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International journal of pharmaceutical compounding最新文献

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Extemporaneous Topical Minoxidil Solutions for the Treatment of Alopecia: Stability Studies and Incorporation Tests of Active Ingredients in ALOPLUS FAST Base. 临时外用米诺地尔溶液治疗脱发:稳定性研究和ALOPLUS FAST碱中有效成分的掺入试验。
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Antonio Spennacchio, Angela Assunta Lopedota, Antonio Lopalco, Maria Teresa Dibenedetto, Flavia Maria la Forgia, Sergio Fontana, Massimo Franco, Nunzio Denora
{"title":"Extemporaneous Topical Minoxidil Solutions for the Treatment of Alopecia: Stability Studies and Incorporation Tests of Active Ingredients in ALOPLUS FAST Base.","authors":"Antonio Spennacchio,&nbsp;Angela Assunta Lopedota,&nbsp;Antonio Lopalco,&nbsp;Maria Teresa Dibenedetto,&nbsp;Flavia Maria la Forgia,&nbsp;Sergio Fontana,&nbsp;Massimo Franco,&nbsp;Nunzio Denora","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Minoxidil is a vasodilator drug generally employed for the treatment of various forms of alopecia. In this article, the authors propose an alternative to the formulation reported in the British Pharmacopoeia for the realization of topical minoxidil -based solutions using ALOPLUS FAST. This liquid vehicle is an ethanol- and propylene glycol-free base which allows the complete solubilization of minoxidil, thanks to the presence of hydroxypropyl-ß-cyclodextrin. Solubility and chemical stability studies of the active ingredient in the formulation at a concentration of 5% w/w and physical stability studies of this extemporaneous preparation are reported. Incorporation tests of various active pharmaceutical ingredients that can be combined with minoxidil for alopecia synergic treatment have been carried out. Analyses were performed by using a high-pressure liquid chromatography analytical method. The results showed that the intrinsic solubility of the drug in the liquid base was 62.37 mg/mL ± 0.85 mg/mL (5.24 w/w ± 0.07% w/w) at 25°C; minoxidil was chemically stable in ALOPLUS FAST; and the formulation was physically stable for more than six months, under different storage conditions. Incorporation tests of several active pharmaceutical ingredients in 2% to 4% w/w minoxidil formulations were successful as well.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PreScription: Shortages Continue--Compounding Pharmacies Fill the Gap…Again! 处方:短缺继续-复合药房填补空白…再一次!
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Loyd V Allen
{"title":"PreScription: Shortages Continue--Compounding Pharmacies Fill the Gap…Again!","authors":"Loyd V Allen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9753500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Show Me the Science: A Perspective. 让我看看科学:一个视角。
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Anthony Grzib
{"title":"Show Me the Science: A Perspective.","authors":"Anthony Grzib","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality Assurance: Compounding Record Audits for Error Prevention. 质量保证:复合记录审核以防止错误。
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Jessica Hawkins
{"title":"Quality Assurance: Compounding Record Audits for Error Prevention.","authors":"Jessica Hawkins","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article looks at taking a proactive approach in discovering inconsistencies in pharmaceutical compounding at a facility level. Details on the requirements for master formulation and compounding records in nonsterile and sterile compounding as laid out in the 2022 publications of United States Pharmacopeia Chapter <795> Pharmaceutical Compounding- Nonsterile Preparations and United States Pharmacopeia Chapter <797> Pharmaceutical Compounding-Sterile Preparations are reviewed. Following this summary, information is then presented on how to utilize the record-keeping requirements to a facility's advantage through regular auditing and reporting and how to incorporate these audits or reports into a facility's quality-assurance program to fulfill error detection and prevention requirements.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Warts: Pathophysiology, Types, Treatments, and Pharmaceutical Compounds. 疣:病理生理学，类型，治疗和药物化合物。
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Robin Touprong, Tara Thompson, LaVonn A Williams
{"title":"Warts: Pathophysiology, Types, Treatments, and Pharmaceutical Compounds.","authors":"Robin Touprong,&nbsp;Tara Thompson,&nbsp;LaVonn A Williams","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Warts are a benign skin growth caused by the deoxyribonucleic acid virus named human papillomavirus, which infects the top layer of the skin and penetrates epithelial cells. Warts shed human papillomavirus, which can then infect other sites in the region or spread to other people. Warts can be transmitted by close skin-to-skin contact; areas of skin that are broken or cut are more susceptible to being infected with the human papillomavirus virus. Warts can also be transmitted from contaminated objects or surfaces. Most adults have developed immunity to the virus that causes warts, but children are more susceptible to warts because their bodies are less likely to have built immunity to the virus. This article discusses the pathophysiology of warts, the different types of warts, the most common treatments for warts, and provides some compounded formulas for the treatment of warts.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9564879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonsterile Basics of Compounding: Compounding with Humectants. 非无菌复合基础:与湿润剂复合。
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Loyd V Allen
{"title":"Nonsterile Basics of Compounding: Compounding with Humectants.","authors":"Loyd V Allen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Humectants are in common use not only in pharmaceuticals but also in foods, cosmetics, etc. The proper selection of a humectant in a pharmaceutical formula depends upon the dosage form, ingredients, physical and chemical characteristics, as well as stability issues. Some of the more typical examples of humectants that are used in pharmaceuticals, foods, and cosmetics are provided in this article, as well as a more detailed list of humectants used in pharmaceuticals, including some physicochemical characteristics.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9564880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunities for Pipeline Programming and Co-curriculum Learning Experiences--A Perspective Commentary. 管道编程和合作课程学习经验的机会——一个观点评论。
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Mary E Fredrickson, Fady Abdlrasul, Zachary Martin, Oliva Knauf
{"title":"Opportunities for Pipeline Programming and Co-curriculum Learning Experiences--A Perspective Commentary.","authors":"Mary E Fredrickson,&nbsp;Fady Abdlrasul,&nbsp;Zachary Martin,&nbsp;Oliva Knauf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Given the variability in compounding education provided by Doctor of Pharmacy (PharmD) programs, incorporation of compounding-focused learning experiences within pipeline programs and co-curricular education may provide students with important exposure, networking opportunities, and skill development. Compounding education can be incorporated into areas outside of the core curriculum, including pipeline programming for pre-pharmacy students and the co-curriculum for current pharmacy students. This article, which is a perspective commentary, will discuss suggestions for designing and implementing these types of learning opportunities, including considerations for faculty and budgets and related benefits for learners. These ideas will be discussed in the context of examples provided by a college of pharmacy who has implemented these learning experiences. To ensure well-trained pharmacists continue to pursue compounding careers, it is vital that pharmacy programs provide ample opportunities for student exposure and training in this area. Pharmacy programs are encouraged to incorporate compounding- focused learning experiences within pipeline programming and the co-curriculum. Future research is needed to investigate the impact of such experiences on students' compounding knowledge and skills and their pursuit of compounding careers.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9564876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sterile Basics: Intravenous Admixture Compounding, Part 2: Parenteral Vehicle Considerations. 无菌基础知识:静脉内混合配制，第2部分:注射用药物注意事项。
International journal of pharmaceutical compounding Pub Date : 2023-05-01
Loyd V Allen
{"title":"Sterile Basics: Intravenous Admixture Compounding, Part 2: Parenteral Vehicle Considerations.","authors":"Loyd V Allen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intravenous admixture compounding is a common practice in most hospitals throughout the world, regardless of the country. The compounding of intravenous medications, however, involves risk, as there is a high potential for error due to their complexity in compounding. Also, working in an aseptic environment itself poses issues for the compounder. This article in an overall series on the topic of intravenous admixture compounding will discuss the vehicles commonly used in intravenous admixtures, as well as the small-volume parenterals often used in compounding intravenous admixtures.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9564881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dimercaptosuccinic Acid: Summary of Evidence. 二巯基琥珀酸:证据综述。
International journal of pharmaceutical compounding Pub Date : 2023-03-01
Jamarius Carvin, Tara Thompson
{"title":"Dimercaptosuccinic Acid: Summary of Evidence.","authors":"Jamarius Carvin,&nbsp;Tara Thompson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dimercaptosuccinic acid, or succimer, is an oral, heavy-metal chelating agent used to treat lead and heavy-metal poisoning. Although the drug is mainly used for the treatment of lead intoxication, initial data has shown encouraging results for the treatment of mercury and arsenic poisoning as well. This article focuses on the use of dimercaptosuccinic acid as a chelating agent and provides some general information on dimercaptosuccinic acid.</p>","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9232910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PreScription: Amoxicillin Shortage Continues: Compounding Pharmacies Filling the Gap! 处方:阿莫西林短缺继续:复合药房填补空白!
International journal of pharmaceutical compounding Pub Date : 2023-03-01
Loyd V Allen
{"title":"PreScription: Amoxicillin Shortage Continues: Compounding Pharmacies Filling the Gap!","authors":"Loyd V Allen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14381,"journal":{"name":"International journal of pharmaceutical compounding","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9809955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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