International Journal of Gynecological Cancer最新文献

{"title":"Correspondence on \"Large-scale analysis to identify risk factors for ovarian cancer\" by Madakkatel et al.","authors":"Souichi Oka, Yoshiyasu Takefuji","doi":"10.1016/j.ijgc.2025.102000","DOIUrl":"10.1016/j.ijgc.2025.102000","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"102000"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upholding standard-of-care oncological treatment in the context of pregnancy.","authors":"Irina Tsibulak, Pedro T Ramirez","doi":"10.1016/j.ijgc.2025.102024","DOIUrl":"10.1016/j.ijgc.2025.102024","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 9","pages":"102024"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clear cell carcinoma of the cervix positive for HPV16.","authors":"Christine G T Nguyen, Benjamin F Smith, Athena Chen, Jenna Emerson","doi":"10.1016/j.ijgc.2025.101907","DOIUrl":"10.1016/j.ijgc.2025.101907","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101907"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of prior adjuvant radiotherapy on immunotherapy outcomes in recurrent endometrial cancer.","authors":"Tao Guo, Yuxi Zhao, Jia Zeng, Enyu Tang, Yuanyuan Zhang, Lingying Wu","doi":"10.1016/j.ijgc.2025.101937","DOIUrl":"10.1016/j.ijgc.2025.101937","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the impact of adjuvant external beam radiotherapy (EBRT) following initial surgery on the efficacy of immunotherapy in patients with recurrent endometrial cancer.</p><p><strong>Methods: </strong>This is a single-institution retrospective cohort study. Patients who underwent initial surgery for endometrial cancer and received immunotherapy for recurrence between January 2020 and December 2023 were recruited. Patients who received post-operative EBRT were assigned to the EBRT group. Patients who did not undergo EBRT or who received brachytherapy without EBRT were assigned to the control group. Progression-free survival was used as the end point. Kaplan-Meier curves were used for comparing progression-free survival. The multi-variate analysis was performed using the Cox proportional hazards regression model.</p><p><strong>Results: </strong>A total of 91 patients were included in the analysis; 33 had a history of EBRT, while 58 had not received prior EBRT. In Kaplan-Meier curves, patients who did not receive EBRT showed a numerically lower risk of disease progression (HR 0.47, 95% CI 0.25 to 0.90, p = .010). In multi-variate analysis, EBRT (HR 5.28, 95% CI 1.54 to 22.06) and proficient mismatch repair/micro-satellite instability-low/micro-satellite stable status (HR 3.15, 95% CI 1.19 to 8.90) were risk factors for disease progression during immunotherapy.</p><p><strong>Conclusions: </strong>In patients with recurrent endometrial cancer who received immunotherapy, the therapeutic efficacy may be compromised by prior post-operative adjuvant EBRT.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101937"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral mucositis associated with antibody-drug conjugates in gynecologic oncology: strategies for prevention and treatment.","authors":"Michelle D S Lightfoot, Maria M Rubinstein, Bradley J Monk, Ramez N Eskander, Kathleen Lutz, Kathleen N Moore, Thomas J Herzog, Bhavana Pothuri","doi":"10.1016/j.ijgc.2025.101997","DOIUrl":"10.1016/j.ijgc.2025.101997","url":null,"abstract":"<p><p>Antibody-drug conjugates (ADCs) have emerged as a promising therapeutic option for the treatment of gynecologic malignancies and have become a key component of treatment strategies for recurrent ovarian, endometrial, and cervical cancers. These agents offer targeted tumor cell specificity while delivering potent cytotoxic agents. Despite their selectivity, ADCs are associated with unique treatment-related adverse events. Oral mucositis (stomatitis) has become a notable on-target, off-tumor toxicity among gynecologic cancer patients receiving certain trophoblast cell surface antigen 2 targeting ADCs. Though often acute and self-limiting, oral mucositis can significantly impact patient quality of life, hinder nutritional intake, increase infection risk, and result in dose delays or discontinuation, ultimately affecting cancer treatment outcomes. This review focuses on prevention and management strategies for ADC-associated oral mucositis in the gynecologic oncology setting. We outline practical, evidence-based approaches including routine symptom monitoring, basic oral care, prophylactic interventions, and graded treatment strategies to address established mucositis. Integrating these strategies can reduce the incidence and severity of oral mucositis, thus preserving both treatment efficacy and quality of life for patients with gynecologic malignancies.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 9","pages":"101997"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional reconstruction and laparoscopic liver resection for recurrent ovarian cancer: quaternary cytoreductive surgery.","authors":"Riccardo Oliva, Agostino Maria De Rose, Francesco Ardito, Giacomo Guidi, Camilla Certelli, Matteo Bruno, Anna Fagotti, Valerio Gallotta","doi":"10.1016/j.ijgc.2025.101914","DOIUrl":"10.1016/j.ijgc.2025.101914","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101914"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights from the third Colombian conference on women's cancers.","authors":"María Clara Santía, Vanessa Alvarenga-Bezerra, William Andrés Piñeros Castillo, Carolina Morante-Caicedo, Heng-Cheng Hsu, Florencia Noll","doi":"10.1016/j.ijgc.2025.101918","DOIUrl":"10.1016/j.ijgc.2025.101918","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101918"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key highlights from American Society of Clinical Oncology 2025: top 10 studies in gynecologic oncology.","authors":"Jéssica Monteiro Vasconcellos, Letícia Vecchi Leis, Mariana Carvalho Gouveia, Mariana Scaranti","doi":"10.1016/j.ijgc.2025.101994","DOIUrl":"10.1016/j.ijgc.2025.101994","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 9","pages":"101994"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Oka and Takefuji's correspondence on the article \"Large-scale analysis to identify risk factors for ovarian cancer\" by Madakkatel et al.","authors":"Elina Hyppönen, Iqbal Madakkatel","doi":"10.1016/j.ijgc.2025.102005","DOIUrl":"10.1016/j.ijgc.2025.102005","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"102005"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESGO/INCIP Guidelines for the management of patients with gynecological cancers during pregnancy.","authors":"Frédéric Amant, François Planchamp, Paul Berveiller, Elyce Cardonick, Anne De Middelaer, Robert Fruscio, Monica Fumagalli, Anna L V Johansson, Matteo Lambertini, Charlotte L LeJeune, Christianne Lok, W Glenn McCluggage, Philip Poortmans, Jacek Sienko, Cristel S Hjortshøj, Marta Swierczynska, Antonia Carla Testa, Indra A Van Assche, Kristel Van Calsteren, Vincent Vandecaveye, Carolien Versteeg, Flora Zagouri, Ignacio Zapardiel, Michael J Halaska","doi":"10.1016/j.ijgc.2025.101975","DOIUrl":"10.1016/j.ijgc.2025.101975","url":null,"abstract":"<p><p>As part of its mission to improve the quality of care for women with gynecological cancers across Europe, the European Society of Gynecological Oncology (ESGO) organized 3 international consensus meetings with leading experts in the field to define protocols and to provide guidance for pregnant patients and healthcare providers on the management of gynecological cancers in pregnancy. Following the third consensus meeting, the guidelines published in 2019 were updated by incorporating new evidence on this field and covering new topics to provide comprehensive evidence-based guidelines on all relevant issues within a multidisciplinary setting. ESGO appointed 21 experts from relevant disciplines and 2 cancer survivors to serve on the international development group. Members of the International Network on Cancer, Infertility and Pregnancy involved in the 3 international consensus meetings were included. To ensure that the guidelines were evidence-based, data identified from a systematic search were reviewed and critically appraised. In the absence of robust scientific evidence, the guidelines were based on the consensus of the international development group. Prior to publication, the guidelines were reviewed by 100 independent international practitioners in cancer care delivery from Asia, Europe, Africa, and North and South Americas, and 3 patient representatives to ensure a global perspective. These ESGO/International Network on Cancer, Infertility and Pregnancy guidelines address all relevant aspects of imaging, pathology, surgery, medical oncology, obstetrics, radiation therapy, psychology, patient perspectives and pediatric follow-up in a multidisciplinary setting for patients with tubo-ovarian, cervical, and vulvar cancers during pregnancy. Treatment algorithms for each tumor type are also defined.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101975"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}