International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes最新文献_第6页

Preparation and stability of a radioiodinated pentamidine isethionate analog 放射性碘化异硫代戊脒类似物的制备及其稳定性

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90193-I

Philip J. Blower , Claire M. Smith , Raymond J. Smith , Gareth E. Moores , Michael J. O'Doherty

引用次数: 5

Behavior of radionuclides in the environment—I. Sorption of Zn(II) on clay minerals 放射性核素在环境中的行为i。黏土矿物对Zn(II)的吸附

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90198-N

Ryoko Fujiyoshi, Andriamisamanana Solofo Eugene, Meiseki Katayama

引用次数: 16

Sensitive GC-MS method for the determination of specific-activity of 16α[18F]fluoro-estra- 1,3,5(10)-triene-3,17β-diol 灵敏的气相色谱-质谱法测定16α[18F]氟酯- 1,3,5(10)-三烯-3,17β-二醇的比活性

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90210-6

F. Magni , R. Casati , S. Todde , F. Colombo , F. Fazio , M.Galli Kienle

引用次数: 3

Complexation des groupes oxoet nitrurotechnétium par les dithioétherdithiols 二硫醚二硫醇对氧和氮-锝基团的络合

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90199-O

S. Drouillard , A. Alagui , M. Apparu , J.P. Mathieu , R. Pasqualini , M. Vidal

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引用次数: 2

2- and 4-[18F]fluorotropapride, two specific D2 receptor ligands for positron emission tomography: N.C.A. syntheses and animal studies 2-和4-[18F]氟托帕利，两种用于正电子发射断层扫描的D2受体配体:nca合成和动物研究

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90205-S

Philippe Damhaut, Robert Cantineau, Christian Lemaire, Alain Plenevaux, Leon Christiaens, Marcel Guillaume

{"title":"2- and 4-[18F]fluorotropapride, two specific D2 receptor ligands for positron emission tomography: N.C.A. syntheses and animal studies","authors":"Philippe Damhaut, Robert Cantineau, Christian Lemaire, Alain Plenevaux, Leon Christiaens, Marcel Guillaume","doi":"10.1016/0883-2889(92)90205-S","DOIUrl":"10.1016/0883-2889(92)90205-S","url":null,"abstract":"<div>Tropapride, (exo)-2,3-dimethoxy-N-[8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, has been labeled with fluorine-18 at the 2- and 4-positions of its benzylic group. Two synthetic pathways were investigated: the first one required the alkylation of the norbenzyl precursor with 2- or 4-[18F]fluorobenzyl bromide (radiochemical yield of 5% EOB, 180 min); the second method consisted of a reductive amination of norbenzyl tropapride with 2- or 4-[18F]fluorobenzaldehyde (20% EOB, 110 min). In both cases, the specific activity was found to be greater than 1 Ci/μmol (EOS). Animal studies in rats showed the percentage of the injected dose localizing in the whole brain to be 0.6 ± 0.09 and 0.2 ± 0.03 at 2 h post injection for the para- and the ortho-[18F]fluoro analogs of tropapride respectively. Cerebral biodistribution studies showed at 4 h a striatum uptake of 5 ± 0.7% of the injected dose per gram of striatum for the para derivative with a low fixation into the frontal cortex and the cerebellum (% ID/gFC < 0.4 and % ID/gCb < 0.3). The selectivity of 4-[18F]fluorotropapride for D2 dopaminergic sites was demonstrated through blocking experiments with ketanserin, spiperone and halopemide. The saturability was confirmed by the use of variable specific activities. These preliminary results showed that 4-[18F]fluorotropapride can be considered as a potent radiopharmaceutical for the study of the dopaminergic system with PET.</div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 10","pages":"Pages 1265-1274"},"PeriodicalIF":0.0,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90205-S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12504411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Determination of effective atomic number and electron density of some fatty acids by gamma-ray attenuation 射线衰减法测定某些脂肪酸的有效原子序数和电子密度

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90192-H

G.S. Bhandal , Ishtiaq Ahmed , K. Singh

引用次数: 10

Validation of the histogram technique for three-dimensional and two-dimensional dosimetric calculations 三维和二维剂量学计算的直方图技术的验证

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90197-M

E.B. van Dieren, A. van Lingen, J.C. Roos, G.J.J. Teule

引用次数: 2

Determination of water content of plant leaves by beta attenuation 用衰减法测定植物叶片含水量

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90200-X

R.K. Batra, Bhupender Singh, Kulwinder Singh

引用次数: 6

Events 事件

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90213-X

引用次数: 0

Nature of gamma background radiation and dose-rate in Ain Shams University 艾因沙姆斯大学伽马本底辐射的性质和剂量率

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-10-01 DOI: 10.1016/0883-2889(92)90207-U

S.U. El-Kameesy, M.S. Abdel-Wahab, N. El-Faramawy

引用次数: 3