International Journal of Scientific Reports最新文献

{"title":"Spinal ossification in mouse embryo is severely compromised by the lead acetate treatment","authors":"S. Kaushik, Mukesh Kumar, Bhupendra K. Kaushik","doi":"10.18203/issn.2454-2156.intjscirep20231098","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20231098","url":null,"abstract":"Background: Bone growth is the vital process that continues throughout the life of living beings. Several pollutants may cause poorer ossification and bone formation. Vertebral ossification is directly correlated to growth, strength and spinal stability therefore the determination of ossification pattern in vertebral column is important to evaluate the bone formation. Bio-accumulation of lead in the body has been known to cause the adverse effects on the bone development through the disruption of mineralization.\u0000Methods: The present study was designed to evaluate the impact of lead exposure on the embryonic ossification in mice during development. For this study 28 pregnant female mice were selected and treated with the lead (as lead acetate 0.5 ppm) for 14 and 21 days periods. At the end of the treatment periods pregnant mice were sacrificed and embryos were excised and processed for further analysis.\u0000Results: Present study revealed damaged and ruptured spinal ossification center with premature chondrocytes present in lyzed condition in lead treated group compared to control.\u0000Conclusions: It is concluded that lead exposure induced bone toxicity that has deteriorated the spinal ossification in the growing mice.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87081341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioleiomyoma of parotid gland: a rare case report","authors":"S. Maingi, Ankita Sharma, Ankur Gupta, Sajal Maingi, Pallavi Paruthi","doi":"10.18203/issn.2454-2156.intjscirep20231101","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20231101","url":null,"abstract":"Angioleiomyoma or vascular leiomyoma first described by Virchow is a very uncommon benign soft tissue tumor. Angioleiomyoma has been defined as frequently painful, benign subcutaneous or deep dermal tumor composed of mature smooth muscle bundles which are surrounded and interlaced by vascular channels. Only 8.5% cases arise in the head and neck. A 39 years old male presented with swelling right side face and upper neck past five years. The swelling was non tender, immobile and non-compressible. There was lateral pharyngeal wall bulge which was pushing the tonsil medially. The patient underwent total conservative parotidectomy and histopathology (HPE) came out to be angioleiomyoma. Angioleiomyoma is difficult to diagnose correctly from clinical manifestations and imaging alone, and a biopsy is mandatory to make the diagnosis.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84725193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, experience and management on premenstrual syndrome among secondary level adolescence girl students of Kirtipur Municipality, Kathmandu, Nepal","authors":"Elina Poudel, Amrit Bist, Amita K. C.","doi":"10.18203/issn.2454-2156.intjscirep20231096","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20231096","url":null,"abstract":"Background: Premenstrual syndrome (PMS) is a common menstrual disorder that affects the quality of life of women. The objective of this study is to identify the knowledge, attitude, experience and management on pre-menstrual syndrome among higher secondary level adolescence girls’ students of Kirtipur Municipality of Kathmandu district. \u0000Methods: A descriptive cross-sectional study was conducted among 322 adolescence girl students of higher secondary school of Kritipur Municipality using pre-tested self-administered questionnaire. \u0000Results: The mean age of the respondents was 17 years. It was found that 90.2% of the respondent had very poor knowledge on premenstrual syndrome and 9.2% of the respondent had fair /below average knowledge regarding PMS. The level of knowledge among the study participants was found statistically significant with education status of mother (p=0.002) and that of father (p=0.013). The prevalence of PMS among the female students of higher secondary level was found to be high (77%). Considerably high proportion of the participants reported having at least one somatic and one affective symptoms of premenstrual syndrome. The most frequent affective symptoms experienced by the respondents were mood swings, headache, irritability and somatic symptom was acnes in this study. \u0000Conclusions: Majority of the respondents had poor knowledge and extremely negative attitude towards PMS. High proportion of the participants reported having at least one somatic and one affective symptom of PMS. Comprehensive education on menstrual health and PMS can be suggested for the adolescence girl in school level.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90658298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological survey of knowledge, attitudes and practices: a preventive intervention strategy against COVID-19 pandemic in Nigeria","authors":"N. Ihua, C. Nwankwo, Tamunonengiye-Ofori Orudukobipi, Aniekan Affia, Umasonye U. Aaron","doi":"10.18203/issn.2454-2156.intjscirep20231095","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20231095","url":null,"abstract":"Background: This study assessed how intervention strategy influenced the attitudes of the Nigerian public and their practices to cause a behavioural change at the peak of the COVID-19 pandemic. An epidemiological survey designed as a cross-sectional descriptive study, was conducted at the height of COVID-19 pandemic in Nigeria to assess the knowledge, attitudes, and practices (KAP) of Nigerians as a preventive intervention strategy against the novel Coronavirus. A self-structured questionnaire was designed specifically for this study. The study objectives were assessed on a three point scale of “maybe, no and yes.” \u0000Method: Online questionnaires were randomly administered to the general Nigerian public. The online survey used Google form and the study was limited to Nigerian residents with access to internet. The questionnaire was sectioned into two parts. The first part captured social demographics and the second part included five items each assessing public KAP towards the COVID-19 pandemic. \u0000Results: Three hundred and forty-seven (347) persons responded to the questionnaires. All respondents (100%) demonstrated adequate knowledge of COVID-19. Reports on attitude towards COVID-19 showed that 287 (82.7%) of the respondents were critical about COVID-19 information while 323 (93.0%) adhered to guidelines about COVID-19 indicating good practice. \u0000Conclusions: This study reveals a good knowledge of COVID-19, right attitudes and appropriate safe practices towards COVID-19 in Nigeria, consequently, good adherence and compliance to the guidelines. However, the few respondents with poor understanding and attitudes presents a cause for concern.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"171 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75981069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical presentation of tuberculosis: a case report highlighting the challenges of diagnosis and management","authors":"Kristiāns Hščanovičs, Mārtiņš Danefelds, Lelde L. Freidenberga, Mārtiņš Petrāns","doi":"10.18203/issn.2454-2156.intjscirep20231066","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20231066","url":null,"abstract":"Tuberculosis (TB) remains a significant public health issue worldwide and can present with atypical symptoms, making it difficult to diagnose. Atypical TB symptoms include non-specific symptoms and extrapulmonary TB, and patients with comorbidities may present with atypical TB due to impaired immune function. TB treatment includes antibiotics, which can cause hepatotoxicity, and require close monitoring for signs of liver injury. A 32-year-old female with intellectual developmental disorders was admitted to the hospital with suspected pneumonia and acute respiratory viral infection. Despite initial treatment with antibiotics, her oxygen saturation decreased, and she developed recurrent pneumothorax on the right side and neutrophilic pleuritis. Computed tomography (CT) scans showed increasing infiltrative changes, and bronchoalveolar lavage eventually revealed Mycobacterium tuberculosis DNA, leading to the diagnosis of tuberculosis pneumonia with pleurisy. This case report highlights the challenges of diagnosing TB and the importance of maintaining a high index of suspicion for TB in patients who do not fit the typical profile of the disease. The case also emphasizes the potential for drug-induced liver damage with TB treatment and the need for close monitoring. Early diagnosis and appropriate management are crucial to prevent further complications and improve outcomes in patients with TB.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78551073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myasthenia gravis masquerading as amyotrophic lateral sclerosis: a case report","authors":"Vladimirs Krutovs, G. Ķauķe, Marija Roddate, Maksims Timčenko, E. Miglāne, V. Ķēniņa","doi":"10.18203/issn.2454-2156.intjscirep20231012","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20231012","url":null,"abstract":"Myasthenia gravis is an autoimmune disease that causes weakness in the skeletal muscles. It is considered to be a relatively rare disease. Most commonly the first symptoms are associated with ocular muscle weakness resulting in ptosis and/or diplopia that may be progressive during the periods of muscle exertion and resolve with rest. However, any skeletal muscle group may be affected leading to the variability of clinical symptoms and potential challenges in diagnostics. We present a case report of a 62-year-old male that initially presented with bulbar symptoms and unintentional weight loss, with atypical findings in electromyography study (the absence of decrement amplification in a combination of spontaneous muscular activity) – suggestive for amyotrophic lateral sclerosis (ALS) diagnosis. After a thorough investigation the diagnosis of ALS was not confirmed but myasthenia gravis was highly suspected and anti-MuSK antibodies came positive. The patient was prescribed Pyridostigmine, Prednisolone and underwent plasmapheresis procedure which led to significant relief of the symptoms.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89977871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical investigation and exploration of the central nervous system depressant activity of ethanolic extract of the flowers of Jasminum grandiflorum L. as folklore medicine in Swiss albino mice","authors":"Irshad Khan, A. Malpani, Nisar Ali","doi":"10.18203/issn.2454-2156.intjscirep20230715","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20230715","url":null,"abstract":"Background: In Indian traditional medicine, the flowers of Jasminum grandiflorum L. (Oleaceae) are claimed to possess powerful central nervous system (CNS) depressant activity. Despite these traditional claims, no in-depth scientific study has been performed on the CNS depressant activity of the flowers of J. grandiflorum. Therefore, the present study was aimed at evaluating the CNS depressant activity of an ethanolic extract of the flowers of J. grandiflorum in Swiss albino mice. \u0000Methods: Acute oral toxicity tests were done at doses of 550, 1750, and 5000 mg/kg. The extract was also subjected to phytochemical tests and TLC tests. The CNS depressant activity of the EEJG was evaluated by various models, such as the forced swimming test, tail suspension test, thiopental sodium-induced sleeping time test, locomotor activity test, and muscle co-ordination test, at two different doses (500 and 1000 mg/kg) in Swiss albino mice. Diazepam (1 mg/kg) was used as a standard drug. \u0000Results: In acute oral toxicity studies, the extract was found to be safe up to a dose level of 5000 mg/kg body weight. EEJG at both doses (500 and 1000 mg/kg) showed significantly (p<0.05, p<0.01) increase in immobility time in the forced swimming test and tail suspension test. In the thiopental-induced sleeping time test, EEJG at 1000 mg/kg showed a significant (p<0.05) effect on the onset of action time and also significantly (p<0.01) increase the duration of sleeping time. EEJG at 1000 mg/kg showed a significant (p<0.01) decrease in locomotor activity, and the EEJG at both doses (500 and 1000 mg/kg) showed a significantly (p<0.05, p<0.01) decreased in muscle co-ordination activity when compared to control group. \u0000Conclusions: The present study confirms the significant CNS depressant activity of the ethanolic extract of the flowers of J. grandiflorum, which may be due to flavonoids and steroids present in the extract as phytoconstituents confirmed by TLC. This study supports the plant's traditional use as a CNS depressant.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83753294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reported high in hospital mortality among adult tuberculosis patients admitted to university of Gondar hospital, North-West Ethiopia","authors":"Sead Hassen Abegaz, Tesfaye Yesuf Yimer, Desalew Getahun Ayalew, G. M. Kassa, Zena Ademasu Yferu, Gebrehiwot Lema Legese, Melaku Abebe","doi":"10.18203/issn.2454-2156.intjscirep20230714","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20230714","url":null,"abstract":"Background: Due to a single infectious pathogen, tuberculosis (TB) is the world's second-greatest cause of mortality. The majority of TB deaths happen during the intensive phase of treatment. The purpose of this study is to determine the incidence and predictors of in-hospital mortality in adult TB patients.\u0000Method: A 4 year retrospective follow-up study was conducted among 200 admitted adult TB patients at the university of Gondar hospital from September 1, 2017 to September 30, 202l. The Cox proportional hazards model was used to calculate the hazard ratios (HR). The Kaplan-Meier method was used to compute survival rates. Cox regression models were used to determine the predictors of mortality.\u0000Results: This study enrolled 200 adult TB patients. Among these 60 (30%) died, 140 (70%) censored with overall incidence of death rate of 165 (95 percent CI: 128, 213)/10,000 days of observation. A multivariate Cox regression analysis revealed that patients with a low WBC count at baseline (AHR=3.16, 95% CI: 1.55, 6.41) and bedridden patients (AHR=3.49, 95% CI: 1.83, 6.66) independent predictors of in-hospital mortality among adult TB patients.\u0000Conclusions: This retrospective study found that hospital mortality among adult TB patients is high in public hospitals in northwest Ethiopia. Patients with a low WBC count and who were bedridden at the time of presentation were independent predictors of in-hospital mortality. ","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76757400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an android-based journaling and mood tracking mobile application for improving mental health using firebase application programming interface","authors":"C. Russel, Alexander Waworuntu, Darren Surya, Joseph Nathanael Zebua, Ray Sandy","doi":"10.18203/issn.2454-2156.intjscirep20230716","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20230716","url":null,"abstract":"The mental health of an individual is a critical aspect of overall well-being and has a significant impact on daily life and relationships. Despite the increasing prevalence of mental health disorders, access to mental health care remains a challenge, especially in low and middle-income countries. The use of mobile apps has the potential to improve access to mental health care and promote self-awareness and well-being. The study aims to design a mental health application that incorporates journaling and mood tracking to promote mindfulness and encourage individuals to regularly reflect on their experiences and emotions. The application is built on the firebase platform and utilizes three key components: firebase storage, firestore database, and firebase authentication. The application also employs two native device features, camera and storage, for capturing profile pictures and cover images. The study provides a comprehensive solution for user management and the delivery of mental health support services.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83478067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miraculous life-saving role of patent foramen ovale: a case report","authors":"Kirils Jeršovs, Sofija Aveniņa, Vladimirs Krutovs, Artjoms Kaļiņins","doi":"10.18203/issn.2454-2156.intjscirep20230697","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20230697","url":null,"abstract":"Patent foramen ovale (PFO) is a relatively uncommon anatomical variant that predisposes patients to several complications, such as atrial septal aneurysm, thromboembolism, stroke, platypnea-orthodeoxia, and paradoxical embolism. Despite this, in rare cases, PFO can be a life-saving factor. We present a 72-year-old man with a PFO and fulfilled Virchov’s triad after being stationary, dehydrated, and suffering from chronic venous insufficiency. A subsequent transesophageal echocardiogram revealed a large thrombus (approx. 20 cm in length) dwelling in the PFO in between both atria. In this case, PFO effectively saved the patient from such complications as pulmonary embolism and paradoxical embolism.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73212868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}