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International Journal of Fertility最新文献

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Androgen response in polycystic ovarian syndrome to FSH treatment after LHRH agonist suppression. LHRH激动剂抑制后多囊卵巢综合征对FSH治疗的雄激素反应。
International Journal of Fertility Pub Date : 1992-05-01
M Hamori, M Zwirner, P Clédon, H R Tinneberg
{"title":"Androgen response in polycystic ovarian syndrome to FSH treatment after LHRH agonist suppression.","authors":"M Hamori,&nbsp;M Zwirner,&nbsp;P Clédon,&nbsp;H R Tinneberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anovulatory patients with clomiphene-resistant polycystic ovarian syndrome were treated by two different stimulation protocols. Follicular maturation was induced in 14 women with hMG; 12 of them received pure FSH in a later series after previous pituitary desensitization with the LHRH agonist D-Trp-6-LHRH (Decapeptyl). Both basal and stimulated serum androstenedione, testosterone, and free testosterone were elevated in the hMG-treated group compared with controls. However, only androstenedione exhibited a significant increase between early and late follicular levels. Marked suppression of these androgens has been observed after two weeks of LHRH agonist pretreatment, but nearly the same concentrations were obtained with pure FSH on the day of hCG administration. Again, only the increase of androstenedione levels proved to be significant. Polycystic follicular maturation, hyperstimulation, and peak estradiol levels were comparable with the two protocols. Nevertheless, more pregnancies were achieved using the LHRH agonist+FSH combination (4 vs. 1). It is suggested that 2 weeks' suppression of ovarian androgens with LHRH agonist is not sufficient to neutralize the unfavourable intraovarian mechanisms interfering with normal folliculogenesis. More data are required to confirm the superiority of LHRH agonist pretreatment in the management of polycystic ovarian syndrome.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 3","pages":"171-5"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference period analysis of vaginal bleeding with triphasic oral contraceptive agents containing norethindrone or levonorgestrel: a comparison study. 含诺瑞酮或左炔诺孕酮的三相口服避孕药阴道出血的对照期分析:一项比较研究。
International Journal of Fertility Pub Date : 1992-05-01
B E Schwarz, C Pierce, C E Walden, R H Knopp
{"title":"Reference period analysis of vaginal bleeding with triphasic oral contraceptive agents containing norethindrone or levonorgestrel: a comparison study.","authors":"B E Schwarz,&nbsp;C Pierce,&nbsp;C E Walden,&nbsp;R H Knopp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The World Health Organization recommends the use of fixed reference periods for quantification of the incidence and severity of vaginal bleeding when patients use various forms of contraception. Ninety- and 110-day reference periods were used in the analysis of data from daily menstrual diaries kept by 72 healthy women in a one-year study of oral contraceptive agents containing ethinyl estradiol and either norethindrone or levonorgestrel. Analysis of bleeding patterns reported during both 90-day and 110-day periods revealed fewer days of bleeding and/or spotting overall with norethindrone than with levonorgestrel (e.g., a mean of 16.06 vs. 19.55 days, respectively, over the first 90-day period; P = .013) and significantly shorter bleeding and/or spotting episodes with the norethindrone preparation. This trend persisted when data were adjusted for a day-1 pill start. Using either method of analysis, duration of bleeding episodes was shorter among subjects taking norethindrone than levonorgestrel. Pills were missed in both study groups, but more women in the LNG/EE group missed from 1 to 3 pills in at least one cycle (31 vs. 21 in the NET/EE group). The between-group difference in bleeding events may be due to intrinsic hormonal differences in regimens or to the greater number of pills missed among levonorgestrel users.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 3","pages":"176-82"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovulation induction increases serum levels of insulin-like growth factor binding protein 1. 促排卵增加胰岛素样生长因子结合蛋白1的血清水平。
International Journal of Fertility Pub Date : 1992-05-01
F Pekonen, E M Rutanen, H Kurunmäki, O Hovatta
{"title":"Ovulation induction increases serum levels of insulin-like growth factor binding protein 1.","authors":"F Pekonen,&nbsp;E M Rutanen,&nbsp;H Kurunmäki,&nbsp;O Hovatta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of ovulation induction on serum insulin-like growth factor binding protein 1 (IGFBP-1) level in relation to sex hormone binding globulin (SHBG) levels was evaluated. Serum samples were collected 8 to 12 days after ovulation from 26 women undergoing ovulation induction with clomiphene citrate (CC), and from 58 women treated with CC in combination with human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG). In addition, serum samples were obtained from 63 spontaneously ovulating women and from 12 women during an anovulatory cycle. Luteal phase serum IGFBP-1 levels were 4.22 +/- 2.95 micrograms/L (P less than .05) in the CC group and 7.31 +/- 6.13 micrograms/L (P less than .001) in the CC/hMG/hCG group as compared to unstimulated ovulatory cycles (2.64 +/- 2.52 micrograms/L). No significant difference in IGFBP-1 levels was seen between spontaneously ovulatory and anovulatory cycles. The serum IGFBP-1 levels correlated positively to SHBG levels (r = .52, P less than .001). The data show that ovulation induction increases serum IGFBP-1 levels in parallel to SHBG levels, indicating that ovarian stimulation, which results in increased steroid hormone production, also induces changes in other factors known to modulate steroid hormone actions.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 3","pages":"188-91"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12553278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonsurgical management of minimal and moderate endometriosis to enhance fertility. 轻度和中度子宫内膜异位症的非手术治疗以提高生育能力。
International Journal of Fertility Pub Date : 1992-05-01
P J Taylor, J V Kredentser
{"title":"Nonsurgical management of minimal and moderate endometriosis to enhance fertility.","authors":"P J Taylor,&nbsp;J V Kredentser","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 3","pages":"138-43"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teratological evaluation of an injectable male antifertility agent, styrene maleic anhydride, in rats. 注射用雄性抗生育剂苯乙烯-马来酸酐对大鼠的致畸性评价。
International Journal of Fertility Pub Date : 1992-05-01
N Sethi, R K Srivastava, D Nath, R K Singh
{"title":"Teratological evaluation of an injectable male antifertility agent, styrene maleic anhydride, in rats.","authors":"N Sethi,&nbsp;R K Srivastava,&nbsp;D Nath,&nbsp;R K Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Polymer styrene Maleic anhydride (SMA) dissolved in dimethylsulphoxide (DMSO) was injected into the lumen in each vas deferens of male rats at dose levels of 0.25 mg, 0.50 mg, 1.0 mg, 2.5 mg, and 5.0 mg, while control rats (groups 1) received 0.03 mL DMSO in each vas deferens. After 4 weeks, the lumen was flushed with 0.1 mL DMSO and the animals were left for another 6 weeks to regain fertility. These rats were mated with virgin and coeval females. No anomaly was observed which could be related to teratogenic action of the polymer in pregnant mothers or fetuses.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 3","pages":"183-7"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ectopic pregnancy, the new gynecological epidemic disease: review of the modern work-up and the nonsurgical treatment option. 异位妊娠，新的妇科流行病:现代体检及非手术治疗方案综述。
International Journal of Fertility Pub Date : 1992-05-01
R Maymon, A Shulman, B B Maymon, F Bar-Levy, M Lotan, C Bahary
{"title":"Ectopic pregnancy, the new gynecological epidemic disease: review of the modern work-up and the nonsurgical treatment option.","authors":"R Maymon,&nbsp;A Shulman,&nbsp;B B Maymon,&nbsp;F Bar-Levy,&nbsp;M Lotan,&nbsp;C Bahary","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Over the past few decades, the incidence of ectopic pregnancy has increased almost to the extent of an \"epidemic disease.\" Early diagnosis of tubal pregnancy, with the aid of serum human chorionic gonadotropin, high-resolution ultrasound, and the more liberal use of laparoscopy, has dramatically reduced both maternal mortality and the need for radical surgery. Despite this, women with previous ectopic pregnancies still have reduced fertility potential. We report on some current aspects of the epidemiology, etiology, and work-up of ectopic pregnancy. In a review of 328 patients, gleaned from the literature, who were treated with various nonsurgical options, 283 (86%) were able to avoid surgery. The benefits, safety, and efficacy of the various treatment options are discussed, with appropriate recommendations for their use.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 3","pages":"146-64"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of congenital uterine anomalies in repeated reproductive wastage and prognosis for pregnancy after metroplasty. 重复生殖萎缩中先天性子宫异常的发生率及子宫成形术后妊娠的预后。
International Journal of Fertility Pub Date : 1992-05-01
T Makino, M Umeuchi, K Nakada, S Nozawa, R Iizuka
{"title":"Incidence of congenital uterine anomalies in repeated reproductive wastage and prognosis for pregnancy after metroplasty.","authors":"T Makino,&nbsp;M Umeuchi,&nbsp;K Nakada,&nbsp;S Nozawa,&nbsp;R Iizuka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To discover the exact incidence of congenital uterine anomalies among infertile patients, hysterosalpingography was performed on 1,200 married women with a history of repeated reproductive wastage. Out of 1,200 hysterosalpingographies, 188 revealed congenital uterine anomaly (15.7%). The degree of uterine cavity deformity in the anomalies was evaluated during hysterosalpingography using the X/M ratio. This indicated that the incidence of repeated spontaneous abortion in cases with low-grade anomalies is as high as the incidence among cases with more severe anomalies. A significant improvement in maintaining pregnancy was observed after metroplasty; more than 84% of postoperative pregnancies were successfully maintained, whereas none of the 233 presurgical pregnancies had lasted full term. As a control group, 47 other women with anomalies were randomly chosen, and their subsequent pregnancies were monitored, without metroplasty. Of their pregnancies, 94.4% terminated spontaneously before 12 weeks of gestation.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 3","pages":"167-70"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Follicular phase hormonal profiles during administration of leuprolide for in vitro fertilization. 在给药期间卵泡期激素分布为体外受精。
International Journal of Fertility Pub Date : 1992-03-01
I Henig, P J Chan, S Prough, A K Pope, D R Tredway, M Cheatwood
{"title":"Follicular phase hormonal profiles during administration of leuprolide for in vitro fertilization.","authors":"I Henig,&nbsp;P J Chan,&nbsp;S Prough,&nbsp;A K Pope,&nbsp;D R Tredway,&nbsp;M Cheatwood","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hormonal changes induced during short-term administration of leuprolide were evaluated during the follicular phase in 57 patients who completed an IVF cycle. They were compared with those of 14 patients who were placed on long-term suppression. There was an unexpected abnormal increase in serum progesterone during the first week of the cycle in nine of the 57, with no significant change in the fertilization and cleavage rate; however, no pregnancy was achieved in this group. Transient mild elevation of progesterone was also detected in 16 patients with no adverse effect on fertilization and the outcome of the IVF. In the long protocol, the tonic levels of LH, FSH, and progesterone remained low throughout the follicular phase. The total number of pregnancies was higher in the short suppression regimen, but the full-term pregnancy rates were similar in both protocols.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 2","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12523810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural features of round-headed human spermatozoa. 圆头人精子的超微结构特征。
International Journal of Fertility Pub Date : 1992-03-01
G Singh
{"title":"Ultrastructural features of round-headed human spermatozoa.","authors":"G Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two cases of the round-headed spermatozoa syndrome are described, with the main emphasis on the ultrastructural features of the spermatozoa. Essentially, the first type (type I) of these cells has round heads, lacks an acrosome and its intrinsic enzymes, and lacks a postacrosomal sheath; patients with this condition are absolutely infertile. This is the classical Schirren-Holstein model for the round-headed spermatozoon. Other types of round-headed spermatozoa might exist (Type II), which may possess remnants of the acrosome and are capable of fertilisation.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 2","pages":"99-102"},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12523812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcervical fallopian tube recanalization: a safe and effective therapy for patients with proximal tubal obstruction. 经宫颈输卵管再通术:治疗输卵管近端梗阻的一种安全有效的方法。
International Journal of Fertility Pub Date : 1992-03-01
K B Isaacson, M Amendola, M Banner, M Glassner, S J Sondheimer
{"title":"Transcervical fallopian tube recanalization: a safe and effective therapy for patients with proximal tubal obstruction.","authors":"K B Isaacson,&nbsp;M Amendola,&nbsp;M Banner,&nbsp;M Glassner,&nbsp;S J Sondheimer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Over a 13-month period, 14 patients with proximal tubal obstruction underwent transcervical fallopian tube recanalization under fluoroscopic guidance in an outpatient setting at the hospital of the University of Pennsylvania. Twenty-one of 24 attempted tubal dilations (87.5%) were successful, as demonstrated by tubal opacification and contrast spillage into the peritoneal cavity at the conclusion of the procedure. Four intrauterine pregnancies, and no ectopic pregnancies, have followed the recanalization. One pregnancy ended in an early miscarriage, one patient delivered a healthy term female, and two pregnancies are ongoing at greater than twenty weeks' gestation. Two procedure-related complications occurred: in one patient, the isthmic segment of a fallopian tube was perforated, but healed without incident, and another patient experienced a low-grade fever, which resolved with p.o. antibiotics. We therefore conclude that fallopian tube recanalization is a well-tolerated, safe, and effective procedure for the treatment of proximal tubal occlusion.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 2","pages":"106-10"},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12521865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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