Proceedings of the Shevchenko Scientific Society. Medical Sciences最新文献

{"title":"COVID-19 PULMONARY PATHOLOGY: A MULTI-INSTITUTIONAL AUTOPSY COHORT FROM LVIV AND LVIV REGION","authors":"J. Kuzyk, O. Gavrilyuk, Marta Semko, B. Ribun, A. Arefyeva","doi":"10.25040/ntsh2022.02.02","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.02","url":null,"abstract":"Introduction. Worldwide, more than 182 million cases of COVID-19 and more than 3.9 million deaths have been confirmed since the virus was first identified. Advanced age and some comorbid conditions, such as diabetes and cardiovascular diseases, are considered risk factors for the adverse course of the discussed pathology. In recent years, several reports have been published about the results of the pathological examination of patients with COVID-19. Most often, in fatal cases, diffuse alveolar damage is described, which is characterized by intraalveolar edema, the appearance of \"hyaline” membranes and the proliferation of pneumocytes and fibroblasts. However, the nature of the damage caused by SARS-CoV-2 remains unclear. The study of pathomorphological changes in severe fatal cases of COVID-19 is important for a better understanding of pathogenetic mechanisms of the development of pulmonary complications and the development of new effective methods of antiviral treatment. The aim of the current study is to evaluate the gross and microscopic findings in COVID-19 patients' autopsy to investigate the clinicopathologic basis for adverse outcomes with a fatal course of the disease. Methods. A retrospective analysis of 1036 consecutive autopsies associated with COVID-19 in 2020 was conducted based on Lviv Regional Office for Autopsy and Lviv Railway Clinical Hospital. The diagnosis of COVID-19 was confirmed by clinical signs of viral pneumonia, nasopharyngeal smear analysis, and radiological changes. A statistical study was performed with IBM SPSS Statistics 24.0. Results. The majority (72.4%) were elderly (60+) males (54.1±1.5%) and females (45.9±1.5%), with an age range from 19 to 93 years (mean age 66.9 ± 0.4 years). All examined patients had pneumonia, which was detected during a clinical examination with CT diagnosis and confirmed at autopsy. The acute exudative phase of pneumonia was diagnosed in 18.5±1.2% of cases, proliferative phase - in 18.5±1.2%, and fibrotic phase - in 5.9±0.7%. And in 53.5±1.5% of cases, signs of progressive fibrosis associated with exudative lesions prevailed. COVID-19 was the single original cause of death in 88.7±1.0% of cases. The following were identified in the lungs: typical virus-induced changes in epithelial cells of the trachea, bronchi, bronchioles and alveoli (100%, n=1036);different phases of diffuse alveolar damage in the majority of cases (96.5±0.6%);manifestations of innate immunity were described;pathological changes in the microvasculature (large vessel thrombi were detected in 37.9±1.5%). Conclusion. Our study results prove the importance of pathological examination of tissues during autopsies to determine the pathophysiological mechanisms and underlying causes of death of patients with COVID-19. © Yuliia Kuzyk, Olena Gavrilyuk, Marta Semko, Borys Ribun, Anna Arefyeva, 2022.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133920442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RELATIONSHIP OF APOPTOSIS AND SECONDARY NECROSIS OF LEUCOCYTES WITH ACTIVITY OF DISEASE AND CLINICAL MANIFESTATION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS","authors":"I. Kril, Jaroslav Tolstyak, A. Havrylyuk, H. Potomkina, V. Chopyak","doi":"10.25040/ntsh2022.02.01","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.01","url":null,"abstract":"","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125474628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREDICTIVE NOMOGRAM OF THE RISK OF PERITONEAL RELAPSE FOLLOWING RADICAL GASTRIC CANCER SURGERY","authors":"R. Yarema, Мyron Оhorchak, P. Hyrya, Y. Kovalchuk, V. Safiyan, Y. Oliynyk, O. Rilinh, M. Matusyak","doi":"10.25040/ntsh2022.02.03","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.03","url":null,"abstract":"","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124636408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETECTION OF SPECIFIC ANTIBODIES USING MPT83-MPT63 FUSION PROTEIN IN PATIENTS WITH DESTRUCTIVE PULMONARY TUBERCULOSIS","authors":"O. Rekalova, O. Panasiukova, Marina Pogrebna, Svitlana Yasir, A. Siromolot, S. Romaniuk, Denis Kolybo, S. Komisarenko, Y. Feschenko","doi":"10.25040/ntsh2022.02.04","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.04","url":null,"abstract":"","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131867524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEIOMYOMA IN CASE OF MAYER-ROKITANSKY-KÜSTER-HAUSER SYNDROME: DIFFICULTIES IN DIAGNOSIS","authors":"L. Markin, Lidia Segedii","doi":"10.25040/ntsh2022.01.11","DOIUrl":"https://doi.org/10.25040/ntsh2022.01.11","url":null,"abstract":"Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) is diagnosed in one in 4000-5000 newborn girls. This syndrome is characterized by the female phenotype, normal karyotype 46, XX, congenital absence of the vagina or its upper part, cervix and uterus. The etiology of MRKH syndrome is still unknown, probably due to its heterogeneity. The article highlights and summarizes the literature on the probable etiological factors of MRKH syndrome development, the possibility of the reproductive function realization of patients with Müllerian agenesis. A rare case of leiomyoma in patients with MRKH, possibilities and diffi culties of diagnosis are described in the article. It is shown that the presence of MRKH syndrome does not exclude the possibility of fi broids of diff erent localization.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131489227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE WAR AND SCIENCE IN UKRAINE: WE CAN CONTRIBUTE TO VICTORY","authors":"Oksana Zayachkivska, Teresa Smiechowska, S. Souchelnytskyi","doi":"10.25040/ntsh2022.01.02","DOIUrl":"https://doi.org/10.25040/ntsh2022.01.02","url":null,"abstract":"We are happy to present a new issue of the Proceedings of the Shevchenko Scientific Society. Medical Sciences, No. 1, 2022. First of all, we are grateful to the Armed Forces of Ukraine for this possibility, as today is the 100th day of the heroic resistance of Ukrainians in the criminal Russian war. We are proud of our defenders who are fighting the biggest threat to humanity in the 21st century. 12 million Ukrainians have been forced to leave their homes, 1,123 educational institutions have been destroyed, and 641 healthcare facilities are no longer functioning, while the number of civil casualties cannot be identified due to the brutality and hostilities of the villains. The number of murdered and deported Ukrainians is impossible to determine. However, the entire world knows about the bravery of Ukrainians, about Mariupol and Azovstal – two symbols of steel resilience and invincibility of the morale of the Ukrainian people in the fight for the independence of its Motherland and resistance to rascism. In the article, Ya. Shuba provides a detailed explanation of the meaning of this term and its similarity to fascism [1]. Today, more than ever, we need a victory in the information and psychological war, waged by the enemy. Therefore, science and art (Fig. 1) are two leading tools in our fight for independence, which are also sensitive indicators of events in real-time not just in Ukraine, but across the globe, too. Be sure to read Y. Yaskiv’s address to the world academic community [2]. Coping with the challenges and hardship of the contemporary times and remembering the bitter experience of World War II, the primary task of the progressive global community is to maintain the functioning of Ukrainian scientific medical publications, publishing houses, and academic communities. Ensuring the possibility to conduct scientific research for our scientists in the laboratories of partner institutions and fellow scientists, will enhance the international presence of Ukrainian science. Such international publications will help successfully boost the readability and quotability of articles prepared by Ukrainian scientists and scientists of Ukrainian origin, as well as represent Ukraine in global science with dignity. Publications by Pishel V. et al. and Kukhlevskyy S. et al. are examples of fruitful cooperation encouraging further development of the international status of Ukrainian science [3, 4]. The success of the consolidation of Ukrainian science in the international arena is related to the need for changes in science management. Science warrants progress. Therefore, the science generating progress, ideas and products at the international level, should be supported. The science to be supported must not be determined by titles, positions and connections, but by actual international achievements. Diversification of funding tools, more freedom in the management of scientific works, and, certainly, personal responsibility of the scientist or supervisor fo","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132572554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHAT IS RUSCIST-STYLE “DENAZIFICATION” LIKE?","authors":"Yaroslav Shuba","doi":"10.25040/ntsh2022.01.05","DOIUrl":"https://doi.org/10.25040/ntsh2022.01.05","url":null,"abstract":"It is well known that one of the demands for capitulation put forward to Ukraine by V. Putin and his clique and the one that they use to justify Russian aggression is denazifi cation. Most people associate this term with Hitler’s Nazism and the desire of humankind after WWII to get rid of this misanthropic ideology, which enshrines the domination of one nation over others. In the late 20th century, no country in the world professed this ideology. Isolated marginalized groups that still keep following it are outlawed and have no infl uence on the public life of any country. This is equally applicable to Ukraine where Nazi ideology is offi cially banned. The matter of how to call a war unleashed by Putinist Russia is sometimes disputed. Some suggest calling it “Patriotic War”, others – “National Liberation War”. However, perhaps it would be better to call it the “Fight for Ukraine”. NRFU web site https://nrfu.org.ua/en/news-en/every-story-must-be-heard-8/ YouTube https://youtu.be/-2wATBxekro https://1drv.ms/u/s!Am4xBomp_lxngYJZYHEowLd-gCs0Sg?e=n9PumF","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117000654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE PLACE OF LEFLUNOMIDE IN DISEASE-MODIFYING THERAPY OF RHEUMATOID ARTHRITIS: NEW ASPECTS","authors":"O. Iaremenko, G. Mikitenko","doi":"10.25040/ntsh2022.01.16","DOIUrl":"https://doi.org/10.25040/ntsh2022.01.16","url":null,"abstract":"A new mechanism of lefl unomide (LEF) action was recently discovered, namely its ability to infl uence the intracellular mechanism of the infl ammatory process by inhibiting JAK kinases, which brings it closer to the new most eff ective group for treatment of rheumatoid arthritis (RA) – Janus kinase inhibitors. The article presents data from both our own and other authors’ studies on the eff ectiveness and safety of the drug in comparison with other synthetic and biological basic agents. The aim of our study was a comparative evaluation of LEF, methotrex- ate (MTX), sulfasalazine (SS) and their combinations (CDT) in 402 patients with RA. Obtained results showed advantages of LEF and СDT over the use of SS (at any RA duration) and MTX (at late RA). Adverse events were the lowest in the SS group, and disease-modifying anti-rheumatic drug (DMARD) discontinuation due to complications was the lowest in the LEF group. Based on the results of multifactor regression analysis, we developed a scheme of individualized selection of the most eff ective DMARD depending on the initial characteristics of RA patients. The article also presents international study data. It analyses the comparative effi cacy of LEF (10-20 mg/d) and low doses of rituximab (500 mg twice daily) in patients refractory to MTX therapy; effi cacy of LEF in monotherapy (5-40 mg/d) and combination with other DMARD; LEF at a dose of 100 mg/week and MTX at a dose of 10 mg/week; LEF at a dose of 50 mg once a week and 10 mg daily. The eff ect of LEF on uric acid levels and bone mineral density of the lumbar spine in patients with RA was studied.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116140472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AORTOARTERITIS AND SEVERE AORTIC INSUFFI CIENCY IN A PATIENT AFTER COVID-19","authors":"N. Oryshchyn, Y. Ivaniv","doi":"10.25040/ntsh2022.01.07","DOIUrl":"https://doi.org/10.25040/ntsh2022.01.07","url":null,"abstract":"Aortoarteritis is a rare cause of the aortic insuffi ciency, but it should be considered among the other causes of aortic regurgitation. A number of cases of autoimmune aortoarteritis have been reported during the COVID-19 pandemic. We present a case report of aortoarteritis with severe aortic insuffi ciency, which developed in a patient after a mild form of coronavirus infection and an episode of arthritis. Echocardiography revealed severe aortic regurgitation, dilatation of the thoracic aorta and thickening of the aortic walls. Ultrasonography showed thickening of the carotid arterial walls. Computed tomography confi rmed the diagnosis of aortoarteritis. Elevated C-reactive protein indicated an acute infl ammatory process. Aortoarteritis was treated with methylprednisolone with good clinical response. Possible causes of aortoarteritis are discussed: Takayasu arteritis, giant cell arteritis, ankylosing spondylitis and polychondritis. After exclusion of all possible causes, aortoarteritis in the patient was diagnosed as an autoimmune process caused by coronavirus infection. Cases of arteritis in patients related to COVID-19 are discussed. Multimodality diagnostics (echocardiography, contrast-enhanced computed tomography, ultrasonography of aortic branches) play a central role in detecting aortic lesions and evaluating the extent of the pathological process in aortitis. A laboratory workup is needed to identify the cause of the aortitis. The fi nal diagnosis should be made on the analysis of clinical manifestations, diagnostic and laboratory fi ndings.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129505741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOCIAL AVOIDANCE AS A PATHOGENETIC LINK BETWEEN SOCIAL ANXIETY DISORDER AND POST- TRAUMATIC EXPERIENCE: THE REVIEW","authors":"O. Avramchuk, Oksana Plevachuk, O. Suvalo","doi":"10.25040/ntsh2022.01.10","DOIUrl":"https://doi.org/10.25040/ntsh2022.01.10","url":null,"abstract":"Social avoidance in the concept of “avoidance of corrective emotional experience” is regarded as one of the pathogenetic factors that aff ect the course and development of mental disorders and increase distress. We conducted a review of studies that studied the role of social avoidance in social anxiety disorder among individuals with or without post-traumatic experience. Inclusion criteria were: 1) subjects were diagnosed with social anxiety disorder; 2) social anxiety disorder and/or post-traumatic stress was a focus of the study; 3) some assessment or review impact of social avoidance was made; 4) subjects were adolescents or adults. The study of the role of avoiding social events as a traumatic trigger and related socially signifi cant factors (stigma, discrimination, living at constant risk, etc.) indicates a correlation between the pathogenesis of social phobia and comorbid symptoms of post-traumatic distress. Managing social avoidance strategies and accepting the conscious experience of social interaction presupposes a person’s readiness to react fl exibly, stay in contact with their emotions and thoughts, and not spend internal resources to get rid of the inner concerns. In our opinion, this will help reduce the perception of social events as a traumatic (retraumatic) factor, reduce clinically signifi cant manifestations of social anxiety and prevent the development of post-traumatic distress. Limitations and implications of these fi ndings for the psychological support and modifying psychotherapeutic interventions of social anxiety disorder are discussed.","PeriodicalId":140699,"journal":{"name":"Proceedings of the Shevchenko Scientific Society. Medical Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132439457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}