Infectious Diseases in Clinical Practice最新文献

Consequence of Antivirals Versus Standard Care on Clinical Situation in Patients With COVID-19 抗病毒药物与标准护理对 COVID-19 患者临床状况的影响

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Infectious Diseases in Clinical Practice Pub Date : 2024-01-08 DOI: 10.1097/ipc.0000000000001336

Marwa N. Alsaraj, M. Qazzaz, M. Abed, F. Alassaf, M. Alfahad, Mahmood H. M. Jasim

{"title":"Consequence of Antivirals Versus Standard Care on Clinical Situation in Patients With COVID-19","authors":"Marwa N. Alsaraj, M. Qazzaz, M. Abed, F. Alassaf, M. Alfahad, Mahmood H. M. Jasim","doi":"10.1097/ipc.0000000000001336","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001336","url":null,"abstract":"\u0000 Favipiravir and remdesivir have recently received more clinical interest for the management of COVID-19. The study aimed to explore the effectiveness of favipiravir or remdesivir on the clinical outcome of SARS-CoV-2 patients in comparison with standard care. All patients were given standard care before being randomized into the following 3 groups: standard care group (standard care only), remdesivir group (remdesivir and standard care), and favipiravir group (group 3, favipiravir and standard care). The primary endpoint of the study was time to recovery or the clinical condition of patients on day 14. A total of 156 patients underwent randomization (53 assigned to standard care group, 51 to favipiravir group, and 52 to remdesivir group). The percentage of death in favipiravir and remdesivir groups was higher than those in the standard care group and likewise the liver enzymes. Studying the time to starting therapy showed that early administration of antivirals resulted in lower percentage of mortality. The ratio of hazard for early favipiravir and remdesivir was lower in comparison with those treated with late administration of the same drugs (hazard ratio, 0.62; 95% confidence interval [CI], 0.62–0.73 vs 3.22; 95% CI, 3.21–3.44, respectively, for favipiravir and 0.11; 95% CI, 0.10–0.12 vs 3.44; 95% CI, 3.43–3.55, respectively, for remdesivir). For favipiravir or remdesivir to have more beneficial effects than standard care alone for SARS-CoV-2 patients, they need to be started as early as possible. However, regular monitoring of liver function is required.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"34 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening and Decolonization Programs for Staphylococcus aureus Carriers in the Slamming-Practice Community: A New Strategy for Harm Reduction? 在抨击实践社区中筛查金黄色葡萄球菌携带者并进行去殖民化计划：减少危害的新策略？

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Infectious Diseases in Clinical Practice Pub Date : 2024-01-08 DOI: 10.1097/ipc.0000000000001337

V. Lobo Antuña, M. Lobo Antuña, Alejandro Fernández Soro, Benjamín Climent

{"title":"Screening and Decolonization Programs for Staphylococcus aureus Carriers in the Slamming-Practice Community: A New Strategy for Harm Reduction?","authors":"V. Lobo Antuña, M. Lobo Antuña, Alejandro Fernández Soro, Benjamín Climent","doi":"10.1097/ipc.0000000000001337","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001337","url":null,"abstract":"\u0000 Slamming is a widespread sexual practice that has been occurring in our society for more than a decade now. It has emerged as a public health issue because it associates many harm and risks, mainly derived from unsafe sexual practice and intravenous drug abuse. In the recent years, an additional concern has emerged regarding the rising occurrence of multidrug-resistant bacteria within the community, particularly strains of methicillin-resistant Staphylococcus aureus (S. aureus). In this report, we present the case of a human immunodeficiency virus patient addicted to parenteral-synthetic-cathinone use in the context of slamming, which developed necrotizing fasciitis by this resistant strain. As prevention measures, assuming the inevitability of slamming practices, harm reduction programs have been developed. Implemented for years, they aim to reduce the risks of addictive behaviors. This clinical case raises the question of whether methicillin-resistant S. aureus carrier screening and consequent decolonization among people who inject drugs, and more specifically among those engaged in slamming, should be included in the daily practice as another tool of these harm reduction programs.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"44 24","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Tale of Mummified Eggs in Urine of a US Veteran 美国退伍军人尿液中的木乃伊蛋的故事

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Infectious Diseases in Clinical Practice Pub Date : 2024-01-08 DOI: 10.1097/ipc.0000000000001338

Lana Abusalem, A. M. Roy, Shagufta Siddiqui, Anissa Hodges, Priyenka Thapa, Ryan Dare

引用次数: 0

Lessons From the Mpox Education and Vaccination Campaign 从麻风腮教育和疫苗接种活动中汲取的经验教训

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Infectious Diseases in Clinical Practice Pub Date : 2023-12-14 DOI: 10.1097/ipc.0000000000001352

David J. Cennimo

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Mpox Knowledge and Vaccine Willingness Among a Representative Analysis of Adults in Pennsylvania 宾夕法尼亚州具有代表性的成人麻疹疫苗知识和接种意愿分析

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Infectious Diseases in Clinical Practice Pub Date : 2023-12-14 DOI: 10.1097/ipc.0000000000001303

Casey N. Pinto, Kathryn A. Risher, William Calo, Jennifer Kraschnewski, Emily S Heilbrunn, Catharine I. Paules

{"title":"Mpox Knowledge and Vaccine Willingness Among a Representative Analysis of Adults in Pennsylvania","authors":"Casey N. Pinto, Kathryn A. Risher, William Calo, Jennifer Kraschnewski, Emily S Heilbrunn, Catharine I. Paules","doi":"10.1097/ipc.0000000000001303","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001303","url":null,"abstract":"\u0000 \u0000 Little has been reported about mpox knowledge and vaccine willingness. We sought to collect timely data on mpox knowledge, perceived risk, and vaccine willingness among a representative sample of Pennsylvania adults.\u0000 \u0000 \u0000 \u0000 A cross-sectional web-based survey was conducted in September 2022. Four survey items were included to assess the population's knowledge and risk awareness surrounding the current mpox outbreak, and vaccine willingness if at risk for mpox. Data analyses included descriptive statistics and logistic regressions.\u0000 \u0000 \u0000 \u0000 Among 1039 survey respondents, few reported “no knowledge of mpox symptoms” (14.2%) or transmission modalities (12.5%). Those who perceived themselves at moderate/high risk were more likely to report knowing mpox symptoms (adjusted odds ratio [aOR] = 2.12) vs no risk. Men who have sex with men were more likely to know that mpox can mimic a sexually transmitted infection (aOR = 3.125), less likely to report not knowing any modes of transmission (aOR = 0.17), and more willing to be vaccinated (aOR = 4.35) than women who have sex with men. Self-perceived mpox risk was associated with willingness to get vaccinated (aOR low risk vs no risk = 3.45 [2.42–4.92], aOR moderate/high risk vs no risk = 9.93 [5.81–16.99]).\u0000 \u0000 \u0000 \u0000 Knowledge of mpox symptoms and transmission is strong in Pennsylvania, specifically among high-risk groups, but lacks a nuanced understanding specific to the current outbreak. Willingness to receive an mpox vaccine is highest in men who have sex with men and those that perceive themselves to be at highest risk. These findings highlight the need for more education on symptoms of the current outbreak and research on impact of the education on vaccine hesitancy.\u0000","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"2021 15","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cryptococcal Infection Presenting as a Pleural Effusion in a Liver Transplant Recipient 一名肝移植受者出现胸腔积液的隐球菌感染

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Infectious Diseases in Clinical Practice Pub Date : 2023-12-11 DOI: 10.1097/ipc.0000000000001312

Basil Al-kaabneh, R. Alpizar-Rivas, S. Chuang, Purba Gupta

引用次数: 0

TikTok's Role in the COVID-19 Pandemic: An Analysis of the Spread of Treatment Information TikTok 在 COVID-19 大流行中的作用：治疗信息传播分析

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Infectious Diseases in Clinical Practice Pub Date : 2023-12-11 DOI: 10.1097/ipc.0000000000001319

Bilal Irfan, Ihsaan Yasin, Aneela Yaqoob

引用次数: 0

Empyema Necessitans Following Bacille Calmette-Guérin Administration for Urothelial Carcinoma 膀胱癌患者服用卡介苗后出现必要水肿

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Infectious Diseases in Clinical Practice Pub Date : 2023-12-11 DOI: 10.1097/ipc.0000000000001318

Maisam Amar, Gabriel Weber, Rabah Yassin, Ola Salah, Pninit Shaked Mishan, Maya Brudenski, Shereen Shehade, R. Najjar-Debbiny

引用次数: 0

Rapid Progression of Cunninghamella Species Leading to Respiratory Compromise 导致呼吸衰竭的坎宁安菌快速发展

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Infectious Diseases in Clinical Practice Pub Date : 2023-12-11 DOI: 10.1097/ipc.0000000000001331

Osejie Oriaifo, Melisa Pasli, Supriya Sivadanam, Brandon Tedder, Nim Chan, Olanrewaju K Adabale, Arthur Dilibe, Paul Cook

{"title":"Rapid Progression of Cunninghamella Species Leading to Respiratory Compromise","authors":"Osejie Oriaifo, Melisa Pasli, Supriya Sivadanam, Brandon Tedder, Nim Chan, Olanrewaju K Adabale, Arthur Dilibe, Paul Cook","doi":"10.1097/ipc.0000000000001331","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001331","url":null,"abstract":"\u0000 \u0000 Cunninghamella spp are a group of filamentous fungi commonly found in soil and decaying matter and can cause infections in immunocompromised individuals, especially those undergoing chemotherapy or with hematologic malignancies. These infections can lead to a rapidly progressive and fatal outcome. Despite accounting for less than 10% of documented mucormycosis cases, disseminated Cunninghamella infections have a higher mortality rate when compared with other mucormycosis.\u0000 We present the case of a patient with chronic myelogenous leukemia and myelodysplastic syndromes/myeloproliferative neoplasms overlap, receiving azacitidine, who initially presented with a diabetic foot ulcer infested with maggots. The patient rapidly developed respiratory distress and encephalopathy, with imaging revealing consolidation in the right upper lung lobe infected with Cunninghamella spp. Treatment with amphotericin B did not improve the patient's condition. Brain imaging also indicated a 24.4 × 16.9-mm lesion, and given the patient's comorbidities and disease progression, surgical intervention was not feasible. The patient was subsequently transitioned to comfort care.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"3 2","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138981066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated Infection With a Previously Undescribed Mycoplasma Species From a Cat Bite 被猫咬伤后感染了一种之前未曾描述过的支原体扩散性感染

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Infectious Diseases in Clinical Practice Pub Date : 2023-12-11 DOI: 10.1097/ipc.0000000000001314

Faisal Khan, Drew W Engers, Joshua A. Lieberman, Varsha Moudgal

引用次数: 0