Iranian journal of allergy, asthma, and immunology最新文献_第2页

Comparative Analysis of Lung Ultrasound Scoring and Oxygen Methods for Neonatal Mechanical Ventilation. 新生儿机械通气肺超声评分与氧法比较分析。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-06-03

Lina Zeng, Jianjun Tang, Tao Deng, Qijie Liu, Huimin Zhao

{"title":"Comparative Analysis of Lung Ultrasound Scoring and Oxygen Methods for Neonatal Mechanical Ventilation.","authors":"Lina Zeng, Jianjun Tang, Tao Deng, Qijie Liu, Huimin Zhao","doi":"","DOIUrl":"","url":null,"abstract":"To investigate the feasibility and effectiveness of targeted lung recruitment and the titration of optimal positive end-expiratory pressure (PEEP) in neonates under the guidance of lung ultrasound. The atelectasis neonates from June 2022 to June 2024 in the Neonatology Department of People's Hospital of Pidu were collected and randomly divided into a lung ultrasound scoring (LUS) group and an oxygen (OXY) group, both of which were given mechanical ventilation treatment. The lung recruitment and optimal PEEP were performed by the LUS and OXY methods, respectively. The optimal PEEP and the respiratory and hemodynamic indexes of the two groups were compared before and after lung recruitment and after the optimal PEEP was titrated. After the intervention, the dynamic lung compliance (Cdyn) in the LUS group increased by 38.2% compared with the baseline (from 30.6 ± 4.3 to 42.3 ± 5.1 mL/cmH2O), which was significantly higher than the 21.4% increase in the OXY group (from 29.8 ± 4.1 to 35.6 ± 4.8 mL/cmH2O). The improvement in PaO2/FiO2 in the LUS group was 22.5% higher than in the OXY group. There was no statistically significant difference in the incidence of complications between the two groups. Lung ultrasound can guide neonatal lung recruitment and optimal PEEP titration, improving lung compliance and oxygenation without affecting the safety of treatment.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 4","pages":"554-564"},"PeriodicalIF":1.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neoantigens in Cancer Immunotherapy: An Overview with a Focus on Non-small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma. 肿瘤免疫治疗中的新抗原：综述，重点是非小细胞肺癌和胰腺导管腺癌。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-06-03

Fatemeh Eskandari-Malayeri, Sajjad Shekarchian, Esmaeil Mortaz

引用次数: 0

Clinical Manifestations and Genetic Findings in Three Patients with Chediak-Higashi Syndrome: Highlighting the Splice Site Variants. 3例Chediak-Higashi综合征的临床表现和遗传学研究：剪接位点变异

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-06-03

Shaghayegh Tajik, Anne Molitor, Zahra Alizadeh, Mohammad Reza Fazlollahi, Raphael Carapito, Maryam Akbari, Mohsen Badalzadeh, Massoud Houshmand, Mostafa Moin, Seiamak Bahram, Zahra Pourpak

{"title":"Clinical Manifestations and Genetic Findings in Three Patients with Chediak-Higashi Syndrome: Highlighting the Splice Site Variants.","authors":"Shaghayegh Tajik, Anne Molitor, Zahra Alizadeh, Mohammad Reza Fazlollahi, Raphael Carapito, Maryam Akbari, Mohsen Badalzadeh, Massoud Houshmand, Mostafa Moin, Seiamak Bahram, Zahra Pourpak","doi":"","DOIUrl":"","url":null,"abstract":"Chédiak-Higashi syndrome (CHS) is a rare autosomal recessive disorder characterized by severe immunodeficiency, partial albinism, recurrent infections, and progressive neurologic dysfunction. Unless patients undergo successful hematopoietic cell transplantation (HCT), a majority of them die during childhood because of an accelerated phase of immune dysfunction and hemophagocytic lymphohistiocytosis (HLH). Herein, we aim to describe the laboratory diagnosis, clinical manifestations, and genetic findings in three patients with CHS. Three patients with partial albinism associated with CHS were included in this study. Immunological screening tests were done. Leukocyte granules in peripheral blood smear (PBS) and hair shafts were examined. Subsequently, genetic analyses were performed by Whole Exome Sequencing (WES) followed by Sanger sequencing for all patients and their parents. Initial immunology screening tests were within normal limits. Light microscopy studies of patients' PBS showed giant granules in the leukocyte cytoplasm. Furthermore, there were evenly distributed melanin granules in the patients' hair shafts. Variant analysis of the LYST gene identified three splicing site defects: one known variant, c.7060-1G>A in intron 24, and two novel variants, c.2363+2T>C in intron 5, and c.10702-3A>G in intron 47. Hair shaft assay and PBS are rapid and suitable tests in early diagnosis and differentiation in CHS patients. WES results revealed 2 novel splice site variants that might contribute to earlier and more accurate diagnosis. This facilitates early enrolment of CHS patients in the HCT protocol-the optimal treatment path-and enables prenatal diagnosis for affected families.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 4","pages":"576-582"},"PeriodicalIF":1.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Mannose-binding Lectin-2 Promoter Genetic Variants in Susceptibility to Sepsis: A Meta and Trial Sequential Analysis. 甘露糖结合凝集素-2启动子基因变异在脓毒症易感性中的作用：荟萃和试验序列分析。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-06-03

Hongyi Shao, Jianfeng Zhang, Dayong Wu, Xiaoyang Zhang, Chunqiong Hu

{"title":"Role of Mannose-binding Lectin-2 Promoter Genetic Variants in Susceptibility to Sepsis: A Meta and Trial Sequential Analysis.","authors":"Hongyi Shao, Jianfeng Zhang, Dayong Wu, Xiaoyang Zhang, Chunqiong Hu","doi":"","DOIUrl":"","url":null,"abstract":"Mannose-binding lectin (MBL) is a critical component of the innate immune system, serving a vital role in the body's initial defense against pathogens. Sepsis, a severe condition triggered by an excessive immune response to infection, has been linked to variations in the MBL2 gene that affect MBL levels and functionality. Numerous studies across various populations have examined the role of MBL-2 promoter polymorphisms (H>L and Y>X), but their results have been conflicting. This study aims to investigate the genetic connection between MBL promoter polymorphisms and susceptibility to sepsis through a meta-analysis of previously published articles. A thorough literature search was conducted using PubMed, Scopus, and ScienceDirect to locate relevant articles for the meta-analysis. Rigorous inclusion and exclusion criteria were implemented to ensure data accuracy. All analyses were performed using Comprehensive Meta-Analysis Software v4. Seven studies were included, examining the role of MBL-2 promoter genetic variants in sepsis (H>L: n=3, sepsis cases: 449, control: 687; Y>X: n=6, sepsis cases: 1211, control: 1694). Egger's regression analysis and funnel plots suggested no publication bias. Heterogeneity analysis indicated homogeneity among the data. The meta-analysis showed no association between MBL-2 promoter variants and susceptibility to sepsis. The trial sequential analysis highlighted the need for further studies on MBL-2 promoter variants in sepsis to draw a definitive conclusion. The promoter variants of the MBL-2 gene (H>L and Y>X) do not appear to increase the risk of sepsis. Further investigation is needed to confirm this conclusion, including more participants from diverse populations and larger sample sizes.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 4","pages":"475-488"},"PeriodicalIF":1.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergies and Lung Cancer: Exploring the Association with Allergic Rhinitis. 过敏与肺癌：探讨与变应性鼻炎的关系。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21251

Mozhgan Moghtaderi, Abbas Rezaianzadeh, Seyed Hesamedin Nabavizadeh, Zahra Kanannejad, Zahra Khosravizadegan, Kimia Asnaashari

{"title":"Allergies and Lung Cancer: Exploring the Association with Allergic Rhinitis.","authors":"Mozhgan Moghtaderi, Abbas Rezaianzadeh, Seyed Hesamedin Nabavizadeh, Zahra Kanannejad, Zahra Khosravizadegan, Kimia Asnaashari","doi":"10.18502/ijaai.v25i3.21251","DOIUrl":"10.18502/ijaai.v25i3.21251","url":null,"abstract":"Allergy and lung cancer are two distinct health concerns. While allergies are typically associated with heightened immune activity, such immune responses may also influence the tumor microenvironment. This study aimed to investigate a potential link between allergic conditions and the risk of lung cancer. We conducted a case-control study analyzing 82 histologically confirmed lung cancer patients and 82 healthy controls from 2019 to 2022. Data were collected through structured questionnaires assessing asthma, allergic rhinitis (AR), food/drug allergies, and chronic urticaria. Statistical analyses included independent samples t-tests and chi-square tests, with significance set at a predetermined threshold. We observed a significant inverse association between AR and lung cancer (8.54% vs 47.56% in controls; OR=0.14, 95% CI: 0.06-0.32). No significant associations were found for asthma (7.32% vs 3.66%), chronic urticaria (3.66% vs 3.66%), drug allergy (4.88% vs 1.22%), or food allergy (2.44% vs 6.10%). The association between AR and lung cancer remained robust after adjustment for demographic factors. AR demonstrated a strong negative association with lung cancer, suggesting potential protective mechanisms distinct from other allergic conditions. These findings support the growing evidence for allergy-cancer immunomodulatory interactions and highlight the need for mechanistic studies on AR-specific pathways in oncogenesis.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"286-292"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Elevated Eosinophil Counts and Neutrophils/Lymphocytes Ratio as Predicting Biomarkers in Non-responders, Chronic Spontaneous Urticarial Patients to Cetirizine/Famotidine Treatment. 对西替利嗪/法莫替丁治疗无反应的慢性自发性荨麻疹患者，升高的嗜酸性粒细胞计数和中性粒细胞/淋巴细胞比率作为预测生物标志物

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21253

Abbas Khalili, Zahra Estakhri, Ali Shams, Yeganeh Lalehzari

{"title":"The Elevated Eosinophil Counts and Neutrophils/Lymphocytes Ratio as Predicting Biomarkers in Non-responders, Chronic Spontaneous Urticarial Patients to Cetirizine/Famotidine Treatment.","authors":"Abbas Khalili, Zahra Estakhri, Ali Shams, Yeganeh Lalehzari","doi":"10.18502/ijaai.v25i3.21253","DOIUrl":"10.18502/ijaai.v25i3.21253","url":null,"abstract":"The responses of patients with chronic spontaneous urticaria (CSU) to regular therapeutic options vary. While these methods are effective for some patients, many do not respond successfully. Despite several studies conducted to identify immunologic and inflammatory biomarkers in patients that can predict response, our current knowledge is insufficient. This study aimed to identify biomarkers that may predict therapeutic response. The present interventional study evaluated 61 moderate-to-severe CSU patients aged 20 to 50 years who presented to our clinic from January 2024 to January 2025. Peripheral blood samples, serum, and plasma were collected to measure inflammatory and immunological variables, and were analyzed at a reference laboratory. Subsequently, patients were treated with cetirizine 10 mg every 12 hours and famotidine 40 mg every night. After 1month, urticarial severity was reassessed using the same questionnaire. Severity scores were compared between patients with elevated biomarkers and those with normal levels. Sixty-one patients with chronic spontaneous urticaria were enrolled; 77% female and 23% male. Forty-one patients experienced a good response to treatment, while 20 patients did not. The average (Urticaria Activity Score) UAS7 scores before and after treatment were 27.72 and 12.67, respectively. Among the serum biomarkers evaluated, only the neutrophil-to-lymphocyte ratio (NLR) and serum eosinophil count showed a significant relationship with treatment response. To conclude, a high eosinophil count and NLR may serve as predictors of a poor clinical response to antihistamine therapy. However, further clinical trials are needed to confirm these findings.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"293-302"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic Diversity of Chronic Granulomatous Disease within a Family Carrying the Same NCF1 Gene Mutation. 携带相同NCF1基因突变的一个家族内慢性肉芽肿病的表型多样性

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21264

Sarvin Yazdizadeh, Mohammad Saberi, Abdollah Karimi, Samin Sharafian, Sedigheh Rafiei Tabatabaei, Sahar Seraj, Maryam Sadat Seyedmehdi, Shahrzad Fallah

引用次数: 0

Comprehensive Analysis of Core Genes, Key Pathways, and Immune Infiltration in Intervertebral Disc Degeneration Using Machine Learning and Experimental Validation. 利用机器学习和实验验证综合分析椎间盘退变的核心基因、关键通路和免疫浸润。

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21260

Haoju Lo, Chunhao Tsai, Tsanwen Huang

引用次数: 0

Effects of Combination Therapy with Empagliflozin and Metformin on Interleukin-1β and Interleukin-6 Secretion in Type 2 Diabetes Patients. 恩格列净联合二甲双胍对2型糖尿病患者白细胞介素-1β和白细胞介素-6分泌的影响

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21258

Amir Pedram Moghis, Mehdi Behzad, Alireza Soltanian, Shiva Borzouei

{"title":"Effects of Combination Therapy with Empagliflozin and Metformin on Interleukin-1β and Interleukin-6 Secretion in Type 2 Diabetes Patients.","authors":"Amir Pedram Moghis, Mehdi Behzad, Alireza Soltanian, Shiva Borzouei","doi":"10.18502/ijaai.v25i3.21258","DOIUrl":"10.18502/ijaai.v25i3.21258","url":null,"abstract":"Type 2 diabetes (T2D) is defined by persistent inflammatory processes. This study evaluated the anti-inflammatory properties of empagliflozin in combination with metformin therapy in patients with T2D. In this prospective cohort study, 50 individuals with type 2 diabetes were non-randomly assigned to receive metformin (MTF, n = 25) or empagliflozin (10 mg/day) and metformin (EMPA+MTF, n = 25) and followed for 6 months. Fasting blood glucose (FPG), HbA1c, body mass index (BMI), glomerular filtration rate (GFR), and urinary albumin were measured at baseline and then 6 months later. Interleukin-1beta (IL-1β) and interleukin-6 (IL-6) secretion from isolated and stimulated peripheral blood mononuclear cells were measured using ELISA and compared in the different study groups. The MTF+EMPA group showed significantly decreased levels of FPG, HbA1C, and body mass index compared to the baseline. FPG and HbA1c in the MTF+EMPA group showed a significant decrease six months after treatment versus the MTF group. A significant reduction in IL-1β levels was observed at the six months post-treatment compared to baseline and in relation to the MTF group after six months. The levels of IL-6 exhibited no significant differences, both within and between the study groups. Significant direct correlations were observed between IL-1β levels and FPG as well as HbA1c within the MTF+EMPA group following six months of treatment. Incorporating empagliflozin (10 mg/day) into metformin treatment markedly enhanced glycemic regulation and lowered IL-1β secretions, indicating a possible anti-inflammatory benefit in overweight individuals with T2D following six months of treatment.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"355-362"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Cell Death-related Genes and Characterization of Immune Microenvironment. 基于细胞死亡相关基因及免疫微环境表征的肝癌预后模型构建

IF 1.5 4区医学

Iranian journal of allergy, asthma, and immunology Pub Date : 2026-04-22 DOI: 10.18502/ijaai.v25i3.21259

Wei Wu, Yingji Wang, Xiaocheng Zhao, Ke Dong, Maode Li, Xiang An, Yingyan Xu, Shuai Wang, Dexin Li

{"title":"Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Cell Death-related Genes and Characterization of Immune Microenvironment.","authors":"Wei Wu, Yingji Wang, Xiaocheng Zhao, Ke Dong, Maode Li, Xiang An, Yingyan Xu, Shuai Wang, Dexin Li","doi":"10.18502/ijaai.v25i3.21259","DOIUrl":"10.18502/ijaai.v25i3.21259","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer. This study aimed to elucidate the involvement of genes associated with 25 cell-death modalities in HCC development and progression. HCC transcriptomic datasets were integrated with curated cell death-related genes. Candidate genes were screened by differential expression analysis and protein-protein interaction network construction. Prognostic genes were identified using univariate Cox regression, proportional hazards assumption testing, and stepwise multivariate Cox regression. A risk score model and a nomogram were established, followed by risk stratification and analyses of immune infiltration, immune checkpoints, somatic mutations, and in silico drug sensitivity. Single-cell RNA sequencing was used to identify key cell types, infer temporal dynamics, and characterize intercellular communication, and findings were validated by quantitative real-time PCR (qRT-PCR). MAPT, CDKN2A, NQO1, CHGA, SERPINE1, and RET were identified as prognostic genes, and the risk model and nomogram showed good prognostic performance. Immune profiling revealed significant differences in multiple immune cell subsets between risk groups, including activated CD4+ T cells. Notably, CDKN2A correlated with activated CD4+ T cells, NQO1 with natural killer cells, RET with CD4+ central memory cells, and SERPINE1 with activated dendritic cells; RET also showed the strongest positive correlation with HAVCR2. Mutation spectra differed across risk groups, and ten drugs displayed significant predicted IC50 differences; all six genes were negatively correlated with KIN001.135. Single-cell analyses highlighted hepatocytes as a key cell type with strong hepatocyte-epithelial communication. qRT-PCR confirmed higher MAPT, CDKN2A, NQO1, and SERPINE1 expression in HCC tissues than in normal tissues.","PeriodicalId":14560,"journal":{"name":"Iranian journal of allergy, asthma, and immunology","volume":"25 3","pages":"363-392"},"PeriodicalIF":1.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0