{"title":"Hypercholesterolemia in a young woman.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 Suppl 2 ","pages":"116-22"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12528533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Family planning and contraception: options for the 1990s--introduction.","authors":"A Yuzpe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"37 Suppl 3 ","pages":"143-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12532948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of impairment of blood supply to the rat uterus.","authors":"E Antebi, J M Lehmann, A Gingold, M Nobel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Over the last decades much attention has been directed to establishing the cause of altered fetal growth and habitual abortion. Great emphasis has been placed on placental blood flow, but relatively few studies have been published on the effect of impaired uterine blood supply. This study examined the effect of impaired uterine blood flow using the white rat, with its bilateral uterine horns. Three groups of rats with bilateral, left unilateral, or right unilateral artery ligation were compared with a control group for number and weight of fetuses at term. The results showed that the impaired rats produced significantly fewer fetuses than controls (means: 8.59 vs. 11.21, respectively; P less than .001) and those fetuses had lower mean birth weights than controls (5.295 g vs. 5.800 g, respectively; P less than .05). While conception was possible even in rats with impaired uterine blood flow, the differences at term suggest that impairment of the maternal blood flow may contribute toward intrauterine growth retardation and habitual abortion. The clinical significance of these findings and suggestions for future research are discussed.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"376-8"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12850366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L C Fuith, D Fuchs, A Hausen, H Hetzel, G Reibnegger, E R Werner, H Wachter
{"title":"Neopterin, a marker of cell-mediated immune activation in human pregnancy.","authors":"L C Fuith, D Fuchs, A Hausen, H Hetzel, G Reibnegger, E R Werner, H Wachter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>High neopterin excretion is closely associated with activation of cell-mediated immunity. We studied urine and serum neopterin concentrations and serum interferon-gamma concentrations in normal pregnant women. In our study population, neopterin concentrations exceeded the normal range in 663 of 840 samples (79%). Neopterin levels increased with the time of pregnancy. Serum samples drawn from women in the third trimester of pregnancy also showed high neopterin concentrations in almost all cases; however, no circulating interferon-gamma was detected. Whereas neopterin is able to penetrate into the blood stream because of its small size (M = 253 D), diffusion of interferon-gamma is limited. Raised neopterin levels provide evidence for activated cell-mediated immunity during pregnancy.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"372-5"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12850357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative analysis of seminiferous epithelium in subfertile carriers of chromosomal translocations.","authors":"T Matsuda, Y Horii, K Hayashi, O Yoshida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to study the effect of structural chromosomal aberrations on spermatogenesis, quantitative analysis of the germinal epithelium was performed on testicular specimens from 12 carriers of balanced chromosomal translocations diagnosed at male infertility clinics: a Y-autosome translocation, eight reciprocal translocations, and three D/D Robertsonian translocations. Spermatogenic arrest at the spermatocyte stage was revealed in the Y-autosome translocation and four of the reciprocal translocations. The number of spermatids was selectively reduced in three carriers, while normal spermatogenesis was found in three. Thus, the majority of carriers with impaired semen quality showed a complete or partial reduction in the number of spermatids, suggesting that the effect of chromosomal aberrations is to arrest the spermatogenic process at the spermatocyte stage.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"344-51"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12849843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nonvisualized endometriosis at laparoscopy.","authors":"F Nezhat, C J Allan, C Nezhat, D C Martin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Apparently conflicting results have been reported regarding the incidence, and even the existence, of endometriosis in visually normal peritoneum. The present study was undertaken in view of the fact that the presence and incidence of nonvisualized deep and/or microscopic endometriosis may be of importance in patient management. One patient in this study demonstrated a 1-mm lesion of endometriosis beneath visually normal peritoneum. Two additional patients had cellular surface zones of possible endometrial stroma without a contiguous epithelial component. The results support the existence of unrecognized subperitoneal and microscopic surface endometriosis.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"340-3"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12849844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M G Subramanian, A G Sacco, K S Moghissi, D M Lawson, R R Gala
{"title":"Prolactin size heterogeneity in human follicular fluid: a preliminary study.","authors":"M G Subramanian, A G Sacco, K S Moghissi, D M Lawson, R R Gala","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Follicular fluid from mature preovulatory follicles was examined for the presence of prolactin (PRL) heterogeneity. Two pools of follicular fluid aspirates were used: one from follicles in which the ova were successfully fertilized in vitro and the other from follicles in which the ova were not successfully fertilized. Follicular fluid aspirates were concentrated by ultrafiltration and subjected to Sephadex G-100 gel chromatography. Fractions were assayed for immunoactive PRL by radioimmunoassay (RIA-PRL) and for bioactive PRL by the Nb2 lymphoma cell bioassay (BA-PRL). The major portion of RIA-PRL activity appeared as a low-molecular-weight component and accounted for 88% of the total PRL activity in the fertilized group and 87% in the unfertilized group. A high-molecular-weight component was also evident (12% and 13% for the two groups, respectively). The high-molecular-weight component in both groups was not active as PRL in the bioassay. These results demonstrate that while two immunoactive, heterogeneous forms of PRL exist in human follicular fluid when measured by RIA, it is only the low-molecular-weight form of PRL that is biologically active as established by Nb2 lymphoma cell bioassay.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"367-71"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12850365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The status of vasectomy reversals.","authors":"J L Marmar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vasectomy reversals are being requested in increasing numbers. Non-urologists are often the first physicians consulted about such procedures. In some instances, these physicians know very little about the procedures, and the consultation leads to confusion and frustration. In this report, current facts on vasectomy reversals will be provided for the benefit of non-urologists.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"352-7"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12849846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Human sperm hypo-osmotic swelling test: relationship to sperm fertilizing ability.","authors":"R D McClure, R Tom","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The simple hypo-osmotic swelling test (HOS) has been proposed as a replacement for the labor-intensive sperm penetration assay (SPA), but its reliability is still controversial. To investigate the clinical correlation between results of the HOS and the SPA, we studied the subpopulation of washed \"motile\" and capacitated spermatozoa as well as sperm in the original sample in both a heterogeneous patient population being evaluated for infertility (n = 47) and a donor population (n = 13). In our patient population, the correlation between HOS results and conventional semen parameters, i.e., motility and vitality, was poor. Although the mean HOS values of the donor and patient populations differed significantly, the overlap in individual variation was too great for practical application. Using motile sperm tested two hours after separation from the seminal plasma, the correlation between a positive HOS and a positive SPA was good, with only a 4% false-negative rate. However, the correlation in capacitated sperm (20 hours) or semen itself was far less reliable. Although HOS tests correlated well with the SPA in individuals with normal sperm, in those with negative results on SPA the predictive value was extremely poor: divergent findings ranged from 32% using semen samples to 74% in the two-hour motile population. The events in the fertilizing process measured by the sperm penetration assay appear to be different from those assessed by the hypo-osmotic test. The HOS test, therefore, could not be used to screen or predict results of the SPA.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"360-6"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12849847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infectious complications of intrauterine insemination: a case report and literature review.","authors":"P C Sacks, J A Simon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intrauterine insemination is commonly performed in the treatment of infertility. Infectious complications associated with intrauterine insemination are frequently cited, though rarely reported. A review of the literature yields only five reported cases of pelvic infections subsequent to intrauterine insemination (IUI), and only two of these show firm evidence of infection, with none presenting bacteriologic confirmation. We report a case of Escherichia coli septicemia subsequent to an IUI performed on a patient with a large adenomyoma. Of 147 patients treated with IUI at Georgetown University from November 1987 through March 1990, this was the only infectious complication. The incidence of infectious complications in our series is thus 0.0068 (6.8 per 1,000 women). A review of infectious complications in 38 reported series on intrauterine inseminations reveals five infections in 3,129 patients. With the addition of our series to the literature, the prevalence of infectious complications is 1.83 per 1,000 women undergoing IUI. The rates were not significantly altered by semen washing with antibiotics, or the administration of prophylactic antibiotics to the woman (P = .81). We conclude that (1) the infection rate following IUI is small, (2) many of the infections subsequent to insemination were not associated with intrauterine insemination, (3) most reported cases of infection fail to show evidence for the actual presence of infection, and (4) the prevalence is unaltered by the administration of prophylactic antibiotics or washing the semen sample with antibiotics.</p>","PeriodicalId":13990,"journal":{"name":"International Journal of Fertility","volume":"36 6","pages":"331-9"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12849842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}