{"title":"Instrumentation, VR and Haptic Systems applied to scanning and micromanipulation platforms: Research and Learning aspects *","authors":"F. Marchi, A. Niguès, N. Castagné","doi":"10.1109/MARSS55884.2022.9870489","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870489","url":null,"abstract":"Mechanical actions and physical measurements at micro and nanoscale required special tools and instrumental platforms. This paper deals with the fabrication of various custom-made Scanning Force Microscopy (SFM) probes, on one hand to perform quantitative physical measurements on soft or magnetic materials, on the other hand to identify and to manipulate in 3D individual (sub)micronic object. Quantitative characterizations on micromagnet arrays achieved thanks to colloidal magnetic probes are presented. Some smart 3D manipulations of micro-spheres in fluid thanks to quartz SFM probes implemented in an interactive micro/nano-manipulation station are described. Finally, virtual reality (VR) stations combined with haptic devices and VR nano-scenes are introduced; their complementary with real micromanipulation stations equipped with haptic systems is underlined.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123288947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell Extraction Automation in Single Cell Surgery using the Aspiration Method","authors":"Basil Abu Zanouneh, J. Mills","doi":"10.1109/MARSS55884.2022.9870497","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870497","url":null,"abstract":"Biological cell micromanipulation is the precise in-vitro study and handling of individual cells, where small errors can be disastrous. An important example is embryo biopsy, in which a blastomere is extracted from a cleavage-stage embryo for genetic profiling, without damaging the embryo and affecting its viability. Today, the success rates of manually performed biopsies are relatively low due to human errors, leading to excessive embryo damage and prolong surgery times. In this paper, the automation of the extraction of a blastomeres from an early-stage embryo using the aspiration method and image feedback is presented. Computer-controlled micromanipulators combined with computer vision algorithms are used for automated extraction of a predefined number of cells, and detecting the extraction event. Preliminary proof of concept experiments to extract a single cell from a 2-cell cleavage-stage embryos obtained success rates ranging from 80 − 95% for different extraction stages, providing a set of tools for moving towards a fully automated single-cell surgery procedures.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124002077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Hsu, R. Pelrine, Rui de Gouvea Pinto, E. Schaler
{"title":"2D-Compliant, Diamagnetic Levitating Micro-Robots for Operation on Non-Flat, Non-Clean Tracks","authors":"A. Hsu, R. Pelrine, Rui de Gouvea Pinto, E. Schaler","doi":"10.1109/MARSS55884.2022.9870462","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870462","url":null,"abstract":"We demonstrate techniques for fabricating 2D-compliant, magnetic micro-robots able to diamagnetically levitate and controllably maneuver over a non-flat and non-clean surfaces. These capabilities were first demonstrated in simulation–identifying passively-stable configurations of magnetic dipole arrays linked by compliant flexures, computing levitation force versus height, and exploring the design space of robot compliance and track curvature versus levitation height. A viable compliant micro-robot design was then fabricated and operated on curved graphite surfaces that are not traversable by rigid micro-robots. Separately, a non-compliant micro-robot was used to demonstrate partial abrasive particle clearing on a dirty track and then subsequent operation for >50,000 cycles / >600 m with no signs of wear. These advancements in diamagnetic micro-robot capabilities will enable applications of the technology in a broader range of environments (including beyond Earth) and size-scales (to support larger payloads).","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115206307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danming Wei, Ruoshi Zhang, Ji-Tzuoh Lin, Dilan Ratnayake, Olalekan O. Olowo, Andrew S. Nimon, Moath H. A. Alqatamin, A. Sherehiy, D. Popa
{"title":"Automated Fabrication of Tactile Sensors Using a Custom Additive Manufacturing Platform","authors":"Danming Wei, Ruoshi Zhang, Ji-Tzuoh Lin, Dilan Ratnayake, Olalekan O. Olowo, Andrew S. Nimon, Moath H. A. Alqatamin, A. Sherehiy, D. Popa","doi":"10.1109/MARSS55884.2022.9870485","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870485","url":null,"abstract":"This paper presents the NeXus, a precision robotic platform with additive manufacturing capabilities that can be used to prototype strain gauge-based tactile sensors – SkinCells - on flexible substrates. An Aerosol Inkjet printer was employed to print the strain gauge structure of the SkinCell sensor. The design of this sensor combines curvilinear geometries representing both a radial shape structure and an arc shape structure, which have opposite gauge responses when the force is applied to the center of the sensor. The fabrication process of the SkinCell sensor is predicated on a parametric kinematic calibration of the NeXus to identify features on the sensor substrate and align them to the printing and metrology tools. Several strain gauge SkinCell sensor samples were printed on pre-fabricated flexible substrates using the NeXus. Results indicate a calibration precision of approximately 170 microns with 60 microns line-width features. This precision is sufficient to ensure that all printed gauges are electrically connected to the pre-fabricated contacts.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131107650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Hybrid Nanorobotic Manipulation Platform: A Sharing Holder between a Cs-TEM and an SEM for Micro to Sub-nanometer Fabrication","authors":"Wenqi Zhang, Donglei Chen, Chaojian Hou, R. Shao, Zhan Yang, Lixin Dong","doi":"10.1109/MARSS55884.2022.9870493","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870493","url":null,"abstract":"Nanorobotic manipulation inside a transmission electron microscope (TEM) and a scanning electron microscope (SEM) has been developed independently with TEM emphasizing the high resolution whereas the SEM focuses on more complex processes using for example multiple probes and taking the advantage of electron beams or focused ion beams (FIB) for nanofabrication and assembly. A merged platform by combining them together is highly demanded for complicated device-level prototyping and characterization. Here we report an advanced hybrid nanorobotic manipulation system with a holder compatible to both a dual-beam SEM with a FIB and electron-beam lithography (EBL) and a spherical aberration corrected (Cs) TEM. Together with multiple nanorobotic manipulators pre-installed inside the SEM, this sharing holder contains a scanning tunneling microscope (STM) as a positioning stage that can work with the TEM, hence highly complex and precise manipulation is achieved in a combined platform. Furthermore, the holder has a variety of physical stimuli integrated with TEM-compatible chips, which greatly expand the application scenarios of the two platforms. The fabrication of a nano-bioelectrical probe is taken as an example to demonstrate the advantages of this system in terms of task complexity, operational accuracy, and efficiency.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127067824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Wang, Zicheng Li, Wei Dai, Rui Liu, Sishen Yuan, Jun Liu
{"title":"On-Chip Transportation and Mixing of Microsample Using Electrohydrodynamic Flow*","authors":"Min Wang, Zicheng Li, Wei Dai, Rui Liu, Sishen Yuan, Jun Liu","doi":"10.1109/MARSS55884.2022.9870510","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870510","url":null,"abstract":"Microfluidic devices and lab-on-a-chip systems are critically helpful in a number of biological and biomedical applications such as cell culture, drug delivery, and immunoassays. Micro-sample transportation, typically driven by hydraulic or pneumatic actuators, is one of the most elemental functions in the microfluidic systems. However, the existing sample transportation modules are difficult to control and observe because the existing of non-linearity and air bubbles. Moreover the closed channels has limited transparency and are inaccessible to microrobotic end-effectors. This study aims to develop a novel flow governing device for active sample transportation and assembly using electrohydrodynamic force. The dielectric liquid is filled in the microchannel as the transfer medium, and the electrodes are vertically integrated on the sidewalls to avoid blockage of the optical path. The dielectric liquid can generate a powerful flow when subjected to high DC voltage, thus providing an on-chip hydraulic power source. The proposed system is more compact than microdevices driven by external fluid sources such as syringe pumps. In addition, the vertically filled electrodes allows for a clearer view for observation and manipulation by other microrobotic tools. The micro-sample transportation experiments confirm that the sample can be transported bi-directionally with the highest transportation speed of 15.68 mm/s. The experiments also suggest that multiple samples could be transported and assembled by controlling the fluid flow in different channels.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123993774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards a compact and low-cost mesoscopic XY positioning system using 3D printing of conductive polymers","authors":"Benjamin Calmé, L. Rubbert, Y. Haddab","doi":"10.1109/MARSS55884.2022.9870471","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870471","url":null,"abstract":"Technological advances in additive manufacturing have made it possible to exploit composite materials, such as carbon-doped filaments, synthesised for specific function with tailored properties. The integration of carbon fibres, with good electrical and thermal conductivity, within an insulating polylactic acid (PLA) matrix produces a conductive functional material. These properties allow to manufacture mesoscopic electrothermal actuators and more complex monolithic structures including them.A compact and monolithic 3D printable positioning system with built-in V-shaped actuators is proposed in this paper. Multi-physics coupling analysis are performed in ANSYS to validate the estimated performances of the actuator and the positioning system. Then, an experimental characterisation based on printed prototypes showed good performances close to those estimated. The prototype measures 92mm×92mm×2mm and has a working space of 10.75mm2. These early results allowed the implementation of a first closed-loop control strategy using a Smith predictor.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124519630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ujjal Dey, Supriti Sen, L. Prasanna Venkatesh, C. Jacob, C. S. Kumar
{"title":"Optimal Path Planning of Micromanipulators in Confined spaces and Nanomanipulation of 1D Nanomaterials","authors":"Ujjal Dey, Supriti Sen, L. Prasanna Venkatesh, C. Jacob, C. S. Kumar","doi":"10.1109/MARSS55884.2022.9870501","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870501","url":null,"abstract":"In recent trends, it has been found that nanorobotics systems inside SEMs facilitate in-situ manipulation and characterization for the assembly of nanodevice. However, the complexity of managing the total manipulation system increases due to constricted workspace and lack of proper process feedback information during nanomanipulation. Multiple components must be controlled simultaneously to perform any experiment, which requires an integrated control interface. For analyzing 1D nanomaterials properties pick and place, nanomanipulation technique is demonstrated here. As shown in the experiments, nanomaterial characterization requires two or more micromanipulators simultaneously for 3D nanomanipulation task. Therefore, changing the micromanipulators configuration is frequently required to initiate the next task sequence in an ongoing experimental process. A MATLAB-based simulation tool is developed, which computes an optimal path for collision-free motion inside an SEM confined workspace.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124901920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design of a Compliant Vertical Micropositioning Stage Inspired by Lamina Emergent Mechanism","authors":"Z. Lyu, Qingsong Xu","doi":"10.1109/MARSS55884.2022.9870463","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870463","url":null,"abstract":"The vertical micropositioning stage is a crucial device of precision measurement instruments. Previous vertical platforms often suffer from the disadvantages of large longitudinal dimensions and small output strokes. Inspired by the motion principle of the lamina emergent mechanism, this paper proposes a novel symmetric double-layer compliant vertical micropositioning stage. Such design saves the system footprint in vertical direction with a centimeter-level stroke output. The design and theoretical analysis of the stage are introduced first. Then, the performance simulation of the stage is given based on finite element analysis. A prototype was fabricated through 3D printing technology and preliminary tests were carried out. The stiffness of the overall mechanism obtained from theoretical model, simulation, and experiments shows a good consistency. According to the simulation data, the stiffness of the involved vertical positioning platform is 0.8271 N/mm and the first resonant frequency is 43.96 Hz. The mechanical design proposed in this paper provides a new reference for the design of compliant vertical micropositioning stage.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125956234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Moqiu Zhang, Lidong Yang, Haojin Yang, Lin Su, Li Zhang
{"title":"A Doppler and B-Mode Hybrid Ultrasound Tracking Method for Microcatheter Navigation in Noisy Environments","authors":"Moqiu Zhang, Lidong Yang, Haojin Yang, Lin Su, Li Zhang","doi":"10.1109/MARSS55884.2022.9870456","DOIUrl":"https://doi.org/10.1109/MARSS55884.2022.9870456","url":null,"abstract":"Robot-assisted ultrasound imaging provides a promising microrobot tracking method for biomedical tasks. However, noise artifacts such as interfaces or acoustic shadows have a direct influence on localization accuracy. This paper introduces a novel ultrasound tracking method that uses an ultrasound Doppler image-based noise filter and a template matching algorithm to accurately localize the microcatheter in Brightness mode(B-mode) images. We also propose a robot-assisted ultrasound imaging system that can switch between in-plane and out-of-plane tracking and provides 3D localization of the microcatheter in noisy environments. A magnetic microcatheter design that can generate strong Doppler signals and perform drug delivery is also presented. The tracking performance of the proposed system is experimentally verified both in a tissue-mimicking agarose phantom and an ex vivo phantom made of chicken breast. The proposed method can robustly navigate the microcatheter to the desired position in noisy environments. A blood clot clearance experiment is also demonstrated to verify the effectiveness of the microcatheter.","PeriodicalId":144730,"journal":{"name":"2022 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS)","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117014176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}