E. Eze, Okpa Precious Nwaka, Igbokwe Ugochukwu Vincent, M. Adams, K. M. Rabiu, Ayikobua Emmanuel Tiyo
{"title":"Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium-challenged rats","authors":"E. Eze, Okpa Precious Nwaka, Igbokwe Ugochukwu Vincent, M. Adams, K. M. Rabiu, Ayikobua Emmanuel Tiyo","doi":"10.5897/JPAP2018.0122","DOIUrl":"https://doi.org/10.5897/JPAP2018.0122","url":null,"abstract":"Cadmium produces a wide range of biological dysfunctions in human and laboratory animals where it chiefly affects the testes, whereas, Carpolobia lutea has been known to have antioxidant benefits. This study was intended to investigate the effects of Carpolobia lutea root extracts on testicular hormone function in cadmium-challenged male rats. 48 male Wistar rats (170-190 g) were divided into six groups, each containing eight rats. Experimental animals in control (Group 1) were given 0.2ml/kg body weight (BW) of 10% tween 80; Group two were administered 1mg/kg BW of cadmium (i.p); Group 3 were given 1mg/kg BW of cadmium (i.p) + 100mg/kg BW extract; Group four took 1mg/kg BW of cadmium (i.p) + 200mg/kg BW extract while Group five and six got 100mg/kg and 200mg/kg BW extract respectively. The administration of vehicle and extract was conducted orally for six weeks. Testicular activity of 17 beta-hydrosteroid dehydrogenase (17β-HSD) and serum testosterone, luteinizing and follicle stimulating hormone (LH, FSH) levels were evaluated. Findings indicated that cadmium statistically (p<0.05) lowered testicular 17β-HSD activity and serum testosterone, LH and FSH levels when compared with those of the control group animals. However, Carpolobia lutea and its co-administration notably (p<0.05) elevated the activity of testicular 17β-HSD and levels of serum testosterone, LH and FSH. The study suggests that Carpolobia lutea extract plays a protective function in ameliorating testicular damage caused by cadmium in rats. This is probably due to the extract’s potential in the management of testicular dysfunction and fecundity in animals. \u0000 \u0000 Key words: Carpolobia lutea, polygalaceae, cadmium, 17 beta-hydrosteroid dehydrogenase, testicular function.","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"2011 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86348181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oluwole Samuel Odeyemi, Mohammed Salman Toyin, Okon Umoh Idiongo, Abraham Taiwo Abayomi
{"title":"Plasma lactate, insulin concentration and intestinal glycogen deposition responses to fructose infusion in male dogs","authors":"Oluwole Samuel Odeyemi, Mohammed Salman Toyin, Okon Umoh Idiongo, Abraham Taiwo Abayomi","doi":"10.5897/JPAP2018.0119","DOIUrl":"https://doi.org/10.5897/JPAP2018.0119","url":null,"abstract":"Ingested carbohydrates digested to monosaccharides are absorbed directly into the bloodstream by the intestinal epithelial cells; recent research has shown intravenous infusion of fructose causes increase intestinal glucose uptake (IGU) and increase in blood glucose, however the fate of glucose has not been reported if it was metabolized or oxidized in the process. Ten fasted male anaesthetized adult dogs (Mongrel) were used for his experiment; the animals were divided into two groups (5 dogs per group). Control group received normal saline while the treatment group were infused with fructose (0.73 mg/kg/min). Through a midline laparotomy, the upper jejunum was cannulated for blood flow measurement and blood samples were obtained for measurement of glucose content of the arterial blood and venous blood from the upper jejunal segment. Mean intestinal glucose uptake (IGU) increased significantly from 38.86±2.44 (mg/dl) to 162.78±7.31 (mg/dl) in 30 min which was at peak uptake. Mean lactate concentration increased significantly from 66.45±2.02 (mg/dl) to 98.00±7.93 (mg/dl). However, there was a marginal increase in insulin concentration from 25.00±1.77 (mg/dl) to 27.25 (mg/dl) and no evidence of glycogen deposition in the small intestine. This study showed that intestinal glucose uptake increased in response to fructose infusion and probably the absorbed glucose after the infusion was converted to lactate with no trace of intestinal glycogen deposition.","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74386601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Reznikov, Sachyns'ka Ov, A. Limareva, O. Faliush, I. G. Perchik
{"title":"Hypersexual Behavior and Hyperandrogenism in F1 Male Rats Caused by Dibutyl Phthalate Treatment of Pregnant Females","authors":"A. Reznikov, Sachyns'ka Ov, A. Limareva, O. Faliush, I. G. Perchik","doi":"10.1615/INTJPHYSPATHOPHYS.V9.I3.20","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V9.I3.20","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"34 1","pages":"203-212"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78422740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Magnetic Field on Blood Oxygen Transport Function during a Hydrogen Sulfide Donor Introduction","authors":"V. Zinchuk, V. Lepeev","doi":"10.1615/intjphyspathophys.v9.i2.80","DOIUrl":"https://doi.org/10.1615/intjphyspathophys.v9.i2.80","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"34 1","pages":"161-168"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78336138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Strutynskyi, R. A. Rovenets, Oleg V. Svarychevskyi, V. Dosenko
{"title":"Incidence of Allelic Polymorphisms of Genes Encoding Subunits ATP-Sensitive Potassium Channels (Ile 337 →Val and Glu 23 →Lys KCNJ11 Gene, and Ser 1369 →Ala ABCC8 Gene) in the Ukrainian Population","authors":"R. Strutynskyi, R. A. Rovenets, Oleg V. Svarychevskyi, V. Dosenko","doi":"10.1615/INTJPHYSPATHOPHYS.V9.I1.80","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V9.I1.80","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"70 1","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86207606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Goryachyi, Yu. G. Karpenko, E. Levchenko, A. Gozhenko
{"title":"Predictors of Left Ventricular Myocardial Structural Remodeling in Patients with Atrial Fibrillation","authors":"A. Goryachyi, Yu. G. Karpenko, E. Levchenko, A. Gozhenko","doi":"10.1615/INTJPHYSPATHOPHYS.V9.I3.50","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V9.I3.50","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"201 1","pages":"229-238"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89014016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EEG Patterns of Differentiation of Visual Stimuli under Auditory Deprivation","authors":"L. Yukhymenko, M. Makarchuk, V. Lyzogub","doi":"10.1615/INTJPHYSPATHOPHYS.V9.I3.80","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V9.I3.80","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"43 1","pages":"257-263"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84629917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Germanium Citrate on Immunophysiological Activity of the Rats' Organism","authors":"R. Fedoruk, M. Khrabko, Olga P. Dolaychuk","doi":"10.1615/INTJPHYSPATHOPHYS.V9.I1.30","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V9.I1.30","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"32 1","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74824914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Iegorova, O. Maximyuk, O. Fisyunov, O. Krishtal
{"title":"Voltage-Gated Calcium Channels: Classification and Pharmacological Properties","authors":"O. Iegorova, O. Maximyuk, O. Fisyunov, O. Krishtal","doi":"10.1615/INTJPHYSPATHOPHYS.V9.I1.100","DOIUrl":"https://doi.org/10.1615/INTJPHYSPATHOPHYS.V9.I1.100","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"28 1","pages":"85-97"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84916708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modulation of Puberty Terms and Sexual Behavior of Rats after Prenatal Exposure to Methyldopa, Phenibut, and Stress","authors":"A. Reznikov, A. Limareva","doi":"10.1615/intjphyspathophys.v9.i1.40","DOIUrl":"https://doi.org/10.1615/intjphyspathophys.v9.i1.40","url":null,"abstract":"","PeriodicalId":14192,"journal":{"name":"International Journal of Physiology and Pathophysiology","volume":"23 1","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84998291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}