Journal of Cancer Biology and Therapeutics最新文献

Percutaneous Biopsy under Simultaneous Ultrasound and Computer Tomography Guidance in Diagnosis of Isolated Pancreatic Metastasis of Clear Cell Renal Cell Carcinoma 超声与计算机断层同时引导下经皮活检诊断透明细胞肾细胞癌胰腺转移

Journal of Cancer Biology and Therapeutics Pub Date : 2019-12-16 DOI: 10.18314/gjct.v5i1.1935

M. Chorazy, A. Kubera, A. Wodołażski

{"title":"Percutaneous Biopsy under Simultaneous Ultrasound and Computer Tomography Guidance in Diagnosis of Isolated Pancreatic Metastasis of Clear Cell Renal Cell Carcinoma","authors":"M. Chorazy, A. Kubera, A. Wodołażski","doi":"10.18314/gjct.v5i1.1935","DOIUrl":"https://doi.org/10.18314/gjct.v5i1.1935","url":null,"abstract":"Cancers of the kidney are a various group of tumors, most of which are of epithelial origin and malignant. Renal cell carcinoma (RCC) classically referred to as clear cell carcinoma is the most common kidney cancer (70- 80% of all kidney cancers). The most common primary cancer site resulting in pancreatic metastases is liver, followed by colorectal cancer, melanoma, breast cancer, lung carcinoma and sarcoma. 65 year old man six years after nephrectomy due to clear cell renal cell carcinoma (ccRCC), attended regular abdominal CT examination, which revealed 28.9 mm focal lesion located in pancreatic tail. No other pathological lesions were detected. Patient underwent US guided biopsy preceded by CT pre-biopsy planning. Histopathological analysis of the obtained material confirmed clear cell carcinoma. The authors being aware of other than renal possible sites of clear cell carcinoma origin, additional tests such as membranous immunoreactivity with renal cell carcinoma (RCC), and immunohistochemical staining applied to identify the cellular origin and confirm the renal origin of the metastasis. This innovative, combined method of US guided biopsy supported by CT pre-biopsy planning can be helpful in the diagnosis of atypically located metastases of RCC. Our described case shows that in contrast to other well-known biopsy methods, our assay enables to obtain material for complete histopathological diagnosis and consequently start treatment. Moreover, presented method is based on diagnostic tools that are routinely available in every hospital such as US and CT. The only required modification is the installation of programme that enables to upload CT images containing marked planned needle path to the biopsy room, and simultaneous display of both - static CT image and US image performed in real time.","PeriodicalId":140922,"journal":{"name":"Journal of Cancer Biology and Therapeutics","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126121149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Wound Complications in Fungating Extremity Soft Tissue Sarcomas 真菌性肢体软组织肉瘤术后伤口并发症

Journal of Cancer Biology and Therapeutics Pub Date : 2019-10-29 DOI: 10.18314/gjct.v5i1.1937

Blakely Am, W. Chow, S. Sampath, Femino Jd, S. Lozano-Calderón, M. Heng, B. Crawford

{"title":"Postoperative Wound Complications in Fungating Extremity Soft Tissue Sarcomas","authors":"Blakely Am, W. Chow, S. Sampath, Femino Jd, S. Lozano-Calderón, M. Heng, B. Crawford","doi":"10.18314/gjct.v5i1.1937","DOIUrl":"https://doi.org/10.18314/gjct.v5i1.1937","url":null,"abstract":"Background: Among deep extremity soft tissue sarcomas, skin ulceration is infrequent. Fungating sarcomas may lead to infection or clinically significant bleeding. Data regarding management of ulcerating sarcomas is lacking. We sought to evaluate the outcomes of different treatments for these tumors.Patients and methods: A retrospective review of patients treated at two sarcoma referral centers with histologically confirmed extremity soft tissue sarcoma was performed from 2000-2018. Patient demographics, clinicopathologic, and treatment factors were analyzed in terms of method of resection, receipt of radiation, and wound complications.Results: Overall, 22 patients had fungating lesions. Most patients were male with tumors of the distal extremity.Median tumor size was 8 cm. Half had undifferentiated pleomorphic sarcoma histology, followed by myxofibrosarcoma (n=5), leiomyosarcoma (n=3), or other (n=3). Fifteen patients (68%) underwent limb-preserving resection, of which 7 underwent adjuvant radiation. Six patients (27%) developed wound complications, which occurred equally between amputation versus local excision (p = 0.93). Among local excision patients, one who received adjuvant radiation developed a wound complication (14%), which was not significantly different from those who did not undergo radiation (n=3 of 8, 38%; p = 0.31).Conclusions: Similar rates of wound complications were seen between amputation and limb-preserving groups.Among patients who underwent local excision, the administration of adjuvant radiation therapy did not significantly increase wound complication rates.","PeriodicalId":140922,"journal":{"name":"Journal of Cancer Biology and Therapeutics","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116360965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Complications in Allogenic Hematopoietic Stem Cell Transplantation 同种异体造血干细胞移植的骨并发症

Journal of Cancer Biology and Therapeutics Pub Date : 2019-10-07 DOI: 10.18314/gjct.v5i1.1926

S. Saowapa, Isenberg Js, B. Salehian

引用次数: 1

KRAS and NRAS Mutations in Moroccan Patients with Colorectal Cancer 摩洛哥结直肠癌患者的KRAS和NRAS突变

Journal of Cancer Biology and Therapeutics Pub Date : 2019-10-05 DOI: 10.18314/gjct.v5i1.1862

H. Dehbi, Ait boujmia Ok, S. Benayad, E. Hh, M. Karkouri

{"title":"KRAS and NRAS Mutations in Moroccan Patients with Colorectal Cancer","authors":"H. Dehbi, Ait boujmia Ok, S. Benayad, E. Hh, M. Karkouri","doi":"10.18314/gjct.v5i1.1862","DOIUrl":"https://doi.org/10.18314/gjct.v5i1.1862","url":null,"abstract":"Objective: Activating mutations in the RAS proto-oncogene (KRAS, HRAS and NRAS) play a crucial role in carcinogenesis and drug resistance in many cancers including, colorectal cancer. The aim of the present study was to evaluate the frequencies of KRAS and NRAS oncogenic mutations in Moroccan CRC patients.Patients and methods: In the present study, formalin-fixed paraffin-embedded CRC specimens from 114 Moroccan CRC patients were analyzed. To detect mutations in codons 12, 13 and 61 of the KRAS and NRAS genes, the pyrosequencing technique was used.Results: 114 colorectal cancer patients were included in this study, 64 were males and 50 were females, the primary tumor was the most frequent type (78.1%) and the commonest histological type was ADK (77.2%). KRAS mutation was found in 49 of all CRC patients and the most frequent KRAS mutations were 35G>T, 35G>A and 38G>A. On the other hand NRAS mutation was detected only in 6 patients. No statistically significant relationship between CRC patient’s characteristics and RAS mutations was found.Conclusion: Our results suggest that the KRAS mutation is more frequent among Moroccan patients with CRC, which is in agreement with the most previous studies. Further studies, with a larger number of CRC patients, are needed to confirm our findings.","PeriodicalId":140922,"journal":{"name":"Journal of Cancer Biology and Therapeutics","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130234413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Phase I/II Clinical Trial of Weekly Intraperitoneal Paclitaxel (IP-PTX) with Monthly Intravenous Carboplatin (IV-CBDCA) for Minimal Residual Disease of Ovarian, Tubal, and Peritoneal Carcinoma 每周一次腹腔注射紫杉醇(IP-PTX)联合每月静脉注射卡铂(IV-CBDCA)治疗卵巢、输卵管和腹膜癌微小残留疾病的I/II期临床试验

Journal of Cancer Biology and Therapeutics Pub Date : 2019-06-11 DOI: 10.18314/GJCT.V5I1.1809

T. S, Terai Y, Tanimura K, Miyamoto T, Omichi M, Takeuchi K

{"title":"Phase I/II Clinical Trial of Weekly Intraperitoneal Paclitaxel (IP-PTX) with Monthly Intravenous Carboplatin (IV-CBDCA) for Minimal Residual Disease of Ovarian, Tubal, and Peritoneal Carcinoma","authors":"T. S, Terai Y, Tanimura K, Miyamoto T, Omichi M, Takeuchi K","doi":"10.18314/GJCT.V5I1.1809","DOIUrl":"https://doi.org/10.18314/GJCT.V5I1.1809","url":null,"abstract":"We conducted weekly intraperitoneal administration of paclitaxel (IP-PTX) with monthly intravenous administration of carboplatin (IV-CBDCA), as a prospective phase 1/2 setting. The purpose of this study was to assess the pharmacokinetics and to decide the recommended dose (RD) according to modified Fibonacci method. Patients aged 20-75 years old with histological confirmed mullerian cancers (epithelial ovarian cancer; EOC, fallopian tubal cancer; FTC, and primary peritoneal cancer; PPC) from stage IC to IV or the patients with recurrent disease with small residual disease (including retention of ascetic fluid, para-aortic nodes recurrence after optimal debulked after interval debulking surgery; IDS) were eligible. The protocol regimen consisted of IP-PTX on day1 (D1), 8, and 15, at a starting dose level 1(DL1) of 45 mg/m2, with 15 mg/ m2 incremental, and IV-CBDCA was fixed dose AUC 5.0 mg/mL.min on D1, monthly. The accrual period was from August 2000 until September 2005. As for result, twelve patients were enrolled. No dose limiting toxicity (DLT) was observed in DL1. In dose level 2 (DL2, 60 mg/m2), one grade 3 (G3) hypersensitive reaction to CBDCA was detected. Further 5 patients had been enrolled but additional DLT was not identified. The RD was decided as DL2, which was the same dose of RD in weekly IP-PTX reported by Francis et al. The serum AUCs of PTX in DL1 and DL2 were 1605 nM.min and 2365 nM.min, respectively. By serum CA125, five complete responses were observed out of 8 evaluable patients by Rustin’s criteria. In conclusion, the combination of weekly IP-PTX and monthly IV-CBDCA at AUC 5.0 mg/mL.min was feasible and the recommended dose of IP-PTX was 60 mg/m2. The therapy was moderate effective for optimal debulking mullerian carcinomas. From our pharmacokinetic results, as for the patients with extra-pelvic lesions, additional IV-PTX would be necessary like GOG 172 experimental arm.","PeriodicalId":140922,"journal":{"name":"Journal of Cancer Biology and Therapeutics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115206315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Peptides and Cancer: Potential Use of Antimicrobial-Like Peptides in Chemotherapy 抗菌肽与癌症:类抗菌肽在化疗中的潜在应用

Journal of Cancer Biology and Therapeutics Pub Date : 2019-06-04 DOI: 10.18314/GJCT.V5I1.1777

Mizejewski Gj

{"title":"Antimicrobial Peptides and Cancer: Potential Use of Antimicrobial-Like Peptides in Chemotherapy","authors":"Mizejewski Gj","doi":"10.18314/GJCT.V5I1.1777","DOIUrl":"https://doi.org/10.18314/GJCT.V5I1.1777","url":null,"abstract":"Antimicrobial peptides (AMPs) constitute host defense peptides found among insects, fish, amphibians, and mammals including man. The targets of AMPs are gram-negative and gram-positive bacteria, fungi, enveloped viruses, and transformed/cancerous cells. The AMPs are broad spectrum antibiotics which display the propensity to serve as therapeutic agents not only in infectious disease, but also in human cancer. AMPs demonstrate unique properties which include cell membrane penetration, destabilization of biological membranes, ability to form and/or interact with membrane channels, and the capability to modulate host immune responses. The three types of AMPs consists a) naturally-occurring; b) artificially synthesized; and c) cleaved peptide fragments from blood and extracellular matrix proteins. The present treatise presents one such example of an AMP-like peptide derived from a naturally-occurring human protein as a potential candidate for future cancer therapy. The biological activities of human AMP-like peptides as cancer therapeutic agents are reviewed and reported in multiple in vitro and in vivo cancer assays. The possibility of using such human protein-derived peptides as primary and adjunct cancer therapeutic agents is addressed.","PeriodicalId":140922,"journal":{"name":"Journal of Cancer Biology and Therapeutics","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124772101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Complete Response to Anti-PD-1 Antibody Monotherapy in Metastatic Melanoma-Can Therapy be Discontinued? A Review of Current Literature 抗pd -1抗体单药治疗转移性黑色素瘤的完全缓解-可以停止治疗吗?当前文献综述

Journal of Cancer Biology and Therapeutics Pub Date : 2019-02-08 DOI: 10.18314/GJCT.V5I1.1543

A. Philip

引用次数: 0

Zoledronic Acid and Leuprolide Acetate Affect Du-145 Migration towards Stem Cell Conditioned Medium 唑来膦酸和醋酸Leuprolide影响Du-145向干细胞条件培养基的迁移

Journal of Cancer Biology and Therapeutics Pub Date : 2019-02-06 DOI: 10.18314/GJCT.V4I1.1052

G. Montagna, F. Bertolini, B. Mognetti, G. Sibille

{"title":"Zoledronic Acid and Leuprolide Acetate Affect Du-145 Migration towards Stem Cell Conditioned Medium","authors":"G. Montagna, F. Bertolini, B. Mognetti, G. Sibille","doi":"10.18314/GJCT.V4I1.1052","DOIUrl":"https://doi.org/10.18314/GJCT.V4I1.1052","url":null,"abstract":"Prostate cancer (PCa) is the most frequent genitourinary tumour and the third specific death cause, mostly because of bone metastasis. Currently, PCa is treated with GnRH analogues (leuprolide acetate-LA) and bisphosphonates (zoledronic acid-ZA) often in association. Thus, the aim of this work has been to study, in vitro, the effects of these drugs on cell line derived from PCa (DU-145). Particularly, we focused on some crucial aspects that drugs might play in tumor evolution and metastatization, by interfering with vitality, migration and interactions with bone cells. ZA cytotoxicity has been confirmed on DU-145 after 48-hours incubation at 5 μM, while LA cytotoxicity appears only after 72-hours contact at higher concentrations (100 μM). Both sub cytotoxic ZA and LA doses decreased 3D (transwell assay) PCa cell migration rate. pAkt/Akt ratio is diminished by LA and, even if less strikingly, by ZA, in agreement with the respective inhibition migration ratios. Cells underwent migration test in mesenchymal stem cells – MSC – conditioned medium (MSC-CM), which significantly increases the rate of migration (210%± 2.2; P<0.05). Addition of both ZA and LA quenched the attractive effect of conditioned medium. Our results suggest that LA and, mostly, ZA have a direct toxic effect on cancer cells. Furthermore, they inhibit cellular migration even under attractive stimuli exerted by MSC, and this might contribute to explain their effect in limiting metastatization.","PeriodicalId":140922,"journal":{"name":"Journal of Cancer Biology and Therapeutics","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131502762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Myeloma and Primary Sjogren’s Syndrome Combined with Unexplained Elevation of CA-125 Levels 多发性骨髓瘤和原发性干燥综合征合并CA-125水平不明原因升高

Journal of Cancer Biology and Therapeutics Pub Date : 2019-01-24 DOI: 10.18314/GJCT.V5I1.1465

Jun Du, S. Deng, L. Qiu, G. An

引用次数: 0

Implications of DNA Damage and Induction of DNA Repair Gene Expression in Cutaneous vs Mucosal Melanoma 皮肤和粘膜黑色素瘤中DNA损伤和DNA修复基因表达诱导的意义

Journal of Cancer Biology and Therapeutics Pub Date : 2018-12-28 DOI: 10.18314/gjct.v4i1.1418

Tyler Kloweit, L. Buckingham, Nicholas Gattuso, B. Tajudeen, P. Batra, V. Reddy, P. Gattuso

{"title":"Implications of DNA Damage and Induction of DNA Repair Gene Expression in Cutaneous vs Mucosal Melanoma","authors":"Tyler Kloweit, L. Buckingham, Nicholas Gattuso, B. Tajudeen, P. Batra, V. Reddy, P. Gattuso","doi":"10.18314/gjct.v4i1.1418","DOIUrl":"https://doi.org/10.18314/gjct.v4i1.1418","url":null,"abstract":"Background: This study addressed implications of DNA damage and repair in radiation induced cutaneous melanoma (CM) compared to de novo arising mucosal melanoma (MM). The role of DNA repair was assessed through two DNA repair genes: the human DNA repair genes XRCC3 and RAD5. These genes were selected based on significant homology to the radio-resistant Deinococcus radiodurans RecA (46.8% and 42.9% homology, respectively).Methods: DNA damage in melanoma was assessed and quantified by immunoassay for a marker of DNA damage, 8-hydroxy-2’-deoxyguanosine (8-OHdG). Gene expression analysis was measured by RT-qPCR.Results: In cutaneous melanoma, DNA damage was significantly higher in tumor than adjacent non-malignant tissue (p = 0.001 < 0.05). In contrast, for MM, DNA damage was similar in the non-malignant tissue and tumor (p = 0.965 > 0.05). Alcohol use was correlated with higher DNA damage in the MM (p = 0.036 < 0.05) than in the cutaneous melanoma patients (p = 0.104 > 0.05). The high DNA damage in mucosal tissue was not accompanied by induction of XRCC3 and RAD51 expression, compared to non-malignant tissue adjacent to CM.Conclusions: These observations are consistent with a pre-cancerous condition in MM, one in which repair functions are not induced and DNA damage is allowed to accumulate. Defects in repair functions may increase susceptibility to therapy with DNA damaging agents.","PeriodicalId":140922,"journal":{"name":"Journal of Cancer Biology and Therapeutics","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130512500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0