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JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS最新文献

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Risk-based Approach to Determine the Need for an Audit: In What Situations Should an Audit Be Performed? （Japanese Translation Version） 确定审计需求的基于风险的方法：在什么情况下应该进行审计？（日语翻译版）
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2023-01-31 DOI: 10.3999/jscpt.54.1_37
Kouji Nakamura, Akiko M. Saito, Kohei Ueda, Kunihiro Ueda, Kumiko Yoshihara, Nobuyoshi Hiramatsu, Yoshie Yamashita, Yuki Kusaka, Hideaki Ui
{"title":"Risk-based Approach to Determine the Need for an Audit: In What Situations Should an Audit Be Performed? （Japanese Translation Version）","authors":"Kouji Nakamura, Akiko M. Saito, Kohei Ueda, Kunihiro Ueda, Kumiko Yoshihara, Nobuyoshi Hiramatsu, Yoshie Yamashita, Yuki Kusaka, Hideaki Ui","doi":"10.3999/jscpt.54.1_37","DOIUrl":"https://doi.org/10.3999/jscpt.54.1_37","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48855750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Relationship Visualization of Clinical Research-related Laws Using Word-matching 基于词匹配的临床研究相关规律关系可视化研究
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2023-01-31 DOI: 10.3999/jscpt.54.1_43
Ayako Ohshiro, T. Okazaki, S. Ueda
{"title":"Study on Relationship Visualization of Clinical Research-related Laws Using Word-matching","authors":"Ayako Ohshiro, T. Okazaki, S. Ueda","doi":"10.3999/jscpt.54.1_43","DOIUrl":"https://doi.org/10.3999/jscpt.54.1_43","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47766671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paid-for Transfer of Human Samples in Research Biobanks and the Applicability of Charitable Trusts 研究生物样本的有偿转移及慈善信托的适用性
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2023-01-31 DOI: 10.3999/jscpt.54.1_29
W. Toya, Keiichiro Yamamoto, K. Aizawa, K. Matsui
{"title":"Paid-for Transfer of Human Samples in Research Biobanks and the Applicability of Charitable Trusts","authors":"W. Toya, Keiichiro Yamamoto, K. Aizawa, K. Matsui","doi":"10.3999/jscpt.54.1_29","DOIUrl":"https://doi.org/10.3999/jscpt.54.1_29","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70396013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doravirine and Rilpivirine Intra Cellular Accumulation in the Clinical Setting Doravirine和Rilpivirine在临床环境中的细胞内积聚
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2022-12-22 DOI: 10.33597/jcpt-03-id1035
Ferrara M, Trevisan G, M. l., Accardo G, Fantino S, A. F., Drappero E, Tettoni M, De Vivo E, I. A., D. A, D. A., Calcagno A, B. S
{"title":"Doravirine and Rilpivirine Intra Cellular Accumulation in the Clinical Setting","authors":"Ferrara M, Trevisan G, M. l., Accardo G, Fantino S, A. F., Drappero E, Tettoni M, De Vivo E, I. A., D. A, D. A., Calcagno A, B. S","doi":"10.33597/jcpt-03-id1035","DOIUrl":"https://doi.org/10.33597/jcpt-03-id1035","url":null,"abstract":"Background: Doravirine (DOR) and Rilpivirine (RPV) are the NNRTIs currently most used in the clinical setting, in dual and triple drug regimens (2DR and 3DR). Intracellular (IC) Pharmacokinetics (PK) of these drugs has not been fully elucidated. Our aim was to compare plasma PK and IC accumulation in real-life experienced patients (pts). Methods: Pts on DOR- and RPV-including Antiretroviral (ARV) regimen were considered. DOR and RPV plasma and IC (PBMCs) concentrations were measured at 12 (37%) (T12) and 24 ± 4 hours (63%) (T24) after last drug intake by means of UHPLC-MSMS validated methods. Results: 90 pts (65% on 3DR and 35% on 2DR) were included: 52% on DOR- and 48% on RPV-containing ARV. RPV IC/plasma ratio was significantly higher than DOR IC/plasma ratio: 6.034 (4.878-7.186) vs. 1.479 (1.256-1.702) (p=0.001) independently from timing T12 (p=0.003) and T24 (p<0.001). RPV in 3DR resulted to have higher plasma and IC accumulation compared to 2DR. Linear and significative correlations between DOR and RPV plasma and IC concentrations were found (+0.749, p<0.001 and +0.733, p<0.001). No significative correlation between overall DOR and RPV PK and creatinine, BMI or age or difference by gender was found. Conclusion: RPV proved to accumulate in PBMCs at a higher degree as compared to DOR: RPV and DOR IC levels were 498% and 50% higher than in plasma. RPV showed an IC PBMC/plasma ratio 3-fold higher than DOR. Potential explanation could rely on the higher lipophilicity of RPV. Clinical significance of these data needs to be investigated in further studies.","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73885391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Report of the 6th Annual Meeting of the Kanto & Koushinetsu Region of the JSCPT 联委会关东和长越地区第六届年会报告
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2022-11-30 DOI: 10.3999/jscpt.53.6_263
T. Fujita
{"title":"Report of the 6th Annual Meeting of the Kanto & Koushinetsu Region of the JSCPT","authors":"T. Fujita","doi":"10.3999/jscpt.53.6_263","DOIUrl":"https://doi.org/10.3999/jscpt.53.6_263","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45318750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Report of the 6th Annual Meeting of the Kinki Region of the JSCPT JSCPT近畿地区第六届年会报告
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2022-11-30 DOI: 10.3999/jscpt.53.6_273
Yoji Nagai
{"title":"Report of the 6th Annual Meeting of the Kinki Region of the JSCPT","authors":"Yoji Nagai","doi":"10.3999/jscpt.53.6_273","DOIUrl":"https://doi.org/10.3999/jscpt.53.6_273","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42274180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National Survey on Clinical Practice of Gene Therapy using Adeno-associated Virus Vector ―The Actual Status and Hurdle on Clinical Practice in Gene Therapy for Spinal Muscular Atrophy― 全国腺相关病毒载体基因治疗临床实践综述——脊髓性肌肉萎缩症基因治疗的现状及临床实践障碍
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2022-11-30 DOI: 10.3999/jscpt.53.6_217
Masayoshi Nakakuni, M. Onodera
{"title":"National Survey on Clinical Practice of Gene Therapy using Adeno-associated Virus Vector ―The Actual Status and Hurdle on Clinical Practice in Gene Therapy for Spinal Muscular Atrophy―","authors":"Masayoshi Nakakuni, M. Onodera","doi":"10.3999/jscpt.53.6_217","DOIUrl":"https://doi.org/10.3999/jscpt.53.6_217","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43800817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Approach for Packaging to Prevent Mix-up of Investigational Drugs 防止研究药物混用的包装方法
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2022-11-30 DOI: 10.3999/jscpt.53.6_243
Yutaka Takahashi, Mirai Kawano, Hidefumi Kobayashi, Hiromitsu Takahashi, R. Koike
{"title":"An Approach for Packaging to Prevent Mix-up of Investigational Drugs","authors":"Yutaka Takahashi, Mirai Kawano, Hidefumi Kobayashi, Hiromitsu Takahashi, R. Koike","doi":"10.3999/jscpt.53.6_243","DOIUrl":"https://doi.org/10.3999/jscpt.53.6_243","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48885597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of GLP‒1 Receptor Agonists on the Cardio-Renal Protective Effects GLP-1受体激动剂对心肾保护作用的机制
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2022-11-30 DOI: 10.3999/jscpt.53.6_249
S. Kuriyama, Kei Matsumoto
{"title":"Mechanisms of GLP‒1 Receptor Agonists on the Cardio-Renal Protective Effects","authors":"S. Kuriyama, Kei Matsumoto","doi":"10.3999/jscpt.53.6_249","DOIUrl":"https://doi.org/10.3999/jscpt.53.6_249","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42307743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient Profiling for Salt Content on Simplified Front-of-package Labels for Japanese Patients with Hypertension 日本高血压患者简化包装标签上盐含量的营养成分分析
JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS Pub Date : 2022-11-30 DOI: 10.3999/jscpt.53.6_207
Motoki Arakawa, M. Wakita, Ayumi Sahashi, Junichi Nishino, Kiyotaka Nakajima, S. Hidaka
{"title":"Nutrient Profiling for Salt Content on Simplified Front-of-package Labels for Japanese Patients with Hypertension","authors":"Motoki Arakawa, M. Wakita, Ayumi Sahashi, Junichi Nishino, Kiyotaka Nakajima, S. Hidaka","doi":"10.3999/jscpt.53.6_207","DOIUrl":"https://doi.org/10.3999/jscpt.53.6_207","url":null,"abstract":"","PeriodicalId":14602,"journal":{"name":"JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42393194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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