International Journal of Rehabilitation Research最新文献_第8页

Psychometric properties of the Obstacles and Curb tests and their discriminative ability across functional levels in ambulatory children with spastic cerebral palsy. 痉挛性脑瘫患儿障碍和抑制测试的心理测量特征及其跨功能水平的判别能力。

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000575

Maha F Algabbani, Banan A Almass, Afaf A M Shaheen, Adel Alhusaini, Muneera M Almurdi, Samiah Alqabbani

{"title":"Psychometric properties of the Obstacles and Curb tests and their discriminative ability across functional levels in ambulatory children with spastic cerebral palsy.","authors":"Maha F Algabbani, Banan A Almass, Afaf A M Shaheen, Adel Alhusaini, Muneera M Almurdi, Samiah Alqabbani","doi":"10.1097/MRR.0000000000000575","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000575","url":null,"abstract":"The Obstacles and Curb tests are timed walking assessments that have emerged from the Spinal Cord Injury Functional Ambulation Profile and have been modified for children; however, their psychometric properties have not been adequately investigated. The aim of this research was to examine the psychometric properties of the Obstacles and Curb tests for children with cerebral palsy (CP). This cross-sectional study included 68 children aged 6-12 years; there were 34 children with CP and 34 age- and sex-matched typically developing children. Validity was examined by correlation with the 10-m Walk Test (10-MWT), Modified Time Up and Go test (mTUG), and Pediatric Balance Scale (PBS). Differences in the Obstacle and Curb test scores were calculated between children with CP and typically developing children and within different Gross Motor Function Classification System (GMFCS) levels. Children with CP completed the tests twice within a 30-min interval in the same session. The tests showed significant strong to very strong correlations with the 10-MWT, mTUG, and PBS. The within-session reliability was excellent, typically developing children were significantly faster than children with CP with high sensitivity and specificity, and the time differed significantly within the GMFCS level. Thus, the Obstacles and Curb tests can be considered valid, reliable, and sensitive walking tests for ambulatory children with CP.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"178-186"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/76/ijrr-46-178.PMC10155681.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is mirror therapy associated with progressive muscle relaxation more effective than mirror therapy alone in reducing phantom limb pain in patients with lower limb amputation? 在减轻下肢截肢患者幻肢痛方面，镜像疗法联合进行性肌肉放松是否比单独镜像疗法更有效?

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000582

Stefano Brunelli, Lucia D'Auria, Andrea Stefani, Filippo Giglioni, Giorgio Mariani, Marcello Ciccarello, Maria Grazia Benedetti

{"title":"Is mirror therapy associated with progressive muscle relaxation more effective than mirror therapy alone in reducing phantom limb pain in patients with lower limb amputation?","authors":"Stefano Brunelli, Lucia D'Auria, Andrea Stefani, Filippo Giglioni, Giorgio Mariani, Marcello Ciccarello, Maria Grazia Benedetti","doi":"10.1097/MRR.0000000000000582","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000582","url":null,"abstract":"Mirror therapy is a widely used treatment for phantom limb pain (PLP) relief in patients with limb loss. Less common is progressive muscle relaxation (PMR), used mostly in other medical conditions (psychological, terminal cancer pain, etc). The purpose of this study is to evaluate the efficacy of a mirror therapy preceded by PMR intervention compared to mirror therapy preceded by unguided generic relaxation-mirror therapy in patients with lower limb amputation suffering from PLP. This pilot study was a single-blind, controlled, randomized trial. Thirty lower limb amputees suffering from PLP were recruited and randomly assigned to three groups respectively undergoing a PMR-mirror therapy rehabilitative intervention, generic relaxation-mirror therapy, and conventional physiotherapy (ConvPT). Selected items from Prosthesis Evaluation Questionnaire (PEQ) and the Brief Pain Inventory (BPI) were used to test the pain features at the beginning and 1 week after 3 weeks of intervention. A decrease of about 65% was found in the rate and duration of PLP at the PEQ in PMR-mirror therapy with respect to generic relaxation-mirror therapy (about 30%) and ConvPT (about 6%). A decrease of about 90% in intensity (worst and average) of PLP in PMR-mirror therapy when compared to generic relaxation-mirror therapy (about 45%) and ConvPT (about 20%) was found at the BPI. We preliminary concluded, albeit with limitations due to the small sample of patients, that mirror therapy can improve PLP when associated with PMR. Further studies are required to confirm that PMR could be an effective technique for more successful PLP management.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"193-198"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Methods to assess the effectiveness and acceptance of information and communication technology-based assistive technology for older adults: a scoping review. 评估老年人基于信息和通信技术的辅助技术的有效性和接受度的方法:范围审查。

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000571

Gabriella Tónay, Tamás Pilissy, András Tóth, Gábor Fazekas

{"title":"Methods to assess the effectiveness and acceptance of information and communication technology-based assistive technology for older adults: a scoping review.","authors":"Gabriella Tónay, Tamás Pilissy, András Tóth, Gábor Fazekas","doi":"10.1097/MRR.0000000000000571","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000571","url":null,"abstract":"An aging society is a growing challenge for families, social and rehabilitation service providers, and economies. Information and communication technology-based assistive technology can bolster the independence of older adults (65 years and above) and reduce their burden on caregivers. Currently, there is no unified methodology to assess the effectiveness and acceptance of these technologies. The present study undertakes a scoping review to (1) identify and characterize the methods for assessing the acceptability and usability of information and communication technology-based assistive technologies, (2) explore the advantages and disadvantages of the assessment methods, (3) determine the possibilities of combining the assessment methods and (4) define the most commonly used assessment method and set of outcome measures. The literature was searched in MEDLINE, Scopus, IEEE Cochrane and Web of Science bibliographic databases using the keywords defined by reviewers for articles in English published between 2011 and 2021. Of the 1696 matches, 31 met the inclusion criteria. It was found that a combination of different assessment methods was common in outcome measurements. Of the 31 studies, assessment methods were combined in 21 studies and multiple questionnaires were used in 11 studies. The most common technique of outcome measurement was the use of questionnaires (81%), conducting interviews (48%) and recording usability-performance measures (39%). The advantages and disadvantages of the assessment methods could not be determined in the selected studies in this scoping review.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"113-125"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10281610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term and long-term predictors of balance function in stroke patients: a 6-month follow-up study. 脑卒中患者平衡功能的短期和长期预测因素:一项6个月的随访研究

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000573

Eun Young Lee, Yoonhye Na, Minjae Cho, Yu Mi Hwang, Hyun-Soo Kim, Hyonggin An, Sung-Bom Pyun

{"title":"Short-term and long-term predictors of balance function in stroke patients: a 6-month follow-up study.","authors":"Eun Young Lee, Yoonhye Na, Minjae Cho, Yu Mi Hwang, Hyun-Soo Kim, Hyonggin An, Sung-Bom Pyun","doi":"10.1097/MRR.0000000000000573","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000573","url":null,"abstract":"We aimed to determine early predictors of balance function (Berg Balance Scale, BBS) at 3 and 6 months after stroke using clinical, neurophysiological, and neuroimaging variables. Seventy-nine patients with hemiparesis after a stroke were included. Demographics, stroke characteristics, and clinical variables [Mini-Mental State Examination, BBS, strength in the hemiparetic hip, knee, and ankle muscles, and Fugl-Meyer Assessment Lower Extremity (FMA-LE)] were evaluated 2 weeks post-stroke, on average. Somatosensory-evoked potentials (SEP) from both tibial nerves and diffusion tensor imaging data were collected respectively within 3 weeks and 4 weeks post-onset to calculate the SEP amplitude ratio and the laterality index of fractional anisotropy of the corticospinal tract. In multiple linear regression analysis, younger age, higher FMA-LE score, and stronger hemiparetic hip extensors were independent predictors of higher BBS at 3 months post-stroke (adjusted R2 = 0.563, P < 0.001). At 6 months post-stroke, significant predictors of higher BBS were younger age, higher FMA-LE, stronger hemiparetic hip extensors, and larger SEP amplitude ratio (adjusted R2 = 0.552, P < 0.001), although the incremental contribution of the latter was rather small ( R2 = 0.019). We conclude that age and the initial motor impairment of the affected lower limb can inform the state of balance function at 3 and 6 months after stroke.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"163-169"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of preoperative muscle strength on postoperative walking ability in patients undergoing total knee arthroplasty. 全膝关节置换术患者术前肌力对术后行走能力的影响。

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000572

Yusuke Terao, Naoki Hosaka, Yuhei Otobe, Mizue Suzuki, Iwao Kojima, Kazuya Yoshizawa, Minoru Yamada, Yasuhide Nakayama, Masahiro Abo

{"title":"The impact of preoperative muscle strength on postoperative walking ability in patients undergoing total knee arthroplasty.","authors":"Yusuke Terao, Naoki Hosaka, Yuhei Otobe, Mizue Suzuki, Iwao Kojima, Kazuya Yoshizawa, Minoru Yamada, Yasuhide Nakayama, Masahiro Abo","doi":"10.1097/MRR.0000000000000572","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000572","url":null,"abstract":"Although knee extensor muscle strength is strongly associated with postoperative walking ability (PWA) in patients undergoing total knee arthroplasty (TKA), few studies have considered the impact of both knee extensor and flexor muscle strength. This study aimed to determine whether operative side knee flexor and extensor muscle strength before surgery affects the PWA of patients who undergo TKA while accounting for potential covariates. This multicenter retrospective cohort study involved four university hospitals, and patients who underwent unilateral primary TKA were included. The outcome measure was the 5-m maximum walking speed test (MWS), which was completed 12 weeks postoperatively. Muscle strength was measured as the maximum isometric muscle strength required for knee flexor and extensor. Three multiple regression models with a progressively larger number of variables were developed to determine the predictors of 5-m MWS at 12 weeks post-TKA surgery. One hundred thirty-one patients who underwent TKA were enrolled in the study (men, 23.7%; mean age, 73.4 ± 6.9 years). Age, sex, operative side knee flexor muscle strength before surgery, Japanese Orthopaedic Association knee score, and preoperative walking ability were significantly associated with PWA in the final model of the multiple regression analysis ( R2 = 0.35). The current findings suggest that the operative side knee flexor muscle strength before surgery is a robust modifiable predictor of improved PWA. We believe that further validation is needed to determine the causal relationship between preoperative muscle strength and PWA.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"157-162"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized clinical trials of physical therapy for cerebral palsy: a review of study outcomes, methodological quality, and publication merits. 脑瘫物理治疗的随机临床试验:研究结果、方法学质量和发表价值的综述。

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000576

André L F Meireles, Natália A Menegol, Giovana A Perin, Luciana S Sanada

{"title":"Randomized clinical trials of physical therapy for cerebral palsy: a review of study outcomes, methodological quality, and publication merits.","authors":"André L F Meireles, Natália A Menegol, Giovana A Perin, Luciana S Sanada","doi":"10.1097/MRR.0000000000000576","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000576","url":null,"abstract":"The study aimed to examine the main characteristics of clinical trials of motor interventions in physical therapy in children with cerebral palsy (CP). The Physiotherapy Evidence Database (PEDro) was used to collect information on clinical trials regarding motor outcomes in physical therapy in children with CP. Two reviewers independently screened, selected the studies, and extracted data. The characteristics extracted were CP subtype; age group; gross motor function and manual motor ability; methodological quality; open access status; 2020 journal impact factor, Consolidated Standards of Reporting Trials (CONSORT) endorsement; primary outcome; intervention adopted, and assessment instruments. The search strategy resulted in 313 articles from 120 different journals. Most of the clinical trials included participants with spastic bilateral subtype, aged between 6 and 12 years old, and with fewer limitations in gross and manual motor abilities. The most used primary outcomes covering the International Classification of Functioning, Disability and Health (ICF) domain of activity were gross motor function (18.8%) and upper limb and hand function (16.3%), with the Gross Motor Function Measurement being the most frequently used instrument (19.8%). Articles with better scores on the PEDro scale were published in journals with a higher impact factor, and higher rates of CONSORT endorsement, and most were not open access. Clinical trials investigating motor interventions used in physical therapy for children with CP tend to focus on patients with milder gross and manual motor function impairments and often explore the body function domain of the ICF. Furthermore, these studies have moderate methodological quality, and a substantial proportion of them fail to follow adequate reporting and methodological recommendations.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"126-132"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simple smartphone-aided program to support meaningful occupation in people with severe neuro-motor and speech disabilities. 一个简单的智能手机辅助程序，支持有严重神经运动和语言障碍的人有意义的职业。

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000583

Fiora D'Amico, Giulio E Lancioni, Flavio De Marinis, Fabiana Abbinante, Paolo Taurisano, Chiara Abbatantuono, Gloria Alberti

引用次数: 0

Stroke impairment, balance, and cognitive status on admission predict walking independence up to 90 days post-stroke but their contributions change over time. 卒中损伤、平衡和入院时的认知状态可预测卒中后90天内的行走独立性，但其作用随时间而变化。

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-03-01 DOI: 10.1097/MRR.0000000000000561

Kenta Hiratsuka, Takamichi Tamiya, Shinji Matsuoka, Kazushi Kimura

{"title":"Stroke impairment, balance, and cognitive status on admission predict walking independence up to 90 days post-stroke but their contributions change over time.","authors":"Kenta Hiratsuka, Takamichi Tamiya, Shinji Matsuoka, Kazushi Kimura","doi":"10.1097/MRR.0000000000000561","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000561","url":null,"abstract":"This study aimed to identify predictors of gait independence in three successive patient cohorts that received inpatient rehabilitation for at least 30 days, 60 days, or 90 days post-stroke. A total of 26 independent variables were collected within 3 days of stroke onset, including basic information (age, sex, stroke type), sensorimotor function (Stroke Impairment Assessment Set), gait function, balance function, and cognitive function. The dependent variable was walking independence (without assistance from another person) at 30, 60, or 90 days post-stroke. A decision tree was developed for predicting gait independence at each assessment time point. The predictors of walking independence differed among the cohorts that received inpatient rehabilitation for at least 30, 60, and 90 days post-stroke. Specifically, the Short Form Berg Balance Scale score was in the higher layer and was a strong predictor of gait at all time points. The cognitive Functional Independence Measure progressed to the higher layer at later time points. The lower extremity motor function was an additional predictor in the 30-day cohort. For later cohorts, the predictive value of balance and cognitive function declined whereas the contribution of the paralyzed grip strength and trunk function increased. These results suggest that sensorimotor and cognitive function within 3 days of stroke can predict walking independence between 1 and 3 months post-stroke; however, the prognostic value of predictors varies among the patients who receive inpatient rehabilitation for shorter versus longer time.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 1","pages":"61-69"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing individual-level measurement precision of the Short Physical Performance Battery using the test information function. 使用测试信息功能评估短物理性能电池的个人水平测量精度。

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-03-01 DOI: 10.1097/MRR.0000000000000557

Franco Franchignoni, Andrea Giordano, Linda Rinaldo, Murat Kara, Levent Özçakar

{"title":"Assessing individual-level measurement precision of the Short Physical Performance Battery using the test information function.","authors":"Franco Franchignoni, Andrea Giordano, Linda Rinaldo, Murat Kara, Levent Özçakar","doi":"10.1097/MRR.0000000000000557","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000557","url":null,"abstract":"The Short Physical Performance Battery (SPPB) is a commonly used tool to assess lower extremity function, composed of three assessments (standing balance, gait speed, and chair stand). While its validity for group-level decisions has been positively demonstrated, the measurement precision at the individual level needs more clarification. We aimed to examine the SPPB's psychometric characteristics including its conditional measurement precision with Rasch methods in a sample of elderly patients admitted to cardiac rehabilitation. We analyzed prospectively collected SPPB data from 637 patients aged ≥75 years, admitted to our cardiac rehabilitation department (January 2018-July 2019). After classical Rasch analysis, we calculated the test information function to examine the measurement precision of the SPPB along the score continuum. The mean SPPB score was 6.3 points (SD 3.4) (potential range 0-12). Our results confirmed the SPPB unidimensionality (variance attributable to the main factor: 84.8%), appropriate functioning of rating scale categories, internal construct validity (infit and outfit mean-square statistics: 0.90-1.09), and no item local dependence (residual correlations <0.2). However, the measurement precision at the individual level was quite limited (SE > 0.94 logits): the confidence intervals for true scores were, at best, about one-third of the score range (four points). This limited measurement precision increases the risk of inappropriate clinical decisions about individuals in diagnostic classification or change assessment. Therefore, further research of high methodological quality is warranted on this point. Moreover, a clearer distinction between group-level vs. individual-level indicators of change is necessary.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 1","pages":"46-52"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10679431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association of obesity and cardiovascular disease and progress in pharmacotherapy: what is next for obesity? 肥胖与心血管疾病的关系及药物治疗进展:肥胖的下一步是什么?

IF 1.7 4区医学

International Journal of Rehabilitation Research Pub Date : 2023-03-01 DOI: 10.1097/MRR.0000000000000565

Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed

{"title":"Association of obesity and cardiovascular disease and progress in pharmacotherapy: what is next for obesity?","authors":"Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed","doi":"10.1097/MRR.0000000000000565","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000565","url":null,"abstract":"Obesity has recently emerged as one of the most severe health concerns. Obesity is a key autonomous risk factor for heart failure and contributes to cardiovascular disease (CVD) risk factors such as hypertension, type 2 diabetes, and metabolic abnormalities. Obesity is caused by a metabolic imbalance, which occurs when calories burnt are fewer than the number of calories consumed. There are several pathways accountable for the adverse impacts of obesity on the cardiovascular system. Inflammatory cell infiltration develops in the adipose tissue, the pancreas, and other issues similar to the progression of obesity. Inflammation is triggered by immune cells that invade dysfunctional adipose tissue. The atherosclerotic inflammation phase, related to obesity, induces coronary calcification. Obesity is linked to elevated levels of leptin and high blood pressure. Leptin causes systemic vasoconstriction, sodium retention, and increased blood pressure by influencing the synthesis of nitric oxide and activating the sympathetic nervous system. Obesity is a well-known risk factor for CVD and is one of the leading causes of the greater risk of diseases, including dyslipidemia, hypertension, depression, metabolic syndrome, atrial fibrillation, and heart failure in adults and children. When used with dietary improvements, antiobesity drugs improve the probability of experiencing clinically healthy (5%) weight loss. This review aimed to address the consequences of obesity on cardiac structure and function, risk factors, the impact of the obesity paradox, pharmacological treatment strategies for managing and recommended exercise and diet.","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 1","pages":"14-25"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1