{"title":"A Noteworthy Way to Predict Acute Decompensated Heart Failure in Patients With End-Stage Renal Disease.","authors":"Jong-Chan Youn, Jin-Jin Kim","doi":"10.36628/ijhf.2022.0012","DOIUrl":"10.36628/ijhf.2022.0012","url":null,"abstract":"","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 3","pages":"142-144"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/4a/ijhf-4-142.PMC9383352.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40573849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Paradox in Defining Obesity in Patients With Heart Failure.","authors":"Se-Eun Kim, Chan Joo Lee","doi":"10.36628/ijhf.2022.0010","DOIUrl":"10.36628/ijhf.2022.0010","url":null,"abstract":"","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 2","pages":"91-94"},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/4b/ijhf-4-91.PMC9383347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bong-Joon Kim, Soo-Jin Kim, Sung-Il Im, Hyun-Su Kim, Jung-Ho Heo, Ho Sik Shin, Ye Na Kim, Yeonsoon Jung, Hark Rim
{"title":"Increased Right Ventricular Pressure as a Predictor of Acute Decompensated Heart Failure in End-Stage Renal Disease Patients on Maintenance Hemodialysis.","authors":"Bong-Joon Kim, Soo-Jin Kim, Sung-Il Im, Hyun-Su Kim, Jung-Ho Heo, Ho Sik Shin, Ye Na Kim, Yeonsoon Jung, Hark Rim","doi":"10.36628/ijhf.2022.0001","DOIUrl":"https://doi.org/10.36628/ijhf.2022.0001","url":null,"abstract":"<p><strong>Background and objectives: </strong>Many patients with end-stage renal disease (ESRD) on hemodialysis (HD) have reduced vascular compliance and are likely to develop heart failure (HF). This study aimed to determine the factors associated with acute decompensation events among ESRD patients undergoing HD.</p><p><strong>Methods: </strong>We retrospectively investigated ESRD patients on HD using a medical record review. We divided the patients into those admitted to hospital due to acute decompensated heart failure (ADHF) and those who were not. We compared the medical histories, electrocardiograms, and echocardiographic and laboratory data between the two groups.</p><p><strong>Results: </strong>Of the 188 ESRD patients on HD, 87 were excluded, and 101 were enrolled (mean age: 63.7 years; 52.1% male). Thirty patients (29.7%) were admitted due to ADHF. These patients exhibited similar left ventricular ejection fraction (LVEF), left ventricular (LV) mass index, and E/E' values compared to the non-ADHF group. However, the ADHF group exhibited significantly higher tricuspid regurgitation (TR) jet velocity (2.9±0.6 vs. 2.5±0.4 m/s; p=0.004) and right ventricular systolic pressure (RVSP) (43.5±17.2 vs. 34.2±9.9 mmHg; p=0.009) than the non-ADHF group, respectively. A multivariate logistic regression analysis demonstrated that the TR jet velocity (odds ratio, 8.356; 95% confidence interval, 1.806-38.658; p=0.007) was an independent predictor of ADHF after adjusting for age and sex, while the LVEF and E/E' were not.</p><p><strong>Conclusions: </strong>Our data showed that an increased TR jet velocity was an independent predictor of ADHF events in ESRD patients on HD, but the LVEF and E/E' were not.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 3","pages":"154-162"},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/cb/ijhf-4-154.PMC9383351.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40573850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac Allograft Injuries: A Review of Approaches to a Common Dilemma, With Emphasis on Emerging Techniques.","authors":"Christopher Hayward","doi":"10.36628/ijhf.2021.0042","DOIUrl":"10.36628/ijhf.2021.0042","url":null,"abstract":"<p><p>Clinical features of allograft injury are often unreliable, and context within the transplant journey is key. In the setting of post-transplant allograft dysfunction, the choice of initial investigation depends on clinical assessment and history. One of the major considerations is the time post transplantation in helping to decide a likely cause for allograft injury. Immediately post transplantation, it is important to consider donor factors (including donor demographics as well as immunological match), ischaemic times, surgical issues as well as early rejection. Clinical suspicion needs to remain high with variable presentations, including haemodynamic instability, arrhythmia, as well as left ventricular dysfunction. Symptoms of allograft dysfunction may include dyspnoea, exertional intolerance, dizziness / lightheadedness, palpitations, as well as right or left heart failure. In the coming weeks and months, endomyocardial biopsy and blood-based biomarkers may be helpful including high sensitivity troponin and donor-derived cell-free DNA. Molecular markers for rejection are hopeful, and may also be useful in non-ischaemic causes of allograft dysfunction. Screening remains important late post heart transplant due to variety of signs associated with rejection (early) and lack of typical anginal symptoms (later). New imaging modalities - especially cardiac magnetic resonance imaging, have been shown to be useful for assessing cause of allograft dysfunction including ischemia, infarction and rejection.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 3","pages":"123-135"},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/a0/ijhf-4-123.PMC9383355.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40573851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In-Chang Hwang, Hong-Mi Choi, Yeonyee E Yoon, Jin Joo Park, Jun-Bean Park, Jae-Hyeong Park, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Goo-Yeong Cho
{"title":"Body Mass Index, Muscle Mass, and All-Cause Mortality in Patients With Acute Heart Failure: The Obesity Paradox Revisited.","authors":"In-Chang Hwang, Hong-Mi Choi, Yeonyee E Yoon, Jin Joo Park, Jun-Bean Park, Jae-Hyeong Park, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Goo-Yeong Cho","doi":"10.36628/ijhf.2022.0007","DOIUrl":"https://doi.org/10.36628/ijhf.2022.0007","url":null,"abstract":"<p><strong>Background and objectives: </strong>Lower body mass index (BMI) is considered a poor prognostic factor in patients with heart failure (HF). We aimed to investigate the clinical impact of BMI on the risk of mortality in patients with acute HF (AHF) across various phenotypes.</p><p><strong>Methods: </strong>We retrospectively identified 4,146 registry patients with AHF and BMI data. The study population was categorized according to the WHO Asia-Pacific BMI classification: BMI <18.5 kg/m<sup>2</sup> (underweight; n=418), BMI 18.5-23 kg/m<sup>2</sup> (ideal; n=1,620), BMI 23-25 kg/m<sup>2</sup> (overweight; n=828), BMI 25-30 kg/m<sup>2</sup> (obesity I; n=1,047), and BMI ≥30 kg/m<sup>2</sup> (obesity II; n=233). The risk of all-cause mortality was compared between these 5 groups.</p><p><strong>Results: </strong>During a median follow-up of 32 months, 1,732 patients (41.8%) died. Compared to patients with obesity II, those with overweight, ideal BMI or underweight status had a higher risk of mortality (overweight: hazard ratio [HR], 1.606; 95% confidence interval [CI], 1.016-2.539; p=0.042) (ideal BMI: HR, 1.744; 95% CI, 1.112-2.734; p=0.015) (underweight: HR, 2.729; 95% CI, 1.686-4.417; p<0.001). Higher risk of mortality among patients with lower BMI was observed regardless of age, sex, hypertension, diabetes, ischemic heart disease, atrial fibrillation, and HF phenotype. Furthermore, low muscle index (total muscle mass/height<sup>2</sup>), calculated using serum cystatin C data in a subset of 579 patients, was associated with higher mortality risk.</p><p><strong>Conclusions: </strong>A lower BMI is associated with a higher risk of mortality in patients with AHF. This obesity paradox is observed in AHF regardless of comorbidities and HF phenotype.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 2","pages":"95-109"},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/cb/ijhf-4-95.PMC9383349.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dong-Hyuk Cho, Jung-Woo Son, Chan Joo Lee, Jimi Choi, Mi-Na Kim, Ju-Hee Lee, Sunki Lee, Dong Heon Yang, Hyun-Jai Cho, Jin-Oh Choi, Eung Ju Kim, Dong-Ju Choi, Byung-Su Yoo
{"title":"Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design.","authors":"Dong-Hyuk Cho, Jung-Woo Son, Chan Joo Lee, Jimi Choi, Mi-Na Kim, Ju-Hee Lee, Sunki Lee, Dong Heon Yang, Hyun-Jai Cho, Jin-Oh Choi, Eung Ju Kim, Dong-Ju Choi, Byung-Su Yoo","doi":"10.36628/ijhf.2022.0005","DOIUrl":"10.36628/ijhf.2022.0005","url":null,"abstract":"<p><p>Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated HF are scarce. We aim to evaluate the prognostic value of short-term follow-up of surrogate biomarkers for predicting the prognosis of hospitalized patients with acute decompensated HF. This multi-center, prospective study will enroll consecutive hospitalized patients with acute decompensated HF. All patients will undergo sampling and comparison of biomarkers, including plasma N-terminal pro-brain natriuretic peptide, growth differentiation factor 15, troponin-T, high-sensitivity C-reactive protein, and urinary albumin/creatinine ratio obtained within 1 month and 6 months after discharge from the index admission. The primary endpoint is a composite of cardiovascular mortality or HF hospitalization during 1 year of follow-up. We will investigate the prognostic value of multiple biomarkers for the primary endpoint. This trial will provide robust evidence for novel multi-biomarker strategies for acute decompensated HF in real-world settings.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04437628.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 2","pages":"110-116"},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/82/ijhf-4-110.PMC9383348.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catarina Costa, Ana Filipa Amador, João Calvão, Roberto Pinto, Pedro Rodrigues Pereira, José Pinheiro Torres, Sandra Amorim, Filipe Macedo
{"title":"Late Cardiac Antibody-Mediated Rejection: A Only Heart Duel.","authors":"Catarina Costa, Ana Filipa Amador, João Calvão, Roberto Pinto, Pedro Rodrigues Pereira, José Pinheiro Torres, Sandra Amorim, Filipe Macedo","doi":"10.36628/ijhf.2021.0027","DOIUrl":"10.36628/ijhf.2021.0027","url":null,"abstract":"","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 2","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/c2/ijhf-4-117.PMC9383344.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic and Therapeutic Implications of Renal Insufficiency in Heart Failure.","authors":"Se Yong Jang, Dong Heon Yang","doi":"10.36628/ijhf.2021.0039","DOIUrl":"10.36628/ijhf.2021.0039","url":null,"abstract":"<p><p>The heart and kidneys are closely related vital organs that significantly affect each other. Cardiorenal syndrome is the term depicting the various spectra of cardiorenal interaction mediated by the hemodynamic, neurohormonal, and biochemical cross-talk between these two organs. In patients with heart failure (HF), both the baseline and worsening renal function are closely related to prognosis. However, for both investigational and clinical purposes, the unified definition and classification of renal injury are still necessary. Renal insufficiency is caused by multiple factors, and categorizing them into monogenous subgroups of phenotype is difficult. Various clinical scenarios related to the chronicity of HF, progression of renal dysfunction, and issues related to pharmacologic therapies associated with the prognosis of patients with HF have been reviewed in this study.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 2","pages":"75-90"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/5c/ijhf-4-75.PMC9383346.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hee-Dong Kim, Dong-Hyuk Cho, Mi-Na Kim, Sung Ho Hwang, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim, Seong-Mi Park
{"title":"Left Atrial Dysfunction, Fibrosis and the Risk of Thromboembolism in Patients With Paroxysmal and Persistent Atrial Fibrillation.","authors":"Hee-Dong Kim, Dong-Hyuk Cho, Mi-Na Kim, Sung Ho Hwang, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim, Seong-Mi Park","doi":"10.36628/ijhf.2021.0043","DOIUrl":"https://doi.org/10.36628/ijhf.2021.0043","url":null,"abstract":"<p><strong>Background and objectives: </strong>Left atrial (LA) fibrosis is an important component of the arrhythmogenic substrate and is related to LA dysfunction in patients with atrial fibrillation (AF). However, its relationship with functional changes and the risk of thrombus in patients with paroxysmal AF (PAF) and persistent AF (PeAF) remains unclear.</p><p><strong>Methods: </strong>We included 139 patients with preprocedural cardiac magnetic resonance imaging (CMR) and transesophageal echocardiography (TEE) for the first AF catheter ablation. Spontaneous echo contrast (SEC) and multiple parameters of LA were measured from TEE and CMR. LA fibrosis was evaluated by late gadolinium enhancement of LA (LA-LGE) of CMR.</p><p><strong>Results: </strong>The presence of SEC was higher in patients with PeAF than in patients with PAF (26.4% vs. 11.9%, p=0.03). The patients with SEC had more enlarged LA size and impaired function of LA and LAA, regardless of AF type. However, the area of LA-LGE was more extensive in patients with SEC in PeAF (27.5±15.9 vs. 20.1±10.3, p=0.033), not in PAF. In PAF, maximal LA volume index was closely related to the presence of SEC with marginal trend toward significance (odd ratio [OR], 1.07; 95% confidence interval [CI], 0.99-1.16; p=0.072). Whereas, a larger area of LA-LGE and lower emptying flux of LA appendage were independently related with SEC (OR, 1.10; 95% CI, 1.0-1.20; p=0.049 and OR, 0.93; 95% CI, 0.86-0.99; p=0.022, respectively) after adjusting related cardiovascular risk factors of SEC.</p><p><strong>Conclusions: </strong>In this study, we suggest that the risk of thrombus is provoked by LA enlargement with dysfunction in early-stage AF and by stiffened LA with fibrosis rather than LA size when it becomes PeAF.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"4 1","pages":"42-53"},"PeriodicalIF":0.0,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/1e/ijhf-4-42.PMC9383342.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40573792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}