Assessment of iodohexadecenoic acid as a tracer of fatty acid metabolism by external detection: a study on isolated rat heart

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology Pub Date : 1992-04-01 DOI:10.1016/0883-2897(92)90120-N

C.M. Keriel , F.M. Dubois , D.S.Marti Batlle , C.R. Pernin , X.M. Leverve , J.P. Mathieu , M. Comet , P.J. Cuchet

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Abstract

Labelled fatty acids have been proposed to explore cardiac metabolism. For the analysis of the external detection curve obtained with 16-iodo 9-hexadecenoic acid (IHA), we developed a mathematical 4-compartment model with compartments 0, 1, 2 and 3 representing vascular IHA, intracellular IHA, esterified forms and iodide, respectively. This model, used here for isolated rat hearts perfused in a recirculating system, is validated by an intracellular analysis, then tested in various metabolic conditions. Thus, the mathematical analysis of the external detection curve gives us numerical data on IHA metabolism, especially the distribution between degradation and storage. Our results confirm the suitability of IHA for assessing myocardial metabolism.

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体外检测评价碘十六烯酸作为脂肪酸代谢示踪剂的作用:离体大鼠心脏的研究

标记脂肪酸已被提出用于探索心脏代谢。为了分析16-碘9-十六烯酸(IHA)获得的外部检测曲线，我们建立了一个数学4室模型，其中室0、1、2和3分别代表血管IHA、细胞内IHA、酯化形式和碘化物。该模型用于在循环系统中灌注的离体大鼠心脏，通过细胞内分析验证，然后在各种代谢条件下进行测试。因此，外部检测曲线的数学分析为我们提供了IHA代谢的数值数据，特别是降解和储存之间的分布。我们的结果证实了IHA评估心肌代谢的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

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