JCO oncology practice最新文献

{"title":"From Foundations to Innovation: Advancing Psychosocial Competency in Oncology Fellowship Training.","authors":"Cristiane Decat Bergerot, Wendy Wing Tak Lam, Dégi L Csaba, Barry D Bultz","doi":"10.1200/OP-25-00602","DOIUrl":"https://doi.org/10.1200/OP-25-00602","url":null,"abstract":"","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500602"},"PeriodicalIF":4.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Volunteer-Led Precision-Medicine Multilevel Intervention on Patient-Reported Outcomes, Receipt of Biomarker Testing, and Time to Treatment: A Randomized Clinical Trial.","authors":"Mikalah Thomas, Madhuri Agrawal, Millie Das, Manali I Patel","doi":"10.1200/OP-25-00531","DOIUrl":"https://doi.org/10.1200/OP-25-00531","url":null,"abstract":"<p><strong>Purpose: </strong>We developed and tested whether a multilevel intervention in which a trained volunteer (1) educated patients and (2) alerted clinicians if biomarker results were unavailable improved patient knowledge of precision medicine (primary outcome) and secondary outcomes including patient activation, satisfaction with decision making, molecular testing, and time to treatment more than usual care alone (control group).</p><p><strong>Methods: </strong>Between April 15, 2023, and May 20, 2024, we enrolled veterans age >18 years with any stage of non-small cell lung cancer. Participants completed assessments at random assignment and 1-month follow-up and were followed for 6 months. We reviewed electronic health records for molecular testing and time to treatment and compared all outcomes using regression models.</p><p><strong>Results: </strong>Of the 75 screened, 46 were eligible and participated. All were male (100%); the mean age (standard deviation [SD]) was 76.3 (5.54) years; 31 (67.4%) were Hispanic or Latino, two (4.4%) Asian, 11 (23.9%) Black, one (2.2%) Native Hawaiian, and 32 (69.6%) White. Knowledge, activation, and satisfaction increased more in the intervention than in the control (mean [SD]: knowledge 2.30 [0.97] <i>v</i> 1.16 [1.15], mean difference over time, 0.25 [95% CI, 0.19 to 0.29], <i>P</i> < .001); mean [SD] activation 46.7 [11.3] <i>v</i> 37.6 [9.26], mean difference over time, 9.28 [95% CI, 3.42 to 15.14], <i>P</i> < .001; mean [SD] satisfaction 34.7 [1.49] <i>v</i> 24.8 [8.67], mean difference over time, 13.9 [95% CI, 3.50 to 24.41], <i>P</i> = .009, respectively). There were no differences in molecular testing (intervention: 95.6% <i>v</i> control: 86.9%, odds ratio, 3.30, 95% CI, 0.32 to 34.9, <i>P</i> = .30). Time to treatment was lower in the intervention by mean (SD) 1.35 (0.58) months (95% CI, 0.19 to 2.53, <i>P</i> = .02).</p><p><strong>Conclusion: </strong>This approach may improve veteran lung cancer care.</p>","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500531"},"PeriodicalIF":4.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-of-Life Care for Older Adults With Blood Cancers With Medicare Advantage Versus Medicare Fee-For-Service Insurance.","authors":"Hari S Raman, Scott Greenwald, Edo Banach, Gregory A Abel, Charlotta Lindvall, Oreofe O Odejide","doi":"10.1200/OP-25-00106","DOIUrl":"https://doi.org/10.1200/OP-25-00106","url":null,"abstract":"<p><strong>Purpose: </strong>Adults with hematologic malignancies (HMs) often experience suboptimal end-of-life (EOL) care, with patients from minoritized racial/ethnic groups at even greater risk. It is unclear whether these disparities are partly driven by modifiable factors such as insurance.</p><p><strong>Methods: </strong>Using the Centers for Medicare and Medicaid Services database, we compared the quality of EOL care as defined by hospice use, high-intensity health care utilization, and advance care planning between Medicare advantage (MA) and Medicare fee-for service (FFS) insurance among patients with HM 66 years and older who died between 2016 and 2020. Multivariate analysis was used to compare EOL care outcomes.</p><p><strong>Results: </strong>The study included 23,130 patients with MA and 46,145 with FFS. Compared with FFS, MA beneficiaries were more likely to be Black (11.1% <i>v</i> 7.8%; <i>P</i> < .001) or Hispanic (8.3% <i>v</i> 4.3%; <i>P</i> < .001). MA was associated with higher odds of hospice enrollment (odds ratio [OR], 1.11; 95% CI, 1.08 to 1.15) and decreased odds of hospice stays ≤7 days (OR, 0.94; 95% CI, 0.90 to 0.98). Compared with FFS, MA beneficiaries had lower odds of ≥2 emergency department visits (OR, 0.80; 95% CI, 0.76 to 0.84) or intensive care unit stays (OR, 0.83; 95% CI, 0.80 to 0.86) in the last month of life and lower odds of in-hospital death (OR, 0.74; 95% CI, 0.71 to 0.77).</p><p><strong>Conclusion: </strong>In this large cohort of HM decedents, MA insurance was associated with greater hospice use and lower rates of high-intensity health care utilization near the EOL compared with FFS, despite being more likely to have beneficiaries of color. This suggests that insurance type may affect the quality of EOL care and partly mitigate existing disparities. Future work characterizing which elements of insurance promote high-quality EOL care may help to improve equitable access to such care.</p>","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500106"},"PeriodicalIF":4.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotin Supplements for Hair and Nail Regrowth: A Caution for Oncologists.","authors":"Layna Mager, Olivia Ueltschi, Lucy Rose, Brittany Dulmage","doi":"10.1200/OP-25-00693","DOIUrl":"https://doi.org/10.1200/OP-25-00693","url":null,"abstract":"","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500693"},"PeriodicalIF":4.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"My Career in Geriatric Oncology.","authors":"Stuart M Lichtman","doi":"10.1200/OP-25-00356","DOIUrl":"https://doi.org/10.1200/OP-25-00356","url":null,"abstract":"","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500356"},"PeriodicalIF":4.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment of Reviewers 2025.","authors":"","doi":"10.1200/OP-25-00841","DOIUrl":"https://doi.org/10.1200/OP-25-00841","url":null,"abstract":"","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500841"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost of Convenience in Cancer Care.","authors":"Bishal Gyawali","doi":"10.1200/OP-25-00715","DOIUrl":"https://doi.org/10.1200/OP-25-00715","url":null,"abstract":"","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500715"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Sticky Are Clinical Trial Interventions? Site-Level Clinical Trial Participation and Differential Post-Trial Use of a Genomic Test.","authors":"Patrick Lewicki, Ralph Jiang, Udit Singhal, Stephanie Daignault-Newton, Kevin Ginsburg, Tudor Borza, Matthew Schipper, Michael Cher, Todd Morgan, Kristian Stensland","doi":"10.1200/OP-25-00475","DOIUrl":"https://doi.org/10.1200/OP-25-00475","url":null,"abstract":"<p><strong>Purpose: </strong>A provider's participation in a randomized clinical trial (RCT) may influence their use of the trial intervention outside of trial contexts. We explored the association between site-level participation in a trial evaluating a postradical prostatectomy (RP) genomic classifier (GC; Genomics in Michigan Impacting Observation or Radiation [G-MINOR], ClinicalTrials.gov identifier: NCT02783950) and use of post-RP GC after completion of the trial's enrollment window.</p><p><strong>Methods: </strong>The Michigan Urological Surgery Improvement Collaborative (MUSIC) data registry, in which G-MINOR was embedded, was queried for G-MINOR-eligible patients outside of the trial context (nonparticipating sites, chronology). A logistic regression model compared time with a patient's receipt of post-RP GC testing at G-MINOR participating and nonparticipating sites, before and after the trial's enrollment window.</p><p><strong>Results: </strong>A total of 7,144 patients (5,822 at G-MINOR sites, 1,322 non-G-MINOR sites) met study inclusion criteria between October 2015 and October 2020. Post-RCT, GC testing peaked among G-MINOR sites at 0.122 tests per eligible patient-quarter; no testing was observed among nonparticipating sites. Adjusting for patient characteristics, an interaction term between site-level RCT participation and pre-/postenrollment was statistically significant (hazard ratio, 21.9 [95% CI, 3.57 to 134]; <i>P</i> < .001).</p><p><strong>Conclusion: </strong>Site-level participation in the G-MINOR RCT was significantly associated with a differential change in post-RCT GC use, where trial sites showed a greater post-RCT increase compared with nontrial sites. Whether this is caused by trial participation or represents a pre-existing intention to adopt an intervention remains unknown. Implementation and deimplementation considerations should be included in trial design.</p>","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500475"},"PeriodicalIF":4.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Health Conditions and Academic Achievement: A Childhood Cancer Survivor Study Report.","authors":"Lisa Bashore, Rachel K Peterson, Chenghong Li, Wei Liu, Mingjuan Wang, Zahra M Jiwani, Aaron J McDonald, Philip J Lupo, Allison King, Deokumar Srivastava, Wendy M Leisenring, Rebecca M Howell, Todd M Gibson, Kevin Oeffinger, Gregory T Armstrong, W Paul Bowman, Kevin R Krull, Kim Edelstein","doi":"10.1200/OP-25-00414","DOIUrl":"10.1200/OP-25-00414","url":null,"abstract":"<p><strong>Purpose: </strong>To examine associations between special education, chronic health conditions (CHCs), and college graduation in survivors of childhood cancer and their siblings.</p><p><strong>Methods: </strong>Childhood Cancer Survivor Study participants included 23,082 5-year survivors (53.7% male; median [IQR] age at diagnosis, 6 [3-13] years; age at evaluation, 31.0 [24-39] years; treated between 1970 and 1999) and 5,037 siblings (47.7% male; 36.0 [28-44] years at evaluation). Special education use, reasons for special education, CHCs, and college graduation were self-reported. Primary cancer diagnosis and treatment exposures were abstracted from medical records. Comparisons between survivors and siblings were made using chi-square statistics; demographic and treatment factors associated with outcomes were examined using modified Poisson regression models.</p><p><strong>Results: </strong>More survivors reported special education use than siblings (26.5% <i>v</i> 8.6%; relative risk [RR], 2.55 [95% CI, 2.32 to 2.80]). Of those survivors and siblings who had special education services, use was highest between kindergarten and fifth grade (64.4% of survivors and 71.9% of siblings in kindergarten-fifth grade, 14.4% of survivors and 12.5% of siblings in sixth-eighth grade, and 9.2% of survivors and 9.0% of siblings in ninth-12th grade), and primarily attributable to learning and concentration problems. Despite receiving special education, survivors were less likely to graduate college compared with siblings requiring special education (RR, 0.76 [95% CI, 0.66 to 0.88]). Risk for not graduating college included history of CNS tumor (RR, 1.47 [95% CI, 1.40 to 1.55]), cranial irradiation (20-29 Gy, RR, 1.16 [95% CI, 1.09 to 1.25]; 30-49 Gy, RR, 1.37 [95% CI, 1.26 to 1.49]; ≥50 Gy, RR, 1.35 [95% CI, 1.28 to 1.42]), or the presence of a severe, disabling or life-threatening CHC (Common Terminology Criteria for Adverse Events grade 3-4, RR, 1.15 [95% CI, 1.07 to 1.24]).</p><p><strong>Conclusion: </strong>Cognitive problems and CHCs increase risk for not graduating college; these problems are not alleviated by special education.</p>","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500414"},"PeriodicalIF":4.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Physician-Driven to Patient-Centered: Transforming Multiple Myeloma Care Decisions.","authors":"Richa Thakur, Samer Al Hadidi","doi":"10.1200/OP-25-00712","DOIUrl":"https://doi.org/10.1200/OP-25-00712","url":null,"abstract":"","PeriodicalId":14612,"journal":{"name":"JCO oncology practice","volume":" ","pages":"OP2500712"},"PeriodicalIF":4.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}