International Journal of Immunogenetics最新文献

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Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta-analysis 白细胞介素17A和17F多态性与哮喘易感性之间的关系:一项荟萃分析
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2023-01-19 DOI: 10.1111/iji.12611
Young Ho Lee, Gwan Gyu Song
{"title":"Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta-analysis","authors":"Young Ho Lee,&nbsp;Gwan Gyu Song","doi":"10.1111/iji.12611","DOIUrl":"10.1111/iji.12611","url":null,"abstract":"<p>Owing to their role in inflammatory reactions and immunological responses as well as their chromosomal location, <i>interleukin (IL) 17A</i> and <i>17F</i> are regarded as candidate causal genes associated with asthma. The aim of this study was to determine whether <i>IL17</i> polymorphisms are associated with susceptibility to asthma. We used the PubMed/Medline and Embase databases to search for studies reporting <i>IL17</i> polymorphisms in patients with asthma and healthy controls. Meta-analyses were conducted to determine the associations between <i>IL17A</i> rs8193036 (−737C/T), rs2275913 (−197G/A), rs3819024 (A/G), rs3748067 (C/T), and rs4711998 (A/G) and <i>IL17F</i> rs763780 (7488A/G), rs2397084 (T/C), rs1889570 (C/T), rs11465553 (G/A), and rs1266828 (T/C) polymorphisms and asthma susceptibility. A total of 20 studies were included in this meta-analysis. Our results revealed the <i>IL17A</i> rs8193036 CC genotype was associated with asthma susceptibility (odds ratio [OR] = 1.490, 95% confidence interval [CI] = 1.027–2.161, <i>p</i> = .036). However, stratification by ethnicity indicated no association between this polymorphism and asthma in European and Asian subjects. Furthermore, no association was found between this polymorphism and asthma using the allele contrast, dominant or homozygous contrast models. No evidence of an association was found between any of the other <i>IL17A</i> and <i>IL17F</i> polymorphisms and asthma susceptibility in this meta-analysis. This meta-analysis showed that, among the studied polymorphisms, only the CC genotype of <i>IL17A</i> rs8193036 is associated with asthma susceptibility.</p>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 2","pages":"53-62"},"PeriodicalIF":2.2,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9723313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
TCR gene segment usage and HLA alleles that are associated with cancer survival rates also represent racial disparities 与癌症存活率相关的TCR基因片段使用和HLA等位基因也表现出种族差异
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-12-30 DOI: 10.1111/iji.12610
George Angelakakis, Karisa S. Serraneau, Vayda R. Barker, Blake M. Callahan, Wei Lue Tong, Saif Zaman, Taha I. Huda, George Blanck
{"title":"TCR gene segment usage and HLA alleles that are associated with cancer survival rates also represent racial disparities","authors":"George Angelakakis,&nbsp;Karisa S. Serraneau,&nbsp;Vayda R. Barker,&nbsp;Blake M. Callahan,&nbsp;Wei Lue Tong,&nbsp;Saif Zaman,&nbsp;Taha I. Huda,&nbsp;George Blanck","doi":"10.1111/iji.12610","DOIUrl":"10.1111/iji.12610","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Understanding racial disparities in cancer outcomes continues to be a challenge, with likely many factors at play, including socioeconomic factors and genetic polymorphisms impacting basic cellular and molecular functions. Additionally, it is possible that specific combinations of environment and genetics have specific impacts. T-cell receptor (TCR) gene segment usage, HLA allele combinations have been associated with autoimmune and infectious disease courses, and more recently, TCR gene segment usage, HLA allele combinations have been associated with distinct survival outcomes in cancer as well. We examined several such, previously reported cancer-related TCR gene segment usage, HLA allele combinations for evidence of racial disparities, with regard to the prevalence of the combination in different racial groups. Results indicated that TCR gene segment usage, potentially reflecting environmental factors related to previous pathogen exposure, in combination with certain HLA alleles or independently, may represent a novel explanation for racial disparities in cancer outcomes. Overall, at this point, a genetic connection to racial disparities in cancer outcomes is detectable but remains modest, suggesting that other factors, such as socioeconomic factors, remain as important considerations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 2","pages":"41-47"},"PeriodicalIF":2.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9097148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of class II HLA alleles with susceptibility to develop immune-mediated diseases in Paraguayan patients 巴拉圭患者ⅱ类HLA等位基因与免疫介导性疾病易感性的关系
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-12-21 DOI: 10.1111/iji.12609
Isabel Acosta-Colman, Sonia Cabrera-Villalba, Ana Ayala-Lugo, Valerie Jolly, Marcos Vazquez, Zoilo Morel, Patricia Langjahr, Margarita Duarte, Ruth Zarate, Maria Eugenia Acosta, Gabriela Avila-Pedretti, Antonio Julià, María Teresa Martinez, Sara Marsal
{"title":"Association of class II HLA alleles with susceptibility to develop immune-mediated diseases in Paraguayan patients","authors":"Isabel Acosta-Colman,&nbsp;Sonia Cabrera-Villalba,&nbsp;Ana Ayala-Lugo,&nbsp;Valerie Jolly,&nbsp;Marcos Vazquez,&nbsp;Zoilo Morel,&nbsp;Patricia Langjahr,&nbsp;Margarita Duarte,&nbsp;Ruth Zarate,&nbsp;Maria Eugenia Acosta,&nbsp;Gabriela Avila-Pedretti,&nbsp;Antonio Julià,&nbsp;María Teresa Martinez,&nbsp;Sara Marsal","doi":"10.1111/iji.12609","DOIUrl":"10.1111/iji.12609","url":null,"abstract":"<p>Genetic and nongenetic factors are involved in the pathogenesis of immune-mediated inflammatory diseases (IMIDs). The best-known genetic factor for susceptibility to IMIDs is the human leukocyte antigen (HLA). The aim of the present study was to evaluate the association of HLA class II genes with the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc) in the Paraguayan population. We included 254 patients with IMIDs (101 SLE, 103 RA, and 50 SSc) and 50 healthy controls. The haplotypes of five genes corresponding to HLA class II genes and their relationship to the IMIDs studied were determined. Note that 84.6% were women, with a mean age of 43.4 ± 14 years. Among the associated HLA alleles, we found the previously identified risk factors in other populations like HLA-DRB1*03:01 and HLA-DRB1*14:02 for RA, as well as new ones not previously identified, such as DPA1*02:01 for SLE and, DB1*02:01 for RA and SSc. In the genetic association analysis, already known associations have been replicated, and unpublished associations have been identified in Paraguayan patients with IMIDs. This is the first genetic association study in Paraguayan patients with IMIDs.</p>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 1","pages":"12-18"},"PeriodicalIF":2.2,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10500031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rheumatoid arthritis-associated antibodies in healthy first-degree relatives of RA patients 类风湿关节炎患者健康一级亲属的相关抗体
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-11-25 DOI: 10.1111/iji.12608
David Vega-Morales, Lorena Pérez-Barbosa, Luis Francisco Vega-Sevilla, Jorge Antonio Esquivel-Valerio, Luis Eduardo Ramírez-Monterrubio, Karina I Gonzalez-Torres, Ana Sofía Leal-Bramasco, Cesar V Elizondo-Solis, Andres Mendiola-Jimenez, Mario Alberto Garza-Elizondo, Dionicio Ángel Galarza-Delgado
{"title":"Rheumatoid arthritis-associated antibodies in healthy first-degree relatives of RA patients","authors":"David Vega-Morales,&nbsp;Lorena Pérez-Barbosa,&nbsp;Luis Francisco Vega-Sevilla,&nbsp;Jorge Antonio Esquivel-Valerio,&nbsp;Luis Eduardo Ramírez-Monterrubio,&nbsp;Karina I Gonzalez-Torres,&nbsp;Ana Sofía Leal-Bramasco,&nbsp;Cesar V Elizondo-Solis,&nbsp;Andres Mendiola-Jimenez,&nbsp;Mario Alberto Garza-Elizondo,&nbsp;Dionicio Ángel Galarza-Delgado","doi":"10.1111/iji.12608","DOIUrl":"10.1111/iji.12608","url":null,"abstract":"<p>Rheumatoid arthritis (RA) affects approximately 1.5% of the population worldwide and 0.5–3.3% of the Mexican population. The presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies has been described in populations at risk of RA development, such as first-degree relatives (FDR). Anti-CarP antibodies are present in RA patients (44%), FDR of RA patients (18%) and healthy controls (4.7%). Anti-CarP antibodies have not been described in FDR of the Mexican population. The objective of this study was to determine the prevalence of Rheumatoid Factors (RF) isotypes, ACPA and anti-CarP antibodies isotypes in FDR of RA patients. An observational, cross-sectional study, in an FDR of RA cohort, was performed. We measured IgA, IgG and IgM isotypes of RF, ACPA and anti-CarP antibodies. A total of 144 FDRs from 99 RA patients were enrolled. The prevalence of anti-CarP antibodies was 2.8% for IgA, 4.2% for IgG, whereas IgM was not detected. The serologic association was for RF/ACPA 4.48%, RF/anti-CarP 2.7%, FR 64.5%, ACPA 1.3%, ACPA/anti-CarP 0.69%, anti-CarP 3.4%, and no RF/ACPA/anti-CarP was observed. We found a low prevalence of anti-CarP antibodies in our cohort of FDR of RA patients, but the prevalence of ACPA and RF were higher than other cohorts previously reported.</p>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 1","pages":"19-23"},"PeriodicalIF":2.2,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10501223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VDR gene polymorphisms and susceptibility to COVID-19: Correspondence VDR基因多态性与COVID-19易感性:对应关系
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-11-08 DOI: 10.1111/iji.12600
Pathum Sookaromdee, Viroj Wiwanitkit
{"title":"VDR gene polymorphisms and susceptibility to COVID-19: Correspondence","authors":"Pathum Sookaromdee,&nbsp;Viroj Wiwanitkit","doi":"10.1111/iji.12600","DOIUrl":"10.1111/iji.12600","url":null,"abstract":"COVID-19 (Jafar-pooretal.,2022).Jafarpooretal.discoveredthataVDRpolymorphism (rs2228570) COVID-19.","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"49 6","pages":"384"},"PeriodicalIF":2.2,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10625720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the novel HLA-DPA1*01:03:43 allele resulting from an intralocus recombination involving the DPA1*04:01:01:03 and DPA1*01:03:01:27 alleles sequenced by Next Generation Sequencing (NGS) 下一代测序技术(NGS)鉴定了DPA1*04:01:01:03和DPA1*01:03:01:27等位基因在基因座内重组后的HLA-DPA1*01:03:43等位基因
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-11-07 DOI: 10.1111/iji.12607
Turnbull Hannah, Brewin Gemma, Peacock Sarah
{"title":"Identification of the novel HLA-DPA1*01:03:43 allele resulting from an intralocus recombination involving the DPA1*04:01:01:03 and DPA1*01:03:01:27 alleles sequenced by Next Generation Sequencing (NGS)","authors":"Turnbull Hannah,&nbsp;Brewin Gemma,&nbsp;Peacock Sarah","doi":"10.1111/iji.12607","DOIUrl":"10.1111/iji.12607","url":null,"abstract":"<p>HLA-DPA1 intralocus recombination between DPA1*04:01:01:03 and DPA1*01:03:01:27, or closely related other alleles, results in a novel allele HLA-DPA1*01:03:43.</p>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 1","pages":"1-4"},"PeriodicalIF":2.2,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10556880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Association between the interleukin-1B polymorphism at rs16944 T>C and diabetic retinopathy rs16944t> C白介素- 1b多态性与糖尿病视网膜病变的关系
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-11-05 DOI: 10.1111/iji.12604
Nengbo Lin, Hua Lu, Xiaoling Cheng, Ya Zhao, Qin Wan, Yi Luo, Ying Miao, Xue Bai, Dan Liu, Chao Wang
{"title":"Association between the interleukin-1B polymorphism at rs16944 T>C and diabetic retinopathy","authors":"Nengbo Lin,&nbsp;Hua Lu,&nbsp;Xiaoling Cheng,&nbsp;Ya Zhao,&nbsp;Qin Wan,&nbsp;Yi Luo,&nbsp;Ying Miao,&nbsp;Xue Bai,&nbsp;Dan Liu,&nbsp;Chao Wang","doi":"10.1111/iji.12604","DOIUrl":"10.1111/iji.12604","url":null,"abstract":"<p>Diabetic retinopathy (DR) is a common microvascular complication of diabetes and the leading cause of blindness at working age. DR is considered to be a chronic low-grade inflammatory subclinical disease, and its pathogenesis is related to genetic and environmental factors. Interleukin (IL)-1 is an important inflammatory cytokine. An association between DR and the rs16944 (<i>IL-1B-511</i>) T&gt;C gene polymorphism has not been reported. The aim of this study was to investigate the association between the rs16944 T&gt;C gene polymorphism and DR in the Han population in southwest China. Participants in this study were 272 patients with DR, 274 patients with type 2 diabetes mellitus (T2DM), and 335 healthy controls (NC). The polymerase chain reaction-restriction fragment length polymorphism method was used to detect the rs16944 T&gt;C genotype of participants. The distribution frequencies of the rs16944 T&gt;C genotype and allele were significantly different among the three groups (<i>p</i> &lt; .05). The distribution frequency of TT, CT, CC genotype (χ<sup>2</sup> = 9.893, <i>p</i> = .007; χ<sup>2</sup> = 6.567, <i>p</i> = .037) and each allele (χ<sup>2</sup> = 5.585, <i>p</i> = .018; χ<sup>2</sup> = 9.187, <i>p</i> = .002) in the DR group was significantly different from the NC and T2DM groups, respectively. Logistic regression analysis showed that the TT + CT genotype was a risk factor for DR, with an odds ratio of 1.731 (95% confidence interval 1.140–2.627, <i>p</i> = .01). The rs16944 T&gt;C gene polymorphism may be associated with DR, and the TT+CT genotype may increase the risk of DR.</p>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 1","pages":"34-40"},"PeriodicalIF":2.2,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10556879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients 伊朗子宫内膜异位症患者IL-12、IL-12受体和IL-27基因多态性与器官受累的关系
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-11-03 DOI: 10.1111/iji.12606
Maryam Zare, Fatemeh Hesampour, Tahereh Poordast, Maryam Valibeigi, Maliheh Enayatmehri, Sahar Ahmadi, Fatemeh Nasri, Behrouz Gharesi-Fard
{"title":"Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients","authors":"Maryam Zare,&nbsp;Fatemeh Hesampour,&nbsp;Tahereh Poordast,&nbsp;Maryam Valibeigi,&nbsp;Maliheh Enayatmehri,&nbsp;Sahar Ahmadi,&nbsp;Fatemeh Nasri,&nbsp;Behrouz Gharesi-Fard","doi":"10.1111/iji.12606","DOIUrl":"10.1111/iji.12606","url":null,"abstract":"<p>Endometriosis is an inflammatory disease characterized by the presence of ectopic endometrial tissue, immune cell dysfunction and abnormal cytokine secretion. In addition to immunological factors, genetic variations that influence endometriosis severity and cytokine expression levels play important roles in the pathogenesis of this disease. Interleukin-12 (IL-12), specifically its p40 subunit encoded by IL-12B gene and the interleukin-12 receptor β1 (IL-12Rβ2) chain of its receptor, as well as interleukin-27 (IL-27) are important in the establishment of endometriosis. So, in this study, we measured IL-12 and IL-27 serum levels and investigated the possible links between IL-12B rs3212227, IL-12Rβ2 rs3790565 and IL-27 rs153109 polymorphisms and the risk of developing endometriosis in a group of Iranian women. In this case-control study, 162 endometriosis patients and 151 healthy women were included and tested for the aforementioned polymorphisms using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The enzyme-linked immunosorbent assay (ELISA) method was also used to measure IL-12 and IL-27 serum levels. Although there was no statistically significant association between the genotypes and alleles of the studied polymorphisms and the development of endometriosis in general, the AA genotype of IL-12B rs3212227 showed a significant association with uterine endometriosis when compared to AC+CC genotypes (<i>p</i> = .04, CI = 0.270–0.988, OR = 0.517). Indeed, the AA genotype of the IL-12B rs3212227 single nucleotide polymorphism (SNP) may be linked with a lower risk of developing uterine endometriosis. There was no significant difference in IL-27 levels between the two studied groups (<i>p</i> = .49), and IL-12 levels were undetectable in both groups. In conclusion, the AA genotype of IL-12B rs3212227 might be associated with a decreased risk of uterine involvement in endometriosis patients.</p>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 1","pages":"24-33"},"PeriodicalIF":2.2,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10491593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic polymorphisms of IL6 gene –174G > C and –597G > A are associated with the risk of COVID-19 severity il - 6基因-174G > C和-597G > A的遗传多态性与COVID-19严重程度的风险相关
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-11-02 DOI: 10.1111/iji.12605
Shrikant Verma, Sushma Verma, Faizan Haider Khan, Zeba Siddiqi, Syed Tasleem Raza, Mohammad Abbas, Farzana Mahdi
{"title":"Genetic polymorphisms of IL6 gene –174G > C and –597G > A are associated with the risk of COVID-19 severity","authors":"Shrikant Verma,&nbsp;Sushma Verma,&nbsp;Faizan Haider Khan,&nbsp;Zeba Siddiqi,&nbsp;Syed Tasleem Raza,&nbsp;Mohammad Abbas,&nbsp;Farzana Mahdi","doi":"10.1111/iji.12605","DOIUrl":"10.1111/iji.12605","url":null,"abstract":"<p>Coronavirus disease-2019 (COVID-19) is pro-inflammatory disorder characterized by acute respiratory distress syndrome. Interleukin-6, a cytokine secreted by macrophages, which mediates an inflammatory response, is frequently increased and associated with the severity in COVID-19 patients. The differential expression of <i>IL6</i> cytokine in COVID-19 patients may be associated with the presence of single nucleotide polymorphisms (SNPs) in regulatory region of cytokine genes. The aim of this study is to investigate the role of two promoter polymorphisms of the <i>IL6</i> gene (–597G &gt; A and –174G &gt; C) with the severity of COVID-19. The study included 242 patients, out of which 97 patients with severe symptoms and 145 patients with mild symptoms of COVID-19. Genotyping of two selected SNPs, rs1800795 (–174G &gt; C) and rs1800797 (–597G &gt; A) of promoter region of <i>IL6</i> gene, was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In our study, individuals with GC genotypes of <i>IL6</i> (–174G &gt; C) polymorphism showed significantly higher risk of severity [adjusted odds (OR) 3.86, <i>p</i> &lt;.001] but we did not observe any association of COVID-19 severity with rs1800797 (–597G &gt; A) polymorphism. The COVID-19 severity was significantly higher in individuals having ‘C’ allele of <i>IL6</i> (–174G &gt; C) polymorphism (<i>p</i> = .014). Linkage disequilibrium between rs1800795 (–174G &gt; C) and rs1800797 (–597G &gt; A) showed that individuals having AC* haplotype significantly association with COVID-19 severity (<i>p</i> = .034). Our results suggest that ‘C’ allele of rs1800795 (–174G &gt; C) polymorphism of <i>IL6</i> may be the risk allele for severity of COVID-19 in North Indian population.</p>","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"50 1","pages":"5-11"},"PeriodicalIF":2.2,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878250/pdf/IJI-50-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Nomenclature for factors of the HLA system, update July, August and September 2022 HLA系统因子命名法,2022年7月、8月和9月更新
IF 2.2 4区 医学
International Journal of Immunogenetics Pub Date : 2022-11-02 DOI: 10.1111/iji.12603
Steven G. E. Marsh
{"title":"Nomenclature for factors of the HLA system, update July, August and September 2022","authors":"Steven G. E. Marsh","doi":"10.1111/iji.12603","DOIUrl":"10.1111/iji.12603","url":null,"abstract":"The following sequences have been submitted to the Nomenclature Committee since the April, May and June 2022 nomenclature update (Marsh, 2022) and, following agreed policy, have been assigned official allele designations (Marsh et al., 2010). Full details of all sequenceswill be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.","PeriodicalId":14003,"journal":{"name":"International Journal of Immunogenetics","volume":"49 6","pages":"385-416"},"PeriodicalIF":2.2,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40676276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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