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PREECLAMPSIA: Parte 2°: fisiopatologia e trattamento 子痫前期第二部分生理病理学和治疗

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-07 DOI: 10.1177/0394936219846823

S. Michelassi

引用次数: 0

La patologia da Citomegalovirus nel paziente portatore di trapianto renale: impatto, prevenzione e trattamento 携带肾移植的患者的细胞病毒病理学:影响、预防和治疗

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-07 DOI: 10.1177/0394936219846415

Carlo Alfieri, M. Gandolfo, E. Favi, Marianna Tangredi, Paola Monciino, P. Messa

引用次数: 0

Densitometria ossea: una breve guida per il nefrologo 骨密度测定:肾病学家的简短指南

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-07 DOI: 10.1177/0394936219846435

Francesco Iannuzzella, Giulio Pioli, M. Maiorana, Mariacristina Gregorini

引用次数: 0

Disuguaglianze e malattia renale cronica: risultati dall’atlante italiano delle disuguaglianze di mortalità per livello di istruzione 不平等和慢性肾病:意大利教育水平死亡率不平等地图集的结果

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-07 DOI: 10.1177/0394936219847105

A. di Napoli, F. Franco, A. Rossi, M. Ventura, A. Petrelli

{"title":"Disuguaglianze e malattia renale cronica: risultati dall’atlante italiano delle disuguaglianze di mortalità per livello di istruzione","authors":"A. di Napoli, F. Franco, A. Rossi, M. Ventura, A. Petrelli","doi":"10.1177/0394936219847105","DOIUrl":"https://doi.org/10.1177/0394936219847105","url":null,"abstract":"Inequalities and chronic kidney disease: findings from the italian atlas of mortality inequalities by education level The findings of the study are taken from the Atlas of Mortality Inequalities, which is the result of the scientific collaboration between the National Institute for Health, Migration and Poverty (INMP) and the Italian National Institute of Statistics (Istat). This Atlas has a longitudinal study design of the population enrolled in the 2011 Census and includes the changes of the population over time by registering any exit due to death or emigration. The following outcomes were calculated: 1) provincial maps showing for each cause of death the distribution in quintiles of smoothed standardized mortality rate (SMR), adjusted for age and education level; 2) regional maps of population attributable fraction (PAF) for low and medium education levels, calculated starting from age-standardised mortality ratios; 3) tables illustrating for each region the mortality rates and standardised years of life lost by age; mortality rate ratios standardised by age. Our study evaluated the geographical and socioeconomic differences in mortality due to diseases of kidney and urethra, using maps and indicators. Excess mortality for diseases of kidney and urethra were found in all the southern regions (24% of women and 18% of men), with a marked north-south gradient. The PAF for diseases of kidney and urethra are generally low among men, while, among women, PAF over 25% were found in the South and the Islands, in Toscana, Umbria, Piemonte and Bolzano.","PeriodicalId":140919,"journal":{"name":"Giornale di Techniche Nefrologiche e Dialitiche","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127674882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Fisiopatologia del rigetto acuto e cronico 急性和慢性排斥的生理病理学

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-07 DOI: 10.1177/0394936219847416

Aris Tsalouchos, M. Salvadori

{"title":"Fisiopatologia del rigetto acuto e cronico","authors":"Aris Tsalouchos, M. Salvadori","doi":"10.1177/0394936219847416","DOIUrl":"https://doi.org/10.1177/0394936219847416","url":null,"abstract":"Physiopathology of acute and chronic rejection Allograft rejection is defined as tissue injury produced by the effector mechanisms of the alloimmune response, leading to deterioration of graft function. There are two types of rejection: T-cell-mediated rejection (TCMR) and antibody-mediated rejection (AMR). Both types of rejection can be early or late, fulminant or indolent, as well as isolated or concomitant and can share pathologic features on biopsy. The immune response to an allograft is an ongoing dialogue between the innate and adaptive immune system, which if unresolved will lead to rejection of the transplanted cells, tissues, or organs. Activation of elements of the innate immune system, triggered by tissue injury sustained during cell isolation or organ retrieval and ischemia reperfusion, will initiate and amplify the adaptive response. T cells require a minimum of two signals for activation: antigen recognition and co-stimulation. Antibody-mediated rejection triggered by alloantibody binding and complement activation is increasingly recognized as a significant contribution to graft loss. Even though one component of the immune system may dominate and lead to rejection, this is usually multifactorial, resulting from the integration of multiple mechanisms. Identifying the molecular pathways that trigger rejection facilitates the identification of targets for the development of immunosuppressive drugs.","PeriodicalId":140919,"journal":{"name":"Giornale di Techniche Nefrologiche e Dialitiche","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133303042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

La Giornata Mondiale del Rene 2019 presso l’Istituto Nazionale Salute Migrazioni e Povertà (INMP) 国家移徙与贫穷研究所(INMP) 2019年世界肾脏日

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-03 DOI: 10.1177/0394936219843217

M. Lombardi, A. di Napoli

引用次数: 0

Il paziente con rene policistico negli ambulatori italiani 意大利诊所的多囊肾病患者

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-03 DOI: 10.1177/0394936219847894

Emanuela Dorigo, Luisa Sternfeld Pavia

{"title":"Il paziente con rene policistico negli ambulatori italiani","authors":"Emanuela Dorigo, Luisa Sternfeld Pavia","doi":"10.1177/0394936219847894","DOIUrl":"https://doi.org/10.1177/0394936219847894","url":null,"abstract":"ADPKD patients in the Italian clinics Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. PKD is a multisystem disorder associated with multiple bilateral renal cysts, slowly increasing kidney size and progressive chronic kidney disease. Approximately 50% of individuals with PKD will require renal replacement therapy by the sixth decade of life. More than 80% will also have multiple liver cysts, which can lead to local pressure effects. Cerebral haemorrhage, secondary to rupture of a berry aneurysm, occurs in up to 8% of individuals. Mitral valve prolapse occurs in up to 25% of patients. Patients with ADPKD have a worsening in the quality of life and a burden of disease similar to cancer patients. The quality of correct information given to patients and a warm reception have a positive impact on patients with ADPKD and contribute to an efficacious treatment program. AIRP conducted a survey to investigate the ADPKD patient journey, meaning the personal experience and expectations of people regarding factors such as disease management, relationships with the nephrologists and their team, and therapies. The survey was conducted on 370 people with ADPKD, using computer-assisted web interviewing (CAWI). The results show that patients with ADPKD with a good relationship with their care team, both nephrologist and nurse, respond better to therapies. Warm reception, dialogue, communication, support, clear explanation, reassurance and guidance altogether contribute to a successful treatment of every single person with ADPKD.","PeriodicalId":140919,"journal":{"name":"Giornale di Techniche Nefrologiche e Dialitiche","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132564750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrafiltrazione peritoneale e sindrome cardiorenale: gestione del sovraccarico di fluidi e ruolo del sodio 腹膜超滤和肾综合征:液体超载管理和钠的作用

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-05-03 DOI: 10.1177/0394936219846414

L. Di Lullo, C. Ronco, F. Floccari, A. De Pascalis, R. Rivera, A. Granata, A. Bellasi

引用次数: 0

Evoluzione della ricerca scientifica nell’ambito della biologia umana: abbiamo raggiunto il momento in cui dobbiamo fermarci e riflettere? 人类生物学科学研究的发展:我们是否已经到了需要停下来思考的时候?

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-03-01 DOI: 10.1177/0394936219836656

A. Barracca, Patrizia Francesca Patricelli, Maria Rinaldi Milani, G. Quintaliani

{"title":"Evoluzione della ricerca scientifica nell’ambito della biologia umana: abbiamo raggiunto il momento in cui dobbiamo fermarci e riflettere?","authors":"A. Barracca, Patrizia Francesca Patricelli, Maria Rinaldi Milani, G. Quintaliani","doi":"10.1177/0394936219836656","DOIUrl":"https://doi.org/10.1177/0394936219836656","url":null,"abstract":"Evolution of scientific research in human biology. Have we reached a point where we have to stop and reflect? No one wants to question the scientific method, which is the method science uses to proceed and expand our knowledge of the reality. However, we can ask ourselves if scientific research has limits that we cannot overcome? In 1942, Julius Robert Oppenheimer, who ran the Manhattan project to develop the first atomic bomb, was the first to understand that the limits should not be overcome in scientific research. With the discovery of the molecular structure of the nucleic acid, and its meaning in the transmission of information in living beings, we have entered the knowledge of the \"mysteries\" of life. We have learned to read DNA, to write it and to modify it, cutting defective parts with the CRISPR/Cas9 technique. With genetic editing we can not only avoid many diseases, but also modify the DNA sequence in future generations. Have we reached a point where we must stop? Perhaps we must begin to consider that science must progress together with philosophical and ethical thought in the interest of the community.","PeriodicalId":140919,"journal":{"name":"Giornale di Techniche Nefrologiche e Dialitiche","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128327696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preeclampsia: Parte 1°: clinica, anatomia patologica e fisiologia 子痫前期:第1部分:临床、病理解剖学和生理学

Giornale di Techniche Nefrologiche e Dialitiche Pub Date : 2019-03-01 DOI: 10.1177/0394936219836633

S. Michelassi

引用次数: 0