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Chiara Di Girolamo, Amaia Aizpurua, Miguel Rodriguez-Barranco, Carmen Santiuste, Marcela Guevara, Dagfinn Aune, Doris S M Chan, David C Muller, Konstantinos K Tsilidis","doi":"10.1093/jncics/pkae070","DOIUrl":"10.1093/jncics/pkae070","url":null,"abstract":"<p><strong>Background: </strong>Adiposity has been characterized as a modifiable risk factor for prostate cancer. Its association with outcomes after prostate cancer diagnosis, however, must be better understood, and more evidence is needed to facilitate the development of lifestyle guidance for patients with prostate cancer.</p><p><strong>Methods: </strong>We investigated the associations between adiposity indices close to prostate cancer diagnosis (up to 2 years before or up to 5 years after diagnosis) and mortality in 1968 men of the European Prospective Investigation into Cancer and Nutrition cohort. Men were followed up for a median of 9.5 years. Cox proportional hazards models were adjusted for age and year of diagnosis, disease stage and grade, and smoking history and stratified by country.</p><p><strong>Results: </strong>Each 5-unit increment in prediagnosis or postdiagnosis body mass index combined was associated with a 30% higher rate of all-cause mortality and a 49% higher rate of prostate cancer-specific mortality. Similarly, each 5-unit increment in prediagnosis body mass index was associated with a 35% higher rate of all-cause mortality and a 51% higher rate of prostate cancer-specific mortality. The associations were less strong for postdiagnosis body mass index, with a lower number of men in analyses. Less clear positive associations were shown for waist circumference, hip circumference, and waist to hip ratio, but data were limited.</p><p><strong>Conclusions: </strong>Elevated levels of adiposity close to prostate cancer diagnosis could lead to higher risk of mortality; therefore, men are encouraged to maintain a healthy weight. Additional research is needed to confirm whether excessive adiposity after prostate cancer diagnosis could worsen prognosis.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11410200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebecca Forman, Jessica B Long, Sarah J Westvold, Khushi Agnish, Hannah D Mcmanus, Michael S Leapman, Michael E Hurwitz, Lisa P Spees, Stephanie B Wheeler, Cary P Gross, Michaela A Dinan
{"title":"Cost trends of metastatic renal cell carcinoma therapy: the impact of oral anticancer agents and immunotherapy.","authors":"Rebecca Forman, Jessica B Long, Sarah J Westvold, Khushi Agnish, Hannah D Mcmanus, Michael S Leapman, Michael E Hurwitz, Lisa P Spees, Stephanie B Wheeler, Cary P Gross, Michaela A Dinan","doi":"10.1093/jncics/pkae067","DOIUrl":"10.1093/jncics/pkae067","url":null,"abstract":"<p><strong>Background: </strong>Immunotherapy (IO) and oral anticancer agents (OAA) have improved outcomes for metastatic renal cell carcinoma (mRCC), but there is a need to understand real-world costs from the perspective of payers and patients.</p><p><strong>Methods: </strong>We used retrospective fee-for-service Medicare 100% claims data to study patients diagnosed with mRCC in 2015-2019. We identified initial treatment type and costs (the year after diagnosis) and analyzed differences in monthly and 12-month costs over time and between OAA, IO, and combination groups and the association between Out-Of-Pocket (OOP) costs and adherence.</p><p><strong>Results: </strong>We identified 15 407 patients with mRCC (61% male; 85% non-Hispanic White). A total of 6196 received OAA, IO, or combination OAA/IO as initial treatment. OAA use decreased (from 31% to 11%) with a simultaneous rise in patients receiving IO (3% to 26%) or combination IO/OAA therapy (1% to 11%). Medicare payments for all patients with mRCC increased by 41%, from $60 320 (95% confidence interval = 58 260 to 62 380) in 2015 to $85 130 (95% confidence interval = 82 630 to 87 630) in 2019. Payments increased in patients who received OAA, IO, or combination OAA/IO but were stable in those with other/no treatment. Initial higher OOP responsibility ($200-$1000) was associated with 13% decrease in percent days covered in patients receiving OAA in the first 90 days of treatment, compared with those whose OOP responsibility was less than $200.</p><p><strong>Conclusion: </strong>From 2015 to 2019, costs for Medicare patients with mRCC rose substantially due to more patients receiving IO or IO/OAA combined therapy and increases in costs among those receiving those therapies. Increased OOP costs was associated with decreased adherence.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Goli Samimi, Sarah M Temkin, Carol J Weil, Paul K Han, Elyse LeeVan, Wendy S Rubinstein, Tessa Swigart, Sarah Caban, Katherine Dent, Lori M Minasian
{"title":"Primary care physicians and laypersons' perceptions of multicancer detection clinical trial designs.","authors":"Goli Samimi, Sarah M Temkin, Carol J Weil, Paul K Han, Elyse LeeVan, Wendy S Rubinstein, Tessa Swigart, Sarah Caban, Katherine Dent, Lori M Minasian","doi":"10.1093/jncics/pkae084","DOIUrl":"10.1093/jncics/pkae084","url":null,"abstract":"<p><strong>Background: </strong>The National Cancer Institute Cancer Screening Research Network is launching a pilot study (Vanguard) to determine feasibility of successful completion of a clinical trial of multicancer detection tests. This focus group study reports perceptions of primary care physicians and laypersons of different clinical trial designs and willingness to participate in a multicancer detection clinical trial.</p><p><strong>Methods: </strong>We undertook 14 focus groups with 88 laypersons and 6 focus groups with 45 primary care physicians. Participants were shown graphics of clinical trial designs and asked for their reactions. Focus group recordings were transcribed verbatim, and thematic analysis of the transcripts were conducted to identify emergent themes.</p><p><strong>Results: </strong>Primary care physician and layperson participants recognized the importance of conducting clinical trials to determine the clinical utility of multicancer detection tests. Primary care physicians expressed reluctance to participate in trials because of workload burden, and laypersons expressed hesitancy about enrolling in the control group. Primary care physicians and laypersons expressed concern about a study design in which multicancer detection test results would not be returned to the control group (intended effect), but they respectively indicated a willingness to refer patients to, or participate in, a multicancer detection test clinical trial given transparent and clear communication on collection and use of biospecimens and data, particularly if a multicancer detection test would eventually be run and results eventually returned.</p><p><strong>Conclusion: </strong>This study yielded important insights to guide trial design in planning prospective evaluation of multicancer detection testing. Maintaining transparency and trust while possibly withholding multicancer detection test results to maximize trial feasibility and efficiency is of particular concern.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa P Spees, Natasha Albaneze, Christopher D Baggett, Laura Green, Katie Johnson, Hayley N Morris, Ana I Salas, Andrew Olshan, Stephanie B Wheeler
{"title":"Catchment area and cancer population health research through a novel population-based statewide database: a scoping review.","authors":"Lisa P Spees, Natasha Albaneze, Christopher D Baggett, Laura Green, Katie Johnson, Hayley N Morris, Ana I Salas, Andrew Olshan, Stephanie B Wheeler","doi":"10.1093/jncics/pkae066","DOIUrl":"10.1093/jncics/pkae066","url":null,"abstract":"<p><strong>Background: </strong>Population-based linked datasets are vital to generate catchment area and population health research. The novel Cancer Information and Population Health Resource (CIPHR) links statewide cancer registry data, public and private insurance claims, and provider- and area-level data, representing more than 80% of North Carolina's large, diverse population of individuals diagnosed with cancer. This scoping review of articles that used CIPHR data characterizes the breadth of research generated and identifies further opportunities for population-based health research.</p><p><strong>Methods: </strong>Articles published between January 2012 and August 2023 were categorized by cancer site and outcomes examined across the care continuum. Statistically significant associations between patient-, provider-, system-, and policy-level factors and outcomes were summarized.</p><p><strong>Results: </strong>Among 51 articles, 42 reported results across 23 unique cancer sites and 13 aggregated across multiple sites. The most common outcomes examined were treatment initiation and/or adherence (n = 14), mortality or survival (n = 9), and health-care resource utilization (n = 9). Few articles focused on cancer recurrence (n = 1) or distance to care (n = 1) as outcomes. Many articles discussed racial, ethnic, geographic, and socioeconomic inequities in care.</p><p><strong>Conclusions: </strong>These findings demonstrate the value of robust, longitudinal, linked, population-based databases to facilitate catchment area and population health research aimed at elucidating cancer risk factors, outcomes, care delivery trends, and inequities that warrant intervention and policy attention. Lessons learned from years of analytics using CIPHR highlight opportunities to explore less frequently studied cancers and outcomes, motivate equity-focused interventions, and inform development of similar resources.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11410196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jenny S Guadamuz, Xiaoliang Wang, Ivy Altomare, Wendy Camelo Castillo, Somnath Sarkar, Ronac Mamtani, Gregory S Calip
{"title":"Mediators of racial and ethnic inequities in clinical trial participation among patients with cancer, 2011-2023.","authors":"Jenny S Guadamuz, Xiaoliang Wang, Ivy Altomare, Wendy Camelo Castillo, Somnath Sarkar, Ronac Mamtani, Gregory S Calip","doi":"10.1093/jncics/pkae085","DOIUrl":"10.1093/jncics/pkae085","url":null,"abstract":"<p><strong>Background: </strong>Although racially and ethnically minoritized populations are less likely to participate in cancer trials, it is unknown whether social determinants of health (SDOH) explain these inequities. Here we identify SDOH factors that contribute to racial and ethnic inequities in clinical trial participation among patients with 22 common cancers.</p><p><strong>Methods: </strong>This retrospective cohort study used electronic health record data (2011-2023) linked to neighborhood (US Census tract) data from multiple sources. Patients were followed from diagnosis to clinical study drug receipt (proxy for trial participation), death, or last recorded activity. Associations were assessed using Cox proportional hazards models adjusted for clinical factors (year of diagnosis, age, sex, performance status, disease stage, cancer type). To elucidate which area-level SDOH underlie racial and ethnic inequities, mediation analysis was performed using nonlinear multiple additive regression tree models.</p><p><strong>Results: </strong>This study included 250 105 patients (64.7% non-Latinx White, 8.9% non-Latinx Black, 5.2% Latinx). Black and Latinx patients were more likely to live in economically or socially marginalized areas (eg, disproportionately minoritized [measure of segregation], limited English proficiency, low vehicle ownership) than White patients. Black (3.7%; hazard ratio = 0.55, 95% confidence interval [CI] = 0.52 to 0.60) and Latinx patients (4.4%; hazard ratio = 0.63, 95% CI = 0.58 to 0.69) were less likely to participate in trials than White patients (6.3%). Fewer patients in economically or socially marginalized neighborhoods participated in trials. Mediators explained 62.2% (95% CI = 49.5% to 74.8%) of participation inequities between Black and White patients; area-level SDOH-including segregation (29.9%, 95% CI = 21.2% to 38.6%) and vehicle ownership (11.6%, 95% CI = 7.0% to 16.1%)-were the most important mediators. Similarly, Latinx-White participation inequities were mediated (65.1%, 95% CI = 49.8% to 80.3%) by area-level SDOH, such as segregation (39.8%, 95% CI = 28.3% to 51.3%), limited English proficiency (11.6%, 95% CI = 2.8% to 20.4%), and vehicle ownership (9.6%, 95% CI = 5.8% to 13.5%).</p><p><strong>Conclusions: </strong>To improve racial and ethnic diversity in cancer trials, efforts to address barriers related to adverse neighborhood SDOH factors are necessary.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica F DiBiase, Elizabeth Scharnetzki, Emily Edelman, E Kate Reed, Petra Helbig, Jens Rueter, Susan Miesfeldt, Cara L Frankenfeld, Paul K J Han, Elizabeth A Jacobs, Eric C Anderson
{"title":"Socioeconomic and urban-rural disparities in genome-matched treatment receipt and survival after genomic tumor testing.","authors":"Jessica F DiBiase, Elizabeth Scharnetzki, Emily Edelman, E Kate Reed, Petra Helbig, Jens Rueter, Susan Miesfeldt, Cara L Frankenfeld, Paul K J Han, Elizabeth A Jacobs, Eric C Anderson","doi":"10.1093/jncics/pkae090","DOIUrl":"10.1093/jncics/pkae090","url":null,"abstract":"<p><strong>Background: </strong>Emerging cancer treatments are often most available to socially advantaged individuals. This study examines the relationship of patient educational attainment, income level, and rurality to the receipt of genome-matched treatment and overall survival.</p><p><strong>Methods: </strong>Survey and clinical data were collected from patients with cancer (n = 1258) enrolled in the Maine Cancer Genomics Initiative. Logistic regression models examined whether receipt of genome-matched treatment differed by patient education, income, and rurality. Kaplan-Meier curves and Cox regression were conducted to evaluate 12-month mortality. We completed additional exploratory analyses using Kaplan-Meier curves and Cox models stratified by receipt of genome-matched treatment. Logistic and Cox regression models were adjusted for age and gender.</p><p><strong>Results: </strong>Educational attainment, income level, and rurality were not associated with genome-matched treatment receipt. Of 1258 patients, 462 (36.7%) died within 365 days of consent. Mortality risk was associated with lower educational attainment (hazard ratio [HR] = 1.30, 95% confidence interval [CI] = 1.06 to 1.59; P = .013). No statistically significant differences in mortality risk were observed for income level or rurality. Exploratory models suggest that patients who did not receive genome-matched treatment with lower educational attainment had higher mortality risk (HR = 1.36, 95% CI = 1.09 to 1.69; P = .006). For patients who did receive genome-matched treatment, there was no difference in mortality risk between the education groups (HR = 1.01, 95% CI = 0.56 to 1.81; P > .9).</p><p><strong>Conclusion: </strong>Although there were no disparities in who received genome-matched treatment, we found a disparity in mortality associated with education level, which was more pronounced for patients who did not receive genome-matched treatment. Future research is warranted to investigate the intersectionality of social disadvantage with clinical outcomes to address survival disparities.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roger Y Kim, Clarisa Yee, Sana Zeb, Jennifer Steltz, Andrew J Vickers, Katharine A Rendle, Nandita Mitra, Lyndsey C Pickup, David M DiBardino, Anil Vachani
{"title":"Clinical utility of an artificial intelligence radiomics-based tool for risk stratification of pulmonary nodules.","authors":"Roger Y Kim, Clarisa Yee, Sana Zeb, Jennifer Steltz, Andrew J Vickers, Katharine A Rendle, Nandita Mitra, Lyndsey C Pickup, David M DiBardino, Anil Vachani","doi":"10.1093/jncics/pkae086","DOIUrl":"10.1093/jncics/pkae086","url":null,"abstract":"<p><strong>Background: </strong>Clinical utility data on pulmonary nodule (PN) risk stratification biomarkers are lacking. We aimed to determine the incremental predictive value and clinical utility of using an artificial intelligence (AI) radiomics-based computer-aided diagnosis (CAD) tool in addition to routine clinical information to risk stratify PNs among real-world patients.</p><p><strong>Methods: </strong>We performed a retrospective cohort study of patients with PNs who underwent lung biopsy. We collected clinical data and used a commercially available AI radiomics-based CAD tool to calculate a Lung Cancer Prediction (LCP) score. We developed logistic regression models to evaluate a well-validated clinical risk prediction model (the Mayo Clinic model) with and without the LCP score (Mayo vs Mayo + LCP) using area under the curve (AUC), risk stratification table, and standardized net benefit analyses.</p><p><strong>Results: </strong>Among the 134 patients undergoing PN biopsy, cancer prevalence was 61%. Addition of the radiomics-based LCP score to the Mayo model was associated with increased predictive accuracy (likelihood ratio test, P = .012). The AUCs for the Mayo and Mayo + LCP models were 0.58 (95% CI = 0.48 to 0.69) and 0.65 (95% CI = 0.56 to 0.75), respectively. At the 65% risk threshold, the Mayo + LCP model was associated with increased sensitivity (56% vs 38%; P = .019), similar false positive rate (33% vs 35%; P = .8), and increased standardized net benefit (18% vs -3.3%) compared with the Mayo model.</p><p><strong>Conclusions: </strong>Use of a commercially available AI radiomics-based CAD tool as a supplement to clinical information improved PN cancer risk prediction and may result in clinically meaningful changes in risk stratification.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cultural shifts: an examination of cervical cancer stigma across age groups in the Caribbean.","authors":"Gaole Song, Kamilah Thomas-Purcell, Diadrey-Anne Sealy, Althea Bailey, Camille Ragin, Kimlin Ashing","doi":"10.1093/jncics/pkae075","DOIUrl":"10.1093/jncics/pkae075","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer-related stigma is common but understudied in the Caribbean. This study aims to describe the age difference of cervical cancer stigma and to evaluate the influence on the prevention practices among the Caribbean nonpatient population in Jamaica, Grenada, and Trinidad and Tobago.</p><p><strong>Methods: </strong>A cross-sectional study involving 1209 participants was conducted using a culturally trans-created Cancer Stigma Scale for the Caribbean context and supplemented with questions on cervical cancer and human papillomavirus (HPV) and HPV vaccine knowledge and beliefs. Descriptive analyses and χ2 tests were conducted.</p><p><strong>Results: </strong>The χ2 tests showed age is statistically significantly related to participants' response to stigma items such as \"community members believe cervical cancer is viewed as shameful\" (P = .0001); \"women with cervical cancer are treated with less respect than usual by others\" (P < .0001); \"women with cervical cancer are rejected by family members\" (P = .0007); \"women with cervical cancer are rejected by intimate partners\" (P < .0001); and \"intimate partners blame women for having cervical cancer\" (P = .0032). Additionally, age has statistically significant associations with endorsements of negative views of cervical cancer from the community (P < .0001) and family (P < .0001) as key barriers to cervical cancer care (item: \"discourage women from seeking and obtaining screening and treatment\"). Notably, younger respondents (18-25 years) are more sensitized to the unfair stigma and hold more stigma.</p><p><strong>Conclusions: </strong>Among Caribbeans, age influences cervical cancer stigma. Younger persons acknowledged greater stigma within families and communities. This study can guide age-informed interventions and programs to reduce stigma and improve cervical cancer screening and care seeking to reduce cervical cancer burden and disparities.</p>","PeriodicalId":14681,"journal":{"name":"JNCI Cancer Spectrum","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}