Sexual Function and Satisfaction in Young Women with Breast Cancer: A Five-Year Prospective Study.

IF 3.4 Q2 ONCOLOGY
Ana Ferrigno Guajardo, Bryan F Vaca-Cartagena, Fernanda Mesa-Chavez, Alejandra Platas, Alan Fonseca, Marlid Cruz-Ramos, Melina Miaja Avila, Ana Laura Rodriguez, Paula Cabrera-Galeana, Alejandro Mohar, Cynthia Villarreal-Garza
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Abstract

Background: Young women with breast cancer (YWBC) face unique challenges that can impact their sexual health. This study aimed to identify factors associated with sexual activity, function, and satisfaction in YWBC up to five years post-diagnosis.

Methods: We conducted a prospective cohort study of 474 women aged ≤40 years diagnosed with non-metastatic breast cancer in Mexico. Sexual function and satisfaction were assessed using the Female Sexual Function Index and the Sexual Satisfaction Inventory, respectively. Factors associated with sexual health outcomes were examined using mixed-effects models.

Results: The prevalence of sexual dysfunction increased from 33.6% at baseline to 52.9% at 4-5 years post-diagnosis. Factors associated with worse sexual function included older age (mean predicted FSFI score -1.35, p = .037), treatment-induced amenorrhea (-2.86, p < .001), depression (-4.11, p < .001), and anxiety (-2.13, p < .001). Lower sexual satisfaction was associated with lower educational attainment (mean predicted SSI score -5.61, p = .002), being single (-6.41, p < .001), treatment induced amenorrhea (-3.76, p = .004), bilateral oophorectomy (-8.21, p = .017), depression (-11.29, p < .001), and anxiety (-7.50, p < .001). Quality of life, body image, and systemic therapy side effects significantly impacted both outcomes. Three distinct trajectories of sexual function were identified: high (62.2%), intermediate (24.3%), and markedly declining (13.5%). Four trajectories of sexual satisfaction were found, ranging from intermediate-to-high (57.3%) to progressively worsening (27.5%).

Conclusion: Sexual dysfunction is prevalent and persistent among YWBC. Multiple biological, psychological, and social factors influence sexual health outcomes in this population. These findings highlight the importance of routine screening and tailored interventions to address the sexual health of YWBC throughout survivorship.

年轻女性乳腺癌患者的性功能和满意度:一项为期五年的前瞻性研究
背景:年轻女性乳腺癌患者(YWBC)面临着可能影响其性健康的独特挑战。本研究旨在确定与 YWBC 诊断后五年内的性活动、性功能和性满足相关的因素:我们对墨西哥 474 名年龄小于 40 岁、确诊为非转移性乳腺癌的女性进行了前瞻性队列研究。性功能和满意度分别通过女性性功能指数和性满意度量表进行评估。采用混合效应模型研究了与性健康结果相关的因素:结果:性功能障碍的发生率从基线时的 33.6% 增加到诊断后 4-5 年的 52.9%。与性功能较差相关的因素包括年龄较大(预测的 FSFI 平均得分-1.35,p = .037)、治疗引起的闭经(-2.86,p 结论:性功能障碍在女性同性恋者中普遍存在:性功能障碍在青年妇女和儿童中普遍存在且持续存在。多种生物、心理和社会因素影响着这一人群的性健康结果。这些研究结果强调了常规筛查和有针对性的干预措施对解决女青年在整个生存期的性健康问题的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JNCI Cancer Spectrum
JNCI Cancer Spectrum Medicine-Oncology
CiteScore
7.70
自引率
0.00%
发文量
80
审稿时长
18 weeks
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