International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology最新文献

{"title":"Evaluation of 99mTc-mercaptoacetyltripeptides in mice and a baboon","authors":"G. Bormans ,&nbsp;B. Cleynhens ,&nbsp;M. Hoogmartens ,&nbsp;M. De Roo ,&nbsp;A. Verbruggen","doi":"10.1016/0883-2897(92)90123-G","DOIUrl":"10.1016/0883-2897(92)90123-G","url":null,"abstract":"<div><p>Different derivatives of MAG₃ carrying amino acids such as <span>d</span>- or <span>l</span>-alanine, <span>d</span>-serine, <span>d</span>-2-aminobutyric acid, <span>d</span>-valine or <span>d</span>-phenylglycine were synthesized and their ^99mTc-complexes were evaluated in mice and a baboon. The efficiency of renal handling of the examined ^99mTc-complexes is influenced not only by their lipophilicity but also to a great extent by their configuration and the site of substitution. The renal excretion characteristics of ^99mTc-MAGAG-DA are superior to those of ^99mTc-MAG₃ and the studied ^99mTc-complexes in both animal species.</p><p>In an attempt to improve the renal handling of ^99mTc-MAG₃ and to evaluate the effect of derivatization we have synthesized different derivatives of MAG₃ in which one or more glycyl groups are replaced by other amino acids such as <span>d</span>- or <span>l</span>-alanine, <span>D</span>-serine, <span>D</span>-2-aminobutyric acid, <span>D</span>-valine or <span>D</span>-phenylglycine. Due to the presence of a chiral centre in the ligand core, exchange labelling of each of the MAG₃ derivatives results in the formation of two diastereomeric technetium complexes. These isomers were separated by HPLC and evaluated in mice. Biodistribution in mice indicates that the efficiency of renal handling of the examined ^99mTc-complexes is not only influenced by their lipophilicity but also to a great extent by their configuration. The renal excretion characteristics of isomer <span>d</span>A of ^99mTc-MAGAG in mice are superior to those of all other studied ^99mTc-complexes and also of the reference compound [¹³¹I]Hippuran. The isomers <span>l</span>B of several alanyl derivatives of ^99mTc-MAG₃ exhibit a pronounced renal retention in both mice and baboon. The results of the evaluation in a baboon confirm the superiority of ^99mTc-MAGAG-<span>d</span>A over ^99mTc-MAG₃ and the other studied ^99mTc-complexes.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 375-385, 387-388"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90123-G","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12557611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of 6-[18F]fluoro-l-DOPA and its metabolism in vivo—a critical review","authors":"","doi":"10.1016/0883-2897(92)90129-M","DOIUrl":"https://doi.org/10.1016/0883-2897(92)90129-M","url":null,"abstract":"","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Page I"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90129-M","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137302472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo binding and autoradiographic imaging of (+)−3-[125I]Iodo-MK-801 to the NMDA receptor-channel complex in rat brain","authors":"Raymond E. Gibson ,&nbsp;H.Donald Burns ,&nbsp;Holly H. Thorpe ,&nbsp;Wai-Si Eng ,&nbsp;Richard Ransom ,&nbsp;Howard Solomon","doi":"10.1016/0883-2897(92)90117-H","DOIUrl":"10.1016/0883-2897(92)90117-H","url":null,"abstract":"<div><p>Radioiodinated (+)−3-Iodo-MK-801 is a high affinity radioligand for the <em>N</em>-methyl-<span>d</span>-aspartate (NMDA) receptor-channel complex. We have demonstrated <em>in vivo</em> localization in the CNS of rat which is stereoselective and blocked by coinjection of unlabeled MK-801. Autoradiography indicates localization <em>in vivo</em> which is in concordance with <em>in vitro</em> autoradiographic studies. These results indicate that radioiodinated (+)−3-Iodo-MK-801 is a useful probe for <em>in vitro</em> and <em>in vivo</em> autoradiographic studies and suggest that radioligands for the NMDA receptor may be developed which will provide <em>in vivo</em> images of receptor distribution in man.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 319-326"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90117-H","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12551314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate","authors":"Ganesan Vaidyanathan,&nbsp;Michael R. Zalutsky","doi":"10.1016/0883-2897(92)90111-B","DOIUrl":"10.1016/0883-2897(92)90111-B","url":null,"abstract":"<div><p>Two methods were investigated for the no-carrier-added synthesis of <em>N</em>-succinimidyl 4-[¹⁸F]fluorobenzoate (S[¹⁸F]FB). The first, an attempted nucleophilic aromatic substitution by [¹⁸F]fluoride on <em>N</em>-succinimidyl 4-nitrobenzoate was unsuccessful. The second method involved three steps; [¹⁸F]fluoride for trimethylammonium substitution on 4-formyl-<em>N,N,N</em>-trimethylanilinium triflate, oxidation to 4-[¹⁸F]fluorobenzoic acid, followed by reaction with <em>N</em>-hydroxysuccinimide and dicyclohexylcarbodiimide to form S[¹⁸F]FB. Total synthesis and purification time was 100 min and the overall radiochemical yield was 25% (decay corrected). A monoclonal antibody F(ab′)₂ fragment could be labeled in 40–60% yield by reaction with S[¹⁸F]FB for 15–20 min. The tissue distribution in normal mice and <em>in vitro</em> tumor binding of the antibody F(ab′)₂ labeled by reaction with S[¹⁸F]FB were comparable to those observed for the fragment after radioiodination using <em>N</em>-succinimidyl 4-[¹²⁵I]iodobenzoate.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 275-281"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90111-B","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12795586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung scintigraphy with [123I]IMP in patients with pulmonary tuberculosis","authors":"S. Nagamachi ,&nbsp;K. Inoue ,&nbsp;H. Hoshi ,&nbsp;S. Jinnouchi ,&nbsp;T. Ohonishi ,&nbsp;S. Futami ,&nbsp;K. Watanabe ,&nbsp;M. Wakisaka ,&nbsp;Y. Morotomi","doi":"10.1016/0883-2897(92)90125-I","DOIUrl":"10.1016/0883-2897(92)90125-I","url":null,"abstract":"<div><p>Lung scintigraphy using <em>N</em>-isopropyl-<em>p</em>-[¹²³I]iodoamphetamine (IMP) was performed on 26 patients with pulmonary tuberculosis. Early (5 min after injection) and late images (4 h after injection) were obtained with a large-field γ-camera equipped with a digital computer. Lung scintigraphy using [^99mTc]MAA (MAA) was also done. Although early IMP images showed the same findings as [^99mTc]MAA images, a discrepancy between delayed IMP images and [^99mTc]MAA images was seen in some patients. Increment of activities seen in late images was demonstrated in most patients whose chest x-ray findings included exudative inflammatory changes. Uptake and clearance of IMP was considered to be affected by the active phase of pulmonary tuberculosis.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 399-404"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90125-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12794843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Labelling of leukocytes with 99mTc-HMPAO for scintigraphy of inflammatory lesions and abscesses","authors":"Nada Vanlić-Razumenić ,&nbsp;Natalija Pujić ,&nbsp;Nasta Dedović ,&nbsp;Kosta Kostić ,&nbsp;Danica Nastić-Mirić","doi":"10.1016/0883-2897(92)90107-A","DOIUrl":"10.1016/0883-2897(92)90107-A","url":null,"abstract":"<div><p>A simplified and efficient procedure for ^99mTc-HMPAO-labelling of leukocytes is described. For this purpose, the pH and concentration of the ^99mTc-HMPAO preparation was modified. Leukocytes were isolated from a 20 mL mixture of patient blood, 5 mL ACD and 0.8 mL methylcellulose after 1 h sedimentation of erythrocytes and centrifugation (at 400 <em>g</em>) of the obtained plasma layer. Simultaneously, ^99mTc-HMPAO was prepared (one single-dose kit for two patients) by adding 2.2 mL ^99mTc-generator eluate and, after 10 min, 0.3 mL of phosphate buffer to lower the pH to 7. The isolated WBCs were then labelled by the addition of 1-1.2 mL of ^99mTc-HMPAO solution and incubated for 20 min. The unbound tracer was then discarded, the labelled WBC washed and finally resuspended in autologous cell-free plasma. Leukocytes labelled by this procedure were used for scintigraphic localization of inflammatory lesions and abscesses in the gastro-intestinal tract.</p><p>The labelling efficiency was 60 ± 9%, with a separation yield of 55 ± 11%.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 251-253, 255-256"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90107-A","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12794972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen receptor imaging with 17α-[123I]iodovinyl-11β-methoxyestradiol (MIVE2)—part II. Preliminary results in patients with breast carcinoma","authors":"M.J. Ribeiro-Barras ,&nbsp;C. Foulon ,&nbsp;J.L. Baulieu ,&nbsp;D. Guilloteau ,&nbsp;P. Bougnoux ,&nbsp;J. Lansac ,&nbsp;J.C. Besnard","doi":"10.1016/0883-2897(92)90109-C","DOIUrl":"10.1016/0883-2897(92)90109-C","url":null,"abstract":"<div><p>17α-[¹²³I]Iodovinyl-11β-methoxyestradiol was injected into 19 women: group 1 (<em>n</em> = 8), initial evaluation of breast cancer; group 2, (<em>n</em> = 11) postoperative follow-up including 9 patients with bone metastases. The primary tumor (size: 8–10 mm) was visualized by breast tomoscintigraphy in <span><math><mtext>2</mtext><mtext>4</mtext></math></span> patients of group 1 with high estrogen receptor concentration (162–445 fmol/mg) and was not detectable in 4 patients with low estrogen receptor concentration (6–32 fmol/mg). Axillary lymph node metastases were detected in 1 patient of group 1 and in 1 patient of group 2. In 4 patients of group 2 with previous primary tumor containing estrogen receptors, MIVE₂ uptake in bone metastases was demonstrated. MIVE₂ scintigraphy is an original, specific and non-invasive method for breast cancer estrogen receptor imaging in primary and in metastatic tumors.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 263-265, 267"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90109-C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12795584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technetium-99m p-iodophenethyldiaminodithiol (DADT-IPE): Potential brain perfusion imaging agent for SPECT","authors":"K. Shiba ,&nbsp;H. Mori ,&nbsp;H. Matsuda ,&nbsp;K. Hisada","doi":"10.1016/0883-2897(92)90115-F","DOIUrl":"10.1016/0883-2897(92)90115-F","url":null,"abstract":"<div><p>A new ligand, an <em>N</em>-<em>p</em>-iodophenethyl diaminodithiol (DADT-IPE), an anlog of <em>N</em>-isopropyl-<em>p</em>-iodoamphetamine (IMP), was synthesized and subsequently complexed with ^99mTc, using stannous chloride as a reducing agent. Two complexes (a and b) were separated from ^99mTc-DADT-IPE by high performance liquid chromatography (HPLC). Competitive inhibition studies showed that the IC₅₀ value of DADT-IPE (70 μM) was similar to that of IMP (49 μM). Biodistribution studies of one of the complexes [^99mTc-DADT-IPE(a)] in rats showed that 0.65% of the injected dose of the tracer remained in the brain at 5 min after intravenous injection, with 0.53% of the dose remaining in the brain at 60 min post-injection, whereas the corresponding values for the other complex [^99mTc-DADT-IPE(b)] were 0.34% dose in the brain at 5 min and 0.28% dose in the brain at 60 min post-injection. The half-life for clearance of ^99mTc-DADT-IPE(a) from rat brain was found to be more than 5 h. These results suggested that ^99mTc-DADT-IPE(a) has characteristics which are suitable for cerebral perfusion imaging.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 303-307, 309-310"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90115-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12795590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of iodohexadecenoic acid as a tracer of fatty acid metabolism by external detection: a study on isolated rat heart","authors":"C.M. Keriel ,&nbsp;F.M. Dubois ,&nbsp;D.S.Marti Batlle ,&nbsp;C.R. Pernin ,&nbsp;X.M. Leverve ,&nbsp;J.P. Mathieu ,&nbsp;M. Comet ,&nbsp;P.J. Cuchet","doi":"10.1016/0883-2897(92)90120-N","DOIUrl":"10.1016/0883-2897(92)90120-N","url":null,"abstract":"<div><p>Labelled fatty acids have been proposed to explore cardiac metabolism. For the analysis of the external detection curve obtained with 16-iodo 9-hexadecenoic acid (IHA), we developed a mathematical 4-compartment model with compartments 0, 1, 2 and 3 representing vascular IHA, intracellular IHA, esterified forms and iodide, respectively. This model, used here for isolated rat hearts perfused in a recirculating system, is validated by an intracellular analysis, then tested in various metabolic conditions. Thus, the mathematical analysis of the external detection curve gives us numerical data on IHA metabolism, especially the distribution between degradation and storage. Our results confirm the suitability of IHA for assessing myocardial metabolism.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 349-355"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90120-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12794839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of osmium(II)-nitrosyl complexes as a method to increase the yield of the 191Os-191mIr generator","authors":"Alan B. Packard,&nbsp;Carol Lambert","doi":"10.1016/0883-2897(92)90121-E","DOIUrl":"10.1016/0883-2897(92)90121-E","url":null,"abstract":"<div><p>The nitrosyl complexes pentachloronitrosylosmate(II), [OsCl₅(NO)]²⁻, and hydroxytetranitronitrosylosmate(II), [Os(OH)(NO₂)₄(NO)]²⁻, were evaluated as parent species for use on the ¹⁹¹Os-^191mIr generator in an attempt to increase the ^191mIr yield of the generator by providing a direct route to a chemically stable ^191mIr daughter. The uptake of the ¹⁹¹Os-labeled complexes by the inorganic ion-exchangers ZrO₂, SnO₂, PbS, MnO₂ and Al₂O₃ and the organic resin AG MP-1 was measured and prototype generators were prepared using those exchangers that demonstrated greater than 90% uptake of the ¹⁹¹Os-labeled complexes. The ^191mIr(III)-nitrosyl complexes produced subsequent to β⁻ decay of the ¹⁹¹Os-nitrosyl parent complexes were found to undergo secondary chemical reactions to form nitro (NO⁻₂) complexes that were tightly retained on the ion exchanger limiting ^191mIr yield to less than 5%.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 3","pages":"Pages 357-362"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90121-E","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12794840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}