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Effects of focused ultrasound on human cervical cancer HeLa cells in vitro. 聚焦超声对体外人类宫颈癌 HeLa 细胞的影响。

Investigación Clínica Pub Date : 2023-11-22 DOI: 10.54817/ic.v64n4a01

Yanbin Liu, Qun Zhao, Panpan Liu, Yanbin Li, Li’an Yi, Haiping Yan

{"title":"Effects of focused ultrasound on human cervical cancer HeLa cells in vitro.","authors":"Yanbin Liu, Qun Zhao, Panpan Liu, Yanbin Li, Li’an Yi, Haiping Yan","doi":"10.54817/ic.v64n4a01","DOIUrl":"https://doi.org/10.54817/ic.v64n4a01","url":null,"abstract":"Cervical cancer is the fourth most common malignant tumor in women. Many studies have confirmed that early childbirth, prolificacy, HPV infection, and smoking are some risk factors. This article explored the effects of exposing human cervical cancer HeLa cells to different focused ultrasound intensities in vitro. The study employed three groups of cells: 1- a high-intensity treated group, 2- a low-intensity treated group, and 3- a control group. Results showed that after 12 hours of focused ultrasound treatment, the growth inhibi-tion rate of the low-intensity group was 55.6% higher than that of the control group, and the growth inhibition rate of the high-intensity group was 41.2% higher than that of the low-intensity group. Therefore, focused ultrasound had a specific inhibitory effect on the growth of HeLa cells, and the higher the intensity of focused ultrasound, the higher the inhibition rate on cancer cells. In addition, the Cycle Threshold (Ct) values of the three groups of cells before treatment were the same, but the Ct values after treatment had changed. The Ct value of the low-intensity group was 18.1% lower than that of the control group, and the Ct value of the high-intensity group was lower than that of the low-intensity group by 27.8%, showing that focused ultrasound can effectively reduce the activity of HeLa cells in vitro.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"197 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139249688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of myocardial infarction by a 12-lead routine electrocardiogram: a case report of an ST-segment elevation. 通过 12 导联常规心电图评估心肌梗死：ST 段抬高的病例报告。

Investigación Clínica Pub Date : 2023-11-22 DOI: 10.54817/ic.v64n4a10

Huayong Jin, Lijiang Ding, Binglei Li, Jianming Zhang

{"title":"Evaluation of myocardial infarction by a 12-lead routine electrocardiogram: a case report of an ST-segment elevation.","authors":"Huayong Jin, Lijiang Ding, Binglei Li, Jianming Zhang","doi":"10.54817/ic.v64n4a10","DOIUrl":"https://doi.org/10.54817/ic.v64n4a10","url":null,"abstract":"The spiked helmet sign (SHS) is a type of ST-segment elevation associated with critical cardiac disease and a high risk of death. We report a case of SHS caused by an ECG artifact. A 60-year-old male patient presented to the clinic after suffering an electric shock. The initial 12-lead routine elec-trocardiogram showed an SHS. The patient received appropriate intravenous fluid replacement therapy, and after 30 minutes, the ST-T changes of the 12-lead electrocardiogram were all restored to normal. The patient was discharged after a 24-hour observation period in the emergency room.Recent studies have pointed out that there may be two different types of SHS. One is the mechanical factor, and the other is the significant prolongation of the QT interval. The two types have different clinical significance. In our report, the radial artery of the patient’s right wrist pulsed strongly, and after the occurrence of SHS, the SHS disappeared after adjusting the contact position of the electrode in his right arm. This SHS caused by mechanical traction was an ECG artifact.Although the SHS may be an essential indicator of critical illness, there are mechanical factors that lead to the appearance of ECG artifacts. Therefore, in clinical work, obtaining a complete medical history and primary conditions of the patient at the time of ECG sampling is necessary to help the diagnosis and thus avoid er-roneous treatment.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"178 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflamasoma, piroptosis y su posible relación con la fisiopatología de la COVID-19 炎症瘤、焦痂病及其与COVID-19病理生理学的可能关系

Investigación Clínica Pub Date : 2020-09-01 DOI: 10.22209/ic.v61n3a07

Adriana Pedreáñez, J. Mosquera, Nelson Muñoz

引用次数: 1

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