Israel journal of medical sciences最新文献_第3页

Repeated BCG vaccination is more effective than a single dose in preventing diabetes in non-obese diabetic (NOD) mice. 在非肥胖型糖尿病(NOD)小鼠中，反复接种卡介苗比单次接种更有效。

Israel journal of medical sciences Pub Date : 1997-11-01

N Shehadeh, A Etzioni, A Cahana, G Teninboum, B Gorodetsky, D Barzilai, E Karnieli

{"title":"Repeated BCG vaccination is more effective than a single dose in preventing diabetes in non-obese diabetic (NOD) mice.","authors":"N Shehadeh, A Etzioni, A Cahana, G Teninboum, B Gorodetsky, D Barzilai, E Karnieli","doi":"","DOIUrl":"","url":null,"abstract":"Stimulation of the non-obese diabetic (NOD) mouse immune-system with a single bacillus Calmette-Guerin (BCG) vaccination can inhibit the development of diabetes. The optimal dose, and the time and number of vaccinations is still to be clarified. In this study we evaluated the protective effect of repeated BCG vaccinations on preventing diabetes in NOD mice. 17/32 (53%) of the control group, 8/31 (26%) of the single vaccine-treated (at age 35 days) mice, and 7/23 (30%) of the single vaccine-treated (at age 90 days) mice developed diabetes, and none of the repeated BCG vaccination (at age 35 & 90 days, n = 14) animals developed the disease, up to 250 days of age (p < 0.05, compared with controls and each of the single-vaccination groups). While the severity of insulitis was lower in repeatedly BCG-treated mice at age 120 days as compared with controls and single BCG-vaccination groups, we could not detect significant differences in the Intracellular adhesion molecule-1 (ICAM-1) expression between the various groups. There were no differences in weight gain and blood hematocrit between the different groups. Our report demonstrates that repeated BCG vaccination is safe and more effective than a single dose in preventing type I diabetes in NOD mice. This data should be considered in planning new human trials with BCG.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 11","pages":"711-5"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20363079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anesthetic management of labor and postpartum bleeding in a patient with Fontan physiology. 分娩和产后出血的麻醉处理在方坦生理病人。

Israel journal of medical sciences Pub Date : 1997-11-01

Z Grunwald, L Friedman, R Hirsch, K Doron

引用次数: 0

Safety and efficacy of [Lys(B28), Pro(B29)]-human insulin in patients with diabetes mellitus. [Lys(B28)， Pro(B29)]-人胰岛素在糖尿病患者中的安全性和有效性

Israel journal of medical sciences Pub Date : 1997-11-01

S Akalin, T Erbas, M T Yilmaz, H Ilkova, I Satman, Z Ersanli, K Karsidag, T Damci, N Bagriacik

{"title":"Safety and efficacy of [Lys(B28), Pro(B29)]-human insulin in patients with diabetes mellitus.","authors":"S Akalin, T Erbas, M T Yilmaz, H Ilkova, I Satman, Z Ersanli, K Karsidag, T Damci, N Bagriacik","doi":"","DOIUrl":"","url":null,"abstract":"The primary objectives of this study were to assess the efficacy and safety of Lys(B28), Pro(B29) in the treatment of patients with diabetes mellitus and to compare Lys(B28), Pro(B29) to currently available regular insulin with respect to quality of life. This study was designed as an open-label, non-comparative one. The number of patients enrolled in the trial was 39. At Visit 1 (week 0), blood samples for fasting, 1- and 2-hour postprandial blood glucose, and HbA1c were taken. At Visit 2 (week 6) and Visit 3 (week 12), fasting, 1- and 2-hour postprandial blood glucose, and HbA1c levels were measured again. There was no significant change in HbA1c, fasting blood glucose and 1- and 2-hour postprandial blood glucose levels. The 1- and 2-hour postprandial blood glucose excursions decreased significantly from Visit 1 to Visit 3. There were no serious adverse events during the study. Half of the patients had less hypoglycemia with LysPro insulin, while 25% had an increase in episodes. Thirty percent of patients were more satisfied with LysPro insulin than with the short-acting insulin that they had previously used. In conclusion, LysPro therapy can be regarded as safe, since there were no unexpected adverse events and no changes in the usual physical parameters.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 11","pages":"716-9"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20363080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The progression of chronic renal disease: immunological, nutritional and intrinsic renal mechanisms. 慢性肾脏疾病的进展:免疫、营养和肾脏内在机制。

Israel journal of medical sciences Pub Date : 1997-11-01

A Drukker

{"title":"The progression of chronic renal disease: immunological, nutritional and intrinsic renal mechanisms.","authors":"A Drukker","doi":"","DOIUrl":"","url":null,"abstract":"The majority of patients with any initial renal insult show progression of renal damage over time. The histological end-result is often the same, whatever the initial lesion, and consists of an increase in extracellular matrix (ECM) and ultimately glomerulosclerosis. The clinical rate of progression correlates mainly with the degree of interstitial, rather than with that of glomerular damage. The main culprits for the ultimate interstitial damage and the rate of progression of renal disease, are the type and degree of the initial (e.g. immunological) insult and the magnitude of the proteinuria. Hypertension (intraglomerular) is an independent risk factor. Control of hypertension with angiotension converting enzyme (ACE) inhibitors or angiotensin II (AII) receptor blockers, reduction of protein and fat intake, anti-oxidative therapy and a variety of experimental measures reduce the progression of renal damage in animal experiments. Some of these interventions have also been shown to be beneficial in a number of controlled clinical studies, in well-defined renal disease entities in humans. These new data provide insight into the pathogenesis of chronic renal damage and raise the hope that in the not too far future, effective strategies can be devised to attenuate the progression of acquired renal disease.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 11","pages":"739-43"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20361700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is immunosuppressive treatment an option for myocarditis? 免疫抑制治疗是心肌炎的一种选择吗?

Israel journal of medical sciences Pub Date : 1997-11-01

M Jonas, H Hod

{"title":"Is immunosuppressive treatment an option for myocarditis?","authors":"M Jonas, H Hod","doi":"","DOIUrl":"","url":null,"abstract":"Although relatively uncommon among cardiac diseases, myocarditis may often have significant sequelea, including heart failure and death. The development of a murine model and the use of myocardial biopsy and Dallas criteria have broadened our understanding of myocarditis and its manifestations. Regrettably, little can still be done to alter the natural course of the disease. The results of the Myocarditis Treatment Trial do not support routine treatment with immunosuppressive drugs for all patients with myocarditis, however the study did not incorporate methods of viral (DNA or RNA) identification or immunohistochemical techniques. Specific viral myocarditis diagnosis, by polymerase chain reaction or in situ hybridization, together with immunohistochemical markers, may help classify patients according to acute or chronic myocarditis and by etiology, and possibly identify subgroups of patients who would be most likely to benefit from immunosuppression. Some important questions regarding therapy for myocarditis may be answered by the ongoing European Study of the Epidemiology and Treatment of Cardiac Inflammatory Disease, while others still await double-blind controlled confirmation. In the interim, therapy is being directed towards the management of symptoms and complications, using conventional medical regimens for heart failure.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 11","pages":"762-6"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20361707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of drug-resistant tuberculosis in Jerusalem: ten-year retrospective review. 耶路撒冷耐药结核病的出现:十年回顾。

Israel journal of medical sciences Pub Date : 1997-11-01

A M Yinnon, A Sasson, Y Schlesinger, D Raveh, Z Jerassi, B Rudensky

{"title":"Emergence of drug-resistant tuberculosis in Jerusalem: ten-year retrospective review.","authors":"A M Yinnon, A Sasson, Y Schlesinger, D Raveh, Z Jerassi, B Rudensky","doi":"","DOIUrl":"","url":null,"abstract":"Drug-resistant tuberculosis (TB) has emerged as a worldwide problem. The annual incidence of TB has increased in Israel in the last decade, mainly due to successive waves of immigration. Few data are available on drug-resistant TB in Israel A 10-year retrospective review was conducted on all patients who had been infected with culture-proven Mycobacterium tuberculosis and had been admitted to our hospital. Forty-seven patients had culture-positive TB; 27 (57%) were male, 20 (43%) were female; mean age (+/- SD) was 56 +/- 23 years. Twenty patients (43%) had pulmonary TB. Three patients (6.4%) had single-drug resistance; 4 patients (8.5%) had multi-drug resistance. Six of the seven patients (86%) with drug-resistant TB had been diagnosed after 1990. Six of the 20 patients (30%) with pulmonary TB had drug-resistant organisms. Six of the 7 patients (86%) with drug-resistant TB had pulmonary infection, as compared to 15/40 (37%) of the patients with drug-susceptible TB (p < 0.001). Six of the 7 patients (86%) with drug-resistant TB had a history of TB. Fifteen percent (14.9%) of all new cases diagnosed with TB in our hospital in the last 10 years had drug-resistant M. tuberculosis. Thirty percent of patients with pulmonary TB had drug-resistant organisms. Drug-resistant TB has evidently emerged in Israel and poses a serious clinical and social threat. A strong case for directly-observed treatment in Israel should be made, especially since the incidence of TB here is still small.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 11","pages":"728-33"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20363083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urgent self-referrals to ambulatory consultant--a prospective evaluation of triage by a qualified family physician. 紧急自我转介到门诊顾问-一个合格的家庭医生的分诊的前瞻性评估。

Israel journal of medical sciences Pub Date : 1997-11-01

Z Alon, S Vinker, S Nakar, H Abu-Amar, G Sadovsky, E Hyam

{"title":"Urgent self-referrals to ambulatory consultant--a prospective evaluation of triage by a qualified family physician.","authors":"Z Alon, S Vinker, S Nakar, H Abu-Amar, G Sadovsky, E Hyam","doi":"","DOIUrl":"","url":null,"abstract":"Direct self-referrals to a consultant, especially on an urgent basis, has not been widely explored before. The health insurance system in Israel permits elective direct self-referrals to various specialists, but the range and reasons of urgent self-referrals has not yet been evaluated. Our aim was to evaluate urgent self-referrals to ambulatory consultants and to see to what extent a qualified family physician can triage and treat those patients. The setting was an urban ambulatory multi-disciplinary consultation center in the city of Ashdod in central Israel, serving a population of approximately 150,000. Over a three-month period, all patients who made urgent self-referrals for an ambulatory consultant in Ophthalmology, Ear, Nose and Throat (ENT) and Dermatology were triaged by an on-duty qualified family physician. The physician was instructed to take care of the patient in one of three ways: 1) immediate referral to a specialist; 2) begin treatment and schedule the patient for a specialist consultation; 3) administration of definitive treatment. Eight hundred and ninety-eight patients aged 46 +/- 22 years were treated by the triaging family physician. Forty-six percent had ophthalmological symptoms, 26% had dermatological symptoms and 20% had ENT-related symptoms. A symptom duration of less than 24 hours was reported by 36% of the patients. Eye problems were more commonly of short duration (p < 0.001). Sixty percent of the patients were given a definitive treatment, another 19% were given immediate treatment and scheduled for elective consultation with a specialist and 21% were referred for an immediate specialist consultation. Of the immediate consultations, 73% were ophthalmological and 27% came from a range of other complaints (p < 0.001). Our conclusion was that a family physician can treat most of the urgent self-referrals to ambulatory consultations in the three domains that were evaluated. A triage system is particularly suitable for urgent self-referrals to ENT as well as dermatological problems.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 11","pages":"744-8"},"PeriodicalIF":0.0,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20361701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity epidemic puts millions at risk from related diseases. 肥胖的流行使数百万人面临相关疾病的风险。

Israel journal of medical sciences Pub Date : 1997-10-01

引用次数: 0

Primary biliary cirrhosis associated with antiphospholipid syndrome. 原发性胆汁性肝硬化与抗磷脂综合征相关。

Israel journal of medical sciences Pub Date : 1997-10-01

M Hoffman, M Burke, M Fried, D Turner, Y Yosipov, I Yust

引用次数: 0

Bilateral brachial plexopathy after E. coli sepsis. 大肠杆菌败血症后的双侧臂丛病变。

Israel journal of medical sciences Pub Date : 1997-10-01

A Tzur, R Shahin

引用次数: 0