Iranian South Medical Journal最新文献_第8页

Design, Production, and Evaluation of Virosomes from H1N1 Influenza Virus 甲型H1N1流感病毒病毒体的设计、生产和评价

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.5.442

Azadeh Alishahi, Mohsen Zargar, A. Ghaemi, F. Fotouhi, M. Zolfaghari

引用次数: 0

Accuracy of Indirect ELISA Prepared from Recombinant Bp26 Gene of Brucella melitensis in Diagnosis of Human Brucellosis 重组梅利特布鲁氏菌Bp26基因间接ELISA试剂盒诊断人布鲁氏菌病的准确性

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.4.292

S. Hoseini, E. Ghaznavirad, A. Farazi

{"title":"Accuracy of Indirect ELISA Prepared from Recombinant Bp26 Gene of Brucella melitensis in Diagnosis of Human Brucellosis","authors":"S. Hoseini, E. Ghaznavirad, A. Farazi","doi":"10.52547/ismj.23.4.292","DOIUrl":"https://doi.org/10.52547/ismj.23.4.292","url":null,"abstract":"Background: Considering the prevalence of brucellosis in Iran, it is necessary to choose a specific and sensitive laboratory method to diagnose it in a rapid and timely manner. The aim of this study was to assess the accuracy of indirect enzyme-linked immunosorbent assay (ELISA) for detecting brucellosis in humans in order to have an appropriate alternative to conventional tests such as Wright, 2ME, and commercial ELISA kits. Materials and Methods: In this study, the recombinant protein produced from the gene (omp28) bp26 Brucella melitensis was used as an antigen for coating microplate wells. A total of 124 serum samples of normal healthy individuals (n=62) and patients with acute brucellosis (n=62) approved by STA and 2 ME tests were entered into the study. The data were analyzed in SPSS (ver.18). Results: The mean age was 39.8±13.5 years in the patient group and 36.1±12.7 years in the healthy group. Furthermore, 66.1% of the patients were male and 62.9% lived in rural regions, while these figures were respectively 71% and 45.2% in the healthy group. The sensitivity of 92% and specificity of 87% and a positive predictive value of 88% and a negative predictive value of 92% and an accuracy of 90% were determined for ELISA kit used in this study. Conclusion: The ELISA diagnostic kit reacted to most of the positive human sera. However, this kit needs to be further evaluated with a larger sample size of clinical specimens from different regions and with various clinical forms of human brucellosis.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42125810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Transcranial Alternating Current Stimulation on Anxiety and Hemodynamic Response in Patients Undergoing Surgery: A Double-Blind Controlled Clinical Trial 经颅交流电刺激对手术患者焦虑和血液动力学反应的影响：一项双盲对照临床试验

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.4.302

Taeibeh Arabzadeh, H. Mirhosseini, M. Sheikhi

引用次数: 0

The Efficacy of Autologous Plasma Therapy in Patients with Chronic Urticaria 自体血浆治疗慢性荨麻疹的疗效观察

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.4.312

A. Shirkani, A. Hadipour, A. Ostovar, A. Movahed, Safora Pordel, Marjan Zamani, Milad Shamshrikar, Fatemeh Omrani, S. Farrokhi

{"title":"The Efficacy of Autologous Plasma Therapy in Patients with Chronic Urticaria","authors":"A. Shirkani, A. Hadipour, A. Ostovar, A. Movahed, Safora Pordel, Marjan Zamani, Milad Shamshrikar, Fatemeh Omrani, S. Farrokhi","doi":"10.52547/ismj.23.4.312","DOIUrl":"https://doi.org/10.52547/ismj.23.4.312","url":null,"abstract":"Background: Chronic urticaria is an allergic skin disease characterized by severe pruritic wheal persisting at least for 6 weeks. This study aimed to evaluate the efficacy of plasma therapy used for the first time for the treatment of idiopathic chronic urticaria. Materials and Methods: In this case series study, the quality of life (QOL) of 30 patients with idiopathic chronic urticaria (autoimmune and spontaneous) referred to allergy clinic was evaluated before and after autologous plasma therapy by using standard questionnaires (DLQI and TSS). Results: The findings showed that the means of DLQI and TSS scores in the patients after plasma therapy was significantly reduced. The findings showed that the means of TSS scores in the patients after plasma therapy was significantly reduced (p<0/001). Moreover, it was found that plasma therapy was significantly effective patients with idiopathic chronic urticaria (autoimmune and spontaneous) by using standard questionnaires (TSS)(p=0.001). The findings showed that the means of DLQI scores in the patients after plasma therapy was significantly reduced (p=<0.001) means of DLQI scores in the women in contrast to men after plasma therapy was significantly reduced ( p=0.04) .This indicates that the improvement of the QOL in the patients. Moreover, it was found that plasma therapy was significantly effective in both sexes. Conclusion: The results of the present study suggest that autologous plasma therapy could be a suitable method for the treatment of patients with idiopathic chronic urticaria.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43063563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Nano-Chitosan Loaded with Donepezil on Ethanol Induced Amnesia in Swiss-type Mice 纳米壳聚糖负载多奈哌齐对乙醇致瑞士型小鼠健忘症的影响

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.5.431

M. Heidari, N. Azami, M. Ebadi

{"title":"Effects of Nano-Chitosan Loaded with Donepezil on Ethanol Induced Amnesia in Swiss-type Mice","authors":"M. Heidari, N. Azami, M. Ebadi","doi":"10.52547/ismj.23.5.431","DOIUrl":"https://doi.org/10.52547/ismj.23.5.431","url":null,"abstract":"alone Abstract Background: Progressive neurodegeneration of nervous system as well as learning and memory disorders is characteristics of Alzheimer’s disease. Drug delivery is one of the research aspects for improving treatment of diseases. Chitosan nanoparticles were used for Donepezil transportation and its effect on dimproving amnesia was investigated. Materials and Methods: In this experimental study, 136 NMRI mice weighing 30-40 mg were used. All injections were done intraperitoneally. The first experiment aimed to determine the optimal dose of ethanol for inducing amnesia, the second experiment was performed to prove nano-chitosan loaded with Donepezil (0.25, 0.5, 0.75, 1 mg/kg) does not impair memory, and the third experiment assessed the effect of nano-chitosan loaded with different doses of Donepezil on amnesia induced by ethanol. Data were recorded as mean ± SD, analyzed in GraphPad Prism software using ANOVA and Tukey post hoc test. P<0.05 was considered as significant. Results: The first experiment showed that ethanol (0.5, 0.75, 1 mg/kg) could significantly induce amnesia. The second experiment showed nano-chitosan loaded with Donepezil doid not impair memory. The third experiment showed that all nano-chitosan groups loaded with different doses of Donepezil could significantly improve amnesia induced by ethanol. Conclusion: on this compound before it can be used for oral drug transportation.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43655838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental Skills of Children with and Without Congenital Hypothyroidism 先天性甲状腺功能减退症患儿与非先天性甲状腺功能减退症患儿的发育技能

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.4.321

Belghes Rovshan, A. Hassanzadeh Rad, S. Dalili, Ali Reza Gholi Famian

{"title":"Developmental Skills of Children with and Without Congenital Hypothyroidism","authors":"Belghes Rovshan, A. Hassanzadeh Rad, S. Dalili, Ali Reza Gholi Famian","doi":"10.52547/ismj.23.4.321","DOIUrl":"https://doi.org/10.52547/ismj.23.4.321","url":null,"abstract":"Background : Congenital hypothyroidism is one of the most common endocrinology diseases in children. Given the importance of evaluating the normal growth and development and identifying growth and development abnormalities, this study aimed to evaluate the developmental skills of patients with congenital hypothyroidism and healthy children. Materials and Methods: This controlled cross-sectional study recruited 30 children with congenital hypothyroidism and 30 healthy children aged three to five years who presented to endocrine clinic of 17 Shahrivar Hospital in Rasht. Ages and Stages Questionnaire, with 5 developmental domains of communication, gross motor skills, fine motor skills, problem solving, and personal-social skills was completed. Results: Comparison of the two groups revealed no significant difference between the groups in the domains of gross motor, problem solving, and personal-social skills (P>0.05), while there was a significant difference between them in the domains of communication and fine motor skills (P<0.05). Although lower mean scores of all skills were noted in patients with congenital hypothyroidism, the scores were acceptable. Conclusion : Based on the results, it appears that addressing congenital hypothyroidism and its complications can affect children’s health.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44632836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Factors Affecting the Satisfaction of Healthcare Workers with the Healthcare System Reform Plan in Healthcare Networks in Bushehr Province in 2018: A Qualitative Study 影响布什尔省医护人员对2018年医疗网络医疗体系改革计划满意度的因素：定性研究

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.5.475

Zenab Allahyari, Azemeh KHodami, A. Farhadi, Razeah Hajiyoni, A. Ansarifar, M. Marzban

{"title":"Factors Affecting the Satisfaction of Healthcare Workers with the Healthcare System Reform Plan in Healthcare Networks in Bushehr Province in 2018: A Qualitative Study","authors":"Zenab Allahyari, Azemeh KHodami, A. Farhadi, Razeah Hajiyoni, A. Ansarifar, M. Marzban","doi":"10.52547/ismj.23.5.475","DOIUrl":"https://doi.org/10.52547/ismj.23.5.475","url":null,"abstract":"Background: Evaluating and identifying existing challenges of the healthcare system reform plan can help policy makers and executives address these shortcomings and achieve the goals of the plan. The purpose of the current study was to evaluate the satisfaction of health network employees with healthcare reform plan in Bushehr province. Materials and Methods: This qualitative study was conducted using conventional content analysis and purposeful sampling in Bushehr province in 2018. The participants were selected from all levels of the health network in the province, and were interviewed with semi-structured questions in focused group discussions until data saturation. After the interviews were completed, all interviews were coded according to the conventional content analysis, and themes were extracted. Results: The results of eight focus group discussions with 54 participants were analyzed, and 1501 initial codes were extracted. The main theme of the study was \"Satisfaction with the Reform Plan\", consisting of two main categories of internal factors (with subcategories of nature of work, professional capabilities, appreciation and respect, independence and freedom at work, development of professional skills and physical burden, family and emotions) and external factors (with subcategories of management and planning, supervision, income, interdepartment and intradepartmen relations, infrastructure, occupational and organizational stability, and beneficiaries). Conclusion: The results led to identification of internal and external factors that affect health network employees’ satisfaction with healthcare reform plan. A future study designed based on these results can eliminate the deficiencies of the healthcare reform plan, and lay the ground for employees’ higher satisfaction, and consequently providing higher quality healthcare services to clients.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46220691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Effects of Some Persian Gulf Marine Sponges 部分波斯湾海绵的抗菌作用

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.5.494

S. Seradj, Seyedeh Zhale Hashemi, Kamyar Zomorodian, M. Moein

{"title":"Antimicrobial Effects of Some Persian Gulf Marine Sponges","authors":"S. Seradj, Seyedeh Zhale Hashemi, Kamyar Zomorodian, M. Moein","doi":"10.52547/ismj.23.5.494","DOIUrl":"https://doi.org/10.52547/ismj.23.5.494","url":null,"abstract":"Background: We investigated in vitro antimicrobial activity of five marine sponge species collected from Kish Island in the Persian Gulf: Fascaplysinopsis reticulata , Callyspongia clavatus , Callyspongia siphonella , Niphates furcata , and Pseudosuberites clavatus against gram positive bacteria, gram negative bacteria, fungi and yeasts. Materials and Methods: Sponage extracts were prepared by two solvents of dichloromethane and methanol in three steps. The extracts were then tested with broth microdilution method. Results: Microorganisms varied in their susceptibility to extracts. Fungi were less sensitive than both gram-positive and gram-negative bacteria. Streptococcus pyogenes and Streptococcus mutans were more sensitive than other bacteria. All extracts showed acceptable antimicrobial activity against at least one bacterial strain. Marine sponge Fascaplysinopsis reticulata had the highest activity against all examined gram-positive bacteria including resistant strains (MIC of dichloromethane and methanolic extracts were in the range of 0.25-8 and 16-32 µg/ml, respectively). Conclusion: The results showed that marine sponge Fascaplysinopsis reticulata had significant antimicrobial activity, and is a promising candidate for further purification and identification of antibacterial compounds.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46469918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synergic Effect of TC99-m Gamma Radiation and Non-ionizing Radiation of Wi-Fi on Count, Morphology and Motility of Sperms in Rats: An Experimental Study TC99-m γ辐射与Wi-Fi非电离辐射对大鼠精子数量、形态和活力的协同效应实验研究

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.4.280

F. Gheisari, M. Atefi, Aref Masoumirad

{"title":"Synergic Effect of TC99-m Gamma Radiation and Non-ionizing Radiation of Wi-Fi on Count, Morphology and Motility of Sperms in Rats: An Experimental Study","authors":"F. Gheisari, M. Atefi, Aref Masoumirad","doi":"10.52547/ismj.23.4.280","DOIUrl":"https://doi.org/10.52547/ismj.23.4.280","url":null,"abstract":"Background: Given the effects of ionizing radiation on biological tissues and their irreversible tissue damage, this project aimed to determine the synergic effect of TC99-m gamma radiation and non-ionizing radiation of Wi-Fi on sperm characteristics in rats. Materials and Methods: Sixty adult male rats, weighing 250-200 g randomly divided into four groups (three experimental groups and one control group). The first experimental group received TC99-m through intraperitoneal injection. The second experimental group was exposed to Wi-Fi radiation daily for one hour in one week. The third experimental group received TC99-m and wireless simultaneously. Data were analyzed in SPSS v. 20. Results: Sperm count, motility and normal morphology significantly decreased respectively in Wi-Fi group, TC99-m group and TC99-m + Wi-Fi group (p <0.001) compared to the control group. The three experimental groups were significantly different (p <0.05). The highest reduction rate in sperm count, motility and normal morphology was observed in TC 99-m + Wi-Fi group (p < 0.05). Conclusion: Based on our results, if glands and other sensitive parts of animals are placed close to electromagnetic wave sources, their normal function will be disturbed.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41454500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnopharmacology of Medicinal Plants in Tangestan county 唐吉斯坦县药用植物的民族药理学

Iranian South Medical Journal Pub Date : 2020-10-01 DOI: 10.52547/ismj.23.4.330

Sepideh Abolzadeh, K. Vahdat, I. Nabipour

{"title":"Ethnopharmacology of Medicinal Plants in Tangestan county","authors":"Sepideh Abolzadeh, K. Vahdat, I. Nabipour","doi":"10.52547/ismj.23.4.330","DOIUrl":"https://doi.org/10.52547/ismj.23.4.330","url":null,"abstract":"Background : Ethnopharmacology is a very diverse approach to drug discovery that involves the observation, description, and experimental study of native drugs and their biological activities based on botany, chemistry, biochemistry, pharmacology, and other disciplines such as anthropology, archeology, history, and linguistics that helps discovering of natural products with biological activity. The aim of this study was to identify medicinal plants that have a traditional use in the Tangestan region of Bushehr in the north of Persian Gulf. Materials and Methods: The medical uses of medicinal plants were gathered from 20 local informants by face to face interviews. The relative frequency of citation (FRC) and cultural importance (CI) indices were calculated. Results: A total of 109 medicinal plants belonging to 55 families were identified. Zataria multiflora , Descuraninia Sophia , Matricarria charmomilla , Achillea eriophora DC , Salvia mirzayanii , Plantago psyllium, Haplophyllum tuberculatum , Teucrium polium , Prunus amygdalus had the highest CI and FRC indices. The highest medical uses were for gastrointestinal problems, infectious diseases, gynecology and obstetrics, metabolic diseases, and skin problems. Conclusion : There is a wide variety of medicinal plants in the Tangestan region of Bushehr province which are used for various diseases that are consistent with the traditional medicine uses that are common in Iran and had been reported in the international medical literature. However, in this region, a number of plants are used to treat diseases that are specific to this region and research on these medicinal plants can be the beginning of a way to discover new drugs in the therapeutic field.","PeriodicalId":14583,"journal":{"name":"Iranian South Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45838740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0