International Journal of Pharmaceutical Chemistry最新文献_第2页

Repurposed application of doxycycline in COVID 19 treatment 强力霉素在新冠肺炎治疗中的重新应用

International Journal of Pharmaceutical Chemistry Pub Date : 2021-01-15 DOI: 10.18231/J.IJPCA.2020.024

D. Dash, N. Chaubey, A. Sahu, Vaibhav Tripathi, L. Pal

引用次数: 0

International Journal of Pharmaceutical Chemistry Pub Date : 2021-01-15 DOI: 10.18231/J.IJPCA.2020.030

S. Chaudhry

引用次数: 0

Synthesis and evaluation for anticonvulsant activity of some N-(5-(substituted)-1,3,4-thiadiazol-2-yl)-2-((5-(substituted)-4H-1,2,4-triazol-3-yl)-amino) acetamide derivatives 若干N-(5-(取代)-1,3,4-噻二唑-2-基)-2-((5-(取代)- 4h -1,2,4-三唑-3-基)氨基)乙酰胺衍生物的合成及抗惊厥活性评价

International Journal of Pharmaceutical Chemistry Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0011

D. Rishipathak, Luketa Alai, P. Udavant

引用次数: 0

Animal models of chronic kidney disease: Screening tool to investigate nephroprotective effects of natural products 慢性肾脏疾病动物模型:研究天然产物肾保护作用的筛选工具

International Journal of Pharmaceutical Chemistry Pub Date : 2020-12-15 DOI: 10.18231/2394-2797.2018.0009

Sachinthi S. Amarasiri, A. Attanayake, K. Jayatilaka, L. Mudduwa

{"title":"Animal models of chronic kidney disease: Screening tool to investigate nephroprotective effects of natural products","authors":"Sachinthi S. Amarasiri, A. Attanayake, K. Jayatilaka, L. Mudduwa","doi":"10.18231/2394-2797.2018.0009","DOIUrl":"https://doi.org/10.18231/2394-2797.2018.0009","url":null,"abstract":"Animals are used as experimental models to reproduce human diseases. To date, various animal models have been successfully developed by numerous methods to simulate human diseases including chronic kidney disease (CKD). Such models have played a central role in developing dialysis, transplantation experiments and more importantly in the discovery of new therapeutic agents from natural product for the care of patients with kidney disease. This review focuses on key information on in vivo models of CKD that have been developed through spontaneous, acquired and genetic approaches. Most of the experiments related to CKD have been carried out on rodent models such as mice and rats. Spontaneous disease models of CKD are generated by various metabolic and immunological methods. Nephrotoxic agents including adenine, adriamycin, cisplatin, folic acid, aristolochic acid and oxalate are used to induce CKD in addition to nephrectomy and unilateral ureteral obstruction models. Further, animal models developed through forward and reverse genetic approaches provide artificial models of CKD. Developing animal models to approximate human CKD is a challenging task since it requires reflecting the effect of age, sex, and comorbidities in addition to the disease condition. But, their usage to tease out the processes which can cause pathologic changes in a biological system is still important for the health care improvements related to CKD. However, no animal model can exactly simulate response in human CKD.\u0000\u0000Keywords: Acquired methods, Animal models, Chronic kidney disease, Genetic approaches, Nephrotoxic agents, Spontaneous models","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"25 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84764783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In silico screening of active constituent of Couroupita guianensis against Mycobacterium 桂皮草抗分枝杆菌活性成分的计算机筛选

International Journal of Pharmaceutical Chemistry Pub Date : 2020-10-28 DOI: 10.18231/j.ijpca.2020.020

Gopinathan Narasimhan

{"title":"In silico screening of active constituent of Couroupita guianensis against Mycobacterium","authors":"Gopinathan Narasimhan","doi":"10.18231/j.ijpca.2020.020","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.020","url":null,"abstract":"Background: A vital need to ascertain novel anti-tubercular agent which is the volatile global spreading of multidrug resistant Mycobacterium tuberculosis. Enoyl-acyl carrier protein reductase is one among such target. It is one of the key enzymes involved in the type II fatty acid biosynthesis pathway of M. tuberculosis. Objective: In this study, in silico evaluations were employed in screening of active constituent of Couroupita guianensis against Enoyl-acyl carrier protein reductase of Mycobacterium tuberculi. Materials and Methods: Totally 16 compounds namely Isatin, Indigo, Coup 2, Indirubin, Calotronaphthalene, Coup, Alpha Amyrin, Nerol, Betasitosterol, Campesterol, Eugenol, Tryptanthrin, Benzyl Alcohol, Betaamyrin and Farnesol were subjected to in silico screening. Glide software of Schrodinger was used to carry out the current work. Results: The compounds exhibit good docking score and few with hydrogen bond interaction. Isoniazid was used as the standard and validation was performed. The results have shown that derivatives were proved to be highly potent inhibitors against Mycobacterium tuberculosis enoyl acyl carrier protein reductase. Conclusion: Most of the compounds exhibit hydrophobic interaction. Then isatin and eugenol can be tested against Mycobacterium tuberculi. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"32 1","pages":"125-134"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79725777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative determination of Trazodoe hydrochloride in bulk and pharmaceutical dosage form by Zero order and AUC by UV-spectrophotometry 紫外分光光度法测定原料药和剂型盐酸曲唑多的零阶和AUC

International Journal of Pharmaceutical Chemistry Pub Date : 2020-10-28 DOI: 10.18231/j.ijpca.2020.022

P. Jain, Santosh B. Bodkhe

引用次数: 0

Cleaning validation in analytical development: Current challenges and future prospectives 分析开发中的清洁验证:当前的挑战和未来的展望

International Journal of Pharmaceutical Chemistry Pub Date : 2020-10-28 DOI: 10.18231/j.ijpca.2020.018

B. R. Jena, Pharmaceutical Analysis, S. Swain, D. Pradhan, D. Ghose

{"title":"Cleaning validation in analytical development: Current challenges and future prospectives","authors":"B. R. Jena, Pharmaceutical Analysis, S. Swain, D. Pradhan, D. Ghose","doi":"10.18231/j.ijpca.2020.018","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.018","url":null,"abstract":"Cleaning validation is a prominent and ideal practice which is employed in industrial aspects to provide utmost shielding to develop drug products, so that a cleaning practice removes the particulate matters, chemicals, as well as the contaminant pathogens reside in active ingredients of drug product in a piece of apparatus, which are produced or being manufactured. The cleaning validation is established as the pre-eminent process that ensures the efficiency, safety, consistency of pharmaceutical equipment and manufactured product of assured quality. The utmost cleaning practice during manufacturing of drug substances affords the appropriate operator safety measures, organized calibration, description and routine monitoring of equipments, Sampling procedures, acceptance criteria’s and detection limits of analytical methods. This also lead to systematic data analysis for estimating of probable contagions in product batches builds up. Abortive cleaning may lead to adulterated product that may be originated from preceding batches, clean-up agents or other superfluous materials produced during methodology. Hence to avoid the harmful contamination, sources, safety measures clean-in-practice is highly recommended as per regulatory and stability point of view. The present review intensifies the current challenges, basic mechanisms and future implication of cleaning validation in various analytical development firms and research organizations. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"1 1","pages":"113-118"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74954303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Method development and validation of RP-HPLC for simultaneous estimation of cilnidipine and valsartan in synthetic mixture 反相高效液相色谱法测定制剂中西尼地平和缬沙坦的含量

International Journal of Pharmaceutical Chemistry Pub Date : 2020-10-28 DOI: 10.18231/j.ijpca.2020.019

Farhana V. Buchiya, H. Raj, V. Jain, Mihirkumar G. Patel, Kaushik P. Patel

{"title":"Method development and validation of RP-HPLC for simultaneous estimation of cilnidipine and valsartan in synthetic mixture","authors":"Farhana V. Buchiya, H. Raj, V. Jain, Mihirkumar G. Patel, Kaushik P. Patel","doi":"10.18231/j.ijpca.2020.019","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.019","url":null,"abstract":"Reverse phase-high performance liquid chromatography (RP-HPLC) method have been developed and validated for the estimation of Cilnidipine and Valsartan in bulk drug and synthetic mixture. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using Luna C18 100A◦ (250 mm×4.6 mm i.d.) 5 μm reverse phase column (phenomenex, luna®) in gradient mode, with mobile phase containing Acetonitrile: Water (85:15, v/v). The flow rate is 1.0 ml/min and effluents are monitored at 240 nm. Chromatogram showed peak at a retention time of 2.083 min for Cilnidipine and 5.458 min for Valsartan. The method is validated for system suitability, linearity, precision, accuracy specificity, ruggedness, robustness, LOD and LOQ. Recovery of Cilnidipine and Valsartan is found to be 100.36% and 100.14% respectively. The LOD and LOQ for estimation of Cilnidipine and Valsartan are found to be 0.037μg/ml, 0.31μg/ml and 0.206μg/ml, 0.62μg/ml respectively. Proposed method can be successfully applied for the quantitative determination of Cilnidipine and Valsartan in bulk drug and in synthetic mixture. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"1 1","pages":"119-124"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73359123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Exploring antibacterial & antiulcer activity of aegle marmelos linn. : A review 凝胶柑桔的抑菌抗溃疡活性研究。:回顾

International Journal of Pharmaceutical Chemistry Pub Date : 2020-10-28 DOI: 10.18231/j.ijpca.2020.017

T. Mahato, Pharmaceutical Analysis

{"title":"Exploring antibacterial & antiulcer activity of aegle marmelos linn. : A review","authors":"T. Mahato, Pharmaceutical Analysis","doi":"10.18231/j.ijpca.2020.017","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.017","url":null,"abstract":"Antimicrobial drugs are those drugs which are used to treat diseases caused by microorganisms. To treat the diseases caused by pathogenic microorganisms antibiotic, antiviral, antifungal and antiparasitic medicines are used. These microbes produces diseases in humans, animals and plants. According to World Health Organization (WHO). The cases of Antimicrobial resistance (AMR) is increasing day by day and it threatens the effective treatment and prevention of infections caused by bacteria, viruses, fungi and parasites. AMR occurs when these microbes gets resistance against the effects of medications, which makes common infections difficult to treat and hence increases the risk of severe illness, disease spread and death. As a result, the medicines becomes ineffective, infections remains in the body and increases the probability of spread to others. WHO recommends that decreased use of synthetic antibiotics and increased use of herbal antimicrobial drugs are the only ways by which the AMR can be controlled or eliminated. Herbal drugs are considered to be effective and free from side effects. In the present article we discussed about Aegle Marmelos Linn. (Bael) which is useful in treating many health ailments. It possess many pharmacological activities like anticonvulsant, antioxidant, antihyperglycemic, anxiolytic, antidepressant, antihistaminic, antimicrobial, hepatoprotective, analgesic, immune modulatory, cardio protective and antithyroid activity. Due to its antibacterial activity it is used to treat many infections caused by bacteria and also have antiulcer activity due to which it is used to treat ulcer patients. The bacteria, Helicobacter pylori is one of the cause of peptic ulcer. This review article discusses about the effect of Aegle Marmelos on this bacteria. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"30 1","pages":"107-112"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82955341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cultivation technology and antibacterial activity of Agaricus bisporus (U-03) 双孢蘑菇(U-03)的培养技术及抑菌活性

International Journal of Pharmaceutical Chemistry Pub Date : 2020-10-28 DOI: 10.18231/j.ijpca.2020.021

M. Shahnaz, Shivani Sharma, D. Dev, D. Prasad

{"title":"Cultivation technology and antibacterial activity of Agaricus bisporus (U-03)","authors":"M. Shahnaz, Shivani Sharma, D. Dev, D. Prasad","doi":"10.18231/j.ijpca.2020.021","DOIUrl":"https://doi.org/10.18231/j.ijpca.2020.021","url":null,"abstract":"Agaricus bisporus, being one of the most commonly white button mushrooms contributes about 4045% to the world mushroom production. Presence of viable cells were measured in terms of viable count or CFU, which exhibit progressive declination in count of thermophilic fungi from initial stage of composting. Similarly, declination of pH ranges from 8.3-7.1 alkaline pH in initial stage was due to microbial decomposition of organic acids and subsequent release of ammonia through mineralization of organic nitrogen sources, declination of weight from 1.465 Kg. to 0.491 Kg and temperature from 44-34◦C was due to extensive utilization of compost as nutrient by inhabiting thermophilic fungi. Result obtained exhibit highest cellulose content in raw material of which horse manure exhibit higher cellulose content then wheat straw, horse manure 2.052mg and wheat straw 1.044mg. Highest cellulolytic activity was observed in horse manure followed by wheat straw in basal material. Horse manure 2.167micromoleglucose released/ml/hr and wheat straw 1.014micromoleglucose released/ml/hr. Highest antimicrobial activity was observed in methanol extract (14mm) against B. cereusas compared to ethanol extract (7mm). Same results obtained for S.aureus(20mm) and B. cereus (14mm) in methanol extract. Least microbial growth inhibition was observed in S. aureus (25mm) followed by B. cereus (7mm) with respect to control in ethanol extract. No antimicrobial activity observed in P. aeruginosa in ethanol but least inhibition was observed in methanol extract. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"81 1","pages":"135-140"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77847332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2