Israel journal of medical sciences最新文献_第10页

The use of DNA markers in the pre-clinical diagnosis of familial adenomatous polyposis. DNA标记在家族性腺瘤性息肉病临床前诊断中的应用。

Israel journal of medical sciences Pub Date : 1997-01-01

D Amikam, D Niv, J Lachter, S Eidelman, Z Ben-Ishai

引用次数: 0

Acute myocardial infarction after extracorporeal shock-wave lithotripsy: a dilemma of management. 体外冲击波碎石后急性心肌梗死:处理的困境。

Israel journal of medical sciences Pub Date : 1997-01-01

M Perouansky, R Pizov

引用次数: 0

Evaluation of domiciliary long-term oxygen therapy with oxygen concentrators. 家用吸氧器长期氧疗效果评价。

Israel journal of medical sciences Pub Date : 1997-01-01

R J Shiner, U Zaretsky, M Mirali, S Benzaray, D Elad

{"title":"Evaluation of domiciliary long-term oxygen therapy with oxygen concentrators.","authors":"R J Shiner, U Zaretsky, M Mirali, S Benzaray, D Elad","doi":"","DOIUrl":"","url":null,"abstract":"Domiciliary long-term oxygen therapy (LTOT) is usually supplied by means of oxygen concentrators (OCs). Various factors that determine the efficacy of such a treatment were evaluated. Sixty-three patients, arbitrarily selected from lists of health care providers, were visited at home by a biomedical engineer and a pulmonary function technician. The evaluation consisted of: i) responses to a directed questionnaire, ii) assessment of the OC output characteristics, and iii) measurement of the patient's oxygen saturation (SaO2) at rest with and without oxygen supplement. Only 33% of patients received oxygen treatment for the recommended 12-24 hours/day and 5% of patients waited the recommended 10 minutes of OC warm-up before connection. Filters were cleaned weekly by only 30% of patients and the concentrator was serviced 3-4 times a year in 25% of cases. The OC was thought to be unduly noisy by 24% of patients and connecting tubing of less than 6 meters was fitted to 90% of OCs, thereby limiting patient mobility. Most of the OCs did not yield the recommended oxygen concentration and the flow rate meters on them tended to underread. Therefore, only 22% of patients received the prescribed oxygen supplement. Whilst breathing room air, a substantial proportion of patients had an SaO2 >90%. Improvements are clearly required in terms of medical indications for LTOT, patient education and supervision, supply and maintenance of concentrators and related equipment.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 1","pages":"23-9"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20149044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposed therapeutic algorithm for the treatment of anemia of chronic renal failure in pre-dialysis patients with low dose once weekly subcutaneous r-HuEPO. Multicenter Study Group, Israel. 提出低剂量r-HuEPO每周一次皮下注射治疗透析前慢性肾功能衰竭患者贫血的治疗算法。多中心研究组，以色列。

Israel journal of medical sciences Pub Date : 1997-01-01

Y Yagil

{"title":"Proposed therapeutic algorithm for the treatment of anemia of chronic renal failure in pre-dialysis patients with low dose once weekly subcutaneous r-HuEPO. Multicenter Study Group, Israel.","authors":"Y Yagil","doi":"","DOIUrl":"","url":null,"abstract":"Anemia of chronic renal failure (CRF) prior to initiation of dialysis is an important cause of morbidity and requires early therapeutic intervention. The current study was designed to investigate the efficacy and tolerability of a therapeutic algorithm for anemia of CRF in pre-dialysis patients which is based on low dose once-a-week subcutaneous (s.c.) administration of recombinant human erythropoietin (r-HuEPO). Thirty-one patients participated in a prospective open-label multicenter study. At baseline, hemoglobin was 8.8+/-0.1 g/dl, transferrin saturation 27+/-2%, ferritin 207+/-28 ng/ml and serum creatinine 4.7+/-0.2 mg/dl. Treatment with r-HuEPO was started at a fixed s.c. dose of 4,000 units once weekly, irrespective of body weight, and titrated upwards or downwards according to a predetermined algorithm. Hemoglobin rose to levels >10 g/dl within 8 weeks and remained stable throughout the remaining period of the study. By week 24, most patients required <or =4,000 units/week as maintenance dose. Transferrin saturation and ferritin concentration tended to fall during the course of r-HuEPO treatment, despite iron supplementation. There was no change in white blood cell or platelet count. Eight patients required an increase in antihypertensive therapy, but blood pressure remained well-controlled. Twelve patients failed to complete the full length of the study, 7 of them because dialysis had to be initiated. The rate of decline in kidney function, however, was not altered by r-HuEPO. We conclude that the proposed therapeutic algorithm is practical, efficacious, safe, and cost-effective.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 1","pages":"36-44"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20149046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Home monitoring for infants at high risk for the sudden infant death syndrome. 婴儿猝死综合征高危人群的家庭监测

Israel journal of medical sciences Pub Date : 1997-01-01

Y Sivan, A Kornecki, A Baharav, N Glaser, Z Spirer

{"title":"Home monitoring for infants at high risk for the sudden infant death syndrome.","authors":"Y Sivan, A Kornecki, A Baharav, N Glaser, Z Spirer","doi":"","DOIUrl":"","url":null,"abstract":"The rate of sudden infant death syndrome (SIDS) In Israel is relatively low (0.5-0.9:1,000). Home cardiorespiratory monitoring (HM) is an accepted practice in infants at high risk for SIDS. We report our experience with 261 infants who were referred to our SIDS prevention program. They included: 52 preterm infants with apneas and bradycardias, 83 SIDS siblings (3 twins), 22 infants of drug-addicted mothers, and 104 infants after an idiopathic apparent life-threatening event (ALTE). HM was performed in 40 of 52 preterms, 38 of 83 SIDS siblings, all 22 infants of addicted mothers and 67 of 104 post-ALTE. All received 24 h/day medical and technical backup as well as emotional support, and were closely followed until 15 months of age. None of the 261 infants died. Five infants experienced six ALTEs that required resuscitative measures; another 28 infants had monitor alarms judged as real by the caregivers. The average duration of HM was 3.2 months (range 1-7). In 8 of 167 cases the parents stopped HM earlier than recommended, and in 34 of 167 cases (20%), parents continued HM beyond the time when discontinuation was recommended by the medical personnel. Among the caregivers, 85% found HM to be reassuring and stated that it helped them to conduct a normal life. We suggest that in our population, HM may have a favorable effect on family life. With close backup and support, most families will benefit from HM and will gain reassurance that will enable them to conduct normal life.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 1","pages":"45-9"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20149047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac contractility: modulation of myofibrillar calcium sensitivity by beta-adrenergic stimulation. 心脏收缩力:β -肾上腺素能刺激对肌原纤维钙敏感性的调节。

Israel journal of medical sciences Pub Date : 1997-01-01

H Kögler, J C Rüegg

{"title":"Cardiac contractility: modulation of myofibrillar calcium sensitivity by beta-adrenergic stimulation.","authors":"H Kögler, J C Rüegg","doi":"","DOIUrl":"","url":null,"abstract":"Under conditions of beta-adrenergic receptor stimulation, cardiac performance is enhanced. cAMP-dependent phosphorylation of proteins located in the sarcolemma, in the membrane of the sarcoplasmic reticulum (SR), and in the myofibrils of the cardiomyocytes, mediates the effects of catecholamines on the heart. Altered Ca2+ handling leads to increased levels of intracellular free Ca2+. This is mainly responsible for the enhanced contractility of the myocardium that can be observed following beta-adrenergic receptor stimulation. Phosphorylation of the thin filament regulatory protein troponin I (TnI), on the other hand, decreases the Ca2+ sensitivity of the myofilaments, which means that the Ca2+ concentration necessary for the development of half-maximal force is increased. Cardiac TnI has a 26-33 amino acid N-terminal extension that is not present in fast and slow skeletal muscle TnI isoforms. Within this segment, two adjacent serine residues can be phosphorylated by a cAMP-dependent protein kinase. Replacement of endogenous TnI by different mutants obtained using site-directed mutagenesis of one or both of the serine residues has shown that only the bis-phosphorylated form decreases the Ca2+ sensitivity. This Ca2+ desensitizing effect, together with an increased rate of Ca2+ uptake into the SR due to phosphorylation of the SR membrane protein phospholamban, is responsible for the relaxation-enhancing effect (lusitropic action) of catecholamines. The latter is an important determinant of coronary perfusion and rapid diastolic filling of the ventricles, and is also a prerequisite for the elevation of heart rate that accompanies beta-adrenergic receptor stimulation.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20149105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fight against AIDS. 抗击艾滋病的斗争。

Israel journal of medical sciences Pub Date : 1997-01-01

E Shafrir

引用次数: 0

A pituitary mass and hypopituitarism: improvement after corticosteroid therapy. 垂体肿块和垂体功能减退:皮质类固醇治疗后的改善。

Israel journal of medical sciences Pub Date : 1997-01-01

I Shimon, M Berezin, M Hadani, R Tadmor, D Gross, A Karasik

引用次数: 0

Effects of oleic acid lung injury and positive end-expiratory pressure on central hemodynamics and regional blood flow. 油酸肺损伤和呼气末正压对中央血流动力学和局部血流的影响。

Israel journal of medical sciences Pub Date : 1997-01-01

S Walfisch, N Weksler, A Fisher, Y Shapira

引用次数: 0

Hepatitis C virus genotypes in patients with persistent infection--a preliminary report. 持续感染患者的丙型肝炎病毒基因型——初步报告

Israel journal of medical sciences Pub Date : 1997-01-01

V Bogomolski-Yahalom, Y Ashur, A Klein, R Tur-Kaspa

{"title":"Hepatitis C virus genotypes in patients with persistent infection--a preliminary report.","authors":"V Bogomolski-Yahalom, Y Ashur, A Klein, R Tur-Kaspa","doi":"","DOIUrl":"","url":null,"abstract":"Hepatitis C virus (HCV) has nucleotide sequence diversity distributed throughout the viral genome, with variants showing even less than 70% homology. There is some evidence that sequence variation of HCV genotypes partly determines the course of infection and response to treatment with interferon. We studied the sera of 29 Israeli HCV patients, all suffering from chronic liver disease, and 34 patients with renal failure necessitating hemodialysis. HCV genotypes were detected using a reverse hybridization assay (LiPA), after reverse transcription polymerase chain reaction, using primers spanning the 5' UTR of the HCV genome. In this preliminary report the predominant HCV type detected was type 1, found in 65% of the chronic hepatitis patients and in 88% of the hemodialysis patients. Subtype 1b was the most prevalent and was detected in >40% of the chronic hepatitis patients and in >70%of the dialysis patients. Other types detected were 2a and 3, and in only two patients was type 4 found. More than 50% of patients with type 1 (1a or 1b) among patients with chronic hepatitis had received blood transfusion in the past, but only 16.6% of patients bearing subtype 2a HCV had such a history. Our preliminary evaluation revealed that patients bearing subtype 1b seemed to have a better response to interferon treatment, as compared with patients infected with subtypes 1a, 2a, who displayed a low response rate.","PeriodicalId":14590,"journal":{"name":"Israel journal of medical sciences","volume":"33 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20149043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0