International Journal of Medical and Biomedical Studies最新文献_第10页

In Silico Phytochemicals Screening for Tuberculosis 肺结核的植物化学物筛选

International Journal of Medical and Biomedical Studies Pub Date : 2022-08-06 DOI: 10.32553/ijmbs.v6i7.2587

Krati Solanki, Radhika.B. S, Rida Fatimah

{"title":"In Silico Phytochemicals Screening for Tuberculosis","authors":"Krati Solanki, Radhika.B. S, Rida Fatimah","doi":"10.32553/ijmbs.v6i7.2587","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i7.2587","url":null,"abstract":"\u0000 \u0000Tuberculosis (TB) is a highly contagious disease, and the increased mortality rate continues to be a cause for concern. Although anti-tuberculosis drugs are available, it still affects mankind, causing millions of deaths each year. By integrating biological data on gene sequences, gene expressions, protein structures, and drug target prioritization. The number of cheminformatics databases for small molecules and tools to assist drug discovery has also grown. Many researchers are investigating potential medication therapies that could assist in this battle along with the medical care system throughout the world. We present a docking?based screening using a quantum mechanical scoring of a library built from approved drugs and compounds that Bergenin, Laccaic acid, Swertiamarin, Magnolol, Curcumin, Emodin, Pasakbumin A, Umckalin, Plumbagin, Maritinone, Tetrahydro3,3?-biplumbagin and epigallocatechin with Proteins with PDB id’s 4W4I, 3Q0V could display antiviral activity against Tuberculosis. Ideally, these compounds should undergo experimental assays and clinical trials to verify their effectiveness against the disease. We hope that these findings may contribute to the rational drug design against Tuberculosis. \u0000 \u0000","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75783244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Phytochemical Screening for Hantavirus 汉坦病毒的硅片植物化学筛选

International Journal of Medical and Biomedical Studies Pub Date : 2022-08-06 DOI: 10.32553/ijmbs.v6i7.2586

Aishwarya Nair, Aleena Stanley, Ayswarya Kiren, Saniga Geo Cheruvathoor

{"title":"In Silico Phytochemical Screening for Hantavirus","authors":"Aishwarya Nair, Aleena Stanley, Ayswarya Kiren, Saniga Geo Cheruvathoor","doi":"10.32553/ijmbs.v6i7.2586","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i7.2586","url":null,"abstract":"\u0000 \u0000Several rodent species are carriers of hantavirus which are present throughout the world. Hantavirus was a group of unknown class of viruses which was first seen in the United States of America in 1993 as an acute respiratory disease now termed hantavirus pulmonary syndrome (HPS). Earlier HPS hantavirus were known as the agents of hemorrhagic fever with renal syndrome which was seen in eastern hemisphere of the world .A lot of research is going around in and around hantavirus Their ubiquity and potential for causing severe human illness make these viruses an important public health concern.We present a docking based screening using a quantum mechanical scoring of a library built from approved drugs and compound that limonin ,curcumin, luteolin, rutin, Baicalin, Quercetin, Resveratrol, Kaempferol, Naringenin, Atropine, 4 Hydroxy Coumarin, Colchicine, Thymoquinone, Glabridin ,Hypericin, Lycorine with proteins having PDB id’s 5E04 and 5E05 could display that the phytochemicals can act against Hantavirus. We hope that our findings may contribute to rational drug design against Hantavirus. \u0000 \u0000","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88616416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Phytochemical Screening for Dengue Virus 登革病毒的硅基植物化学筛选

International Journal of Medical and Biomedical Studies Pub Date : 2022-08-06 DOI: 10.32553/ijmbs.v6i7.2585

Annliya Raju, Ann Maria Jacob, Mary Anagha C. X

{"title":"In Silico Phytochemical Screening for Dengue Virus","authors":"Annliya Raju, Ann Maria Jacob, Mary Anagha C. X","doi":"10.32553/ijmbs.v6i7.2585","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i7.2585","url":null,"abstract":"\u0000 \u0000By and by, the world is fighting with dengue for long decades. However, the pathogenesis of dengue has not yet been fully elucidated. Dengue fever is a virus infection that is spread by the Aedes aegypti mosquito and can cause severe disease especially in children. Dengue fever is a major problem throughout the world especially tropical and sub-tropical regions of the world.The disease is still tearing down the world. Millions of researchers are still continuing for the potential medication up-and-comer that could help the medical care framework to keep world health. We present a docking?based screening using a quantum mechanical scoring of a library built from approved drugs and compounds that Gingerol, Honokiol, Thiosulfinate, Saponin, Coumarin, Apigenin, Limonin, Baicalin, Quercetin, Tannin amine, Ajoene, Curcumin, with proteins with PDB id’s 4OIG, 6VSO could display antiviral activity against destructive dengue virus. Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the disease. We hope that these findings may contribute to the rational drug design against Dengue virus. \u0000 \u0000","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74136541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gingival Crevicular Blood as a Diagnostic aid for the Detection of Diabetes Mellitus: an in-Office Chairside Test in Dental Practice 龈沟血作为诊断糖尿病的辅助工具:一种在牙科诊所椅子旁进行的测试

International Journal of Medical and Biomedical Studies Pub Date : 2022-07-05 DOI: 10.32553/ijmbs.v6i7.2579

Battu Pragna, P. Shukla, A. Ahsan, G. Shirisha, B. Goud, Kothuri Padma

{"title":"Gingival Crevicular Blood as a Diagnostic aid for the Detection of Diabetes Mellitus: an in-Office Chairside Test in Dental Practice","authors":"Battu Pragna, P. Shukla, A. Ahsan, G. Shirisha, B. Goud, Kothuri Padma","doi":"10.32553/ijmbs.v6i7.2579","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i7.2579","url":null,"abstract":"Background: Diabetes is a chronic metabolic disease because of the elevated levels of glucose in the blood. And usually most of the diabetic patients are left undiagnosed in their early stages of the disease because of the unnoticeable symptomsby the patients \u0000which could lead to the severe damage to the body system, hence an early diagnosis is very important and life saving indiabetic patients. \u0000Aim: aim of the present study is to evaluate the accuracy of gingival crevicular blood as a diagnostic tool in diabeticpatients. \u0000Methods: This study involves total 50 patients 25 diabetic and 25 non diabetic patients, with moderate to severe periodontitis. Regular dental check-up is done including periodontal pocket depth probing. Blood oozing from the gingival crevice was collected with the strips of glucose self monitoring devise. To the same patient finger stick Blood glucose level and venous blood[ VB] glucose level with standardized laboratory method was taken. \u0000Results: The results showed significant strong correlation between all three groups. With p value (P < 0.001). \u0000Conclusion: Blood oozing during the pocket detection can be used for diagnosing aid in diabetes. \u0000Keywords: gingival crevicular blood, Finger stick blood, venous blood, diabetes mellitus, Glucometer, chronicperiodontitis.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77923283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation of Platelet Indices in Sepsis 脓毒症患者血小板指数的变化

International Journal of Medical and Biomedical Studies Pub Date : 2022-06-26 DOI: 10.32553/ijmbs.v6i6.2573

Shivani Sharma, Kavita Sharma, Vanita Kumar

{"title":"Variation of Platelet Indices in Sepsis","authors":"Shivani Sharma, Kavita Sharma, Vanita Kumar","doi":"10.32553/ijmbs.v6i6.2573","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i6.2573","url":null,"abstract":"Introduction: Almost every organ can be affected in the case of sepsis. In fact, the hemostatic system has also been known to be adversely affected in case of sepsis. Platelet indices are cheap and readily accessible, laboratory parameters that can be used to assess the severity of sepsis. \u0000Aims and objectives- This study was aimed at comparing the parameters of platelet indices in patients with fever and sepsis leading to multiorgan dysfunction. \u0000Materials and methods: This was a hospital-based cross-sectional study conducted in our pathology department in patients admitted with sepsis in the medicine in-patient department over 1 year. Inclusion criteria were patients with sepsis. Two ml of blood was withdrawn from the antecubital vein of the cases and samples were collected in an EDTA vial, which was kept at room temperature on day 1 and day 7 of admission. The complete hemogram reports were analyzed. The collected data was recorded on a prestructured proforma. \u0000Results: This study included 100 serially recruited patients having sepsis. The mean age of cases was 48.3 ± 16.3 years. While 63% of cases were male, 37% were females. The rise of PDW from day 1 to day 7 was statistically insignificant (p value= 0.24). However, the plateletcrit (PCT) fell significantly from day 1 to day 7 (p value=0.02). In our study, there were 76% survivors and 24% non-survivors. Platelet volume (MPV) rose significantly (p value=0.01), and TC fell significantly (p value<0.0001). Similarly, the platelet count also fell significantly (p value<0.05). \u0000Conclusion: Platelet indices, especially MPV, PDW, and platelet count are reliable indicators of sepsis prognosis.","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91231918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Profile of Ectopic Pregnancy 异位妊娠的临床特点

International Journal of Medical and Biomedical Studies Pub Date : 2022-06-15 DOI: 10.32553/ijmbs.v6i6.2567

Savitri Sharma, A. Bai, Aditya P. Rathore

引用次数: 0

A Prospective Clinical Study of FETO-Maternal Outcome in Pregnancies with Abnormal Amniotic Fluid Index 羊水指数异常妊娠胎儿与母体结局的前瞻性临床研究

International Journal of Medical and Biomedical Studies Pub Date : 2022-06-05 DOI: 10.32553/ijmbs.v6i6.2558

Laleeta Meena, Suman Budania, M. Meena

{"title":"A Prospective Clinical Study of FETO-Maternal Outcome in Pregnancies with Abnormal Amniotic Fluid Index","authors":"Laleeta Meena, Suman Budania, M. Meena","doi":"10.32553/ijmbs.v6i6.2558","DOIUrl":"https://doi.org/10.32553/ijmbs.v6i6.2558","url":null,"abstract":"Background: We report a clinical study of fetomaternal outcome in pregnancies with abnormal liquor volume managed at a tertiary care hospital \u0000Methods: This study was conducted in the Department of Obstetrics and Gynaecology, S.P Medical College, Bikaner \u0000Results- In. In oligohydramnios group 90.8%babies were healthy while8.4%were died in NICU and0.8% were still birth while in polyhydramnios group 76% babies were healthy while 4% were died in NICU and20%babies were still birth. Still birth rate in very high in polyhydramnios group. This difference was found statistically highly significant (p<0.001). \u0000Conclusion: Development of abnormal liquor volume during pregnancy signals danger to the foetus. It is associated with an increased incidence of caesarean section, labour complications and adverse perinatal outcome. But isolated oligo and polyhydramnios in term gestation has better perinatal outcome compared to early onset and with associated conditions like hypertensive diseases of pregnancy, GDM, IUGR. Ultrasound is the ideal method to detect any abnormality in liquor volume. If any abnormality is detected during the ultrasound, a careful search should be made to detect any identifiable congenital anomalies. \u0000Keywords: Oligohydramnios, Polyhydramnios, Fetomaternal","PeriodicalId":14139,"journal":{"name":"International Journal of Medical and Biomedical Studies","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79463017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socio-demographic Spectrum of Neoplastic and Nonneoplastic Bone Lesions 肿瘤性和非肿瘤性骨病变的社会人口学谱

International Journal of Medical and Biomedical Studies Pub Date : 2022-06-01 DOI: 10.32553/ijmbs.v6i5.2556

Kavita Choudhary, Ankit Singh, Kaustubh Singh

引用次数: 0

Histopathological Spectrum of Neoplastic and Nonneoplastic Bone Lesions 肿瘤性和非肿瘤性骨病变的组织病理学谱

International Journal of Medical and Biomedical Studies Pub Date : 2022-06-01 DOI: 10.32553/ijmbs.v6i5.2555

Kavita Choudhary, Ankit Singh, Kaustubh Singh

引用次数: 0

Assessment of Functional Outcome of Surgical Management of Proximal Humerus Fracture Treated with PHILOS Plate PHILOS钢板治疗肱骨近端骨折手术治疗的功能效果评价

International Journal of Medical and Biomedical Studies Pub Date : 2022-06-01 DOI: 10.32553/ijmbs.v6i5.2548

M. Shekhawat, Ankit Narang, Ankit Singh

引用次数: 0