International Journal of Medical and Biomedical Studies最新文献

{"title":"Evaluation of Antibacterial Effect of Obturating Material and Different Sealers on the Expression of Enterococcus Faecalis","authors":"Dr. Vandana James, D. Balagopal, Dr. C Charanya, Dr. S. T. Gowtham, D. A. Sebatni","doi":"10.32553/ijmbs.v6i12.2648","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i12.2648","url":null,"abstract":"no abstract","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78894171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Fluids and Electrolyte Management in Sepsis","authors":"Rakesh Kumar, E. Ramanan, Irene Rose Antony","doi":"10.32553/ijmbs.v6i12.2633","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i12.2633","url":null,"abstract":"Sepsis condition can cause life-threatening complications including organ dysfunction, circulatory failure, or mortality. Electrolyte abnormalities, including hyperkalaemia, hyponatremia, hypophosphatemia, and hypocalcaemia, have been observed in the later stages of sepsis due to cellular damage or ion channel dysfunction. Fluid resuscitation has been suggested as the common intervention to improve the patient’s condition when in septic shock. Fluids can help in an enhanced distribution of both intravascular and extravascular compartments, thereby increasing cardiac output. Timely fluid administration has shown improved survival rates with fewer severe microcirculatory alterations and mitochondrial dysfunctions. Fluid and electrolyte management is an effective strategy for treating sepsis but certain factors including timing, dosage, type of fluid and the health status of the individual needs to be carefully considered. Early intervention therapy seems to be effective in individuals with sepsis and has minimized the requirement for additional fluid administration. Certain aspects of fluid management including the future potentiality of dynamic fluid responsiveness and the role of albumin administration in sepsis treatment still need to be clarified. This review focuses on the updated management strategies that can be used for fluid and electrolyte management in individuals with sepsis.\u0000Keywords: Sepsis; Fluid resuscitation; electrolyte replacement therapy; albumin; intravenous therapy; septic shock\u0000Highlights\u0000\u0000In patients with sepsis, fluid resuscitation has been an effective intervention and earlier administration of therapy has minimized the need for additional fluid administration.\u0000\u0000Future research lends scope for improvement and advancements in electrolyte replacement therapy, effects of resuscitation, the effectiveness of fluid responsiveness and role of albumin in fluid management.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85030894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Iron Deficiency Anemia and Febrile Convulsions in Paediatric Patients: A Prospective Case Control Study","authors":"Dr. Shaik Mohammed Owaiz, Dr. Subiya Tarannum, Dr. K. Devaraj","doi":"10.32553/ijmbs.v7i1.2646","DOIUrl":"https://doi.org/10.32553/ijmbs.v7i1.2646","url":null,"abstract":"Background: Febrile seizure is among the most common convulsion disorders in children, in the first five years of life. \u0000 \u0000It affects about 2% to 5% of all children between 6 to 60 months of age; coinciding with the peak age of incidence of Iron deficiency anemia. \u0000Some of the recent studies have reported that iron deficiency could be a risk factor for febrile seizure because febrile seizure is more common in children under two years and iron deficiency anemia is also common in children of the same age. \u0000Due to the presence of iron in the hemoglobin structure, it plays a crucial role in the transport of oxygen to different tissues such as the brain. \u0000Iron deficiency reduces the metabolism of some neurotransmitters. \u0000 \u0000Aims & Objectives: This study aims to determine the association between iron status and febrile seizures in children aged 6 months to 60 months of age. \u0000Material & Methods: In this prospective case-control study, we evaluated 50 children aged 6 to 60months in two 25 persons group. \u0000 \u0000Cases consisted of 25 children with diagnosis of febrile seizures and controls group consisted of 25 children with febrile illness without convulsions, who were admitted at the Paediatric Intensive Care Unit and Paediatric wards at Shadan Institute of Medical Sciences, Hyderabad from November 2020 to April 2022. \u0000Both groups were reviewed to determine the iron status using Hemoglobin concentration, Mean corpuscular volume, Mean corpuscular hemoglobin, serum ferritin, serum iron, TIBC and serum transferrin to make the diagnosis of Iron deficiency anemia. \u0000 \u0000Results: The 2 groups were compared and no significant difference was found with regards to age, gender and disease causing the febrile illness. \u0000 \u0000Iron deficiency anemia was found in 48% (12 children) of the cases and 20% (5 children) of the controls group. \u0000This indicates a statistically significant association between iron deficiency anemia and febrile seizures. \u0000 \u0000Conclusion: Iron deficiency anemia is more frequent among children with febrile seizures than with febrile illness alone.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78998768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Prevalence of Cleft Palate Patients in RSUP dr. Hasan Sadikin Bandung, Indonesia: 3 Years Retrospective Study","authors":"Nurul Rizqina, Farah Asnely Putri, S. Adiantoro","doi":"10.32553/ijmbs.v6i12.2638","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i12.2638","url":null,"abstract":"Introduction: Cleft lip and palate are the most common congenital malformation affecting the head and neck and the second most common congenital abnormalities in general. This study aimed to determine the characteristics and prevalence of cleft palate in the RSUP dr. Hasan Sadikin Bandung. Method: This retrospective study evaluated 79 patients diagnosed with cleft palate and underwent palatoplasty in RSUP dr. Hasan Sadikin Bandung between September 2018 and September 2021. The extracted data included based on characteristics of age, gender, type classification according to Veau, family history with cleft lip/palate, domicile of origin, and other accompanying syndromes. Incomplete medical record was excluded. Result: 79 patients were included in this study with 53% male, under 2 years old 62%. 76 patients (96,2%) were nonsyndromic cleft palate with Veau type III were the most common diagnosis 38%. No familial history in most patients (93%). Majority patients came from Bandung City (29,11%). Conclusion: In our study cleft palate involving lip unilateral was the most cleft type. These findings may provide references for understanding the characteristics of cleft palate in RSUP dr. Hasan Sadikin Bandung, Indonesia. \u0000 ","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"519 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77191215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vildagliptin Induced Bullous Pemphigoid in a Diabetic Patient","authors":"Dr Syed Asif, Dr. M. A. Sameer, Dr Basvaraj Puranik","doi":"10.32553/ijmbs.v6i12.2636","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i12.2636","url":null,"abstract":"Bullous pemphigoid is a polymorphic immunobullous disorder that occurs more commonly in the elderly and can be drug induced 1,2 rarely, lesions are induced by ultraviolet light or radiation therapy.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83455420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Techniques and Applications of Gastroretentive Drug Delivery System","authors":"Hrishabh Sharma, Ashutosh Sharma, Dr. Mayank Bansal, Dr. Rakesh Kumar Gupta","doi":"10.32553/ijmbs.v6i12.2632","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i12.2632","url":null,"abstract":"A Controlled release dose forms have been widely utilized to enhance treatment with a number of significant medications. However, a number of physiological challenges, including the inability to control and localize the system within the target region of the gastrointestinal tract and the extremely changeable nature of the gastric emptying process, pose challenges to the development processes. The bioavailability and periods needed to reach peak plasma levels may be unpredictable as a result of this diversity. The goal of this review on gastro retentive drug delivery systems was to gather the most recent research with a special emphasis on the numerous gastro retentive technologies that have lately emerged as leading approaches in the area of site-specific oral controlled release drug delivery. We have included crucial elements in order to comprehend numerous physiological challenges to achieve stomach retention.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"151 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75685048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Injectable Platelet Rich Fibrin (I-PRF) with DFDBA and Titatium Prepared Platelet Rich Fibrin (T-PRF) with DFDBA In The Treatment of Infrabony Defects In Chronic Periodontitis Patients - A Clinico-Radiographical Study","authors":"Bushra Shams, P. Kataria, P. Sukla, Mona Dagar","doi":"10.32553/ijmbs.v6i11.2630","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i11.2630","url":null,"abstract":"Objectives: The main objective of this study was to evaluate the efficacy of Titanium prepared platelet-rich Fibrin (T-PRF)  and Injectable Platelet Rich Fibrin (I-PRF) with demineralized freeze-dried bone allograft (DFDBA) in order to improve the clinical and radiographic results obtained in treatment of periodontal infrabony defects. \u0000Materials and Methods: This  split-mouth randomized controlled clinical trial was conducted on 30 subjects with two comparable bilateral infrabony defects. Plaque Index(PI), Gingival Index(GI) Clinical attachment level (CAL), Periodontal Pocket depth (PD), as well as radiographic parameters IOPA including the radiographic defect size,  were measured at six months post-operatively. \u0000Results: The mean reductions in PD and CAL were 4.0±0.77 mm and 2.5±0.68 mm in sites treated with I-PRF+DFDBA, respectively (P<0.05); these reductions were 4.2±0.86 mm and 3.1±0.62 mm, respectively in T-PRF+DFDBA group (P<0.05). Radiographic evaluation revealed reduction in the radiographic defect size in the I-PRF+DFDBA and T-PRF+DFDBA sites. Statistically, there were no significant differences between the two treatment modalities.? \u0000Conclusion: This study showed that both treatments resulted in significant improvement in the probing depth reduction, clinical attachment level gain and radiographic size of the infrabony defect at six months after surgery. I-PRF with DFDBA membrane in treatment of infrabony osseous defect showed more defect fill followed by T- PRF along with DFDBA membrane.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86866187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of maxillary fractures at Hasan Sadikin Hospital Bandung between 2015 and 2020","authors":"Fauzan Akmal, A. Nurwiadh, Winarno Priyanto","doi":"10.32553/ijmbs.v6i11.2627","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i11.2627","url":null,"abstract":"AbstractIntroduction: Maxillofacial trauma includes injuries to the lower, middle, or upper thirds of the face and oral cavity. As these fractures have the potential to cause morbidity and even mortality, they require careful examination and management based on their severity. This study aimed to provide information regarding the number and types of maxillary fracture cases at Hasan Sadikin General Hospital, Bandung. Methods: The design of this study was a descriptive study. Patients diagnosed with unilateral maxillary fractures, palatal fractures, Le Fort I fractures, Le Fort II fractures, and Le Fort III fractures admitted to Hasan Sadikin Hospital, Bandung, from January 2015 - December 2020, were included. Patients with incomplete medical records were excluded from this study.Results: This study found 157 maxillary fracture patients out of 1221 maxillofacial trauma patients treated at the Oral and Maxillofacial Surgery Department of Hasan Sadikin General Hospital between January 2015 and December 2020. Male patients had a more significant number of cases (87.26%). The ages 11 to 20 years had the highest incidence of maxillary fractures (29.29%). Maxillary fractures accompanied by palatal fractures were the most prevalent, followed by Le Fort II fractures and unilateral maxillary fractures (28.66%, 21.01%, and 11.46%, respectively). About 42.67% of patients who experienced maxillary trauma also sustained mild head injuries. The most frequent mechanism of injury was motor vehicle accidents (95.54%).Conclusion: This study reported the prevalence of maxillary fractures at Dr. Hasan Sadikin Bandung between 2015 and 2020 based on fracture types, sex, age groups, head injuries, and mechanism of injury. Future study is required to measure the force, direction, impact mechanism, use of helmets, and types of helmets to prevent maxillofacial trauma. \u0000Keyword : Maxillary fracture, le fort I, le fort II, palatal fracture","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77419570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Sida Veronicaefolia against RIF+INH Induce Hepatotoxicity in Experimental Animals","authors":"Vidhi Jain, Ajay Kumar, Shilpi Mishra, Manmeet Singh Saluja","doi":"10.32553/ijmbs.v6i11.2628","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i11.2628","url":null,"abstract":"In the current research, rats will be given RIF+INH (hepatotoxic), and the hydoethanol (HEESV) extract of the leaves of Sida veronicaefolia will be tested to see how well it protects the rats' livers from damage caused by the RIF+INH. Liver function tests and serum profiles were used to provide an estimate of the hepatoprotective effects of HEESV at a dose of 500 mg/kg. According to the findings, the extracts of Sida veronicaefolia not only provide a strong hepatoprotective impact by lowering blood levels of serum transaminases (SGPT and SGOT), alkaline phosphate, and total bilirubin, but they also considerably enhance the levels of total protein. The effects of HEESV were quite similar to those of the standard medication silymarin.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89683695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Hepatoprotective Activity of Aqueous Extract of Nyctanthes Arbortristis Bark against Paracetamol-Induced Liver Damage","authors":"Ajay Mahaputra Kumar, Dr. Manmeet Singh Saluja, Shilpi Mishra, A. Pandey","doi":"10.32553/ijmbs.v6i11.2621","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i11.2621","url":null,"abstract":"Herbal drugs aimed to determine the hepatoprotective activity of aqueous extract of Nyctanthes arbortristis bark (AQENA) against paracetamol-induced liver damage (PILD) in rat models. Four groups of rats (n=6) were givens one daily administration of 1gm/kg (negative control), 25mg/kg silymarin (positive control) and AQENA (500mg/kg) for 7 days fallowed by induction of hepatotoxicity using of paracetamol. Various parameters, such as physical parameters, biochemical parameters and microscopic analysis ware used to evaluate the hepatoprotective activity. Results indicate that bark extract would a significant (p<0.05) hepatoprotective activity against inducers. These observations were supported by the histological finding. Conclusions: Findings indicate that AQENA possesses a potent hepatoprotective activity against paracetamol.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90432022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}