International Journal of Research and Development in Pharmacy & Life Sciences最新文献_第2页

Oxidative stress, Mitochondrial dysfunction and Neuro-degenerative diseases: A Review 氧化应激、线粒体功能障碍与神经退行性疾病:综述

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-01-01 DOI: 10.21276/ijrdpl.2278-0238.2019.8(1).1-5

Shalini K. Sawhney

{"title":"Oxidative stress, Mitochondrial dysfunction and Neuro-degenerative diseases: A Review","authors":"Shalini K. Sawhney","doi":"10.21276/ijrdpl.2278-0238.2019.8(1).1-5","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(1).1-5","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).1-5 ABSTRACT: Oxidative stress is produced by the reactive oxygen/nitrogen species (ROS/RNS) which involves mitochondrial dysfunction. Mitochondria is one of the main sources of oxidative stress, as it utilizes the oxygen for the energy production. Overproduction of ROS, results in oxidative stress, which injures the cell structures, lipids, proteins, and DNA. Various oxidative events implicated in many diseases is due to oxidative stress which include alteration in mitochondrial proteins, mitochondrial lipids and mitochondrial DNA, which in turn leads to damage nerve cells as they are metabolically very active. Reactive oxygen/nitrogen species at moderate concentrations also play roles in normal physiology of many processes like signalling pathways, induction of mitogenic response and in defence against infectious pathogens. Oxidative stress has been considered to be the main cause in the etiology of neurodegenerative diseases, which includes Parkinson’s disease (PD) and Alzheimer’s disease (AD). Recent research on the dysfunction and function of PD associated genes has provided new fundamental insights into biochemical pathways that are linked with the disease process This review includes source of free radical generation, mitochondrial dysfunction and the mechanism involved in neurodegenerative diseases which involves both PD as well as in AD. This makes the mitochondria, the main target of PD and AD research.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87605568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of mitochondrial DNA profiling (COX 2) in ovarian cancer patients � A population-based study in South India 卵巢癌患者线粒体DNA谱(COX 2)的鉴定——印度南部一项基于人群的研究

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-01-01 DOI: 10.21276/ijrdpl.2278-0238.2019.8(1).25-28

Mahalaxmi Iyer, Kaavya Jayaramayya, G. Bupesh, S. Kumaran

{"title":"Identification of mitochondrial DNA profiling (COX 2) in ovarian cancer patients � A population-based study in South India","authors":"Mahalaxmi Iyer, Kaavya Jayaramayya, G. Bupesh, S. Kumaran","doi":"10.21276/ijrdpl.2278-0238.2019.8(1).25-28","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(1).25-28","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(1).25-28 ABSTRACT: Objectives: Ovarian cancer (OC) is a most dangerous gynecological cancer affecting women aged mostly in 50s and above due to its poor prognosis. mtDNA has been emerging as a prime hotspot candidate for the progression of OC. Thus, the objective of the present study was to investigate polymorphisms in COX – 2 gene in mtDNA by using PCR – RFLP. Methods: In the present study, detailed questionnaire and consent forms have been obtained from the OC patients and the age – matched controls. Blood samples from OC patients (n = 72) were collected from oncological clinics, and by population-based survey in South India. Control subjects (n=72) who had no history of tumors were selected and they were matched for age, sex and race. Peripheral blood was collected to detect polymorphism in the COX – 2 gene using PCR – RFLP. Result: In the present study, we found that OC patients with COX – 2 CC homozygous genotype showed higher risk for OC progression, whereas, the GG genotype in controls revealed its protection against the OC risk. Conclusion: In conclusion, our results suggests that, COX – 2 CC genotype may contribute to the development of OC pathogenesis. Though genetic polymorphism investigation was very limited to modulate the OC risks, the outcome of this study may help in future genotypic analysis. Thus, in future more genetic studies are warranted to prove that genotypic variation, mutations in COX – 2 would be a prime factor in Ovarian Carcinogenesis, and it can be used as candidate biomarker in treatment strategies.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75532560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Chemistry: A study on acid-base indicator property of various flower pigments 绿色化学:各种花卉色素酸碱指示剂性能的研究

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-11-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(6).3155-3163

L. D, G. G, Purushothom A, P. A

引用次数: 1

Design and evaluation of Mucoadhesive Buccal Tablets of an anti-hypertensive drug - Valsartan 抗高血压药物缬沙坦黏附口腔片的设计与评价

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-10-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(5).3110-3114

R. Mathur, Bhumika Tamrakar, A. Anita, B. Lal, Rajmani Mafidar, M. Bhowmick, J. Rathi

引用次数: 0

Formulation and evaluation of Microspheres for Colon targeted delivery of Ondansetron 昂丹司琼结肠靶向给药微球的研制与评价

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-10-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(5).3083-3091

Saurav Kumar, Rajwinder Kaur, R. Sharma

{"title":"Formulation and evaluation of Microspheres for Colon targeted delivery of Ondansetron","authors":"Saurav Kumar, Rajwinder Kaur, R. Sharma","doi":"10.21276/IJRDPL.2278-0238.2018.7(5).3083-3091","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(5).3083-3091","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(5).3083-3091 ABSTRACT: Objective: The main objective of the present study was to evolve and characterize the microspheres for colon specific target delivery of Ondansetron HCl for the treatment of Inflammatory Bowel Disease. Methods: Ondansetron HCl loaded microspheres were devised by using emulsion solvent evaporation method. HPMC and Ethyl cellulose were used as polymers. Results and Discussion: The preformulation compatibility studies between drug, excipients and microsphere formulations were carried out by Fourier transform infra-red spectroscopy (FTIR). The optimization of the process and formulation was done with respect to the different parameters like drug-polymer ratio, stirring speed, volume of internal phase and amount of emulsifying agent. The microspheres were filled into hard gelatin capsule shells which are sealed and coated with ethanolic solutions of ethyl cellulose and shellac. Drug release profile of microspheres was investigated in GIT pH specific media (0.1M HCl & Phosphate buffer pH 6.8). The FTIR spectra showed that no chemical interaction or changes take place during perpetration of formulations. The drug was stable in all the formulations. The process parameter modulation results showed that the production yields and particle size was decreased with increased stirring speed and increasing the volume of internal phase. Conclusion: In-vitro drug release study of all ondansetron HCl loaded microsphere formulations OF1-OF4 show the release of drug released by non-Fickian diffusion n<0.85.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78071732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Niosomes A Promising Carrier for Drug Delivery 一种有前途的药物递送载体

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-08-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(4).3015-3021

Sultan Ahmad, Deepak Teotia, Kapil Kumar

引用次数: 2

Diabetes mellitus: An Overview 糖尿病:综述

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-08-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(4).3030-3033

Nitin Chaudhary, N. Tyagi

{"title":"Diabetes mellitus: An Overview","authors":"Nitin Chaudhary, N. Tyagi","doi":"10.21276/IJRDPL.2278-0238.2018.7(4).3030-3033","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(4).3030-3033","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(4).3030-3033 ABSTRACT: Diabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin action or both. The condition itself introduces a need for patient’s lifestyle adjustment to the disease and a number of everyday therapeutic and diagnostic restrictions. The main indication of diabetes mellitus is a hyperglycemia in blood which is due to inappropriate pancreatic insulin secretion or low insulin-directed fostering of glucose by target cells. It is silent killer disease and affects millions of people in the world. It is estimated that in 2010 there was globally 285 million people suffering from this disease. This number is estimated to increase to 430 million in the absence of better control or cure. Different types of diabetes mellitus, type 1, type 2, gestational diabetes and other types of diabetes mellitus are compared in terms of diagnostic criteria, etiology and genetics. As the disease progresses tissue or vascular damage ensures leading to severe diabetic complications such as retinopathy, neuropathy, nephropathy, cardiovascular complications and ulceration. Currently available pharmacotherapy for the treatment of diabetes mellitus includes insulin and hypoglycemic agents. These drugs act by increasing the secretion of insulin form pancreas or reducing plasma glucose concentrations by increasing glucose uptake and decreasing gluconeogenesis. Comobrid mental diseases can further negatively influence the course of diabetes. They are specially depression, anxiety disorders, eating disorders and cognitive disorders including dementia. Various herbal drugs have been also proved effective due to their beneficial contents in treatment of diabetes. This article focuses on the causes, types, diagnosis and treatment of diabetes.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83414063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of Polypharmacy and Drug related problems among Geriatric patients in a Multispecialty hospital 某综合专科医院老年患者多药及药物相关问题的发生率

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-08-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(4).3055-3059

T. Tamilselvan, T. Kumutha, M. Priyanka, R. Bose, M. Sindhuja

{"title":"Incidence of Polypharmacy and Drug related problems among Geriatric patients in a Multispecialty hospital","authors":"T. Tamilselvan, T. Kumutha, M. Priyanka, R. Bose, M. Sindhuja","doi":"10.21276/IJRDPL.2278-0238.2018.7(4).3055-3059","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(4).3055-3059","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(4).3055-3059 ABSTRACT:The study objectives were to assess the incidence of polypharmacy and drug-related problems among geriatric patients. This prospective, observational study was conducted in 150 geriatric patients at Vivekanandha medical care hospital. The severities of adverse drug reactions were assessed using Naranjo scale and inappropriate medications were examined using BEER’s criteria. The highest frequency of geriatric patients with polypharmacy was from the age group of 65-70 years (65%). Most of the patients (43%) were taking 5-10 drugs. Out of 150 patients, 124(83%) patients had comorbidities and 26(17%) patients were found without comorbidity. The percentage of patients suffering from DM and HTN were found to be the highest. Antihypertensive was mostly prescribed. The major incidence of drug-drug interaction was found in the moderate category (59.50%). DRP's were assessed. The incidence of 119 drug duplications was found in 62 cases. Inappropriate prescription of drugs was found in 61 cases (101 medications). A total of 34 ADRs were found in 34 cases. From 83 case sheets, 91 medication errors were identified. The incidence of drug related problems was highest in the general medicine department. The incidence of polypharmacy and drug-related problems were high in geriatric population of general medicine department. Benzodiazepine class of drugs was the commonly prescribed inappropriate medication as per the BEER's criteria. The incidence of probable ADR was highly observed in this study.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84243071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Clinico-microbiological profile of Chronic Suppurative Otitis media in a Tertiary Care Hospital 三级医院慢性化脓性中耳炎的临床微生物学分析

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-06-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(3).2995-2998

D. Sandhu, Veenu Gupta, D. Chhina, M. Munjal

引用次数: 2

Morphological Spectrum of Glial Tumors in J.A. Group of Hospitals, G.R. Medical College, Gwalior 瓜廖尔G.R.医学院J.A.附属医院神经胶质瘤的形态谱

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2018-06-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(3).3011-3014

Bhavna Karnwal, R. Sharma, R. Jain, Bharat Jain

引用次数: 0