Genel Tip Dergisi最新文献_第7页

CaSR Gen Polimorfizmin Kroner Arter Hastaların Patogenezinde Rolünün Araştırılması

Genel Tip Dergisi Pub Date : 2018-09-20 DOI: 10.15321/GENELTIPDER.2018343485

Kürşat Kargün

{"title":"CaSR Gen Polimorfizmin Kroner Arter Hastaların Patogenezinde Rolünün Araştırılması","authors":"Kürşat Kargün","doi":"10.15321/GENELTIPDER.2018343485","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018343485","url":null,"abstract":"Objective: Coronary artery disease is one of the most commonly seen heart diseases worldwide. Given high prevalence in developing countries, it is considered as most frequent causes of death worldwide. Disorders of calcium homeostasis such as primary hyperparathyroidism can increase mortality risk due to cardiovascular causes. In this study, we aimed to investigate role of rs1048213 and rs9883099 polymorphisms in CaSR gene in the pathogenesis of coronary artery disease and to determine whether they are associated to all-causes death and mortality. Material and Method: Data from patients with 135 coronary artery disease and 139 healthy volunteer without heart disease were compared in this study. rs1048213 and rs9883099 polymorphisms were screened by using real-time PCR in blood samples obtained from patients. Results: Significant differences were detected in biochemical parameters, BMI, hypertension, diabetes mellitus, smoking, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol when compared to controls (p<0.05). No significant difference was detected in rs1048312 polymorphism between patients with coronary artery disease and healthy controls while significant differences were detected in rs0993099 polymorphism and A allele (p<0.05). Conclusion: This study showed that there is a significant relationship between rs9883099 polymorphism, A allele and coronary artery disease.","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126268947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Akut Yüzme Egzersizi Yaptırılan Diyabetik Sıçanlarda İntraperitoneal Çinko Sülfat Uygulamasının Kas Dokusundaki Lipid Peroksidasyonuna Etkisi

Genel Tip Dergisi Pub Date : 2018-09-20 DOI: 10.15321/GENELTIPDER.2018343482

M. Biçer

引用次数: 1

Transfusion Transmitted Virüs (TTV) Prevalansı İnaktif Hepatit B Taşıyıcılarında Hemodiyalizden Etkileniyor Mu

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/geneltipder.2018241191

Servet Kolgelier, Nazlım Aktuğ Demir, Şua Sümer, L. Demir, Abdullah Arpacı

引用次数: 0

Kistik İntraserebral Görüntüleme Örneği İle Başvuran Multiple Skleroz Hastalığı: Olgu Sunumu 呈现脑内囊肿成像模式的多发性硬化症：病例报告

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/GENELTIPDER.2018241197

Fettah Eren, Gözde Öngün, Aslıhan Gezer, Hakan Ekmekçi

引用次数: 0

Uterin Serviksin Minimal Deviasyon Adenokarsinomu: Vaka Sunumu

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/GENELTIPDER.2018241198

Ayhan Gül, Z. E. Çelik, Tansel Çakir, Ersin Çintesun

引用次数: 0

Sağlık çalışanlarının cam tavan algısı 卫生工作者对玻璃天花板的看法

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/GENELTIPDER.2018241192

Hüseyin Demir

引用次数: 2

Hipertiroidili sıçanlarda uzamsal öğrenme performansına cinsiyetin etkisi

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/GENELTIPDER.2018241195

B. Tan, E. Babur, Hikmet Fırat Örnek, Cem Süer, Nurcan Dursun

{"title":"Hipertiroidili sıçanlarda uzamsal öğrenme performansına cinsiyetin etkisi","authors":"B. Tan, E. Babur, Hikmet Fırat Örnek, Cem Süer, Nurcan Dursun","doi":"10.15321/GENELTIPDER.2018241195","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018241195","url":null,"abstract":"Objective: In thyroid hormone level disorders such as hypothyroidism and hyperthyroidism in developmental period, experimental studies have shown that structural and functional changes in the brain. These changes are known to cause neurological disorders and impairments in cognitive processes, such as learning and memory, in which the hippocampus plays an important role. For this purpose, it is aimed to investigate spatial learning performance between hyperthyroidized male and female rats. Materials and Methods: Male and female rats were administered with L-thyroxine intraperitoneally at a dose of 0.2 mg/kg for 21 days to induce hyperthyroidism. Morris water maze (MWM) was used to assess learning and memory performance. Results: When repeated ANOVA tests were performed, the gender factor significantly affected the mean distance to the platform (p <0.001). In the following days and trials, the average distance of female rats to the platform is greater than male rats. This data suggest that female rats were swum longer distance to the platform and found the platform later. This effect of the gender factor was not affected by hyperthyroidism. In terms of memory performance, hyperthyroid group rats showed a significant decrease compared to the control group (p=0,023). It was also observed that gender difference increased this decrease in hyperthyroid state (p=0,020). It was observed that the ratio in the target quadrant of female hyperthyroid rats was lesser. Conclusion: As a result, spatial learning and memory performance in hyperthyroid rats varies according to sex.","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129764665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatrik Hastalarda Manyetik Rezonans Ürografi İle İntravenöz Piyelografinin Etkinliğinin Karşılaştırılması

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/GENELTIPDER.2018241196

Gökhan Polat

{"title":"Pediatrik Hastalarda Manyetik Rezonans Ürografi İle İntravenöz Piyelografinin Etkinliğinin Karşılaştırılması","authors":"Gökhan Polat","doi":"10.15321/GENELTIPDER.2018241196","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018241196","url":null,"abstract":"Objective: Intravenous pyelography (IVP) is a method of showing renal functions and anatomical features. However, it is not appropriate to use it in the pediatric age group because of ionizing radiation. For this reason, we are trying to evaluate urinary pathologies with magnetic resonance urography (MRU), which has become popular in recent years. In our study, we aimed to investigate the differences between MRU and IVU, showing dilution of urinary system. Materials and Methods: Male and female rats were administered with L-thyroxine intraperitoneally at a dose of 0.2 mg/kg for 21 days to induce hyperthyroidism. Morris water maze (MWM) was used to assess learning and memory performance. Results: There was no significant difference in the detection of pelvicalyceal dilatation between MRU and IVP (P <0.0001). MRU was found to be effective in evaluating parenchymal pathologies and in determining the underlying pathologies in patients with no nephrogram phase in IVP. Conclusion: There was no significant difference in the detection of pelvicalyceal dilatation between MRU and IVP (P <0.0001). MRU was found to be effective in evaluating parenchymal pathologies and in determining the underlying pathologies in patients with no nephrogram phase in IVP.","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116386951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/GENELTIPDER.2018241194

Z. E. Çelik, Güler Yavaş, Bursu Sanal Yılmaz, Tolga Tuyan Ilhan, Çağdaş Yavaş, Ozlem Ata

引用次数: 0

Artan Yüke Karşı Egzersiz Testi Sırasında Solunum Etkinliğinin Antrenmanlı ve Sedanter Erkek Deneklerde Karşılaştırılmalı İncelenmesi

Genel Tip Dergisi Pub Date : 2018-07-06 DOI: 10.15321/GENELTIPDER.2018241193

Çağrı Özdenk

引用次数: 0