International Journal of Gynecological Cancer最新文献

{"title":"Cerebellar metastasis in a patient with endometrial adenocarcinoma.","authors":"Nerea Peñalver Vargas, José Antonio Pérez Álvarez","doi":"10.1136/ijgc-2024-005625","DOIUrl":"10.1136/ijgc-2024-005625","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101886"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silva pattern-based classification and oncological outcomes in women undergoing fertility-sparing surgery for early-stage cervical cancer.","authors":"Kristine Krüger Hagen, Agnes Kathrine Lie, Gunn Fallås Dahl, Brynhildur Eyjolfsdottir, Yun Wang, Petter Ranum, Miguel Skilbrei, Kjersti Vassmo Lund, Meryam Sugulle, Anne Cathrine Staff, Milada Hagen, Ane Gerda Z Eriksson","doi":"10.1016/j.ijgc.2025.102012","DOIUrl":"10.1016/j.ijgc.2025.102012","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between Silva pattern-based classification, lymphovascular invasion, and oncological outcomes in women undergoing fertility-sparing surgery for cervical cancer.</p><p><strong>Methods: </strong>Retrospective nationwide cohort study of patients with human papillomavirus (HPV)-associated cervical adenocarcinomas <2 cm undergoing radical vaginal trachelectomy, simple vaginal trachelectomy, or conization with nodal assessment between 2000 and 2022. Clinical data were retrieved from electronic medical records and institutional databases. Histological specimens were retrospectively assigned the Silva pattern classification after review by an expert gynecologic oncology pathologist. The primary endpoint was recurrence-free survival categorized by the Silva pattern classification. Survival rates were compared between groups defined by the Silva pattern classification using Kaplan-Meier estimates.</p><p><strong>Results: </strong>Of 61 women with cervical adenocarcinoma, 59 were HPV-associated, with HPV 16 and 18 being the most prevalent genotypes. Among HPV-associated adenocarcinomas, 20 (33.9%) were classified as pattern A, 26 (44.1%) as pattern B, and 13 (22.0%) as pattern C. HPV 18 was noted in 9 (69.2%) of tumors with pattern C, compared to 7 (35.5%) and 10 (38.5%) in patterns A and B, respectively. Most cases were International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IB1 (N = 50 [84.8%]). Lymphovascular invasion was present in 6 (23.1%) of cases with pattern B and in 7 (53.9%) with pattern C. There was no difference in surgical radicality between groups. Five women abandoned fertility preservation due to nodal metastasis (N = 2), positive surgical margins (N = 2), or multifocal disease (N = 1). Of these, 3 tumors exhibited pattern C, 1 pattern B with lymphovascular invasion, and 1 pattern B without lymphovascular invasion. Median follow-up was 79 months (range; 14-248 months). Five-year recurrence-free survival was 100% for the Silva patterns A and B, compared to 75.5% for pattern C (95% CI 41.6% to 91.4%).</p><p><strong>Conclusions: </strong>Recurrence occurred exclusively among patients with the Silva pattern C, highlighting the prognostic potential of this classification system. Silva classification should be considered when counseling women regarding fertility-sparing surgery.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 9","pages":"102012"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Is it possible to change the whole system? I hope so\": a UK national survey on workplace behaviors and burnout in Gynecologic Oncology.","authors":"Hannah Pierce, Charlotte Towner, Christina Uwins, Alison Montgomery, Thomas Ind, Simon Butler-Manuel, Stephen Dobbs","doi":"10.1016/j.ijgc.2025.102134","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102134","url":null,"abstract":"<p><strong>Objective: </strong>From incivility to bullying and harassment, poor workplace behavior covers a spectrum of behaviors. As many as 1 in 3 health professionals report experiencing bullying, costing the National Health Service £2.28 billion per year due to increased sickness, higher employee turnover, litigation, and lost productivity. This national survey highlighted the reality of workplace behavior and burnout in Gynecologic Oncology in the United Kingdom.</p><p><strong>Methods: </strong>An online peer-reviewed survey was distributed to all British Gynaecological Cancer Society members using Microsoft Forms. The survey ran from October 4 to November 16, 2024. Results were analyzed using Microsoft Excel (v 16.89).</p><p><strong>Results: </strong>A total of 118 responses were received from 691 British Gynaecological Cancer Society members (17% response rate). Seventy-eight percent (92/118) of respondents had experienced poor workplace behaviors in the last 12 months. The most common behaviors reported were persistent attempts to belittle and undermine work (55%, 65/118), freezing out/ignoring/excluding (41%, 48/118), and undue pressure to produce work (42%, 50/118). High levels of burnout were reported, with 79% (93/118) finding work emotionally exhausting and 58% (69/118) feeling burned out by their work. Teamwork is particularly important within Gynecologic Oncology; however, 24% (28/118) felt that people are rejected for being different, and 14% (16/118) felt mistakes are held against them. Subspecialty trainees, women, and ethnic minorities experienced the worst workplace behavior compared to other groups.</p><p><strong>Conclusions: </strong>Gynecologic Oncology team members experience persistent incivility, bullying, and poor psychological safety in the workplace. Burnout levels in Gynecologic Oncology exceed those seen in other specialties. This survey provides key insights into Gynecologic Oncology workplace culture, laying the groundwork to develop meaningful solutions to improve team culture, reduce attrition, and protect staff well-being and patient outcomes.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 11","pages":"102134"},"PeriodicalIF":4.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The missing link in SHAPE: standardizing magnetic resonance imaging assessment of stromal invasion for cervical cancer.","authors":"Vanessa Murad, Tanya Chawla, Ciara O Brien","doi":"10.1016/j.ijgc.2025.102133","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102133","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 11","pages":"102133"},"PeriodicalIF":4.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on \"Silicon dioxide, sodium selenite, and citric acid vaginal gel, HPV infection, and cervical preinvasive disease: a narrative review\" by Diaz et al.","authors":"Attila Louis Major, Ivanna Mayboroda","doi":"10.1016/j.ijgc.2025.102136","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102136","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"102136"},"PeriodicalIF":4.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on \"Cytoreductive surgery in advanced epithelial ovarian cancer: a real-world analysis guided by clinical variables, homologous recombination, and BRCA status\" by Shachar et al.","authors":"Fatma Ferda Verit","doi":"10.1016/j.ijgc.2025.102130","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102130","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"102130"},"PeriodicalIF":4.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From silence to action: Egypt's path to national cervical cancer prevention.","authors":"Mariam Ismail, Basel Refky, Nermin Mostafa, Mohamed Elazab, Khaled Abdelaziz Kamal","doi":"10.1016/j.ijgc.2025.102121","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102121","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"102121"},"PeriodicalIF":4.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contralateral pelvic lymph node metastases in patients with unilateral early-stage epithelial ovarian cancer: a systematic review and meta-analysis.","authors":"Santiago Vieira-Serna, Julieth Flórez, Angélica Fletcher, Jonathan Peralta, Oscar Serrano, David Viveros-Carreño, Juliana Rodríguez, John Edwin Feliciano-Alfonso, René Pareja","doi":"10.1016/j.ijgc.2025.102123","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102123","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to assess the rate of contralateral pelvic lymph node metastases in macroscopically unilateral early-stage epithelial ovarian cancer.</p><p><strong>Methods: </strong>A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist, and the protocol was registered in PROSPERO (CRD42024513857). MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception until June 2024. The inclusion criteria were studies involving patients with macroscopically unilateral early-stage (International Federation of Gynecology and Obstetrics stage I-II) epithelial ovarian cancer with surgical staging.</p><p><strong>Results: </strong>Ten studies met the inclusion criteria. All studies were observational; 9 were retrospective and 1 was prospective, including a total of 668 patients. The pooled rate of isolated contralateral pelvic lymph node metastases was 0.9% (95% CI 0.1 to 2.3, I² = 24.6%, 4 studies; 391 participants; 5 events). The pooled rate of contralateral (isolated or bilateral) pelvic lymph node metastases was 1.9% (95% CI 0.1 to 5.2, I² = 57.3%, 4 studies; 391 participants; 7 events). The overall pooled rate of lymph node metastases was 10.8% (95% CI 8.4 to 13.5, I² = 0%, 7 studies; 605 participants; 68 events). The rate of microscopic contralateral ovarian disease was reported in 3 studies, at 3.5%.</p><p><strong>Conclusions: </strong>The rate of isolated contralateral pelvic lymph node metastases in macroscopically unilateral early-stage epithelial ovarian cancer is 0.9%. Therefore, para-aortic and ipsilateral pelvic and lymph node dissection may be adequate in cases of macroscopically unilateral ovarian disease. However, given the limited evidence, these findings must be interpreted with caution.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"102123"},"PeriodicalIF":4.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective long-term follow-up of sexuality and body image in women with primary vulvar cancer.","authors":"Diana Zach, Joanne de Hullu, Ivette Raices Cruz, Zuzana Kolkova, Johanna Sjöberg, Katja Stenström Bohlin, Angelique Flöter Rådestad","doi":"10.1016/j.ijgc.2025.102120","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102120","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the development of sexual activity, sexual function, and body image in women with primary vulvar cancer from the time of diagnosis to 24 months after the end of treatment.</p><p><strong>Methods: </strong>This nationwide prospective cohort study assessed health-related quality of life in women with newly diagnosed vulvar cancer using validated patient-reported outcome measures (EORTC-QLQ-VU34 [European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Vulva 34], Supportive Care Needs Survey Short Form) and self-constructed questions at diagnosis, and at 3, 12, and 24 months after the end of treatment. For this study, outcomes concerning sexuality and body image were analyzed. Results were displayed as mean scale scores and proportions. The longitudinal changes of scale and item scores were estimated by linear mixed-effects models with patient random intercept for continuous/numerical outcomes, and by generalized linear mixed models for binary response variables.</p><p><strong>Results: </strong>Between August 2019 and August 2021, 138 of 153 consenting women (90%) returned at least 1 questionnaire, and 90 women (59%) completed the questionnaires at all 4 time points. Sexual activity increased from 9.8% at diagnosis to 22.8% after 24 months (odds of being sexually active at 24 months were 6 times higher than at baseline, p = .003). Vulvar cancer was one of the reasons for not being sexually active for 37.5% of the participants at baseline and 26.9% at 24 months. Most women (73.5%) were not satisfied with their sex life at baseline. At least at one time point, 25.4% of the women found sex important, and 32.6% needed help with changes in sexual feelings. The mean scale scores of sexual functioning and body image did not change over time.</p><p><strong>Conclusions: </strong>Sexual activity was low, largely due to the vulvar cancer diagnosis. Most women were not satisfied with their sex life. A substantial proportion of the women found sex important and expressed a need for help with sexual feelings.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 10","pages":"102120"},"PeriodicalIF":4.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment tolerability associated with carboplatin dose based on actual versus adjusted body weight in patients with a body mass index ≥25 kg/m² with advanced ovarian cancer.","authors":"Matthew Savas, Erin Bailey, Erik Harrington, Eleni Gamvroulas, T Joseph Mattingly, Theresa L Werner","doi":"10.1016/j.ijgc.2025.102122","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.102122","url":null,"abstract":"<p><strong>Objective: </strong>We sought to describe the treatment tolerability of carboplatin when dosed based on actual versus adjusted body weight in patients with a body mass index (BMI) ≥25 kg/m² who had advanced ovarian cancer.</p><p><strong>Methods: </strong>In this single-center, retrospective, descriptive analysis, we included patients with advanced-stage epithelial ovarian cancer who had a BMI ≥25 kg/m² and received first-line treatment with carboplatin and paclitaxel. We compared patients who received carboplatin dosed based on actual body weight with those whose dosing was based on adjusted body weight. The primary endpoint was the composite incidence of treatment modifications.</p><p><strong>Results: </strong>A total of 101 patients were included in this study: 61 in the actual body weight-based dosing group and 40 in the adjusted body weight-based dosing group. There was no significant difference in the incidence of treatment modifications between groups (73.8% vs 57.5%, p = .09). Dose reductions of carboplatin and treatment delays were more common in the actual body weight-based dosing group (39.3% vs 15.0%, p = .009) and (32.8 vs 5.0%, p = .001), respectively. Grade ≥3 neutropenia (19.7% vs 12.5%) and thrombocytopenia (13.1% vs 0.0%) were higher in the actual body weight group. More patients in the adjusted body weight-based dosing group initiated next-line therapy (55% vs 26.2%, p = .004). Median time to next treatment or death was not reached in the actual body weight-based dosing group but was 19.3 months (95% CI 12.4 to 24.0) in the adjusted body weight-based dosing group (HR 0.32, 95% CI 0.18 to 0.58, p = .0001). Death from any cause was lower in the actual body weight group (19.7% vs 60.0%, HR 0.35, 95% CI 0.18 to 0.71, p = .003).</p><p><strong>Conclusions: </strong>Dosing carboplatin using adjusted body weight in patients with a BMI ≥25 kg/m² may lead to fewer carboplatin dose reductions and treatment delays.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 11","pages":"102122"},"PeriodicalIF":4.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}