International Journal of Research In Pharmaceutical Chemistry and Analysis最新文献_第2页

Synthesis, Characterize and Evaluation of anti-bacterial and anti-fungal activity of thiazines 噻嗪类化合物的合成、表征及抑菌活性评价

International Journal of Research In Pharmaceutical Chemistry and Analysis Pub Date : 2019-01-12 DOI: 10.33974/ijrpca.v1i1.26

Arsalan Sarmad, R. Sultana, B. Salman

引用次数: 2

Development and validation of new analytical method for the simultaneous estimation of ibuprofen and diphenhydramine in bulk and pharmaceutical dosage form by RP-HPLC 反相高效液相色谱法同时测定布洛芬和苯海拉明原料药和制剂含量的新方法的建立与验证

International Journal of Research In Pharmaceutical Chemistry and Analysis Pub Date : 2018-09-19 DOI: 10.33974/ijrpca.v1i1.16

Pavan Kumar, T. Supriya, B. Sivagami, R. Sireesha, R. C. Kumar, M. Babu

引用次数: 1

Stability indicating RP-HPLC method development and validation for the simultaneous estimation of Grazoprevir and Elbasvir in bulk and pharmaceutical dosage form 稳定性指示RP-HPLC方法的建立和验证，用于同时估计Grazoprevir和Elbasvir的散装和药物剂型

International Journal of Research In Pharmaceutical Chemistry and Analysis Pub Date : 2018-07-11 DOI: 10.33974/ijrpca.v1i1.4

V. P. Kumar, A. Kumar, B. Sivagami, R. C. Kumar, M. Babu

{"title":"Stability indicating RP-HPLC method development and validation for the simultaneous estimation of Grazoprevir and Elbasvir in bulk and pharmaceutical dosage form","authors":"V. P. Kumar, A. Kumar, B. Sivagami, R. C. Kumar, M. Babu","doi":"10.33974/ijrpca.v1i1.4","DOIUrl":"https://doi.org/10.33974/ijrpca.v1i1.4","url":null,"abstract":"A simple, Accurate and precise method was developed for the simultaneous estimation of the Grazoprevir and Elbasvir in Tablet dosage form. Chromatogram was run through Kromosil C18 (250 x 4.6 mm), 5m. Mobile phase containing Buffer: Acetonitrile taken in the ratio 45:55 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was Di Potassium Hydrogen ortho Phosphate. Temperature was maintained at 30°C. Optimized wavelength selected was 215 nm. Retention time of Elbasvir and Grazoprevir and were found to be 2.503 min and 3.004. %RSD of the Elbasvir and Grazoprevir were and found to be 0.3 and 0.4 respectively. %Recovery was obtained as 98.17% and 99.83% for Grazoprevir and Elbasvir respectively. LOD, LOQ values obtained from regression equations of Grazoprevir and Elbasvir were 0.24, 0.73 and 0.06, 0.19 respectively. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":14207,"journal":{"name":"International Journal of Research In Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76534217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Method development and method validation of guaifenesin and dextromethorphan by RP-HPLC 用反相高效液相色谱法建立愈创甘油醚和右美沙芬的方法及方法验证

International Journal of Research In Pharmaceutical Chemistry and Analysis Pub Date : 2018-06-30 DOI: 10.33974/ijrpca.v1i1.25

P. Salomi, D. Nayak, T. Vimalakannan, K. Reddy

{"title":"Method development and method validation of guaifenesin and dextromethorphan by RP-HPLC","authors":"P. Salomi, D. Nayak, T. Vimalakannan, K. Reddy","doi":"10.33974/ijrpca.v1i1.25","DOIUrl":"https://doi.org/10.33974/ijrpca.v1i1.25","url":null,"abstract":"A new, simple, precise, accurate and reproducible RP-HPLC method for Simultaneous estimation of bulk and pharmaceutical formulations. Separation of Guaifenesin and Dextromethorphan was successfully achieve THERMO, C18, 250X4.6mm, 5µm or equivalent in an isocratic mode utilizing 0.1M KH2PO4: Methanol (60:40) at a flow rate of 1.0ml/min and eluate was monitored at 280nm, with a retention time of 3.259 and 4.164 minutes for Guaifenesin and Dextromethorphan respectively. The method was validated and there response was found to be linear in the drug concentration range of 50µg/ml to150 µg/ml for Guaifenesin and 50µg/ml to150 µg/ml for Dextromethorphan. The values of the correlation coefficient were found to 0.999 for Guaifenesin and 1for Dextromethorphan. respectively. The LOD and LOQ for Guaifenesin were found to be 0.597 and 1.991 respectively. The LOD and LOQ for Dextromethorphan were found to be 0.1072 and 0.3572 respectively. This method was found to be good percentage recovery for were found to be 99 and 100 respectively indicates that the proposed method is highly accurate. The specificity of the method shows good correlation between retention times of standard with the sample so, the method specifically determines the analyte in the sample without interference from excipients of tablet dosage forms. The method was extensively validated according to ICH guidelines for Linearity, Accuracy, Precision, Specificity and Robustness.","PeriodicalId":14207,"journal":{"name":"International Journal of Research In Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78254919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RP-HPLC method development and validation for the estimation of antifungal drug terbinafine HCL in bulk and pharmaceutical dosage form 反相高效液相色谱法测定抗真菌药物特比萘芬HCL原料药和制剂剂型的含量及验证

International Journal of Research In Pharmaceutical Chemistry and Analysis Pub Date : 2018-06-30 DOI: 10.33974/ijrpca.v1i1.8

R. Sireesha, P Syam Vijayakar, V. P. Kumar, B. Sivagami, P. Sikdar, M. Babu

引用次数: 0