International Journal of Medicine and Medical Research最新文献_第10页

DYNAMICS OF PERIODONTAL TISSUES MICROBIOCENOSIS UNDER THE COMPLEX TREATMENT OF CATARRHAL GINGIVITIS AND CHRONIC GASTRODUODENITIS IN THE ADOLESCENTS 青少年卡他性牙龈炎和慢性胃十二指肠炎综合治疗下牙周组织微生物病的动态变化

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/IJMMR.2413-6077.2018.2.9650

I. Lisetska, M. Rozhko, R. Kutsyk

{"title":"DYNAMICS OF PERIODONTAL TISSUES MICROBIOCENOSIS UNDER THE COMPLEX TREATMENT OF CATARRHAL GINGIVITIS AND CHRONIC GASTRODUODENITIS IN THE ADOLESCENTS","authors":"I. Lisetska, M. Rozhko, R. Kutsyk","doi":"10.11603/IJMMR.2413-6077.2018.2.9650","DOIUrl":"https://doi.org/10.11603/IJMMR.2413-6077.2018.2.9650","url":null,"abstract":"Background. The key links in the etiology and pathogenesis of periodontal tissue diseases are the quantitative and qualitative changes in the composition of the microflora of oral cavity, with the simultaneous deterioration of oral hygiene, reduction of local and general immunity, which occurs more often in the presence of somatic diseases. \u0000Objective. The aim of the research was to determine the clinical and microbiological efficacy of the developed treatment-prophylactic complex in the adolescents with catarrhal gingivitis and chronic gastroduodenitis before and after treatment. \u0000Methods. Changes were made to and before the treatment of clinical parameters, gingival microbiocenosis of 38 adolescents with generalized catarrhal gingivitis and chronic gastroduodenitis aged 12-18 years old, who comprised the main group. In the comparison group 25 adolescents of similar age diagnosed with generalized catarrhal gingivitis without any somatic diseases were involved. \u0000Results. It has been established that used combination (drug of plant origin with antimicrobial properties + dental gel with Metronidazole benzoate and Chlorhexidine digluconate + capsules of probiotics) yields the conventional treatment as well as exceeds it for examined clinical indicators and indexes. The treatment and prophylaxis with suggested complex have proved a significant positive effect on the gums microbiocenosis in adolescents with generalized catarrhal gingivitis and underlying concomitant gastroduodenitis. \u0000Conclusions. The suggested therapeutic and prophylactic complex provides a reduction in the massiveness and colonization frequency of the gum mucosa by pathogenic aerobic microflora (β-hemolytic streptococcus, golden staphylococcus, and yeast-like Candida fungi).","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42510641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RECONSTRUCTIVE SURGERY OF SEVERE DAMAGES OF LOWER EXTREMITIES INTEGUMENT AFTER INJURY 损伤后下肢表皮严重损伤的重建手术

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/ijmmr.2413-6077.2018.2.9696

O. Ponomarenko

{"title":"RECONSTRUCTIVE SURGERY OF SEVERE DAMAGES OF LOWER EXTREMITIES INTEGUMENT AFTER INJURY","authors":"O. Ponomarenko","doi":"10.11603/ijmmr.2413-6077.2018.2.9696","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2018.2.9696","url":null,"abstract":"Background. Injury of lower extremities requires the fastest and most effective method of closing wound surfaces. Objective. The aim of the study was to define the indications and improve the reconstructive interventions for severe damage of lower extremities integument due to mechanical trauma. Methods. During 2008-2016, 242 patients with defects of cover tissues of the body and extremities were operated in the clinic. Depending on the size, depth and degree of tissues damage, all were divided into 4 groups. Results. The lower extremity was the most vulnerable segment (75.2% of patients). Damage Control tactics was used in 83% of cases. To protect the functionally tense areas, free plastics by a split skin graft (the 1st group – 12.8%, the 2nd – 20.4%, the 3rd – 37%, the 4th – 8.9%) were used for closure of the defect. If the wound defect affected functionally significant structures up to 1% of the body surface, the complex flaps of local tissues, tissues close to the defect and anatomically distant areas (the 2nd group – 6%, the 3rd – 10.6%, the 4th – 4.3%) were used. If the defect was more than 1% of the body surface only functionally tense areas were closed with compound complexes of tissues. The rest of the skin was restored by means of autodermoplastics. We suggested and approved our specific protocol of treatment of such injury. Conclusions. Implementation of the suggested protocol of reconstructive interventions for closure of the defects of cover tissues of lower limbs allowed attaining a positive result in 98.8% of the interventions.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46327338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MELPHALAN-INDUCED CYTOTOXICITY IN THE BONE MARROW OF RATS BY FLOW CYTOMETRY MEASUREMENTS 流式细胞术测定美法仑对大鼠骨髓的细胞毒性

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/IJMMR.2413-6077.2018.2.9836

B. Gerashchenko, I. Todor, O. Shevchuk, V. Nikolaev

{"title":"MELPHALAN-INDUCED CYTOTOXICITY IN THE BONE MARROW OF RATS BY FLOW CYTOMETRY MEASUREMENTS","authors":"B. Gerashchenko, I. Todor, O. Shevchuk, V. Nikolaev","doi":"10.11603/IJMMR.2413-6077.2018.2.9836","DOIUrl":"https://doi.org/10.11603/IJMMR.2413-6077.2018.2.9836","url":null,"abstract":"Background. Bone marrow (BM) that contains hematopoietic cells of various lineages is a sensitive target for a number of cytotoxic agents including chemotherapy drugs. \u0000Objective. Flow cytometry (FCM) was chosen to test cytotoxicity in BM of rats, that received melphalan either intravenously (i.v.) or intraperitoneally (i.p.). \u0000Methods. One group of rats received melphalan i.v. (3 mg/kg) followed by the BM examination on the 3rd and 7th day after drug administration, whereas another group of animals received this drug i.p. in total doses of 9 and 15 mg/kg followed by the BM examination on the next day after the 3rd and 5th injection of the drug. BM cells were stained with acridine orange and analyzed by FCM. Cytotoxicity was assessed by determining the percentage of total nucleated cells (TNC%) among the whole BM cell population and by determining the percentage of polychromatic erythrocytes (PCE%) among the whole population of enucleated erythrocytes. \u0000Results. Regardless of the dose and regimen of melphalan administration, either i.v. or i.p. administered drug caused a significant reduction of TNC%. On the average, the i.p. administered drug resulted in about 2.0-fold decrease of TNC% (P<0.05), while the i.v. administered drug resulted in about 1.3-fold decrease of TNC% (P<0.05). As for enucleated erythrocytes, the i.p. administered drug resulted in about 1.4-fold decrease of PCE% (P<0.05), whereas the i.v. administered drug did not cause any changes in the PCE%. \u0000Conclusions. Under these experimental conditions, i.p. administrated melphalan is considerably more cytotoxic than i.v. administered melphalan. This cytotoxic effect is preferentially due to impaired erythropoiesis.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49224688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PREVALENCE OF GESTATIONAL DIABETES MELLITUS IN AN URBAN INDIAN COHORT USING DIABETES IN PREGNANCY STUDY GROUP IN INDIA (DIPSI) CRITERIA – VALIDATING ONE-STEP APPROACH 使用印度妊娠期糖尿病研究组（DIPSI）标准的印度城市队列中妊娠期糖尿病的患病率&验证一步法

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/ijmmr.2413-6077.2018.2.9317

Shazia Khan, H. Bal, Inam Danish Khan, D. Paul

{"title":"PREVALENCE OF GESTATIONAL DIABETES MELLITUS IN AN URBAN INDIAN COHORT USING DIABETES IN PREGNANCY STUDY GROUP IN INDIA (DIPSI) CRITERIA – VALIDATING ONE-STEP APPROACH","authors":"Shazia Khan, H. Bal, Inam Danish Khan, D. Paul","doi":"10.11603/ijmmr.2413-6077.2018.2.9317","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2018.2.9317","url":null,"abstract":"Background. India is the “World’s Diabetes capital”, with half the diabetic population being women. Early detection of glucose intolerance during pregnancy offers a timely opportunity for screening, management and prevention of gestational diabetes mellitus (GDM) and prevents fetal complications. \u0000Objective. The study assessed the prevalence of GDM in an Indian cohort using the Diabetes in Pregnancy Study group of India (DIPSI) criteria. \u0000Methods. 200 pregnant women underwent two-phase testing with non-fasting 75-gram glucose challenge under Diabetes in Pregnancy Study group of India (DIPSI) criteria at <20 weeks and between 24-28 weeks period of gestation. A 3-hour 100-gm oral glucose tolerance test (OGTT) was used for confirmation. Repeat testing was done for women negative during the first-phase. \u0000Results. Mean age was 24.26±3.75 years with 52.5% multigravidas. Mean Body Mass Index (BMI) was 20.7±3.07 kg/m2. The prevalence of GDM in study cohort was found to be 15.5% using the DIPSI criteria while the prevalence of GDM after 100 g OGTT was 13.0%. GDM was mostly seen to occur in women of 26-30-year age group. Statistically significant associations for age and GDM, and BMI and GDM were evidenced. \u0000Conclusions. Maternal age of ≥25 years should be adopted as a risk factor for the development of GDM. The DIPSI criteria offer a cost-effective and an evidence-based protocol for a single-step definitive glucose test for both screening and diagnosis of pregnant patients belonging to any socio-economic strata; furthering its implementation for public health obstetrics.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47602258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PREVALENCE AND RISK FACTORS FOR VITAMIN D DEFICIENCY IN OVERWEIGHT AND OBESE ADOLESCENTS IN UKRAINE 乌克兰超重和肥胖青少年维生素D缺乏的患病率和危险因素

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/IJMMR.2413-6077.2018.2.9694

Anna-Mariia Shulhai, H. Pavlyshyn

{"title":"PREVALENCE AND RISK FACTORS FOR VITAMIN D DEFICIENCY IN OVERWEIGHT AND OBESE ADOLESCENTS IN UKRAINE","authors":"Anna-Mariia Shulhai, H. Pavlyshyn","doi":"10.11603/IJMMR.2413-6077.2018.2.9694","DOIUrl":"https://doi.org/10.11603/IJMMR.2413-6077.2018.2.9694","url":null,"abstract":"Background. Vitamin D affects the function of many organs and systems. Lipid metabolism disorder is established to be one of the risk factors for vitamin D deficiency, and the amount of adipose tissue is crucial. \u0000Objective. The aim of the study was to determine the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents. \u0000Methods. 146 children with excessive weight and obesity as well as 63 healthy children with normal body weight were examined. In the study groups, there were no children taking vitamin D. Vitamin D status was evaluated by the level of 25(OH)D in blood serum. Vitamin D deficiency was diagnosed at the level of 25(OH)D between 20 and 29 ng/ml, and significant deficiency – below 20 ng/ml, normal calcidiol content was 30-100 ng/ml. \u0000Results. The average level of 25(OH)D in the adolescents with normal body weight was 19.76±4.28 ng/ml, in the adolescents with excessive body weight – 15.24±3.47 ng/ml, and in the obese children – 13.87±2.71 ng/ml. The prevalence of vitamin D deficiency in the overweight adolescents was 70.62%, and in the adolescents with obesity – 77.19%. \u0000Conclusions. Vitamin D deficiency is prevalent in the adolescents with overweight and obesity. To prevent the development of hypovitaminosis and vitamin D deficiency, it is necessary to carry out educational activities with adolescents for promotion of healthy lifestyle and healthy food, as well as to develop an optimal program for improving vitamin D status in the obese children.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47615800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BULLOUS PEMPHIGOID A RARE AUTOIMMUNE DISEASE: A CASE REPORT 大疱性类天疱疮是一种罕见的自身免疫性疾病

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/ijmmr.2413-6077.2018.2.9248

S. Biradar, S. Dhanavidya, P. Kavya, T. Keerthi, N. Sunanda, S. Marapur, V. Warad, N. Kalyane

{"title":"BULLOUS PEMPHIGOID A RARE AUTOIMMUNE DISEASE: A CASE REPORT","authors":"S. Biradar, S. Dhanavidya, P. Kavya, T. Keerthi, N. Sunanda, S. Marapur, V. Warad, N. Kalyane","doi":"10.11603/ijmmr.2413-6077.2018.2.9248","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2018.2.9248","url":null,"abstract":"Background. Bullous pemphigoid (BP) is a rare autoimmune blistering skin disease in the elderly and it is manifested by cutaneous blisters on the skin lesions. \u0000The objective was to emphasize the rare case of BP. \u0000Methods. A case report of BP in a 58-year-old male patient admitted to a dermatology ward is presented. \u0000Results. A 58-year-old male patient with complaints of fluid-filled skin lesions, was examined initially over the trunk, gradually progressed involving B/L upper and lower extremities. Even though the patient was treated with the recommended therapy of corticosteroid (Dexamethasone) along with adjuvant drugs, new skin lesions continued to develop, and the patient’s condition worsened. The Prednisolone was started in place of Dexamethasone on the fifth day of treatment at its higher dose (50mg/day), the Prednisolone proved its efficacy to combat the extensive condition of BP. \u0000Conclusions. Bullous pemphigoid is a distressing blistering skin disease. Untreated disease is often fatal because of the susceptibility to infection and fluid-electrolyte disturbances. The mortality of patients with bullous pemphigoid has been significantly reduced with the advent of new therapies and treatment modalities. The treatment with systemic and topical corticosteroids forms the mainstay of treatment along with other adjuvant drugs. In the present case study, the use of Prednisolone has proven its efficacy in the extensive disease state of BP and improved the patient’s quality of life.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47650783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MORPHOLOGICAL RESPONSE TO IMPLANTATION OF A POLYPROPYLENE MESH WITH A PRF MEMBRANE IN PATIENTS WITH POSTOPERATIVE VENTRAL HERNIA AND UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA 聚丙烯网片植入PRF膜对术后腹疝和未分化结缔组织发育不良患者的形态学反应

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/ijmmr.2413-6077.2018.2.9695

V. I. Piatnochka, A. Prodan

{"title":"MORPHOLOGICAL RESPONSE TO IMPLANTATION OF A POLYPROPYLENE MESH WITH A PRF MEMBRANE IN PATIENTS WITH POSTOPERATIVE VENTRAL HERNIA AND UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA","authors":"V. I. Piatnochka, A. Prodan","doi":"10.11603/ijmmr.2413-6077.2018.2.9695","DOIUrl":"https://doi.org/10.11603/ijmmr.2413-6077.2018.2.9695","url":null,"abstract":"Background. Current herniology promotes the widespread usage of mesh implants in the primary treatment and, especially, in the for postoperative ventral hernias. \u0000Objective. The aim of the research was to study the morphological response of the tissues of muscular aponeurotic layer to implantation of a polypropylene mesh with using PRF membrane-enriched platelets in the patients with postoperative ventral hernia and concomitant undifferentiated dysplasia of connective tissues. \u0000Methods. The research involved 98 patients with postoperative ventral hernia, who underwent retro-muscular alogernioplasty by the Sublay technique of implantation of ‘light’ meshes, and a ‘light’ polypropylene mesh (PPM) in combination with a platelet-rich fibrin (PRF) membrane. The patients were divided into experimental groups according to the presence of undifferentiated connective tissue dysplasia syndrome. \u0000Results. Microscopic studies carried out after the implantation of a polypropylene mesh with a PRF membrane has proved that structural changes in connective tissues are like those of a polypropylene mesh, but they are less significant. There was a leukocyte infiltration near the mesh material, but its area was small. The enlargement and blood filling of the vessels of microcirculatory channel was a manifestation of the increased vascularization of this area. \u0000Conclusions. The usage of a polypropylene mesh in combination with a PRF membrane in the surgical treatment of postoperative ventral hernias reduces inflammatory changes in the tissues significantly and increases the activation of fibroblasts and signs of collagen fibers around the mesh material that is relevant especially for the patients with connective tissue pathology.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43977740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INFRASTRUCTURE, RESOURCES, SERVICES EVALUATION AND GAP ANALYSIS OF INTEGRATED MATERNAL AND CHILD DEVELOPMENT SERVICES IN INDIA 印度综合妇幼发展服务的基础设施、资源、服务评价和差距分析

International Journal of Medicine and Medical Research Pub Date : 2019-03-01 DOI: 10.11603/IJMMR.2413-6077.2018.2.9286

S. Kaur, R. Gupta, Inam Danish Khan, S. Jindal, S. Prajapati, Anuradha Makkar, K. Rajmohan

{"title":"INFRASTRUCTURE, RESOURCES, SERVICES EVALUATION AND GAP ANALYSIS OF INTEGRATED MATERNAL AND CHILD DEVELOPMENT SERVICES IN INDIA","authors":"S. Kaur, R. Gupta, Inam Danish Khan, S. Jindal, S. Prajapati, Anuradha Makkar, K. Rajmohan","doi":"10.11603/IJMMR.2413-6077.2018.2.9286","DOIUrl":"https://doi.org/10.11603/IJMMR.2413-6077.2018.2.9286","url":null,"abstract":"Background. Integrated Child Development Services (ICDS) is an Indian community-centric government program organized under Anganwadi centres catering to supplementary nutrition, health and preschool education, primary healthcare, growth monitoring and counselling the children under six years old along with their mothers. It is the world’s largest outreach program in a developing country covering a population of 1.35 billion; the variations in service delivery were analysed involving cross-sectional rural and urban Anganwadi centers in New Delhi. \u0000Methods. Data were collected by assessment of children and mothers, interview of Anganwadi workers and observation of service delivery parameters and conduction of activities. Infrastructural, beneficiaries, services and content were evaluated by a suitable pre-tested questionnaire based on the National Institute of Public Cooperation and Child Development (NIPCCD) evaluation proforma. The data was analysed by a descriptive statistics. \u0000Results. Gaps were found in respect of infrastructure, resources, health and nutrition facilities especially at rural Anganwadi centre which was inadequate in terms of implementation of nutrition and health program, supplementary nutrition, preschool education and nutrition rehabilitation centre for existing beneficiaries. Both Anganwadi centres were not catering for new WHO growth standards and adolescent health. \u0000Conclusions. Gaps found in respect of infrastructure, resources, health and nutrition facilities can affect performance of ICDS program and the services delivered by Anganwadi centres, which need a boost. Both urban and rural centres have a direct opportunity towards delivering adolescent health program focusing on nutrition and education of girls prior to their pregnancy, and adoption of new WHO growth standards.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47697594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

IS METABOLOMICS THE DIAGNOSTIC TOOL FOR MEDICAL DIAGNOSTICS OF CANCER? AN EXAMPLE BASED ON LUNG AND BREAST CANCER 代谢组学是癌症医学诊断的诊断工具吗?以肺癌和乳腺癌为例

International Journal of Medicine and Medical Research Pub Date : 2018-07-25 DOI: 10.11603/IJMMR.2413-6077.2018.1.8921

A. Lamasz, W. Barg, P. Młynarz

{"title":"IS METABOLOMICS THE DIAGNOSTIC TOOL FOR MEDICAL DIAGNOSTICS OF CANCER? AN EXAMPLE BASED ON LUNG AND BREAST CANCER","authors":"A. Lamasz, W. Barg, P. Młynarz","doi":"10.11603/IJMMR.2413-6077.2018.1.8921","DOIUrl":"https://doi.org/10.11603/IJMMR.2413-6077.2018.1.8921","url":null,"abstract":"Background. Metabolomics is a relatively new diagnostic tool that allows a deep insight into the body metabolism at a cellular level. Objective. This paper provides a comprehensive view into the metabolomic methodology and shows usefulness of this approach in diagnosing and stratifying lung and breast cancers. Methods. Literature review of metabolomics studies and its clinical application in the diagnosis of cancer-selected studies.Results. In general, the metabolomic approach comprises three steps: 1) sampling and preparing biofluids or tissue homogenates, 2) identification of low-molecular weight compounds up to 1.0 kDa using nuclear magnetic resonance, mostly 1H-NMR and/or mass spectrometry, and finally 3) data processing and analysing. It is possible to identify a set of metabolites which is specific for a certain metabolic status (the metabolic fingerprint). Furthermore, this set of metabolites provides information of possible pathomechanisms involved in the disease process i.e. information about the disease etiology. It has been proven that the change in metabolome precedes other biomarkers of the disease; not only clinical symptoms but other laboratory findings as well. Consequently, this approach, if sufficiently validated, seems to be very promising especially in screening and early diagnosing. Conclusions. It was demonstrated that metabolomic approach allows to discriminate patients with cancer from healthy persons, as well as to differentiate between clinical stages of the cancer.","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43214989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EPIDEMIOLOGIC EVALUATION OF THYROID DISEASES MORBIDITY OF UKRAINIAN ADULT POPULATION FROM 2000 TO 2013 2000-2003年乌克兰成年人群甲状腺疾病发病率的流行病学评估

International Journal of Medicine and Medical Research Pub Date : 2018-07-25 DOI: 10.11603/IJMMR.2413-6077.2018.1.8971

A. Antonenko, M. Korshun, O. Vavrinevych, S. Omelchuk, V. Bardov

{"title":"EPIDEMIOLOGIC EVALUATION OF THYROID DISEASES MORBIDITY OF UKRAINIAN ADULT POPULATION FROM 2000 TO 2013","authors":"A. Antonenko, M. Korshun, O. Vavrinevych, S. Omelchuk, V. Bardov","doi":"10.11603/IJMMR.2413-6077.2018.1.8971","DOIUrl":"https://doi.org/10.11603/IJMMR.2413-6077.2018.1.8971","url":null,"abstract":"Background. The diseases of thyroid gland have been attracting considerable attention in recent decades. This is partly due to the fact that thyroid gland reacts actively to geochemical state and pollution of the environment with industrial and agricultural waste products with the subsequent incidence of certain pathological processes. The objective of the research was to analyze the morbidity of adult population of Ukraine for thyroid gland diseases in the period from 2000 to 2013.Methods. The methods of empirical and theoretical research of scientific information: analysis, synthesis, induction, deduction and systematization, as well as epidemiological and statistical methods were used. Using the Microsoft Office Excel (2007) and IBM SPSS StatisticsBase v.22 program the correlation and regression analyzes were conducted.Results. From 2000 to 2013, high levels of adult population endocrinopathies, thyroid in general and diffuse goiter of varying degrees, general and primary morbidity were registered in the western and northern regions of Ukraine, low – in the central, eastern and southern regions. Statistically significant (p<0.001) positive correlation between the level of prevalence and the level of incidence of endocrine pathology, diseases of thyroid gland as a whole, as well as individual nosology was detected. Conclusions. Regional peculiarities of the levels and dynamics of changes in the incidence rates of thyroid morbidity among adult population of Ukraine can be related to the urgent environmental factors for each region. This factor requires further study to develop effective methods of prophylaxis and defense. ","PeriodicalId":14059,"journal":{"name":"International Journal of Medicine and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43833413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2