International Journal of Pharmaceutical Quality Assurance最新文献_第5页

Development, Optimization, and Validation of a RP-HPLC Method with PDA Detection for the Concurrent Quantification of Emtricitabine, Tenofovir Alafenamide, and Dolutegravir in Both Bulk and Pharmaceutical Dosage Forms PDA反相高效液相色谱同时定量恩曲他滨、替诺福韦和多替替韦的方法的建立、优化和验证

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.05

Chandrudu J, Gandhimathi R

{"title":"Development, Optimization, and Validation of a RP-HPLC Method with PDA Detection for the Concurrent Quantification of Emtricitabine, Tenofovir Alafenamide, and Dolutegravir in Both Bulk and Pharmaceutical Dosage Forms","authors":"Chandrudu J, Gandhimathi R","doi":"10.25258/ijpqa.14.3.05","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.05","url":null,"abstract":"A simple, quick, precise and accurate HPLC (reverse phase) approach has been designed and optimized using a chemometric tool to estimate dolutegravir, emtricitabine and tenofovir alafenamide, respectively. A design of central composite was used to optimize the response surface. As a result of trial and error, the parameters such as rate of solvent flow, buffer pH, and methanol concentration in the solvent system were determined. System responsiveness was estimated using the optimization process’s capacity factor, resolution, and retention time. The separation was achieved by using a solvent system containing 58.90% methanol and 41.10 triethylamine buffer (4.56 pH) at the rate of flow of 0.8 mL per minute on a phenomenex carbon (18) column (150.4 4.6 mm; I.D., 5) under optimal conditions. The duration of retention for emtricitabine was 2.91 minutes, for tenofovir alafenamide it was 6.114 minutes; and for dolutegravir it was 8.824 minutes. A correlation coefficient of 0.9998, 0.9997, and 0.9999 was determined for emtricitabine’s calibration curves from 40 to 200 g/mL, tenofovir alafenamide’s from 5 to 25 g/mL, and emtricitabine’s from 10 to 50 g/mL, respectively. This approach was effective in estimating the simultaneous doses of medications in commercial combination forms","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Herbal Remedy for Cough 治疗咳嗽的中药配方及疗效评价

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.51

Anjali Bedse, Ashwini Nalawade, Suchita Dhamane, Ramanlal Kachave, Vijay Wagh, Harshal Tare, Gauri Ghangale

{"title":"Formulation and Evaluation of Herbal Remedy for Cough","authors":"Anjali Bedse, Ashwini Nalawade, Suchita Dhamane, Ramanlal Kachave, Vijay Wagh, Harshal Tare, Gauri Ghangale","doi":"10.25258/ijpqa.14.3.51","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.51","url":null,"abstract":"The most frequent reason patients seek medical assistance is because of a persistent cough, despite the fact that coughing is both a crucial defensive reflex and a universal indication of health. According to an epidemiologic study, up to 40% of people report coughing. Upper respiratory tract infections (URTIs) and the common cold are the most frequent causes of cough, but other causes include post-infectious cough, undiagnosed chronic cough, and cough brought on by pulmonary diseases like asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and lung cancer. The most common causes of cough in children are viral URTI, chronic bacterial bronchitis, and asthma. Whether acute or chronic, cough is linked to considerably reducing health-related quality of life. Patients with chronic cough commonly report sleep disturbance, nausea, chest pains, lethargy, social humiliation, urine incontinence, and low mood. Coughing may not be effective in certain circumstances (such as respiratory tract inflammation, neoplasia, eosinophilic bronchitis, airway irritation from various pollutants, airway hyperresponsiveness from infection, gastroesophageal reflux disease, and coughing without any known cause, also known as idiopathic cough). Opioidergic central cough suppressants, such as opioids, codeine, pholcodine, noscapine, and dextromethorphan, are useful when coughing is ineffective. Constipation, sedation, respiratory depression, dependence, drowsiness, addiction, and even mortality can result from prolonged use of these cough suppressants, which restricts their use in people. The proposed research project’s objective is to develop and assess herbal dosage forms that contain the widely used spice Piper longum L. (Piperaceae).","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Synthesis and Characterization of Novel 1,3,4-Oxadiazinoindole Derivatives for the Purpose of Antidepressant Activity 新型1,3,4-恶二嗪吲哚衍生物的合成及抗抑郁活性的表征

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.33

Mahadev Agarwal, Neelam Singla, S.K Singh

引用次数: 0

Formulation And Evaluation of Quercetin Loaded Nanosponges of Abiraterone Acetate 槲皮素负载醋酸阿比特龙纳米海绵的制备及评价

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.32

Suvarna Thorat, Manoj Tare

{"title":"Formulation And Evaluation of Quercetin Loaded Nanosponges of Abiraterone Acetate","authors":"Suvarna Thorat, Manoj Tare","doi":"10.25258/ijpqa.14.3.32","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.32","url":null,"abstract":"A novel idea in medicine delivery is the use of nanosponges. In the current research, an effort was made to create in-situ gel based on nanosponges that contained abiraterone acetate loaded with quercetin. The major purpose of nanosponges is to offer a prolonged release, lessen the negative effects of conventional dosage forms, and enhance the bioavailability of abiraterone acetate by using quercetin as a natural bioenhancer. Combining ethyl cellulose and eudragit in varying quantities, the quasi emulsion solvent diffusion technique was used to create nanosponges and quercetin as a natural bioenhancer. The formulation properties of the produced nanosponges were assessed. All batches of nanosponges had their manufacturing yield and trapping effectiveness assessed. Formulations F 03-P1 and F 07-P2 were found to be the optimum formulations based on results. Both F 03- P1 and F 07-P2 were used to create the gels G1 and G2. Viscosity, spreadability, drug content, and in-vitro tests showing 28.88% drug release after 24 hours all favored G2 as the optimal formulation. A gel base was created using the optimized formulation after it had been tested for scanning electron microscopy (SEM) analysis. Nanosponges containing gel had evaluated for different tests. According to the study, adding drugs to nanosponges can increase the rate of drug release, improve medication targeting at a particular spot, and hence lessen systemic toxicity.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Applications of Alpha Nanocellulose from Cow Dung in Biomedicine: A Comprehensive Review 牛粪α纳米纤维素在生物医学中的潜在应用综述

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.57

Dharmesh Trivedi, Seema Joshi, Amit Jain, Sagar S Jadkar, Rahul I Jadhav, Gajendra S Rathore, Anshu Sharma

{"title":"Potential Applications of Alpha Nanocellulose from Cow Dung in Biomedicine: A Comprehensive Review","authors":"Dharmesh Trivedi, Seema Joshi, Amit Jain, Sagar S Jadkar, Rahul I Jadhav, Gajendra S Rathore, Anshu Sharma","doi":"10.25258/ijpqa.14.3.57","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.57","url":null,"abstract":"It is feasible to extract nanocellulose, in particular alpha nanocellulose, from agricultural waste products such as cow dung. This is the case. Nanocellulose of this particular form exhibits unique properties, making it an excellent candidate for biological applications. This review aims to discuss the biomedical applications of cow dung-derived alpha nanocellulose. Nanocellulose has a larger surface area, greater mechanical strength, and better biocompatibility than other cellulose nanomaterials. It starts off by walking through the process of removing nanocellulose from cow manure. Alpha nanocellulose has applications in tissue engineering, the administration of medicines, the healing of wounds, as well as biosensing. Each application is broken down into its component parts, providing insights into the underlying mechanisms, experimental investigations, as well as in-vitro and in-vivo evaluations to establish the viability and effectiveness of alpha nanocellulose. The review paper also discusses the difficulties encountered and the potential future applications of alpha nanocellulose derived from cow dung in biomedicine. These difficulties include the requirement for standardized extraction processes, the optimization of material properties, and the consideration of regulatory issues. This in-depth study demonstrates that alpha nanocellulose that is generated from cow dung is a versatile and environmentally friendly nanomaterial that can be used for medical applications. It is hoped that the findings of this study will inspire more research and creative applications based on the unique properties of alpha nanocellulose, possibly resulting in biomedical breakthroughs by consolidating knowledge and exploring new areas.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Correlative Dissolution Study of Oral Drug Delivery Systems through Reverse Phase-HPLC Analysis 反相高效液相色谱法研究口服给药系统的相关溶出度

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.15

S Poongothai, R Srinivasan, M Rama

{"title":"A Correlative Dissolution Study of Oral Drug Delivery Systems through Reverse Phase-HPLC Analysis","authors":"S Poongothai, R Srinivasan, M Rama","doi":"10.25258/ijpqa.14.3.15","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.15","url":null,"abstract":"Oral drug administration is essential for treating diverse diseases due to its acceptable route, non-invasiveness, minimal off-target side effects, versatility, and painless patient delivery. However, multiple drug accessibility is increasing currently but there is often a deficiency of indication in developing procedures with assessment of two diverse medicinal formulations. Oral administration of a novel antiepileptic drug, levetiracetam in grouping with either L-dopa unaccompanied or L-dopa/Ropinirole treatments was associated with dyskinesia. Altered shooting patterns of neurons relating to a compulsive harmonization process may back to the origin of dyskinesia. The current study aims to develop a dissolution technique and validate the antiparkinsonian drug-ropinirole and antiepileptic drug-levetiracetam tablets by RP-HPLC, which plays a major part in pharmaceutical formulations. The optimal dissolution conditions were experienced for the products respective to the pharmaceutical formulation and applied to assess the dissolution profiles. Ideal settings for the dissolution method were 500 mL of pH of 4.0 citrate buffer, 50 rpm and 250 nm for ropinirole tablets and 900 mL of distilled water, the rotation speed of paddle 50 rpm and 217 nm for levetiracetam tablets, then 3.84 and 3.87 minutes were set as the retention time of ropinirole and levetiracetam tablets, respectively. Technique optimization and validation process helps to reduce the bioequivalence of both dosage forms. The current study ensues detailed information on the drug release, even if there is a change in pH medium, filter, rpm, instrumentation, etc. Focusing on current pharmaceutical sciences, the proposed correlative dissolution study coupled with RP-HPLC analysis could offer a holistic insight into the performance of future oral drug delivery systems","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability Indicating Assay Method Development and Validation of Sitagliptin and Metformin Combination Tablets by Reverse Phase - HPLC 西格列汀二甲双胍联合片稳定性指示分析方法的建立及反相高效液相色谱法的验证

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.19

Gogada V.P Rao, Meka Lingam, Bavisetti Lakshmi, Anantha L Vadivelu, Duvvuri Suryakala

引用次数: 0

Investigation of Antidiabetic Activity of Isolated Molecule from the Bark of Olax scandens 山茱萸树皮分离分子抗糖尿病活性的研究

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.04

Johnsymary F, Komala M

{"title":"Investigation of Antidiabetic Activity of Isolated Molecule from the Bark of Olax scandens","authors":"Johnsymary F, Komala M","doi":"10.25258/ijpqa.14.3.04","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.04","url":null,"abstract":"Hyperglycemia caused by defects in insulin synthesis and/or activity characterizes diabetes mellitus (DM), which is categorized as a metabolic condition. Some patients may develop side effects or drug interactions when treating these disorders with synthetic drugs. Due to this, there is an increased interest in researching the medical properties of plants and herbal substances while also considering synthetic medications’ interactions and negative effects. To isolate and identify the flavonoid 5-hydroxy-apigenin-7-O-Dglucopyranoside, the bark of Olax scandens was extracted with methanol in a soxhlet system (5HAG). The current study set out to examine 5HAG’s potential ability to treat albino wistar rats with STZ-induced diabetes. The chemical component significantly lowered rats’ blood glucose levels and improved lipid markers. Hepatic enzymes improved significantly, including SGOT, SGPT, ALP, plasma insulin, and total proteins. Overall, this study exposes new avenues for researching how 5HAG reduces blood sugar levels so drastically, but according to the aforementioned study, the flavonoid possesses antidiabetic properties because of its antioxidant activity. In addition, the isolated flavonoid may significantly impact the reduction of blood sugar and its complications by acting as a lead molecule in the identification of novel antidiabetic drug candidates.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Impact of Temperature Management Interventions on Survival Outcomes in Adult Out-of-Hospital Cardiac Arrest: A Comprehensive Review of Randomized Controlled Trials 评估温度管理干预对成人院外心脏骤停患者生存结果的影响:一项随机对照试验的综合综述

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.09

Ahmed M. Asiri, Salman A. Alzahrani, Afrah Y. Saddeek, Faisal A. Ghazwani, Abdulhakeem Alotaibi, Shahalil Alqani

{"title":"Assessing the Impact of Temperature Management Interventions on Survival Outcomes in Adult Out-of-Hospital Cardiac Arrest: A Comprehensive Review of Randomized Controlled Trials","authors":"Ahmed M. Asiri, Salman A. Alzahrani, Afrah Y. Saddeek, Faisal A. Ghazwani, Abdulhakeem Alotaibi, Shahalil Alqani","doi":"10.25258/ijpqa.14.3.09","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.09","url":null,"abstract":"A cardiac arrest patient who has recovered outside the hospital, managing body temperature is beneficial. There is still uncertainty as to what specific circumstances should be met in order for such interventions to be initiated. Researchers have used different methods to study OHCA TTM interventions due to the uncertainty surrounding their outcomes. The study’s main objective is to determine if temperature management affects survival outcomes in adult cardiac arrests occurring outside of the hospital. Several online databases were examined to collect data, including Web of Science, PubMed Central, Medline, Embase and Cochrane. Our study examined several randomized controlled trials, including randomized clinical trials and randomized controlled trials that involved TTM interventions in adult OHCA patients. An analysis was conducted based on the search criteria for screening, collecting, and extracting data. Based primarily on qualitative analysis, a synthesis was conducted. There were 21 studies with a total of 11435 participants, with a median sample of 355, and none of them demonstrated sufficient qualitative and quantitative evidence indicating that TTM interventional variants were safe, feasible, efficient, and effective on neurological and mortality outcomes in OHCA patients.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"280 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Antibiotic Prescribing Patterns for Dental Infections: A Retrospective Study in a Dental Clinic 口腔感染抗生素处方模式的比较分析:一项牙科诊所的回顾性研究

International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI: 10.25258/ijpqa.14.3.42

Hiroj Bagde, Ashwini Dhopte

{"title":"Comparative Analysis of Antibiotic Prescribing Patterns for Dental Infections: A Retrospective Study in a Dental Clinic","authors":"Hiroj Bagde, Ashwini Dhopte","doi":"10.25258/ijpqa.14.3.42","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.42","url":null,"abstract":"This research aimed to analyze and contrast the antibiotic prescription trends that occur in dentistry offices. for the management of dental infections. To fill out the data, each dentist enrolled in the study was asked to record antibiotics prescribed for 6 -8 months and then the records were collected. Recorded dental prescriptions for antibiotics served as the study’s source population, and the list of patients who brought their prescription cards to the dental office within the allotted window of time (January 1 to December 31, 2015) served as its sampling frame. Using a statistical technique, After selecting patient record cards that included at least one antibiotic during the course of the investigation, the appropriate size of the sample was determined. The study employed a retrospective analysis of prescribing data from 10 private dental clinics, encompassing a sample of dental infection cases and corresponding antibiotic prescriptions. Data on the type and frequency of antibiotics and patient medical history and age were collected and analyzed. Descriptive statistics and statistical tests were used to examine the relationships between antibiotic prescribing patterns and patient factors. The results revealed significant associations between medical history, patient age, and antibiotic prescribing patterns. The findings highlight the need for personalized prescribing approaches based on patient factors, standardized clinical processes, and cost-effective antibiotic choices. Improving compliance with clinical guidelines can help optimize antibiotic use and enhance patient outcomes in dental practice.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0