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A Systems Biology Approach Unveils a Critical Role of DPP4 in Upper Gastrointestinal Cancer Patient Outcomes. 系统生物学方法揭示了 DPP4 在上消化道癌症患者预后中的关键作用。
International Ophthalmology Clinics Pub Date : 2024-01-01 DOI: 10.1615/JEnvironPatholToxicolOncol.2023048056
Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali M Yallapu, Manish K Tripathi, Meena Jaggi, Subhash C Chauhan
{"title":"A Systems Biology Approach Unveils a Critical Role of DPP4 in Upper Gastrointestinal Cancer Patient Outcomes.","authors":"Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali M Yallapu, Manish K Tripathi, Meena Jaggi, Subhash C Chauhan","doi":"10.1615/JEnvironPatholToxicolOncol.2023048056","DOIUrl":"10.1615/JEnvironPatholToxicolOncol.2023048056","url":null,"abstract":"<p><p>Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive. However, the link between DPP4 and tumor-infiltrating cells, as well as its prognostic significance in malignancies, still require further investigation. This study was intended to elucidate the correlation of DPP4 expression and survival along with prognosis, followed by its associated enriched molecular pathways and immune cell marker levels in upper GI cancers. Results demonstrated a strong correlation between increased DPP4 expression and a worse prognosis in esophageal and gastric cancer and the co-expressed common genes with DPP4 were associated with crucial molecular pathways involved in tumorigenesis. Additionally, DPP4 was shown to be significantly linked to several immune infiltrating cell marker genes, including Macrophages (M1, M2 and Tumor Associated Macrophages), neutrophils, Treg, T-cell exhaustion, Th1 and Th2. Overall, our findings suggest that DPP4 may serve as a substantial prognostic biomarker, a possible therapeutic target, as well as it can play a critical role in the regulation of immune cell invasion in patients with gastroesophageal (esophageal, gastroesophageal junction and gastric) cancer. KEY WORDS: DPP4, integrated analysis, GI cancer, gastroesophageal cancer, gastroesophageal junction, prognosis.</p>","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"21 2 1","pages":"43-55"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83540043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydroxychloroquine Screening Guidelines: Best Evidence, Controversies, and Future Areas of Research. 羟氯喹筛查指南：最佳证据、争议和未来研究领域。
International Ophthalmology Clinics Pub Date : 2024-01-01 Epub Date: 2023-12-26 DOI: 10.1097/IIO.0000000000000508
Alexi Geevarghese, Alexis Kaiser, Sheel Patel, Amit Saxena, Michael H Belmont, Yasha S Modi
{"title":"Hydroxychloroquine Screening Guidelines: Best Evidence, Controversies, and Future Areas of Research.","authors":"Alexi Geevarghese, Alexis Kaiser, Sheel Patel, Amit Saxena, Michael H Belmont, Yasha S Modi","doi":"10.1097/IIO.0000000000000508","DOIUrl":"10.1097/IIO.0000000000000508","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"64 1","pages":"195-207"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Teleophthalmology Screening for Diabetic Retinopathy. 远程眼科筛查糖尿病视网膜病变的进展。
International Ophthalmology Clinics Pub Date : 2024-01-01 Epub Date: 2023-12-26 DOI: 10.1097/IIO.0000000000000505
Ailin Song, Durga S Borkar
{"title":"Advances in Teleophthalmology Screening for Diabetic Retinopathy.","authors":"Ailin Song, Durga S Borkar","doi":"10.1097/IIO.0000000000000505","DOIUrl":"10.1097/IIO.0000000000000505","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"64 1","pages":"97-113"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosimilars for Retinal Diseases: A Review of the Literature. 治疗视网膜疾病的生物仿制药：文献综述。
International Ophthalmology Clinics Pub Date : 2024-01-01 Epub Date: 2023-12-26 DOI: 10.1097/IIO.0000000000000509
Rachel N Israilevich, Kannan Sharma, Matthew R Starr
{"title":"Biosimilars for Retinal Diseases: A Review of the Literature.","authors":"Rachel N Israilevich, Kannan Sharma, Matthew R Starr","doi":"10.1097/IIO.0000000000000509","DOIUrl":"10.1097/IIO.0000000000000509","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"64 1","pages":"129-139"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of Gene Therapy Clinical Trials for Retinal Diseases. 视网膜疾病基因疗法临床试验回顾。
International Ophthalmology Clinics Pub Date : 2024-01-01 Epub Date: 2023-12-26 DOI: 10.1097/IIO.0000000000000517
Aamir A Aziz, Hannah Khan, Zoha A Khanani, Mathew J Thomas, Huma Khan, Abrahim Ahmed, Greggory M Gahn, Arshad M Khanani
{"title":"Review of Gene Therapy Clinical Trials for Retinal Diseases.","authors":"Aamir A Aziz, Hannah Khan, Zoha A Khanani, Mathew J Thomas, Huma Khan, Abrahim Ahmed, Greggory M Gahn, Arshad M Khanani","doi":"10.1097/IIO.0000000000000517","DOIUrl":"10.1097/IIO.0000000000000517","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"64 1","pages":"141-151"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glaucoma Drainage Device Implantation, Outcomes, and Complications. 青光眼引流装置的植入、结果和并发症。
International Ophthalmology Clinics Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.1097/IIO.0000000000000499
Julius T Oatts, Ying Han
{"title":"Glaucoma Drainage Device Implantation, Outcomes, and Complications.","authors":"Julius T Oatts, Ying Han","doi":"10.1097/IIO.0000000000000499","DOIUrl":"10.1097/IIO.0000000000000499","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"63 4","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10807850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41127150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized Clinical Trials Comparing Initial Therapies for Glaucoma. 比较青光眼初始治疗的随机临床试验。
International Ophthalmology Clinics Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.1097/IIO.0000000000000485
Eileen C Bowden, Joseph F Panarelli
{"title":"Randomized Clinical Trials Comparing Initial Therapies for Glaucoma.","authors":"Eileen C Bowden, Joseph F Panarelli","doi":"10.1097/IIO.0000000000000485","DOIUrl":"10.1097/IIO.0000000000000485","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"63 4","pages":"3-12"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41128521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Brief Review of Historical and Current Trends in Trabeculectomy. 简论小梁切除术的历史和发展趋势。
International Ophthalmology Clinics Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.1097/IIO.0000000000000484
Anh H Pham, Rebecca Lees, Naomi E Gutkind
{"title":"A Brief Review of Historical and Current Trends in Trabeculectomy.","authors":"Anh H Pham, Rebecca Lees, Naomi E Gutkind","doi":"10.1097/IIO.0000000000000484","DOIUrl":"10.1097/IIO.0000000000000484","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"63 4","pages":"61-92"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41135756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Laser Trabeculoplasty. 选择性激光小梁成形术。
International Ophthalmology Clinics Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.1097/IIO.0000000000000483
Connie Mao Wu, Ta Chen Chang
{"title":"Selective Laser Trabeculoplasty.","authors":"Connie Mao Wu, Ta Chen Chang","doi":"10.1097/IIO.0000000000000483","DOIUrl":"10.1097/IIO.0000000000000483","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"63 4","pages":"23-32"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Treatment of Glaucoma: An Evolving Paradigm. 青光眼的治疗：一个不断发展的范式。
International Ophthalmology Clinics Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.1097/IIO.0000000000000477
Steven J Gedde
{"title":"The Treatment of Glaucoma: An Evolving Paradigm.","authors":"Steven J Gedde","doi":"10.1097/IIO.0000000000000477","DOIUrl":"10.1097/IIO.0000000000000477","url":null,"abstract":"","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"63 4","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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