International Journal of Research and Development in Pharmacy & Life Sciences最新文献

Estimation of bone mineral density and its correlations with homocysteine, and various other biochemical bone markers in postmenopausal women 绝经后妇女骨矿物质密度及其与同型半胱氨酸和其他骨生化指标的相关性的评估

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-10-15 DOI: 10.21276/ijrdpl.2278-0238.2019.8(4).22-28

R. Verma, Satish Kumar, I. Atam, V. Atam, S. Verma, S. Sonkar, Ajay Kumar, S. Chaudhary

{"title":"Estimation of bone mineral density and its correlations with homocysteine, and various other biochemical bone markers in postmenopausal women","authors":"R. Verma, Satish Kumar, I. Atam, V. Atam, S. Verma, S. Sonkar, Ajay Kumar, S. Chaudhary","doi":"10.21276/ijrdpl.2278-0238.2019.8(4).22-28","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(4).22-28","url":null,"abstract":"Introduction- Omocysteine (HCY) prevents collagen cross-linking and activates osteoclast function within the bones. Bone mineral density (BMD) may be affected by Hyperhomocysteinemia via Cathepsin K. Aim- To find the correlation of BMD with biochemical bone markers. Methods- BMD was investigated by the DXA scan with the help of the Hologic QDR1000 system. As per WHO guidelines, subjects were divided into three different subsets with; normal bone mass, osteopenia, and osteoporosis. Every subject underwent routine biochemical laboratory investigations, HCY, Vitamin B12, and folic acid levels. Results-Among 355 postmenopausal women, 69% (245) had osteoporosis while 11.27% (40) had normal BMD (mean age, 53 ± 8.35 years) and 19.72% (70) had osteopenia (mean age 52.86 ± 7.93 years). The mean age in the osteoporotic group was 56.49 ± 6.65 years. The mean levels of HCY in the three groups were 15.58± 7.92 μmol/L, 16.13± 7.34μmol/L and 17.05± 5.13μmol/L, respectively. Hip BMD showed a strong inverse correlation with age (r=-0.360, p=0.002), while no significant correlations were found between weight and BMI. PTH was consistently seen to be negatively correlated with BMD at Spine (r=-0.0339, p=0.004), Forearm (r=-0.267, p=0.027), and Hip (r=-0.224, p=0.064). Conclusion- Low BMD is an important problem in postmenopausal female patients. Age and duration of menopause are independent risk predictors for the development of osteoporosis. Vitamin D levels do not predict low BMD in postmenopausal females. Weight is protective for osteoporosis especially at spine and forearm BMD. Vitamin B12 and Hcy levels did not correlate with low BMD.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90623442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The study of the effect of C-PAP therapy in type-II diabetic patients with obesity and obstructive sleep apnea C-PAP治疗ii型糖尿病合并肥胖和阻塞性睡眠呼吸暂停的疗效研究

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-10-15 DOI: 10.21276/ijrdpl.2278-0238.2019.8(4).18-21

P. Sarkar, Arun Kumar, K. Gopal, Poonam Kachhawa, Seema Singh

{"title":"The study of the effect of C-PAP therapy in type-II diabetic patients with obesity and obstructive sleep apnea","authors":"P. Sarkar, Arun Kumar, K. Gopal, Poonam Kachhawa, Seema Singh","doi":"10.21276/ijrdpl.2278-0238.2019.8(4).18-21","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(4).18-21","url":null,"abstract":"Type II diabetes mellitus (T2DM) is closely associated with Obstructive sleep apnea (OSA) and obesity. Type 2 diabetes and OSA may be pathophysiologically independent conditions although the joint association with obesity or visceral adiposity. There is a consistent relationship between obesity and OSA, which has been reported in 60-90% of OSA patients. The prevalence of obesity increases with a parallel increase in the prevalence of OSA. Continuous positive airway pressure (CPAP) therapy is an effective choice of treatment for OSA, an overnight test, or titration some patients may reduce apnea events by minimizes airway collapse by CPAP. Several studies showed that the effect of drug treatment with 3 months of C-PAP in patients with type 2 diabetes. In the present study, we include 300 patients in different groups, out of the 100 patients undergoing treatment of CPAP therapy minimum for three months. Blood sugar, HbA1c, and lipid profile were measured and an overnight sleep study was done. The obtained data shows the significant effect of therapy on physiological and biochemical parameters. AHI and BMI were highly significant in group II and Group III when compared to group I. FBS, HbA1C, and Lipid profile parameters also gave significance results (p-value <0.001) in group II and group III when compared with healthy subjects (group I).","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81932034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of Novel Drug Delivery Systems for Acne 痤疮的新型药物输送系统综述

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-10-15 DOI: 10.21276/ijrdpl.2278-0238.2019.8(4).1-12

Neha Singh, Maneesh Kumar Singh, Surbhi Panwar

{"title":"An overview of Novel Drug Delivery Systems for Acne","authors":"Neha Singh, Maneesh Kumar Singh, Surbhi Panwar","doi":"10.21276/ijrdpl.2278-0238.2019.8(4).1-12","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(4).1-12","url":null,"abstract":"Acne vulgaris is a type of chronic disease of the skin which is mainly caused by the blockage in the sebaceous gland or having any inflammation in those glands which is together is known as pilosebaceous units. It mainly affects the areas having the highest number of sebaceous follicles; those are the face, the back and upper region of the chest. It is a disease that mainly affects the adolescent age group but can be found in any age group. These are present as inflammatory pustules, papules, cysts and nodules, non-inflammatory closed comedones (whiteheads), ripen comedones (blackheads), or a mixture of lesions. Acne is most commonly seen in almost every human being at some point in their lives. There are 20-25 chances of progression of acne to the severe case which leads to permanent scarring. These complications lead to psychological problems like depression, social isolation, lowered self-esteem, and lowered self-confidence. The aim of treating acne is to prevent severe and long-term complications. The present review focuses on novel drug delivery systems for the treatment of acne. It also includes conventional treatments currently available in the market, its limitation and different strategies to overcome these limitations.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85710116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A comparative evaluation of total antioxidant capacity of saliva in children with and without Gingivitis 有和无牙龈炎儿童唾液总抗氧化能力的比较评价

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-06-15 DOI: 10.21276/ijrdpl.2278-0238.2019.8(3).7-11

Bharat Kumar, A. Ansari, S. Tiwari, M. Waseem, Seema Singh, A. Mahdi, R. K. Chak

{"title":"A comparative evaluation of total antioxidant capacity of saliva in children with and without Gingivitis","authors":"Bharat Kumar, A. Ansari, S. Tiwari, M. Waseem, Seema Singh, A. Mahdi, R. K. Chak","doi":"10.21276/ijrdpl.2278-0238.2019.8(3).7-11","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(3).7-11","url":null,"abstract":"Gingivitis is a reversible and non-destructive form of periodontal disease. Oxidative stress contributes in the pathogenesis of periodontal diseases5. The oxidative stress has been implicated as one of the important contributory etiologic factors in many of the oral inflammatory pathologies including gingivitis. This research analyzed the \"Total antioxidant capacity\" (TAC) of biological fluids including saliva. The present cross-sectional study was conducted to evaluate the total antioxidant capacity (TAC) of saliva in children with/ without gingivitis and its relation with Age and Gender. For measuring the TAC of saliva: Cayman's Antioxidant Assay Kit was used and Gingival Index Measured through The Gingival Index (Loe and Silness, 1963). The results were analyzed using descriptive statistics and making comparisons between cases and control by using SPSS software version 20. In this result, mean TAC of saliva in case children group was found lower 0.203 ± 0.053 compared to control children group was higher 0.236 ± 0.048. While, in male and female children of aged 3-5 years were found antioxidant activity (TAC) lower in compared to control groups. But among males aged 6-13 years it was found that the mean antioxidant capacity of saliva in case group was 0.259 ± 0.040 while in control group it was 0.295 ± 0.026. The TAC of saliva in males was found high compared to female. A weak negative correlation was found between the TAC and gingival index. In conclusion TAC decreases in children with gingivitis compared to healthy children. The gingivitis was more observed in female leading to lower TAC value","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85828032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral manifestation in pre-renal transplant patients in Tertiary Care Hospital in Punjab 旁遮普三级医院肾移植前患者的口腔表现

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-06-01 DOI: 10.21276/ijrdpl.2278-0238.2019.8(3).20-23

N. Namita, Veenu Gupta, R. Rai, Gagandeep Satia

{"title":"Oral manifestation in pre-renal transplant patients in Tertiary Care Hospital in Punjab","authors":"N. Namita, Veenu Gupta, R. Rai, Gagandeep Satia","doi":"10.21276/ijrdpl.2278-0238.2019.8(3).20-23","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(3).20-23","url":null,"abstract":"The incidence of renal failure is known to be increasing globally. Kidney transplant are considered the most efficient renal replacement therapy for a significant number of patients with end- stage renal disease. Renal failure can give rise to a large spectrum of oral manifestations, affecting overall health of patients with renal disease. End-stage renal disease (ESRD) patients have a plethora of oral findings. The aim of this study was to study oral symptoms and lesions in pre-renal transplant patients. This prospective study was conducted over a 6-month period. A total of 80 individuals (40 pre renal transplant patients and 40 controls) were recruited. Each patient was interviewed individually using questionnaire about oral symptoms. Each patient was examined for oral lesions and documented. For Caries DMFT and for Gingivitis CPITN index was used. In both study and control group majority were males and majority were in age group 21-30 years. In study group knowledge of importance of oral hygiene was more. The most common symptoms were dry mouth (20%), altered taste (52.5%) and bleeding gums (42.5%). Study group showed significantly more oral changes than those in the control group. DMFT index was positive in 60% of study and 80% control group. CPITN index was equally positive (92.5%) in both study and control group. Mucosal pallor, suburral tongue, leukoplakia and hyperplastic gingivitis was seen in 27.5%, 10%, 10% and 2.5% respectively in the study group. Prevalence of oral lesions is significantly higher in renal patients. The potential source of active infective lesions in medically compromised patients with ESRD must be treated before transplant.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81464667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colon targeted tablets of Albendazole with enhanced solubility by Complexation and Micellar Solubilization 通过络合和胶束增溶提高溶解度的阿苯达唑结肠靶向片

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-06-01 DOI: 10.21276/ijrdpl.2278-0238.2019.8(3).12-19

Ashok Thulluru, K. Anuradha, K. Saravanakumar, N. Mahammed, C. S. P. Kumar, K. Mohan

引用次数: 0

Association of GLUT-1 (XbaI) Gene Polymorphism in Diabetes and Diabetes Nephropathy Patients of North Indian Population 北印度人群糖尿病和糖尿病肾病患者GLUT-1 (XbaI)基因多态性的相关性

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-05-15 DOI: 10.21276/ijrdpl.2278-0238.2019.8(3).1-6

S. Tiwari, Roshan Alam, I. Ahmad, Seema Singh, Satyendra Kumar, S. Sonkar, G. Sonkar, M. Ahmad

{"title":"Association of GLUT-1 (XbaI) Gene Polymorphism in Diabetes and Diabetes Nephropathy Patients of North Indian Population","authors":"S. Tiwari, Roshan Alam, I. Ahmad, Seema Singh, Satyendra Kumar, S. Sonkar, G. Sonkar, M. Ahmad","doi":"10.21276/ijrdpl.2278-0238.2019.8(3).1-6","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(3).1-6","url":null,"abstract":"Diabetic nephropathy (DN) is a chronic complication of both type 1 and type 2 diabetes. However, there is still inadequate understanding of the exact mechanism related to progressive diabetic renal disease. The GLUT-1 XbaI gene polymorphism in the glucose transporter has been suggested in the development of DN. However, its association with T2DM and DN is controversial and has not been established in different ethnic populations. To enhance the understanding of GLUT-1 XbaI gene polymorphism in the context of T2DM and DN. We investigated the possible genetic association of GLUT-1 XbaI polymorphism with T2DM and DN in North Indian population. 100 T2DM patients and 100 patients of DN with 100 healthy controls were included in the study. GLUT-1 XbaI polymorphism was determined by PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism). The obtained data showed no significant association between GLUT-1 XbaI gene polymorphism with T2DM and DN leading us to conclude that GLUT-1 XbaI gene polymorphism may not have major effects on T2DM and DN in North Indian population.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87449251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of adipokines in obstructive airway disease and diabetes mellitus 脂肪因子在阻塞性气道疾病和糖尿病中的作用

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-04-25 DOI: 10.21276/ijrdpl.2278-0238.2019.8(4).13-17

Seema Singh, Sunita Singh, Santosh Kumar, S. Verma, S. Kant

{"title":"Role of adipokines in obstructive airway disease and diabetes mellitus","authors":"Seema Singh, Sunita Singh, Santosh Kumar, S. Verma, S. Kant","doi":"10.21276/ijrdpl.2278-0238.2019.8(4).13-17","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(4).13-17","url":null,"abstract":"This review summarizes the state of the current literature relating to the associations of lung disease and adipokines (proteins produced by adipose tissue) in humans. The mechanistic basis for these associations in humans is not established, although a possible role for adipokines has been invoked. Leptin, a pro-inflammatory adipokine, and adiponectin, an anti-inflammatory adipokine, are causally associated with asthma in mice. Although human studies are currently inconclusive, high-serum leptin and low-serum adiponectin concentrations predict asthma, independent of obesity, in select population groups, such as premenopausal women in the United States. In contradistinction, low-serum leptin and high-serum adiponectin concentrations are associated with stable COPD, although these associations are likely confounded by fat mass. Interestingly, leptin may promote systemic and airway inflammation in stable COPD patients. On the other hand, COPD may upregulate systemic and lung adiponectin expression. The precise mechanism and significance of the associations between these adipokines and lung disease at the current stage are confusing and frankly paradoxical in places. It is now known that adipose tissue is not an inert organ simply for energy storage, but regulates systemic inflammation via a variety of secreted proteins (called adipokines). While the associations of obesity and adipokines with cardiovascular, endocrine, and rheumatological diseases are well described, the respiratory effects of obesity and adipokines are less well known. This review will focus on the effect of obesity and adipokines on asthma and chronic obstructive pulmonary disease (COPD) in humans. This area of research needs additional study that may open up novel therapeutic strategies for these lung diseases.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"49 16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76372359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updated therapeutic approach in the management of Polycystic Ovary Syndrome (PCOS): A Review 多囊卵巢综合征(PCOS)的最新治疗方法:综述

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-04-01 DOI: 10.21276/ijrdpl.2278-0238.2019.8(2).37-42

A. Kaul, N. Zar, Shruti Shangloo, Parminder Nain

{"title":"Updated therapeutic approach in the management of Polycystic Ovary Syndrome (PCOS): A Review","authors":"A. Kaul, N. Zar, Shruti Shangloo, Parminder Nain","doi":"10.21276/ijrdpl.2278-0238.2019.8(2).37-42","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(2).37-42","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(2).37-42 ABSTRACT: Polycystic ovary syndrome (PCOS) is a heterogeneous clinical entity that is defined as the association of hyperandrogenism with chronic an ovulation in women without specific underlying diseases of the adrenal or pituitary glands. PCOS is also associated with a metabolic disturbance with complex inter relation of obesity, insulin resistance and endocrine abnormalities remains unresolved. However, several studies link obesity, body fat distribution and nutritional habits with the hormonal and metabolic profiles of PCOS. Moreover, intervention studies have suggested that reducing weight and hyper insulinaemia either by diet alone or by a combination of diet with drugs improves hirsutism, fertility, hormonal and metabolic profiles of PCOS. In fact, the evaluation of nutritional factors in PCOS is helpful for the screening of metabolic abnormalities and the management of women with PCOS. A point of particular interest in the management of PCOS is that the choice of contraception remains difficult in these high cardiovascular risk women. The lack of prospective studies to evaluate long-term metabolic and cardiovascular tolerance necessitates care and the assessment of other hormonal possibilities","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87970830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of line probe assay in diagnosis and detection of drug resistance in Mycobacterium tuberculosis 线探针法在结核分枝杆菌耐药诊断和检测中的作用

International Journal of Research and Development in Pharmacy & Life Sciences Pub Date : 2019-04-01 DOI: 10.21276/ijrdpl.2278-0238.2019.8(2).46-49

Phalguni Malhotra, D. Chhina, Veenu Gupta, Akashdeep Singh, D. Sandhu

{"title":"Role of line probe assay in diagnosis and detection of drug resistance in Mycobacterium tuberculosis","authors":"Phalguni Malhotra, D. Chhina, Veenu Gupta, Akashdeep Singh, D. Sandhu","doi":"10.21276/ijrdpl.2278-0238.2019.8(2).46-49","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2019.8(2).46-49","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2019.8(2).46-49 ABSTRACT: Tuberculosis caused by Mycobacterium tuberculosis has remained a major global health problem worldwide. TB requires prolonged period of time for isolation by conventional culture methods. The emergence and spread of multi drug resistant (MDR-TB) poses great threats and challenges in controlling the infection. MDR-TB is resistant to both first line drugs rifampicin and isoniazid. PCR tests are based on targeting the mutation in rpoB, katG and inhA genes which can detect resistance to these drugs. To compare microscopy, conventional culture and Line probe assay for the detection of M. tuberculosis & detect rifampicin and isoniazid resistance using Lineprobe assay in various clinical samples. A total of 347 suspected patients of tuberculosis were included in the study. Demographic details & clinical presentation was noted. Various samples were received & processed for ZN staining, culture on LJ media and Line probe assay. Out of 347 cases, majority of cases were in the age group of 51-60 years (18.4%). Majority of the population was males (65.1%). Among suspected tuberculosis patients, cough with expectoration (55.9%) was the commonest complaint. Microscopy was positive in 17.3%, conventional culture was positive in 16.1% and line probe assay was positive in 26.2%. Out of 347, 91 were diagnosed with MTB, out of which 85.7% were sensitive to both rifampicin and isoniazid whereas 14.3% showed resistance to either rifampicin / isoniazid or both. LPA & direct microscopy are a good screening method for early diagnosis and detection of drug resistance but are not a complete replacement of conventional culture which is still a gold standard.","PeriodicalId":14211,"journal":{"name":"International Journal of Research and Development in Pharmacy & Life Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75271793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1