International journal of oncology最新文献_第2页

[Expression of Concern] MicroRNA‑195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways. 【表达关注】MicroRNA‑195靶向VEGFR2，通过PI3K/Akt和Raf/MEK/ERK信号通路在ACHN细胞中具有肿瘤抑制作用。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-11-01 Epub Date: 2025-08-24 DOI: 10.3892/ijo.2025.5792

Pengcheng Sun, Lu Wang, Yunhan Lu, Yuwei Liu, Lechen Li, Luyao Yin, Cheng Zhang, Weiming Zhao, Baozhong Shen, Wanhai Xu

{"title":"[Expression of Concern] MicroRNA‑195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways.","authors":"Pengcheng Sun, Lu Wang, Yunhan Lu, Yuwei Liu, Lechen Li, Luyao Yin, Cheng Zhang, Weiming Zhao, Baozhong Shen, Wanhai Xu","doi":"10.3892/ijo.2025.5792","DOIUrl":"10.3892/ijo.2025.5792","url":null,"abstract":"Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the Transwell migration and invasion assay data shown in Fig. 3A and B, two pairs of panels appeared to contain overlapping sections of data (out of a total of ten panels), such that data which were intended to show the results from differently performed experiments appeared to have been derived from the same original sources. Upon analyzing the data independently in the Editorial Office, a third pair of data panels in the same figure were found to be similarly affected. The authors were contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in this paper, although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office conitnues to investigate this matter further. [International Journal of Oncology 49: 1155‑1163, 2016; DOI: 10.3892/ijo.2016.3608].","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Corrigendum] Lithium chloride induces mesenchymal‑to‑epithelial reverting transition in primary colon cancer cell cultures. [勘误]氯化锂诱导原发性结肠癌细胞培养中间充质向上皮的转化。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-11-01 Epub Date: 2025-09-12 DOI: 10.3892/ijo.2025.5800

Valeria Costabile, Francesca Duraturo, Paolo Delrio, Daniela Rega, Ugo Pace, Raffaella Liccardo, Giovanni Battista Rossi, Rita Genesio, Lucio Nitsch, Paola Izzo, Marina De Rosa

{"title":"[Corrigendum] Lithium chloride induces mesenchymal‑to‑epithelial reverting transition in primary colon cancer cell cultures.","authors":"Valeria Costabile, Francesca Duraturo, Paolo Delrio, Daniela Rega, Ugo Pace, Raffaella Liccardo, Giovanni Battista Rossi, Rita Genesio, Lucio Nitsch, Paola Izzo, Marina De Rosa","doi":"10.3892/ijo.2025.5800","DOIUrl":"10.3892/ijo.2025.5800","url":null,"abstract":"Following the publication of the above article, an interested reader drew the authors' attention to the fact that the CTK18 panel in Fig. 2E on p. 1917, showing the results of RT‑PCR analysis of cytokeratin 18 from patient no. 88, appeared to be very similar to the CTK18 panel in Fig. 2F (showing the results from patient no. 93). After having re‑examined their original data, which were also presented to the Editorial Office, and considering that the observed experiment is an end-point RT-PCR performed more than ten years ago, the authors cannot definitively rule out the possibility that Fig. 2E was inadvertently misassembled. Therefore, given the high similarity of the two images, it was decided to publish a revised version of Fig. 2, which now shows data from a different replicate of the experiment for the CTK18 panel in Fig. 2E, shown on the next page. Note that this revision did not affect the overall conclusions reported in the study. The authors are grateful to the Editor of International Journal of Oncology for allowing them this opportunity to publish a Corrigendum, and all the authors agree with its publication. Furthermore, the authors apologize to the readership for any inconvenience caused. [International Journal of Oncology 46: 1913‑1923, 2015; DOI: 10.3892/ijo.2015.2911].","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cooperation between ZEB2 and SP1 upregulates PD‑L1 and CCL2 to promote the immunosuppressive activity of tumor cells. ZEB2和SP1协同上调PD‑L1和CCL2，促进肿瘤细胞的免疫抑制活性。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-11-01 Epub Date: 2025-09-19 DOI: 10.3892/ijo.2025.5801

Dongjoon Ko, Yunhee Lee, Junghwa Yoon, Eun Kyoung Choi, Donghwan Jang, Semi Kim

{"title":"Cooperation between ZEB2 and SP1 upregulates PD‑L1 and CCL2 to promote the immunosuppressive activity of tumor cells.","authors":"Dongjoon Ko, Yunhee Lee, Junghwa Yoon, Eun Kyoung Choi, Donghwan Jang, Semi Kim","doi":"10.3892/ijo.2025.5801","DOIUrl":"10.3892/ijo.2025.5801","url":null,"abstract":"Epithelial‑mesenchymal transition (EMT) is implicated in tumor progression and EMT‑inducing transcription factors play multifaceted roles; however, the molecular mechanisms underlying these processes are not well understood. Previously, we showed that ZEB2 acts cooperatively with the transcription factor SP1 to function as a transcriptional activator that promotes cancer cell invasion and survival, as well as angiogenesis. The present study reported a novel role for Zinc Finger E‑Box Binding Homeobox 2 (ZEB2) in conferring immunosuppressive activity on cancer cells, as well as the underlying molecular mechanism. ZEB2 cooperated with SP1 to upregulate transcription of CD274 and CCL2 by interacting with the proximal SP1 element in their promoters. ZEB2‑mediated programmed cell death 1 ligand 1 (PD‑L1) upregulation on tumor cells inhibited T cell activation and cytokine secretion in a co‑culture system. ZEB2 upregulated C‑C motif chemokine ligand 2 (CCL2) secretion to promote migration of macrophages and drive polarization to an M2‑like phenotype. ZEB2 suppressed the activity of tumor‑infiltrating T cells in a syngeneic mouse tumor model. Furthermore, SUMOylation of ZEB2 by PC2 was required for efficient cooperation between ZEB2 and SP1, as well as for subsequent gene expression. Clinical data showed that ZEB2 expression is associated positively with expression of CD274 and CCL2. Expression of both ZEB2 and CD274 or CBX4 has prognostic significance for predicting survival of colon cancer patients. The present study demonstrated a previously unrecognized role for ZEB2: Direct modulation of the interaction between tumor cells and immune cells. Taken together, the data increased our understanding of the molecular mechanism underlying immunosuppression mediated by an EMT‑inducing transcription factor.","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Expression of Concern] 4‑Hydroxybutenolide impairs cell migration, and invasion of human oral cancer SCC‑4 cells via the inhibition of NF‑κB and MAPK signaling pathways. [关注表达]4‑羟基丁烯内酯通过抑制NF‑κB和MAPK信号通路，损害细胞迁移和侵袭人口腔癌SCC‑4细胞。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-11-01 Epub Date: 2025-08-29 DOI: 10.3892/ijo.2025.5795

Fu-Shun Yu, Meng-Liang Lin, Shu-Chun Hsu, Chien-Chih Yu, Yi-Ping Huang, Yueh-Hsiung Kuo, Jing-Gung Chung

{"title":"[Expression of Concern] 4‑Hydroxybutenolide impairs cell migration, and invasion of human oral cancer SCC‑4 cells via the inhibition of NF‑κB and MAPK signaling pathways.","authors":"Fu-Shun Yu, Meng-Liang Lin, Shu-Chun Hsu, Chien-Chih Yu, Yi-Ping Huang, Yueh-Hsiung Kuo, Jing-Gung Chung","doi":"10.3892/ijo.2025.5795","DOIUrl":"10.3892/ijo.2025.5795","url":null,"abstract":"Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, for the Transwell assay data shown in Fig. 2C on p. 582, the '24 h/1 µM' and '24 h/2.5 µM' data panels contained an overlapping section of cellular data; in addition, the '24 h/Control' and '48 h/Control' panels in Fig. 2E similarly contained an overlapping section of data, such that data which were intended to show the results from differently performed experiments appeared to have been derived from the same original sources. Upon analyzing the data independently in the Editorial Office, it came to light that the '0 h/1 µM' and '12 h/2.5 µM' data panels in Fig. 2A (showing the results of scratch‑wound assay experiments) also contained an overlapping area, albeit the 12 h/2.5 µM' data panel had been rotated through 180° relative to the '0 h/1 µM' panel. The authors were contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in this paper, although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office conitnues to investigate this matter further. [International Journal of Oncology 49: 579‑588, 2016; DOI: 10.3892/ijo.2016.3537].","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Notch3 mediated TGF‑β1 activation enhances epithelial‑mesenchymal transition and cancer stemness in non‑small lung cancer. Notch3介导的TGF - β1激活增强非小细胞肺癌的上皮-间质转化和癌变。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-10-01 Epub Date: 2025-08-24 DOI: 10.3892/ijo.2025.5791

Fang Wang, Siqi Hu, Jiangrong Bian, Qing Gao, Liuzhao Cao, Linli Sang, Junjun Yang, Xingxiang Xu

{"title":"Notch3 mediated TGF‑β1 activation enhances epithelial‑mesenchymal transition and cancer stemness in non‑small lung cancer.","authors":"Fang Wang, Siqi Hu, Jiangrong Bian, Qing Gao, Liuzhao Cao, Linli Sang, Junjun Yang, Xingxiang Xu","doi":"10.3892/ijo.2025.5791","DOIUrl":"https://doi.org/10.3892/ijo.2025.5791","url":null,"abstract":"Notch3 is a key regulator in various cancers, playing a crucial role in maintaining stemness and promoting epithelial‑mesenchymal transition (EMT). However, its differential expression and regulatory mechanisms in non‑small cell lung cancer (NSCLC) and cancer stem cells remain poorly understood. To investigate this, the present study examined Notch3 expression in NSCLC through Oncomine, The Cancer Genome Atlas and Gene Expression Omnibus databases and validated the results with immunohistochemistry, reverse transcription‑quantitative PCR and western blotting. EMT was induced by TGF‑β1 in NSCLC cells and functional assays (Transwell, wound healing and sphere formation) were performed to assess cellular changes. In vivo experiments using a xenograft mouse model were conducted to evaluate tumor growth and metastasis. The results showed that high Notch3 expression was associated with poor prognosis in NSCLC patients. Downregulation of Notch3 inhibited TGF‑β1‑induced EMT and CSC characteristics, resulting in reduced tumorigenic potential, whereas overexpression of the Notch3 intracellular domain enhanced these effects. Silencing Notch3 suppressed EMT and markedly inhibited tumor growth and metastasis in vivo. These findings demonstrated that Notch3 regulated EMT and CSC properties in NSCLC, promoting tumor recurrence and metastasis. Notch3 thus represents a promising therapeutic target and prognostic marker for NSCLC.","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 4","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Expression of Concern] ETS‑1: A potential target of glycolysis for metabolic therapy by regulating glucose metabolism in pancreatic cancer. [关注表达]ETS‑1：糖酵解通过调节胰腺癌的糖代谢来进行代谢治疗的潜在靶点。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-10-01 Epub Date: 2025-08-14 DOI: 10.3892/ijo.2025.5786

Xiu Zhang, Dan Wu, Mohanad Aldarouish, Xiaodong Yin, Chunyan Li, Cailian Wang

引用次数: 0

Functional mechanisms of circular RNA‑encoded peptides and future research strategies and directions in nasopharyngeal carcinoma (Review). 环状RNA编码肽在鼻咽癌中的作用机制及未来研究策略和方向（综述）。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-10-01 Epub Date: 2025-08-24 DOI: 10.3892/ijo.2025.5788

Weihua Xu, Zhichao Ma, Wei Gong, Shengmiao Fu, Xinping Chen

{"title":"Functional mechanisms of circular RNA‑encoded peptides and future research strategies and directions in nasopharyngeal carcinoma (Review).","authors":"Weihua Xu, Zhichao Ma, Wei Gong, Shengmiao Fu, Xinping Chen","doi":"10.3892/ijo.2025.5788","DOIUrl":"https://doi.org/10.3892/ijo.2025.5788","url":null,"abstract":"Nasopharyngeal carcinoma (NPC) is an epithelial malignancy closely associated with Epstein‑Barr virus (EBV) infection. Although patients with early‑stage NPC can achieve a high cure rate through radiotherapy, recurrence and distant metastasis remain the primary causes of treatment failure in patients with advanced‑stage NPC. Circular RNA (circRNA) is a class of covalently closed non‑coding RNAs involved in multiple aspects of tumor biology. Recent evidence has shown that certain circRNAs can encode functional peptides, which participate in the regulation of tumor‑related signaling pathways. In NPC, circRNAs have been implicated in the modulation of signaling pathways, including NF‑κB and JAK/STAT, both of which are activated in the EBV‑infected microenvironment. Furthermore, frequently mutated genes in NPC, such as TNF receptor‑associated factor 3 and cylindromatosis lysine 63 deubiquitinase, are known regulators of the NF‑κB pathway, suggesting a potential link between genetic alterations and circRNA‑related mechanisms. This article systematically reviews the biological mechanisms of circRNA‑encoded peptides, summarizes the expression and function of circRNA in NPC and focuses on discussing the potential roles of circRNA‑encoded peptides in tumor microenvironment regulation, immune escape and clinical application prospects. By integrating existing research results, this article aims to provide a new perspective and theoretical basis for the in‑depth exploration of circRNA‑encoded peptides in the field of NPC.","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 4","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer‑associated fibroblasts in human malignancies, with a particular emphasis on sarcomas (Review). 人类恶性肿瘤中与癌症相关的成纤维细胞，尤其是肉瘤（综述）。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.3892/ijo.2025.5785

Iva Benesova, Katerina Kalkusova, Yea Seo Kwon, Pavla Taborska, Dmitry Stakheev, Katerina Krausova, Jitka Smetanova, Andrej Ozaniak, Jirina Bartunkova, Daniel Smrž, Zuzana Ozaniak Strizova

{"title":"Cancer‑associated fibroblasts in human malignancies, with a particular emphasis on sarcomas (Review).","authors":"Iva Benesova, Katerina Kalkusova, Yea Seo Kwon, Pavla Taborska, Dmitry Stakheev, Katerina Krausova, Jitka Smetanova, Andrej Ozaniak, Jirina Bartunkova, Daniel Smrž, Zuzana Ozaniak Strizova","doi":"10.3892/ijo.2025.5785","DOIUrl":"10.3892/ijo.2025.5785","url":null,"abstract":"Over the course of the last 10 years, clinical oncology has seen significant changes. Although there has been much interest in targeting cancer cells with immunotherapy, the initial enthusiasm has waned as clinical trial results have not met the initial expectations, especially for solid tumors. As a result, research efforts are now shifting towards the study of other cells in the tumor microenvironment. Cancer‑associated fibroblasts (CAFs) are one of the main adversarial cell types that help cancer cells to resist oncological treatment. However, although CAFs have been extensively studied in different types of carcinomas, their role in sarcomas remains poorly understood. Despite this topic being of especial importance, to the best of the authors' knowledge, no literature review currently addresses and summarizes the up‑to‑date knowledge on the role of CAFs in sarcomas. The present review article aimed to address this literature gap by summarizing our current understanding of CAFs in carcinomas and integrating this information with what is currently known about CAFs in sarcomas. The review also suggested novel approaches for targeting CAFs, and outlines new avenues for identifying novel therapeutic targets, which may markedly impact future research in this field.","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 4","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling tumor cell‑tumor microenvironment crosstalk through antibody array technologies (Review). 通过抗体阵列技术揭示肿瘤细胞-肿瘤微环境串扰（综述）。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-10-01 Epub Date: 2025-08-24 DOI: 10.3892/ijo.2025.5787

Yanlin Wang, Shuhong Luo, Hua Dong, Ruo-Pan Huang

{"title":"Unraveling tumor cell‑tumor microenvironment crosstalk through antibody array technologies (Review).","authors":"Yanlin Wang, Shuhong Luo, Hua Dong, Ruo-Pan Huang","doi":"10.3892/ijo.2025.5787","DOIUrl":"https://doi.org/10.3892/ijo.2025.5787","url":null,"abstract":"The tumor microenvironment (TME) consists of tumor cells, stromal cells, infiltrating immune cells and non‑cellular components such as extracellular matrix, blood vessels and a wide variety of secreted proteins. Evidence shows that beyond supporting tumor growth, the TME also promotes tumor cell proliferation and invasion and contributes to treatment resistance, ultimately affecting patient prognosis. Cell‑to‑cell communication within the TME is driven by secreted proteins such as cytokines, chemokines, growth factors and interferons, which are produced not only by tumor cells but also by various stromal cells and immune cells. These proteins form a complex signaling network that promotes tumor cell proliferation and invasion and enables tumors to evade innate and adaptive immune responses. Antibody arrays are a technology that can simultaneously screen hundreds of secreted proteins in complex biological samples, aiding in the exploration of this complex signaling network. By combining high‑throughput multiplex immunoassays such as antibody arrays with cellular and molecular biology techniques, researchers have uncovered complex regulatory mechanisms of cytokine networks within the TME. The present review summarized recent findings on the communication between tumor cells and the TME, as well as key secreted proteins essential for tumor progression and the development of therapeutic resistance. In addition, it discusses how high‑throughput antibody arrays contribute to our understanding of regulatory networks of secreted proteins in the TME.","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 4","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle‑based delivery systems for targeted therapy in brain tumors: Progress, challenges and perspectives (Review). 基于纳米颗粒的脑肿瘤靶向治疗递送系统：进展、挑战和前景（综述）。

IF 4.9 3区医学

International journal of oncology Pub Date : 2025-10-01 Epub Date: 2025-08-24 DOI: 10.3892/ijo.2025.5789

Jing-Xing Si, Zheng-Chuang Liu, Fang Gu, Xiaoli Jin, Ying-Yu Ma

{"title":"Nanoparticle‑based delivery systems for targeted therapy in brain tumors: Progress, challenges and perspectives (Review).","authors":"Jing-Xing Si, Zheng-Chuang Liu, Fang Gu, Xiaoli Jin, Ying-Yu Ma","doi":"10.3892/ijo.2025.5789","DOIUrl":"https://doi.org/10.3892/ijo.2025.5789","url":null,"abstract":"Brain tumors, particularly gliomas, are among the most lethal malignancies, with high mortality driven by a delayed diagnosis and limited therapeutic efficacy. A central challenge lies in the presence of the blood‑brain barrier (BBB), which severely impedes the delivery of systemically administered therapeutics to tumor sites. Addressing this clinical urgency, nanoparticle (NP)‑based delivery systems have emerged as a transformative strategy to enhance brain‑specific drug accumulation, minimize off‑target toxicity and improve treatment outcomes. The present review systematically examined the recent advances in nanocarrier technologies for targeted brain tumor therapy, including liposomes, solid lipid NPs, dendrimers, polymeric nanoplatforms and inorganic nanomaterials. The design principles, mechanisms for BBB traversal, therapeutic payload compatibility and tumor‑targeting capabilities of NP technologies demonstrated in preclinical models have also been highlighted. In addition to drug delivery, emerging applications of nanocarriers in gene therapy were explored and the impact of protein corona formation on NP behavior in vivo was discussed. Finally, current translational bottlenecks were identified and future design considerations to achieve clinically viable, precision‑targeted nanomedicines for brain tumors were outlined.","PeriodicalId":14175,"journal":{"name":"International journal of oncology","volume":"67 4","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0